Vascular contributions to cognitive impairment and dementia (VCID) have high morbidity and mortality, and diabetes is a leading factor for VCID. The signaling mechanisms for diabetes-induced VCID are largely unknown, and the current treatments for VCID are neither very specific n [....] » Read More
An analysis of 1200+ existing missense ACE mutations revealed that more than 400 mutations are predicted to be damaging and led us to hypothesize that heterozygous carriers of these loss-of-function (LoF) ACE mutations (which result in low ACE levels) may be at risk for the [....] » Read More
Background: Hydrocephalus is a common and lifelong neurological condition in children, most often managed by cerebrospinal fluid (CSF) shunt systems. Due to the potentially life-threatening consequences of shunt failure, even subtle symptoms such as headache, vomiting, or letharg [....] » Read More
Objective: To evaluate the outcomes of surgical decompression and determine the factors predicting post-operative motor recovery in patients with unilateral footdrop and to propose a critical time frame for operative management. Design: Systematic review and meta-analysis (using [....] » Read More
Astrocytes, as key components of the neurovascular unit, play a significant role in maintaining blood-brain barrier (BBB), regulating neurotransmitter homeostasis, and modulating neuroimmune signaling. Changes in astrocyte density can influence the stability and permeability of t [....] » Read More
Ischemic stroke is one of the leading causes of death and long-term disability worldwide. While tissue plasminogen activator (t-PA) is a primary clinical treatment in Emergency care, its efficacy is limited to a narrow therapeutic window, which is less than 4.5 hours post-onset. [....] » Read More
Parkinson’s disease (PD) is a prevalent neurologic disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). This augments the indirect pathway by over-exciting the sub-thalamic nucleus (STN) causing excessive suppressio [....] » Read More
White matter deterioration is a hallmark of cognitive aging and a core feature of many neurodegenerative disorders. Cardiorespiratory fitness (CRF) has emerged as a modifiable factor that may support white matter integrity across the adult lifespan. This meta-analytic review synt [....] » Read More
Background: Progressive supranuclear palsy (PSP) is the second most common parkinsonian disorder after idiopathic Parkinson’s disease; yet, it remains frequently misdiagnosed, with only 4,000 confirmed cases reported in the UK by the PSP Association .While neuropsychiatric [....] » Read More
Care homes play a crucial role in providing specialized care and support to individuals with neurological conditions such as Alzheimer's disease, Parkinson's disease, and stroke survivors. These facilities offer a safe and structured environment, tailored to meet the uniq [....] » Read More
Definition and Types: TBI is an injury to the brain caused by external force, resulting in a range of effects. It can be classified as mild (concussions), moderate, or severe based on symptoms and impact. Causes: Common causes include falls, vehicle accidents, sports in [....] » Read More
Implant infection is rising with the U.S. Centers for Disease Control predicting one person every three seconds will die from a bacteria infection by 2050. Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundr [....] » Read More
Healthcare systems around the world are undergoing an organizational, methodological and technological transformation towards personalized, preventive, predictive, participative precision (5P) medicine ecosystems. These ecosystems consider individual health status, conditions, ge [....] » Read More
As the world’s population ages, Cognitive Frailty (CF) is becoming one of the most serious health problems and elucidating its biological mechanisms along with prevention and treatments becomes increasingly important also considering the associated health costs. We thus per [....] » Read More
Background: Autism spectrum disorders (ASD) are a series of neurodevelopmental disorders characterized by social disorders, rigid behaviors and narrow interests.The World Health Organization (WHO) estimates that the prevalence of ASD has been increasing over the past 50 years. Wi [....] » Read More
Background: Oxaliplatin (OXA), a platinum-based chemotherapeutic agent, is widely used in colorectal cancer treatment but frequently induces severe side effects, including peripheral neuropathy, motor deficits, and muscle wasting. These complications often limit treatment adheren [....] » Read More
Paroxysmal Dyskinesia (PD) stands as a rare and heterogenous group of movement disorders represented by sudden, involuntary movements. The Term “Paroxysmal” means it appears instantaneously, and the term “Dyskinesia” means movements of the Body that are in [....] » Read More
Intracerebral hemorrhage is a worldwide cause of morbidity and mortality.1 Bouchard aneurysms represent a very small percentage of these cases. However, its appreciation and consideration of rupture due to volume overflow and hypertension must never be ignored. We present the cas [....] » Read More
In recent decades, research has attempted to identify biomarkers associated with Alzheimer's disease. Among the substances, the most prominent are beta amyloid protein and TAU protein, the latter of which can be described as total, phosphorylated, 181, 217, 231 and others. Th [....] » Read More
Introduction: Paroxysmal sympathetic hyperactivity (PSH) which was previously called sympathetic storming, is a clinical disorder mainly caused by traumatic brain injury, stroke, hypoxic brain injury or encephalitis. The clinical features include sudden episodes of hypertens [....] » Read More
Innovative neuromodulation technologies like Neurofeedback and Transcranial Pulse Stimulation (TPS) are offering hope for individuals diagnosed with severe depression. These non-invasive approaches target specific brain regions involved in mood regulation and emotional processing [....] » Read More
Alzheimer's patients frequently experience anxiety, disorientation, memory loss, and trouble navigating space, which disrupts their daily lives. As cognitive decline advances, fundamental activities like locating a restroom, identifying personal areas, or experiencing safety [....] » Read More
Introduction: Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide, with significant neurocognitive consequences. In Morocco, particularly at Idrissi Hospital in Kénitra, TBIs represent a frequent cause of hospital admissions, yet data [....] » Read More
Neurodevelopmental Disorders (NDDs) are disabilities primarily caused by impairment of the neurological system and brain functioning. They are characterized by impairments in cognition, communication, behavior and/or motor skills as a result of abnormal brain development usually [....] » Read More
Pediatric stroke is an underrecognized yet significant cause of morbidity and mortality among children, particularly in low- and middle-income countries (LMICs) like Bangladesh, where it remains underdiagnosed, undertreated, and underreported due to limited awareness, inadequate [....] » Read More
After a year of treatment, only 11% of Major Depressive Disorder (MDD) patients achieved remission. This low recovery rate is not simply due to a lack of effective medications, as there are over 20 FDA approved, effective treatments for MDD. The challenge lies in identifying the [....] » Read More
Induction of autophagy is a prospective approach to the treatment of neurodegeneration. In the recent decade, trehalose attracted special attention. It is an autophagy inducer with negligible adverse effects and is approved for use in humans according to FDA requirements. Trehalo [....] » Read More
Statement of the Problem: Women who suffer mental health issues, because of Autism Spectrum Disorder has a significant impact on their lives, especially if they’ve suffered trauma because of the bullying/discrimination/cruel remarks & actions from other people. Autis [....] » Read More
Background: Burnout is associated with cognitive impairment. Research has shown a link between burnout and difficulties in executive functions in daily life, as well as changes in underlying neural processes. This cross-sectional study aimed to examine the impact of burnout on co [....] » Read More
Background: Varicella-zoster virus (VZV) commonly causes chickenpox in childhood and may later reactivate as shingles. Neurological complications such as meningitis, encephalitis, and myelitis are more frequent in immunocompromised or elderly patients. VZV encephalitis is rare in [....] » Read More
Dementia is a global health challenge, with over 55 million diagnosed cases and a significant portion of undiagnosed individuals, particularly in low-income countries. Early detection is critical for effective intervention, yet traditional screening methods like the Clock Drawing [....] » Read More
Neurological and physiological disorders such as Autism Spectrum Disorder (ASD), ADHD, PTSD, and Bipolar Disorder uniquely impair emotional regulation, presenting complex challenges for therapeutic intervention. This research explores the potential of EEG-based Brain-Computer Int [....] » Read More
Frena are congenital remnants of tissue comprised of collagen, soft mucosa and fascia that can support or restrict movement. When this tissue is too short, too thick, too tight, or in the wrong location it is tethered. Tethered oral tissue(s) (TOTs) can impede feeding, swallowing [....] » Read More
In recent scientific and technological advances, many boundaries among science, engineering and cognitive informatics are cross-linked in the face of combinations of knowledge and tools as demonstrated in the areas of scientific computing, network computing, bio-molecular computi [....] » Read More
Alzheimer’s disease (AD) is a prevalent neurodegenerative disease that affects at least 50 million people worldwide and is on the rise to affect about 152 million by 2050. This progressive disease burdens both the patients and their family/caregiver, bringing upon social, e [....] » Read More
Sleep serves a vital restorative function, yet the precise mechanisms underlying brain activity during sleep deprivation remain unclear. Alpha waves (8-12 Hz), typically associated with relaxed wakefulness, also appear in various sleep stages, particularly during the transition f [....] » Read More
Background: Convergence insufficiency (CI) is common in traumatic brain injury (mTBI), causing headaches, blurry vision, reading problems and reduced quality of life. Standard near point of convergence (NPC) testing may miss subtle deficits. This proof-of-concept study evaluates [....] » Read More
Background: Multiple Sclerosis (MS) is an inflammatory condition associated with the demyelination of axons. The inflammatory phase of MS is named “relapse”, and the following recovery phase is named “remission”. The MS which cycles between relapses and re [....] » Read More
Objective: The study aims to present a rare case signifying the co-occurrence of Fregoli delusion, erotomania, and Incubus syndrome in a patient with schizophrenia, and to explore neurological dysfunctions contributing to these overlapping delusions. Introduction: Fregoli syndro [....] » Read More
Stroke is a significant cause of mortality and disability globally. It can disrupt the blood- brain barrier (BBB), leading to neuroinflammation. Stem cell therapy is a fundamental part of regenerative medicine, enabling the repair or replacement of damaged tissues using living ce [....] » Read More
Eosinophilic Granulomatosis with Polyangiitis (EGPA), previously known as Churg-Strauss Syndrome, is a rare systemic autoimmune vasculitis affecting small to medium-sized vessels. It is characterized by a triad of asthma, eosinophilia, and necrotizing vasculitis, and typically pr [....] » Read More
Introduction: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative disorders. Both conditions are progressive, reduce quality of life, and represent a major burden for aging populations worldwide. Objective This review [....] » Read More
Osmotic Demyelination Syndrome (ODS) is a rare but serious complication that can occur following the rapid correction of chronic hyponatremia. Characterized by demyelination in the central pons and other brain regions, it presents with a wide spectrum of neurological deficits inc [....] » Read More
GM1 gangliosidosis is a rare lysosomal storage disorder inherited in an autosomal recessive pattern. It is caused by a deficiency of the enzyme beta-galactosidase, encoded by a gene on chromosome 3. The resulting enzymatic defect leads to pathological accumulation of GM1 ganglios [....] » Read More
Ollier’s disease is a dysplasia of cartilage characterized by multiple enchondromas. Previous literature did not observe the concurrence of Ollier’s disease and gliomas, however, the presence of these two comorbidities is now becoming evident. In patients with Ollier& [....] » Read More
Alzheimer's disease (AD) is a progressive neurodegenerative disease that accounts for more than 60% of cases of dementia worldwide. Notably, women are disproportionately affected, comprising nearly two-thirds of all AD diagnoses and experiencing more rapid and severe cognitiv [....] » Read More
This project introduces Cognitive-Based Emulation (CBE), a new theoretical field that reframes trauma, cognition, and identity through symbolic systems and recursive feedback. CBE distinguishes biologically inherited traits from those formed by symbolic reinforcement, proposing t [....] » Read More
Background: Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles in the hippocampus and cerebral cortex of the brain. This may result in cognitive impairment, inflammation, a [....] » Read More
The Triple Network Model—comprising the Salience Network (SN), Default Mode Network (DMN), and Central Executive Network (CEN)—provides a framework for understanding how anxiety alters brain connectivity. We investigated these network interactions using a previously p [....] » Read More
Teenagers today are sleeping less than past generations, largely due to the ongoing digital revolution as Seton and Fitzgerald discuss, “Technology is largely to blame for keeping people perpetually connected in the digital world which is in turn driven by changing social d [....] » Read More
In this research, dopamine’s involvement in working memory and cognitive functioning was investigated. The current youth has been experiencing a decline in cognitive functioning, and many have attributed this to a dopamine rewiring stemming from micro reward chasing habits [....] » Read More
Background: In pediatric neurology practice, a significant number of patients present with neurological symptoms lacking a definitive etiological diagnosis. Many are given diagnoses such as global developmental delay, cerebral palsy, autism, unspecified epilepsy, intellectual imp [....] » Read More
This research introduces BlindNeuralGen, a brain-inspired deep learning framework that synthesizes electroencephalogram (EEG) signals from visual inputs, bridging artificial and biological vision systems. Inspired by neurophysiological processes, the architecture incorporates neu [....] » Read More
Introduction: Musical tempo has not been definitively proven to alter memory such as storage and retrieval (Proverbio et al. 2015; Cournoyer Lemaire et al. 2019; Kwon et al. 2022). Prior studies have shown little research toward the effect of differing music tempos on the st [....] » Read More
Neonatal seizures go frequently undetected since an estimated 85% lack obvious clinical signs. This poses significant risk of severe neurological damage or mortality if not promptly diagnosed and treated. Existing technologies are complex and rely on expert interpretation, which [....] » Read More
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease in which early diagnosis is complicated by the presence of early non-specific and atypical presentations. Sporadic CJD, the most common type of CJD, is caused by the spread of a disease-forming prion known as PrP [....] » Read More
Title : A case of vile vindictive primary CNS vasculitis
George Diaz, Memorial Healthcare Systems, United States
Introduction/Objective: Primary Angiitis of the Central Nervous System (PACNS) is rare and causes inflammation of the small and medium vessels of the brain, leptomeninges and spinal cord. We present a case of PACNS, demonstrate the diagnostic challenges, and appreciate outco [....] » Read More
Title : Alzheimer's disease counteracted by intravenous antioxidants biosupplements administration
Juan Moreira, Centro Neurointegrativo Gnosis, Puerto Rico
Background: Alzheimer’s disease is the most common form of dementia, accounting for 60% to 70% of cases. (1) Current research indicates that oxidative stress is the principal cause of pathology linked to Alzheimer’s disease. (2-6) Neuronal degeneration in this disorde [....] » Read More
Title : Cervical stenosis-induced chronic cerebrospinal fluid flow restriction as a contributing cause of dementia
Joe Sam Robinson, Mercer University, United States
Statement of the Problem: Obvious CSF flow obstruction is a well-established cause of acute and subacute dementia, as well as a host of other neurological dysfunction processes. Unfortunately, the less-obvious vagaries of CSF production and absorption remain relatively unexplored [....] » Read More
Title : The role of beliefs, perception, and behavioural patterns in the evolution of psychophysical disorders
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
In accounts of the development and progression of psychophysical disorders such as Hereditary Spastic Paraplegia (HSP) and Facioscapulohumeral Muscular Dystrophy (FSHD), the role of beliefs, perceptions, and behavioural patterns has often been overlooked in favour of a geneticall [....] » Read More
Title : Traumatic Spinal Cord Injuries (TSCI) - Are the radiologically based “advances” in the management of the injured spine evidence-based?
W S El Masri, Keele University, United Kingdom
Prior to WWII the majority patients with tSCI died in hospitals. There was however no shortage of Clinicians experimenting with the management of the injured spine. During WWII L. Guttmann (a well-trained aggressive Neurosurgeon) was given the task of looking after injured sol [....] » Read More
Title : Narrative medicine: A communication therapy for the communication disorder of Functional Seizures (FS) [also known as Psychogenic Non-Epileptic Seizures (PNES)]
Robert B Slocum, University of Kentucky HealthCare, United States
Patients with Functional Seizures (FS) (also known as Psychogenic Non-Epileptic Seizures (PNES), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Many patients with FS have a history of sexual, physical, or emotional abuse or oth [....] » Read More
Title : Towards solving the hard problem of consciousness: The varieties of brain resonances and the conscious experiences that they support
Stephen Grossberg, Boston University, United States
The hard problem of consciousness is the problem of explaining how we experience qualia or phenomenal experiences, such as seeing, hearing, and feeling, and knowing what they are. To solve this problem, a theory of consciousness needs to link brain to mind by modeling how emergen [....] » Read More
Title : Dietary methanol as a factor in seizures, mood disorders and autism spectrum disorders
Ralph G Walton MD, Northeastern Ohio Medical University, United States
The artificial sweetener aspartame (L-aspartyl L-phenylalanine methyl ester) is a significant dietary source of methanol, a known neuro-toxic agent. Aspartame alone can almost double rat brain phenylalanine levels, while aspartame-carbohydrate combinations can raise brain t [....] » Read More
Title : Improvement of brain function by wasabi component “hexaraphane”
Isao Okunishi, Kinjirushi Co., Ltd, Japan
Hexaraphane (6-methylsulfinylhexyl isothiocyanate; 6-MSITC) is an isothiocyanate present in the rhizomes and roots of Wasabi (Eutrema japonicum (Miq.) Kiudz.). Here we present the results of two clinical trials conducted on healthy subjects and patients with chronic fatigue syndr [....] » Read More
Title : Challenges in translating science into medicine in the field of brain health
Younok Dumortier Shin, OnusBio, United States
From dementia to depression to pain, neurological diseases affect almost everyone at some point in our lives. The medical research has advanced tremendously, thanks to the advanced technologies such as high-resolution imaging systems, genetic diagnostic tools, and high-throughput [....] » Read More
Title : An audit on the assessment and management of osteoporosis in a parkinson’s and related diseases clinic in Australia
Nethmi Nuwanji Amarasekera, Imperial College London, United Kingdom
Osteoporosis is characterised by low bone mineral density and is associated with minimal trauma fractures. Patients with Parkinson’s disease (PD) and atypical parkinsonian syndromes are at increased risk of falls and should be actively screened and treated for osteoporosis. [....] » Read More
Title : Transcutaneous vagus nerve stimulation modulates hippocampal glutamate–glutamine levels and brain activation in a rat model of chronic stress
Agata Chudzik, University of Toronto, Canada
Introduction: Transcutaneous vagus nerve stimulation (tVNS) has gained attention as a non-invasive, drug-free approach for treating neurological and psychiatric disorders [1]. This preliminary study aimed to assess neurometabolic and brain activation changes following tVNS in an [....] » Read More
Title : A case of acute disseminated encephalomyelitis presenting with catatonia and psychosis in a patient with schizophrenia
Shrihita Ganga, Southern Illinois University School of Medicine, United States
Introduction: Acute disseminated encephalomyelitis (ADEM) is a rare, immune-mediated inflammatory disorder of the central nervous system (CNS) characterized by multifocal neurological deficits and encephalopathy. Often triggered by infections or vaccinations, ADEM primarily affec [....] » Read More
Title : Validity and reliability of the Japanese behavior rating inventory of executive function-adult version (J-BRIEF-A): Gender differences and age variations in adults
Mako Momoda, Hyogo Institute for Traumatic Stress, Japan
Executive function (EF) refers to higher-order cognitive processes associated with the prefrontal cortex, playing a critical role in goal-directed behavior and daily functioning. The present study aimed to evaluate the reliability and validity of the Japanese version of the Behav [....] » Read More
Title : Neuropathic foot pain: Therapeutic insights from a biomechanical perspective
Tung Liang Lin, Taichung Veterans General Hospital, Taiwan
Neuropathic foot pain is a significant clinical issue, as its persistent and distressing nature severely impacts patients' quality of life. Neuropathic foot pain arises from damage or dysfunction within the somatosensory nervous system, leading to pain that is often dispropor [....] » Read More
Title : Neurosarcoidosis with cranial nerve polyneuropathy: A case report highlighting the potential role of Serial Systemic Immune- Inflammatory Indices (SSIIi)
Robert Beggerow, North Middlesex University Hospital, United Kingdom
Neurosarcoidosis is an uncommon but serious manifestation of systemic sarcoidosis, often posing a diagnostic challenge due to its varied presentation and the absence of definitive testing. This case report outlines a rare presentation of neurosarcoidosis and the comprehensive dia [....] » Read More
Title : Uncommon presentation of spontaneous intracranial hypotension in an older adult: A case complicated by bilateral cerebral venous sinus thrombosis
Zubiar Haque, The Princess Alexandra Hospital NHS Trust, United Kingdom
Spontaneous intracranial hypotension (SIH) is a rare condition caused by reduced cerebrospinal fluid (CSF) pressure, often secondary to spontaneous CSF leaks. Although classically presenting with orthostatic headaches, SIH can have atypical manifestations, making diagnosis challe [....] » Read More
Title : Uncommon presentation of spontaneous intracranial hypotension in an older adult: A case complicated by bilateral cerebral venous sinus thrombosis
Ganesh Arunachalam, The Princess Alexandra Hospital NHS Trust, United Kingdom
Spontaneous intracranial hypotension (SIH) is a rare condition caused by reduced cerebrospinal fluid (CSF) pressure, often secondary to spontaneous CSF leaks. Although classically presenting with orthostatic headaches, SIH can have atypical manifestations, making diagnosis challe [....] » Read More
Title : When the mind plays tricks: LGI1 encephalitis mimicking psychiatric illness
Akshayaa Kumar Aggarawal, Walsall Manor Hospital, United Kingdom
Background: LGI1 antibody-associated autoimmune encephalitis is a rare condition typically affecting older adults, presenting with seizures, cognitive decline, and behavioural changes. Diagnosis is often delayed due to normal imaging, EEG, and CSF findings. Early recognition [....] » Read More
Title : Differential gene expression analysis reveals NF-kB subunit as a potential biomarker for alcohol use disorder
Archit Sonaje, miRcore, United States
Alcohol Use Disorder is a chronic disease that causes an individual to lose control of their ability to stop drinking, diagnosed by state markers and biomarkers. We analyzed a publicly available RNA-seq dataset comparing patients with Alcohol Dependence (now AUD) to controls. W [....] » Read More
Title : Performance and predictive accuracy of machine learning prognostic models in traumatic spinal cord injury: A systematic review and meta-analysis
Atta Boateng, Columbia University, United States
Traumatic spinal cord injury (SCI) is a leading cause of long-term neurological disability, profoundly affecting function and quality of life. Advances in artificial intelligence, particularly machine learning (ML), have enabled prognostic models to estimate recovery, functional [....] » Read More
Title : Antithrombotic strategies for the secondary prevention of ischemic stroke: A systematic review and network meta-analysis
Forough Yazdanian, Harvard Medical School, United States
Background: The optimal antithrombotic regimen for secondary stroke prevention remains debated due to trade-offs between ischemic recurrence and bleeding risk. We conducted a network meta-analysis (NMA) comparing antiplatelets, vitamin K antagonists, and direct oral anticoag [....] » Read More
Title : Narrative medicine applications for neuro-oncology patient identity and quality of life
Robert B Slocum, University of Kentucky HealthCare, United States
Brain cancer and its treatments bring a unique threat to the patient’s identity and quality of life by challenging their essential identity in significant ways, possibly including impaired cognitive skills, loss of memory, reduced coordination, altered feeling states, and l [....] » Read More
Title : Disparities in mortality, hospitalization costs, and length of stay after intracerebral hemorrhage: Cross-sectional analysis of the 2022 U.S. national inpatient sample
Atta Boateng, Columbia University, United States
Intracerebral hemorrhage (ICH) is among the most devastating forms of stroke, carrying high mortality, prolonged hospitalization, and substantial financial burden. Whether disparities in outcomes across racial, insurance, and socioeconomic groups persist in the era of contemporar [....] » Read More
Title : Deep Convolutional Neural Network (CNN) for threedimensional (3-D) objects classification using phase-only digital holographic information
Uma Mahesh R N, ATME College of Engineering, India
A deep CNN-based binary classification of three-dimensional (3-D) objects for phase-only digital holographic information has been presented. The 3-D objects considered for the binary classification task are ‘triangle-square’, ‘circle-square’, ‘square [....] » Read More
Title : Rare bismuth-induced neurotoxicity case report
Sriyaa Suresh, University of Virginia, United States
Bismuth encephalopathy is a rare cause of neurological dysfunction that can result in confusion, gait disturbances, myoclonus, and dysarthria. Due to the rarity of this condition, a bismuth toxicology workup is usually not immediately initiated upon presentation of neurological s [....] » Read More
Title : Treatment of chronic muscle spasm and pain with the CMECD procedure
Roger H Coletti, Interventional Health, PA, United States
It has been noted by multiple researchers that there is Spontaneous Electrical Activity (SEA) at painful trigger points. This author has studied chronic muscle spasm and found that SEA is always present and appears to be the cause for the chronic nature of muscle spasm and result [....] » Read More
Title : Digital health narratives in neuro-oncology: evaluating educational quality through NLP-augmented discern analysis
Shweta Kalita, University of Texas Health Center, United States
Background: Online visual health content is a widely used source of medical information, especially in emotionally charged fields like neuro-oncology, where patients and caregivers often turn to digital platforms for accessible education. However, the unregulated nature of such p [....] » Read More
Title : The effects of music tempo on the episodic memory of pre-school children
Kendall Lee, Crystal Springs Uplands School, United States
Musical tempo has not been definitively proven to alter memory such as storage and retrieval (Proverbio et al. 2015; Cournoyer Lemaire et al. 2019; Kwon et al. 2022). Prior studies have shown little research toward the effect of differing music tempos on the storage and retrieval [....] » Read More
Title : Caregiver-reported needs assessment for emerging adults with cerebral palsy
Carlos A Herrero Rivera, Kennedy Krieger Institute, United States
Cerebral palsy (CP) is the most common cause of childhood-onset physical disability; it is a group of nonprogressive movement disorders that require coordinated, multidisciplinary care. Adolescents with CP often face significant challenges during the transition from pediatric to [....] » Read More
Title : Assessing the role of neurogenesis in learning & memory following exposure to High Frequency Head Impacts (HF-HI) and Controlled Cortical Impacts (CCI)
Faisal Attiah, Georgetown University, United States
Neurogenesis in the hippocampal dentate gyrus (HDG) is linked to learning and memory and contributes to normal hippocampal function, and TBI has been shown to disrupt the normal process of neurogenesis (Leng & Bonaguidi., 2018).Due to the different TBI models and available, t [....] » Read More
Title : Baseline results of REINTEGRA: A comprehensive rehabilitation program for people with serious mental disorders
Jaime Carmona Huerta, Universidad de Guadalajara CUCS, Mexico
Introduction: Despite the increasing use of comprehensive rehabilitation models for people with severe mental illness (SMI), there are still limitations to their implementation and replicability in a consensual way, particularly in Latin American countries. The REINTEGRA pro [....] » Read More
Title : Effects of probiotic supplementation on behaviour and hippocampal neurometabolites in pregnant rats exposed to chronic stress
Agata Chudzik, University of Toronto, Canada
Introduction: Chronic stress during pregnancy increases the risk of anxiety and adverse outcomes in mothers and offspring [1]. Probiotics may improve mental health and modulate biochemical processes during pregnancy, as supported by clinical and preclinical studies [2– [....] » Read More
Title : Stroke- diagnosis and treatment methods
Shradha Kakde, MGM Medical College, India
Background: Stroke is a major global health burden, representing a leading cause of death and long-term disability. Rapid diagnosis and effective intervention are critical to improving patient outcomes. Objective: This abstract aims to provide an updated overview of current di [....] » Read More
Title : Prognostic significance of vascular endothelial growth factor changes in the acute phase of hemorrhagic strokes
Gulchekhra Usmanova, Tashkent Medical University, Uzbekistan
Background and Aims: Vascular Endothelial Growth Factor (VEGF) plays a crucial role in the regulation of angiogenesis and neurogenesis, particularly in response to cerebral injury. Experimental studies have demonstrated the presence of VEGF in brain tissue surrounding hemorr [....] » Read More
Title : A multiscale systems biology framework integrating ODE-based kinetics and MD-derived structural affinities to model mBDNF–proBDNF-mediated bifurcation dynamics in CNS neurotrophin signaling
Abhay Murthy, Boston University, United States
Brain-Derived Neurotrophic Factor (BDNF), a key member of the neurotrophin family, is implicated in the regulation of synaptic plasticity, neuronal differentiation, and long-term survival in the Central Nervous System (CNS). The dualistic signaling pathways mediated by the mature [....] » Read More
Title : A multiscale systems biology framework integrating ODE-based kinetics and MD-derived structural affinities to model mBDNF–proBDNF-mediated bifurcation dynamics in CNS neurotrophin signalling
Ethan Liu, Boston University, United States
Brain-Derived Neurotrophic Factor (BDNF), a key member of the neurotrophin family, is implicated in the regulation of synaptic plasticity, neuronal differentiation, and long-term survival in the Central Nervous System (CNS). The dualistic signaling pathways mediated by the mature [....] » Read More
Title : A multiscale systems biology framework integrating ODE-based kinetics and MD-derived structural affinities to model mBDNF–proBDNF-mediated bifurcation dynamics in CNS neurotrophin signaling
Krishna Moorjani, Boston University, United States
Brain-Derived Neurotrophic Factor (BDNF), a key member of the neurotrophin family, is implicated in the regulation of synaptic plasticity, neuronal differentiation, and long-term survival in the Central Nervous System (CNS). The dualistic signaling pathways mediated by the mature [....] » Read More
Title : A multiscale systems biology framework integrating ODE-based kinetics and MD-derived structural affinities to model mBDNF–proBDNF-mediated bifurcation dynamics in CNS neurotrophin signaling
Arpit Ramani, Wheeler Magnet High School, United States
Brain-Derived Neurotrophic Factor (BDNF), a key member of the neurotrophin family, is implicated in the regulation of synaptic plasticity, neuronal differentiation, and long-term survival in the Central Nervous System (CNS). The dualistic signaling pathways mediated by the mature [....] » Read More
Title : Using speech acoustics as biomarkers in the early detection of early-onset parkinson’s disease
Akhil Medikonda, Dublin Jerome High School, United States
Early-Onset Parkinson’s Disease (EOPD) is a neurodegenerative disorder caused by the degeneration of dopaminergic neurons in the substantia nigra. Over 500,000 individuals in the U.S. have been diagnosed with Parkinson’s disease, but the actual number, including und [....] » Read More
Title : TCD HITS and infective endocarditis: Illustrative case report and series
Alexis Angelette, NYP-Weill Cornell, United States
Introduction: Infective endocarditis (IE) has a high risk of neurovascular complications, including ischemic and hemorrhagic stroke from septic emboli, and mycotic aneurysms. Treatment of this condition requires antibiotics and often valve replacement surgery, however the op [....] » Read More
Title : Racial disparities in access to deep brain stimulation surgery
Bryn Taylor, University of Florida, United States
Deep brain stimulation (DBS) surgery is an elective surgery offered to Parkinson disease (PD) patients who meet certain symptom criteria. Despite the success of DBS and increasing use, racial disparities in utilization are prevalent [1, 2]. To date, no study has carefully examine [....] » Read More
Title : A systematic review and meta-analysis on the effect of metformin on glioblastoma multiforme
Daniel Gonzales Portillo, Nova Southeastern University, United States
Glioblastoma multiforme (GBM) is a highly aggressive disease with a poor prognosis for most of the patients. The costs of care can overwhelm these patients at times where work is difficult, so there is a need to evaluate affordable alternatives. There exists a body of literature [....] » Read More
Title : The impact of different video features for long term memory
Diane Kim, Westwood High School, United States
As the world is shifting more towards relying on technology and the internet, videos are being more commonly used for information intake. This study aims to identify the features of video that can improve content retention, which may contribute to the development of more effectiv [....] » Read More
Title : The impact of different video features for long term memory
Noelle Lim, Valley Christian School, United States
As the world is shifting more towards relying on technology and the internet, videos are being more commonly used for information intake. This study aims to identify the features of video that can improve content retention, which may contribute to the development of more effectiv [....] » Read More
Title : The impact of different video features for long term memory
Seoyun Yuna Chong, Archbishop Mitty High School, United States
As the world is shifting more towards relying on technology and the internet, videos are being more commonly used for information intake. This study aims to identify the features of video that can improve content retention, which may contribute to the development of more effectiv [....] » Read More
Title : The use of cephalexin to inhibit alpha-synuclein aggregation: A new paradigm in parkinson's disease
Divya Jayam, The Wheatley School, United States
Introduction: Parkinson’s Disease (PD) is characterized by the degeneration of dopaminergic neurons due to the aggregation of a protein named α-Synuclein in the substantia nigra region of the brain. Current therapies for PD do not address this pathology. This paper pr [....] » Read More
Title : Mutation-driven multi-model ensemble learning framework for glioma subtype classification
Isabella Shen, Archbishop Mitty High School, United States
Gliomas are tumors originating from glial cells that support and protect neurons in the nervous system but can become malignant and quickly invade healthy brain tissue. Glioma subtypes have varying growth rates and respond differently to treatment options. Early identification of [....] » Read More