Title : Serum interleukins- 2,6 and tumor necrosis factor -alpha levels in children with attention deficit hyperactivity disorder
Abstract:
Background: ADHD is a behavioural disorder with symptoms of inattention, impulsivity and hyperactivity. A low dopaminergic and noradrenergic activity is noted in ADHD. The etiopathogenesis is not completely understood. A physiological role of IL- 6 on neuronal stem cell migration, proliferation and synaptic plasticity is noted. An increase in levels of IL-6 may modify the neural connections of developing brain thus affecting the memory and attention. This variation in the normal brain development and function may play a role in the pathogenesis of ADHD.
Methods: A cross-sectional study conducted among 30 patients already diagnosed with ADHD against age and sex matched controls, coming to OPD in a tertiary care hospital. Levels of Inflammatory markers are tested using sandwich ELISA technique. A predesigned and pretested questionnaire conner’s 3 parent short was administered to assess the severity of symptoms of ADHD and comparison of the variables were analysed using Independent t test and ANOVA(for more than two groups).The comparison of the variables which were qualitative in nature were analysed using Fisher’s exact test & Pearson correlation coefficient was used for correlation.
