Title : Identification of solanum nigrum (leaves extract) phenolic compounds, their effects on behavior and blood biochemistry of rotenone induced parkinson’s rat model
Abstract:
Parkinson's disease (PD) is a chronic disease of the central nervous system that affects almost 1% of the elderly population. In recent years, phytocomponents have aroused considerable interest in research for PD treatment as they provide a variety of active compounds, including antioxidant and anti-inflammatory compounds. The study aimed to find out the toxic effects of chemicals on ROS+, levels of neurotransmitters, interlinked disfunction of body organs, and possible therapy with Solanum nigrum leaf active compounds. GCMS analysis of SNE leaf extract revealed phenolic chemicals with high antioxidant potential. Results demonstrated that consecutive treatment with rotenone creates oxidative stress in the brain and body, as confirmed by blood biochemistry, serum, and neurochemical analysis. 28-days treatment with SN leaf extract significantly decreased symptoms of PD by decreasing oxidative stress in the whole body. Behavior analysis indicated that PD carriers lost basal ganglion movement, muscle strength, coordination, balance, and muscle stability. A low level of hemoglobin is associated with iron deficiency, an indicator of reduced dopaminergic activity and the basic cause of PD. A high level of glucose reduced dopaminergic activity. SNE-treated groups have a higher level of hemoglobin as compared to control and rotenone-treated groups; alternatively, platelet counts were very low in the SN-treated group. Low levels of urea, creatinine, ALT, ALP, and cholesterol were found in the SN-treated group as compared to the control, diseased, and SOL+ROT groups. It concluded that SN has a therapeutic effect on neuron degeneration and oxidation.
Audience Take Away Notes:
- Audience can use the dietary preferences to prevent the Parkinson.
- how the mechanism involved and benefits of phytochemicals in that sense faculty can use the basic outlines for further approaches.
- Accuracy in out experimental designs will guide the other researchers to follow it abd move on.
- How food items and preferences will improve the life style and health.
