Importance of physiological researches of the altered states of consciousness (ASC) arising at adaptation of the person to performance of a certain activity is known (for example illusions of monototy in pilots, cosmonauts, operators of complex systems). This importance follows at least from the fact that the majority of accidents are caused by a h [....] » Read More
The experiments established a number of patterns in the development of demyelinating and degenerative changes in the brain, spinal cord and sciatic nerve in the acute and long term after stroke. An experimental model of unilateral hemorrhagic stroke, characterized by 100% hematoma reproduction in the right inner capsule of the brain and the develop [....] » Read More
In order to assess the current therapeutic potential of cannabis and cannabinoids in brain diseases, a meta-analysis was performed through Medline and PubMed up to september 1, 2019.The key words used were cannabis,marijuana,marihuana,hashish,hashich,cannabinoids,tetrahydrocannabinol,THC,dronabinol,nabilone,nabiximols,cannabidiol, CBD, randomized, [....] » Read More
15-year-old patient presented with long term chronic migraines. Pre NeuroPhysics Therapy (NPT) the patient spent just 10 days at school throughout the year due to the severity of the migraines. The medical approach was to attempt to manage the symptoms/condition through long term intensive medication. Despite all previous intense conventional medic [....] » Read More
The visualization of nerve cells is important for the advancement of neurological research and the comprehension of the foundations of the functioning of the human brain. At the cellular level, dendritic spines are the smallest multifunctional units that reflect cellular connectivity and can modulate postsynaptic processing and plasticity. Differen [....] » Read More
Copy number variations (CNVs) of the 3p26.3 region are often the cause of neurodevelopmental disorders, including intellectual disability, developmental delay and autism spectrum disorder. Recently, a publication appeared with description a patient-carrier of a duplication involving the CNTN6 (encoding contactin-6) gene with manifestation neurodeve [....] » Read More
Misfolding and aggregation of proteins such as amyloid-β (Aβ), tau and alpha-synuclein (?-syn) is the predominant pathology underlying the neurodegenerative disorders, Alzheimer’s disease (AD) and Parkinson’s disease (PD). Although end stage insoluble products of aggregates are the key pathological hallmark of the diseases, th [....] » Read More
Introduction Congenital myopathies are heterogeneous group of neuromuscular disorders and characterised by hypotonia early onset muscular weakness, developmental delay. Congenital myopathies are classified into centranuclear myopathies, nemaline myopathies, core myopathies and congenital fiber-type disproportion based on major pathological f [....] » Read More
Background: The prevalence of dementia, which presents as cognitive decline in one or more cognitive domains affecting function, is increasing worldwide. Traditional cognitive screening tools for dementia have their limitations, with emphasis on memory and, to a lesser extent, on the cognitive domain of executive function. The use of virtual realit [....] » Read More
Aims. The problem of medical rehabilitation and social adaptation of children with organic diseases of a nervous system, first, with the cerebral palsy (CP), remains relevant. The considerable prevalence, complexity and versatility of clinical manifestations, severity and high percent of an invalidism create difficulties in rehabilitation of childr [....] » Read More
Background Neurologic disorders are caused by a either neural cell loss or neurologic cell injury processes. Management of these disorders would therefore be to replace the lost cells, clear the pathological hallmarks or repair cell function. Stem cells offer the possibility of a renewable source of replacement cells and tissues as a form of treat [....] » Read More
The End-Stage Renal Disease (ESRD) is a worldwide public health problem. For about 70 years, the scientific community has been aware of and has focused on the study of kidney function deficiencies and cognitive decline. There is empirical evidence that ESRD is associated with various brain function disorders (Sedaghat, S. et. al (2014). It is also [....] » Read More
Sensorineural hearing loss is an urgent problem, it significantly reduces the quality of life of patients, the molecular mechanisms of its occurrence are not fully understood, and in fact there are no effective and safe methods of treatment that stop the progression of the process. Aim: to study the dependence of the rate of SNHL progression of pr [....] » Read More
Lymphangiomatous lesions are rare congenital malformations of the lymphatic system that occur throughout the body with greater frequency in the cervico facial area. The incidence of lymphangiomas has been reported to range from 1.2 to 2.8 per 1000 newborns. The most prominent sign or symptom of all lymphangiomas is the presence of mass. It had asso [....] » Read More
Tau proteins help maintaining the structure of a neuron, including tiny tube-like structures called microtubules, which deliver nutrients throughout cells. However, when hyperphosphorylated, these proteins can become toxic for neurons by forming tangles in the hippocampus; one important region of the brain early affected by Alzheimer’s diseas [....] » Read More
Introduction Motor neuron disease (MND) refers to a heterogeneous group of conditions characterized by degeneration. Lower Motor Neurons (those that have a cell bodies in the cranial nerve nuclei or in the anterior horn of the spinal cord and synapse directly on muscle)andUpper Motor Neurons (those that have cell bodies in the brain and synapse on [....] » Read More
Mild cognitive impairment (MCI) is the transitional stage between normal aging and Alzheimer’s disease.The criteria for mild cognitive impairment for person with memory loss but without dementia given by Petersen et al., 1991 were memory issue, abnormal memory for age, general cognitive function preserved rather than memory deficit, unaffecte [....] » Read More
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive loss of neurons.. Recent studies indicate that before the AD ,emerges a process of hypometabolism with a simultaneous reduction of the autophagy ;this fact promotes the increase of urea in brain This study aims to demonstrate how the adminis [....] » Read More
Oxidative stress has been described as a major cause of nigrostriatal degeneration in familial and idiopathic Parkinson’s disease (PD). Moreover, NADPH oxidase 2 (NOX2) and the mitochondrial electron transport chain, the major enzymatic sources of reactive oxygen species (ROS) in neural cells, appear intimately related in a redox regulatory p [....] » Read More
Translingual neurostimulation (TLNS) and new neurorehabilitation technology represent a synthesis of a non-invasive brain stimulation technique with multiple applications in physical medicine, cognitive, and affective neurosciences. Our new stimulation method appears promising for the treatment of a full spectrum of balance, posture, movement disor [....] » Read More
Ageing is associated with declining immune responses and Alzheimer’s disease (AD). Infective agents, both bacteria and viruses, have been suggested to play a role in the clinical progression of AD. Decreased immune efficiency viruses might increase the brain risk of chronic infections and inflammation. Antimicrobial brain immune responses in [....] » Read More
Alzheimer’s disease (AD) is an illness manifested by a number of pathological and clinical features, which including amyloid beta (Aβ) peptide deposits, neurofibrillary tangles (NFTs), dystrophic neurites, cholinergic impairment and neuronal death. To date, three acetylcholinesterase inhibitors (AChEi) (donepezil, rivastigmine and galant [....] » Read More
The proportion of cognitive dysfunction occurring three months after stroke has been estimated between 24% and 39%. Post-stroke cognitive impairment (PSCI) seriously reduces patients’ quality of life. The active control of hyperglycemia and hyperlipidemia is recommended for the prevention of PSCI. The impact of controlling behavior-related ca [....] » Read More
Spinal muscular atrophies (SMA), prevalence of 1.5:100.000, recessive inheritance, neuromuscular diseases with anterior medullary horn degeneration, are caused by mutations in the survival of motor neuron protein, represented by SMN1 and SMN2 genes, supporting the motor neurons in the medulla and brainstem. They’re classified according to sym [....] » Read More
15-year-old patient presented with long term chronic migraines. Pre NeuroPhysics Therapy (NPT) the patient spent just 10 days at school throughout the year due to the severity of the migraines. The medical approach was to attempt to manage the symptoms/condition through long term intensive medication. Despite all previous intense conventional medic [....] » Read More
Quality of life (QOL) is a broad multidimensional conception that includes subjective evaluations of both positive and negative aspects of life. Although health is one of the important domains of overall quality of life, there are other domains as well- like jobs, housing, schools, the neighborhood. Aspects of culture, values, and spirituality are [....] » Read More
Most vertebrates show concussion responses when their heads are hit suddenly by heavy objects. Previous studies have focused on the direct physical injuries to the neural tissue caused by the concussive blow. We study a similar behaviour in a simple vertebrate, the Xenopus Laevis tadpole. We find that concussion-like behaviour can [....] » Read More
Background: Seizures often occur in substance abusers. The present work aimed to study the etiology of non-response to antiepileptic drugs by estimating their serum levels and screening of drugs and substance abuse in patients with resistant epilepsy. Methods; this study was conducted in epilepsy outpatient clinic, neurology department, Mansoura U [....] » Read More
Refractory Spasticity is a harmful and disabling condition, caused by upper motor lesions of different aetiologies, producing with time motor dysfunction, skeletal deformities, muscle atrophy, etc, which has poor options of treatment hence basic and clinical research is being conducted. The goal for its treatment is to reduce the number of abnorma [....] » Read More
Multiple sclerosis is among the most common causes of neurological disabilities in young adults. Over the past decade, several therapeutic strategies have emerged as having potential neuroprotective and neuroregenerative properties. We investigated the effect of intranasal administration of LINGO-1–directed siRNA-loaded chitosan nanoparticles [....] » Read More
Title : New ideas and approaches in treatments for chronic and complex neurological conditions
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
An initial study involving a random selection of 5 patients who were diagnosed MND positive and who were in at a moderately advanced stage (e.g. not able to walk unassisted, voice impedance and moderate upper limb and discriminative fine motor impairments), was implemented initially out of curiosity and patient desperation requests, to determine if [....] » Read More
Title : Functional Neuroimaging for Prognostics and Diagnostics in Brain Disorders
Radu Mutihac, University of Bucharest, Romania
Although the diagnosis of neurological disorders still depends on clinical criteria, recent advances in neuroimaging techniques, such as magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), diffusion tensor imaging (DTI), diffusion spectroscopic imaging (DSI), tractography, magnet [....] » Read More
Title : Dynamics for/with fractals and applications
Marat Akhmet, Middle East Technical University, Turkey
The comprehension of the world through fractals promises to be one of the effective ways for creative scientific, biological, social, medical, and industrial activities. We are confident that self-similarity extended to arbitrary small scales of real world subjects is in the core of effectiveness of researches of the universe and helps to optimize [....] » Read More
Title : Exploring the therapeutic value of infrared thermography during NeuroPhysics Therapy
Jeff Erichsen, NeuroPhysics Therapy Rehabilitation, Australia
The distribution of emitted thermal energy and more predominately calculated temperatures from the skin have long been explored as a method in determining symmetry, balance and health in the human system; or lack thereof. In recent years, the Infrared Thermography (IRT) camera has come to the forefront as a fast and accurate evaluation tool in this [....] » Read More
Title : Quantitative and Pathological Specific MRI Biomarkers of Spinal Cord Injury
Li Min Chen, Vanderbilt University Medical Center, USA
SCI has devastating consequences for patients with severe impairments of motor and/or sensory functions, and has a significant impact on quality of life, life expectancy and economic burden. There are no fully restorative therapies for SCI as yet, but preclinical studies have found that SCI creates tissue cavities, disrupts the proper functioning o [....] » Read More
Title : Bullying at Workplace and Brain-Imaging Correlates
Alberto Negro, University of Campania Luigi Vanvitelli, Italy
The relationship between psychosocial stress at work and mental health outcome is well-known. Brain-imaging studies hypothesize morphological brain modifications connected to work-related stress.To our knowledge this is the first study describing the link between work c haracteristics and brain imaging in a sample of work-related psychiatric patien [....] » Read More
Title : Heterochromatization of a large-scale duplication in 3p26.3 region involving the CNTN6 gene in a patient with neurodevelopmental disorders and intellectual disability
Maria Gridina, Institute of Cytology and Genetics SB RAS, Russia
Copy number variations (CNVs) of the 3p26.3 region are often the cause of neurodevelopmental disorders, including intellectual disability, developmental delay and autism spectrum disorder. Recently, a publication appeared with description a patient-carrier of a duplication involving the CNTN6 (encoding contactin-6) gene with manifestation neurodeve [....] » Read More
Title : Sporadic Creutzfeldt-Jakob Disease: a retrospective analysis of 104 cases
Jia-Tang Zhang, Department of Neurology, Chinese PLA General Hospital, Beijing, China
Background Sporadic Creutzfeldt-Jakob disease (sCJD) is an extremely rare fatal and infectious neurodegenerative brain disorder characterized by rapidly progressive dementia, cerebellar ataxia and visual disturbance. This study summarized 104 sCJD cases in the First Medical Center of Chinese PLA General Hospital from 2003 to 2019. Methods A retr [....] » Read More
Title : What Big Data Analytics can do for Stroke Patients
Deanna Anderlini, The University of Queensland, Australia
Introduction Data from UK and USA’ studies show that the average age of stroke patients is falling. Give that stroke is the main cause of adult disability, it becomes essential for policy makers to know the trends and the outcomes of the prevention campaigns/therapies. Methods Our retrospective study included 244,276 admissions to Hosp [....] » Read More
Title : The role of branched-chain amino acids in the epileptic brain: recent advances and controversies
Shaun Gruenbaum, Mayo Clinic, Jacksonville, Florida, United States
Epilepsy is a heterogeneous group of chronic neurological disorders characterized by recurrent, spontaneous seizures. Epilepsy affects approximately 1% of the population worldwide and carries a significant societal burden. The treatment of epilepsy is focused on reducing the frequency and severity of seizures, minimizing side effects of treatment, [....] » Read More