Title : Components of event-related potentials N170, VPP, LPP, and P3 individually or combinatorically measured for assessing depression in temporal lobe epilepsy
Abstract:
Objective: This study explored whether the event-related potential (ERP) components of N170, VPP, LPP, and P3 could be sensitive neurophysiological markers for assessing depression in temporal lobe epilepsy (TLE).
Methods: Patients with TLE were divided into two groups with matched age, education, and seizure-related parameters: patients comorbid with depression (EPD) and those without (EPN) according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V). Matched volunteers without epilepsy and depression were included in the control group. Participants were performed electroencephalographic (EEG) recordings, the oddball task, and the emotional conflict Stroop face-word task simultaneously. The EEG data were post-analyzed by the EEGLAB software.
Results: There were 20 patients in the EPD group and 16 in the EPN group, with matched age, gender, and seizure-related parameters. The peak amplitude and latency of N170, the peak latency of VPP, and the area under the LPP waveform were all significantly greater, while the peak latency of P3 was shorter in the EPD group compared with the EPN group. The areas under the curve (AUC) for N170, VPP, LPP, and P3 were 0.755, 0.692, 0.645, and 0.731, respectively, and it was as highest as 0.922 for the four combinatorial ERP components, with a sensitivity of 0.950 and a specificity of 0.812 for assessing depression based on the HAMD-17 score.
Conclusion: Combination of N170, VPP, LPP, and P3 components exhibits a high sensitivity and specificity for assessing depression in TLE, which expects to be an aiding neurophysiological biomarker for physicians to make a more precise diagnosis.
Audience Take Away Notes:
- The event-related potential (ERP) components of N170, VPP, LPP, and P3 could be sensitive neurophysiological markers for assessing depression in temporal lobe epilepsy (TLE).
- Combination of N170, VPP, LPP, and P3 components exhibits a high sensitivity and specificity for assessing depression in TLE, which expects to be an aiding neurophysiological biomarker for physicians to make a more precise diagnosis.
- I think other faculty could use this research to expand their research.
- I think this research provides a practical solution to objectively assess depression in patients with epilepsy.
- I think the research provides new information to assist in making a more precise diagnosis.
