Jingsen Ma, Dynaflow, Inc, United States
Focused Ultrasound (FUS), especially when amplified by Microbubbles (MB), offers non-invasive options for treating deep-seated and brain tumors and other neurodisorders, by enabling targeted surgical ablation and/or local blood-brain-barrier opening (BBBO) for effective drug deli [....] » Read More
Title : Neural nanomedicine: Fighting stroke, improving stem cell delivery, healing nerves and using artificial intelligence
Thomas J Webster, Interstellar Therapeutics, United States
Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For exa [....] » Read More
Title : Human understanding and machine intelligence: A systems neuroscience perspective
Yan M Yufik, Virtual Structures Research, Inc, United States
Aristotle’s “Metaphysics” starts with a pronouncement “Humans desire to understand”, establishing understanding capacity as the defining characteristic of human intellect separating humans from the other species. Throughout history, cognitive capacit [....] » Read More
Title : Novel stem cell therapy to boost recovery from ischemic brain injury
Xiaofeng Jia, University of Maryland School of Medicine, United States
Ischemic brain injury after Cardiac Arrest (CA) remains challenging with high mortality and disability and causes irreversible neurological dysfunction in over 90% of CA survivors. Current medical treatments do not effectively combat neuronal loss. Neural Stem Cell (NSC) engrafti [....] » Read More
Title : Cannabis/CBD for treating neurological disorders
Jag H Khalsa, GWU School of Medicine and Health Sciences, United States
Cannabis is the most used illegal drug in the world with an estimated 2.5% of the world’s population (180 million) using it regularly (World Drug Report 2017)1. Medicinal and/or recreational cannabis use is associated with significant health consequences) (WHO, 20162; Volko [....] » Read More
Title : Therapeutic inhibition of PI3K? attenuates neuronal endoplasmic reticulum stress improves functional recovery after traumatic brain injury in mice
Guohong Li, Penn State College of Medicine, United States
Traumatic brain injury (TBI) is a major cause of death and disability, often leading to persistent motor and cognitive deficits. Phosphoinositide 3-kinase γ (PI3Kγ), primarily expressed in immune cells, has been implicated in neuroinflammation in various neuropatholog [....] » Read More
Title : Therapeutic efficacy of cinnamein in controlled cortical impact mouse model of TBI
Jit Poddar, Rush University, United States
Traumatic brain injury (TBI) remains a major health concern which causes long-term neurological disability particularly in war veterans, athletes and young adults in United States. Despite of intense clinical and research investigations, there is no effective therapy to cease the [....] » Read More
Title : A case of nitrous oxide induced vitamin B12 deficiency with secondary myelopathy
George Diaz, Memorial Healthcare Systems, United States
Objective: To present a unique case of nitrous oxide (NO2)-induced vitamin B12 deficiency with secondary myelopathy. Background: Nitrous oxide (NO2), commonly known as “laughing gas”, is frequently used as an anesthetic agent, but is also abused recreationally in t [....] » Read More
Title : miR-590-3p delivery via nanoparticle technology inhibits recurrent GBM tumor growth by targeting multiple oncogenic nodes downstream of TGFBR2
Sophie Sall, Kennedy Krieger Institute, United States
Glioblastoma (GBM) is the most common central nervous system cancer diagnosed in adults. Heterogeneous and aggressive in nature, GBM is often found to resist standard of care (SOC) treatment and is almost guaranteed to recur. Upon recurrence, treatment options are very limited an [....] » Read More
Title : Neurochemical and behavioral effects of olanzapine in a high-risk schizophrenia mouse model
Sindhu Sriramoji Virdi, Rutgers University, New Jersey Medical School, United States
Schizophrenia is a mental disorder affecting behavior, cognition, and emotion. While schizophrenia is characterized by the dysregulation of dopamine in the brain, specifically the striatum, its physiology is undetermined. Olanzapine, an atypical antipsychotic, is commonly prescri [....] » Read More
Title : Serum levels of ferritin, iron and TIBC in cerebral venous sinus thrombosis
Nazanin Azizi, University of California Davis, United States
Background: Cerebral venous sinus thrombosis (CVST) is a potentially life-threatening condition with a wide range of clinical presentations from localized headache (the most common symptom) to mental status disturbances, seizure and coma. The main purpose of this study is to eval [....] » Read More
Title : Choroid plexus volume and microstructural changes in prodromal Parkinson’s disease: Insights from 7 Tesla MRI
Firdaus Fabrice Hannanu, Massachusetts General Hospital and Harvard Medical School, United States
The choroid plexus (ChP) is increasingly recognized as a pivotal contributor to neurosecretory and neuroimmune processes. Alteration in ChP volume has been extensively studied in the context of aging, psychiatric disorders, and Alzheimer's disease, and it has been recently li [....] » Read More
Title : Clinical characteristics and management practices of pediatric status dystonicus
Karissa Chesky, Baylor College of Medicine, United States
Objective: We present 20 cases of pediatric status dystonicus at a major pediatric center and describe their clinical course. Background: Status dystonicus (SD) is a rare, life-threatening neurological emergency characterized by continuous, severe episodes of general [....] » Read More
Title : Intermittent hypoxic conditioning-induced exosome: Intervention for Ischemic stroke treatment
Myoung-gwi Ryou, Tarleton State University, United States
Ischemic stroke is a leading cause of death and adult disability worldwide. Currently, the only FDA-approved treatment is tissue plasminogen activator (tPA). Over two decades ago, normobaric Intermittent Hypoxic Training (nIHT) was identified as beneficial for ischemia and reperf [....] » Read More
Title : Autism spectrum disorder detection using FMRI imaging with convolutional neural networks
Xiao Chang, Tuskegee University, United States
Purpose: Autism spectrum disorder (ASD) is a neurological and developmental disorder that affects how people interact with others, communicate, learn, and behave. The number of children diagnosed with autism spectrum disorder (ASD) has risen consistently and dramatically since th [....] » Read More
Title : Targeting oncogenic YY1 in resistant glioblastoma multiforme
Inesa Navasardyan, Western University of Health Sciences, United States
Background: The oncogenic transcription factor Yin Yang 1 (YY1) is critical in the pathogenesis of glioblastoma multiforme (GBM), a highly aggressive brain tumor Given the poor response of GBM to current treatments, there is an urgent need for a new therapeutic intervention. [....] » Read More
Title : Application of AI and computational approaches supporting new generation healthcare aiming at prevention with focus on gender differences
Erwin L J Roggen, ToxGenSolutions BV, Netherlands
ToxGenSolutions is a biotech company focused on developing novel and innovative methods to drive the discovery of impactful and personalized early-stage diagnostics and therapeutics with focus on prevention of chronic disease (Alzheimer’s disease, pain syndromes and long-CO [....] » Read More
Title : Auricular vagal nerve stimulation in patients with mild cognitive impairment due to Alzheimer’s disease: A randomized placebo double-blind study
Adam Broncel, Neuromedical, Poland
Background: This study was conducted on patients who were diagnosed with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). Methods: Auricular transcutaneous vagal nerve stimulation (atVNS) was applied using a VGuard device specifically designed to minimize m [....] » Read More
Title : Intracranial vein of galen malformation and its management: A case report
Jubran Al Hooti, University College Dublin, Ireland
Introduction: Vein of Galen Malformation (VOGM) is a rare congenital arteriovenous malformation affecting the pediatric population. It is characterized by a fistula between the diencephalon and a dilated vein of Galen. VOGMs occur when the prosencephalic vein of Markowski, the fe [....] » Read More
Title : Biomarkers in alzheimer´s disease – New perspectives
Gustavo Alves A dos Santos, Sao Leopoldo Mandic Araras, Brazil
The development of an early and assertive diagnosis of Alzheimer’s Dementia can contribute to a better quality of life for patients, mainly by providing targeted therapy with measurable results. Biomarkers can be detected in blood levels and, more recently, the feasibility [....] » Read More
Title : Development of novel miR-dependent genome-editing Adeno-associated virus that selectively eradicates glioblastoma-initiating cells
Toru Kondo, Hokkaido University, Japan
Glioblastoma (GBM), one of the most malignant human cancers, frequently recurs despite multimodal treatment with surgery and chemo/radiotherapies. One of the reasons of why GBM recues is likely the existence of GBM-initiating cells (GICs) that have strong proliferative and tumori [....] » Read More
Title : Necrobotics 360: Shaping the future of healthcare
Raul V Rodriguez, Woxsen University, India
Necrobotics 360: Shaping the Future of Healthcare" presents a transformative vision where cutting-edge artificial intelligence (AI) technologies converge with healthcare, redefining the future of medical practices. It is an innovative approach that integrates AI, machine lea [....] » Read More
Title : The role of the circadian rhythm in alzheimer's disease and aging
Mohamad Sultan Khan, University of Hyderabad, India
During the course of evolution and earth’s rotation round its axis, the surface inhabitants are exposed to daily a predictable light and dark condition which impose specific demands on the physiology and influences the behaviour of an organism. Such cyclic patterns in the p [....] » Read More
Title : A collaborative innovation in developing the novel Head And Trunk Control Rehabilitation (HATCoRe) device for children with cerebral palsy: Revolutionizing pediatric rehabilitation
Shristi Shakya, Manipal College of Health Professions, India
Background and objectives: A delay in achieving head and trunk control can present numerous challenges in the activities of daily living for children with Cerebral Palsy (CP). This frequently require extended therapy, which may become repetitive, leading to decreased engagement i [....] » Read More
Title : Probiotics and rTMS synergistically alleviate cognitive and motor deficits in 6-OHDA-induced parkinson’s disease rats
Shweta Sharma, All India Institute of Medical Sciences, India
Introduction: Non-invasive repetitive Transcranial Magnetic Stimulation (rTMS) and probiotics intervention have been demonstrated to improve motor functions and alleviate cognitive deficits in 6-OHDA rat model of Parkinson’s disease (PD). Despite this, it is still unknown w [....] » Read More
Title : Microglial activation visualized by 18F-DPA714 PET is a potential marker of severity and prognosis for Anti-LGI1 encephalitis
Jingguo Wang, Fudan University, China
Background and Purpose: Whether microglial activation plays important role in the pathogenesis of autoimmune encephalitis (AE), such as anti-leucine-rich, glioma-inactivated-1 (LGI1) encephalitis, remains unknown. 18F-DPA714 PET targeting the translocator protein (TSPO [....] » Read More
Title : Insomnia and its correlates in migraine patients with or without aura
Khalid Alquliti, Taibah University, Saudi Arabia
Introduction: Migraine, the second leading cause of disability, is a primary headache disease prevalent throughout the world, causing malaise, loss of quality of life, and a substantial cost in medical care Migraine and sleep disturbances are widely prevalent, and usually bidirec [....] » Read More
Title : Cavernous angioma of the cauda equina: A case report
Joao Victor Ribeiro, Sao Leopoldo Mandic Medical School, Brazil
Introduction: Cavernous angiomas are benign vascular malformations characterized by abnormally dilated vessels that lack interposing neural tissue. The presentation can occur in any region of the central nervous system, but most commonly, supratentorial. This report details a rar [....] » Read More
Title : Dorsal dysraphism with lipoma (lipomyeloschisis): Case report
Joao Victor Ribeiro, Sao Leopoldo Mandic Medical School, Brazil
Introduction: Neural tube defects (NTDs) are secondary abnormalities during the embryogenic development of the central nervous system (CNS). Between the 17th and the 28th day after fertilization, neurulation happens in two moments: primary and secondary neurulation. Secondar [....] » Read More
Title : Developing an online task to examine how attention to detail affects learning dynamics
Mary Avella, Hunter College, United States
Autism Spectrum Disorder is a neurological disorder that affects how a person communicates and interacts with others. One way people on the spectrum are different from neurotypical people is in their attentional focus. In particular, those on the spectrum have been shown to pay c [....] » Read More
Title : Projective testing as windows to the mind: Unveiling anxiety's expression through artistic mediums in teenagers
Aryan Shah, William P. Clements High School, United States
Nearly one in three of all Americans aged 13 to 18 experience an anxiety disorder. It is important now to accurately diagnose anxiety in adolescents. Current methods of diagnosis involve psychological evaluations and questionnaires. However, unconscious bias and stereotypes can i [....] » Read More
Title : Projective testing as windows to the mind: Unveiling anxiety's expression through artistic mediums in teenagers
Rhea Ahuja, William P Clements High School, United States
Nearly one in three of all Americans aged 13 to 18 experience an anxiety disorder. It is important now to accurately diagnose anxiety in adolescents. Current methods of diagnosis involve psychological evaluations and questionnaires. However, unconscious bias and stereotypes can i [....] » Read More
Title : A case of normal pressure hydrocephalus in an elderly male
Michael Sulaiman, Edward Via College of Osteopathic Medicine, United States
Normal pressure hydrocephalus is a rare neurologic disorder primarily impacting older adults, classically presenting with clinical triad of gait dysfunction, cognitive impairment, and urinary incontinence, in addition to hydrocephalus on brain imaging. Normal pressure hydrocephal [....] » Read More
Title : Traumatic iatrogenic posterior interosseus nerve axonotmesis due to peripheral intravenous insertion: A case report
Dominique Smith, Loma Linda University Education & Health Consortium, United States
We present a case of a 43-year-old patient with a past medical history of intravenous drug abuse who presented with one month of numbness, pain, and paresthesia localized to the left posterior forearm and dorsum of hand. The patient also endorsed subjective weakness affecting gri [....] » Read More
Title : Decoding complexity: Readability analysis of public online health information on common neurological diagnoses
Puja Punukollu, Augusta University, United States
Neurological disorders, comprising conditions like dementia, migraines, and stroke, pose significant health challenges globally. In the digital age, individuals increasingly turn to online platforms for health information. Given the intricate nature of neurological conditions, ev [....] » Read More
Title : Evaluate the efficacy of AXL inhibitor bemcentinib in the rNLS8 mouse model of amyotrophic lateral sclerosis
Guyin Chen, University of Pennsylvania, United States
Aim and Methods: We aim to evaluate if the pharmacological inhibition of the myeloid/microglial receptor tyrosine kinase AXL could be used as a novel therapeutic approach for Amyotrophic Lateral Sclerosis (ALS). The objective of the present research is to evaluate the efficacy of [....] » Read More
Title : Effect of lower extremity proprioceptive neuromuscular facilitation on stair ambulation in persons with stroke: A pre-post study
Rikesh Shrestha, Sentara Health, United States
Background and objectives: Persons with stroke often encounter challenges in ambulation due to impaired motor function and coordination. The aftermath of stroke can significantly affect a person’s ability to ambulate independently, necessitating tailored intervention for re [....] » Read More
Title : Innovative sEEG based device for neural recordings, ablation and drug delivery into the brain
Aura Kullmann, NeuroOne Medical Technologies, United States
Stereoelectroencephalography (sEEG) electrodes are routinely used to identify the epileptogenic zone (EZ) in patients with drug resistant epilepsy. The sEEG electrodes are FDA-cleared for temporary (<30 days) neural activity monitoring, recording and stimulation. Here we prese [....] » Read More
Title : A rare case of paroxysmal kinesigenic dyskinesia
Abhishek Pant, Texas Tech University of Health Science Center El Paso- Transmountain, United States
Introduction: Paroxysmal Kinesigenic Dyskinesia (PKD) is a rare neurologic disorder characterized by transient, episodic, involuntary hyperkinetic movements such as chorea, dystonia, myoclonus, or ballism. It is triggered by sudden voluntary movements, commonly present in yo [....] » Read More
Title : Golexanolone, a GABAA receptor-modulating steroid antagonist, improves microglia activation and tyrosine hydroxylase levels in substantia nigra, dopamine in striatum and several motor and non-motor alterations in 6-OHDA rats
Magnus Doverskog, Umecrine Cognition AB, Sweden
There are no drugs available for Parkinson’s disease (PD) that alter progression of disease. Current symptomatic treatments provide imperfect relief and have side effects. Enhanced GABAergic neurotransmission contributes to PD pathogenesis. In animal models, GABA levels are [....] » Read More
Title : Taekwondo as a transformative treatment plan for mental disabilities and disorders
William Breska, University of Central Florida, United States
The application and study of combat sports and martial arts can be found throughout human history. From the development of wrestling in Greece over the course of millennia to the 1950s and the development of taekwondo in Korea, martial arts are a cornerstone of human development [....] » Read More
Title : IgG4-related hypophysitis: A unique presentation of a rare disease
Maxime A Braun, University of Connecticut School of Medicine, United States
Immunoglobulin G4-related disease (IgG4-RD) is an autoimmune condition in which IgG4-positive plasma cells locally or systemically infiltrate tissues and cause damage through inflammation and fibrosis. While IgG4-RD has been reported in nearly every organ, it preferentially manif [....] » Read More
Title : Mapping brain responses to emotional stimuli: ERP investigation of children with reading difficulties during affectively modulated Go/No-Go
Anesa Shahid, Syracuse University, United States
Having reading difficulties during early childhood significantly impacts both academic performance and daily functioning. Children with reading difficulties often struggle to perform well in school activities compared to their peers. In their daily lives, they encounter challenge [....] » Read More
Title : Investigating visuospatial working memory for facial emotion and identity
BriAnna Lowe, Western Kentucky University, United States
The central executive plays a key role in the encoding of visual stimuli in working memory, including the memory for faces in a social context. Faces often contain important details about the identity of social targets as well as the emotion that these targets are expressing. Enc [....] » Read More
Title : The effects of exam question formats on teenage neurodivergent student performance
Suhani Gupta, Neuro Health Alliance, United States
As of 2024, up to 30% of teenagers worldwide are neurodivergent, not even including comorbid conditions such as anxiety and depression. This study investigates the impact of different exam question formats on the academic performance of neurodivergent teenagers compared to their [....] » Read More
Title : miR30c-mimic ameliorates acute ischemic stroke in mice by reducing thromboinflammation and attenuating neuronal ER stress
Rong Jin, Penn State Hershey Medical Center, United States
Decreased expression of endogenous miR-30c has been linked to numerous pathological conditions in both patients and animal models, including various cancers, hyperlipidemia, atherosclerosis, hyperglycemia, and diabetes. Systemic administration of a miR-30c mimic has been de [....] » Read More
Title : J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress via the AMPK/ SREBP-1 pathway
Rong Jin, Penn State Hershey Medical Center, United States
Endoplasmic Reticulum (ER) stress is recognized as a crucial contributor to the progression of Traumatic Brain Injury (TBI) and represents a potential target for therapeutic intervention. This study aimed to assess the potential of J147, a novel neurotrophic compound, in alleviat [....] » Read More
Title : Diagnostic cerebral and spinal digital subtraction angiography at Punjab institute of neurosciences Lahore: A single center experience
Rana Muhammad Usama, Punjab Institute of Neurosciences, Pakistan
For cerebrovascular diseases, catheter based cerebral and spinal digital subtraction angiography (DSA) prevails as the the preferred imaging modality. The role of digital subtraction angiography is flourishing since the incorporation of diverse endovascular therapeutic approaches [....] » Read More
Title : CNS coccidiomycosis in an individual with multiple sclerosis on fingolimod – A case report
Pantea Sazegar, University of Arizona College of Medicine - Tucson, United States
Introduction: Fingolimod is an FDA-approved oral disease-modifying therapy for relapsing-remitting forms of multiple sclerosis and works through inhibition of lymphocyte egress from secondary lymphoid organs, reducing circulating levels of lymphocytes. While Fingolimod, and [....] » Read More
Title : The neurobiology of cognitive load: A comparative study of neurodivergent and neurotypical brains
Christina Barrios Arguello, University of California, United States
Working memory is essential for various important cognitive processes, including reasoning and decision-making. While changes in working memory have been noted among neurodivergent groups, there is a lack of comprehensive and focused research outlining how cognitive load and the [....] » Read More