Title : Serum levels of ferritin, iron and TIBC in cerebral venous sinus thrombosis
Abstract:
Background: Cerebral venous sinus thrombosis (CVST) is a potentially life-threatening condition with a wide range of clinical presentations from localized headache (the most common symptom) to mental status disturbances, seizure and coma. The main purpose of this study is to evaluate serum levels of ferritin, iron and total iron binding capacity (TIBC) and their possible relationship with different parameters in CVST patients.
Methods and materials: Thirty patients with definitive diagnosis of CVST based on brain MRI and MRV results participated in the study. During the first 24 hours after admission, a vial of 5 cc blood sample was collected from each patient and delivered to the laboratory to measure serum ferritin, iron and TIBC levels.
Results: 24 women and 6 men (mean age, 42.6 ± 16.33) participated in the study. The mean ± standard deviation (SD) levels of serum ferritin, iron and TIBC were within normal ranges (99.40 ± 29.97 mg/dl, 324.50 ± 49.57 mg/dl, 87.36 ± 88.84 ng/ml respectively). There were no significant relationships between serum ferritin, iron and TIBC levels with study variables such as oral contraceptive pills consumption, history of CVST or cerebrovascular accident (CVA), underlying diseases and the involved sinus.
Conclusion: The current study showed no possible benefits of using serum ferritin, iron and TIBC indices in CVST patients.
Keywords: Cerebral venous sinus thrombosis, ferritin, iron, stroke, TIBC
