Pervasive use of pesticides in all over the word that may affect human nervous system extensively. Likewise pyrethroids are the major group of pesticides that is used in household products from where human get affected and suffer with various neurological disorders such as Parkin [....] » Read More
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and presence of intra- cytoplasmic inclusion bodies known as lewy body containing α- synuclein aggregate . [....] » Read More
Background: In Ethiopia, the pattern of neurosurgical disorders and operations is poorly known. The aim of this study was to describe the neurosurgical disease and surgery patterns at two major hospitals in southern Ethiopia. Patients and Methods: This is a retrospective analysi [....] » Read More
Explanation of the most fundamental roles of neurotransmitters is missing from current medical science. A good description of function should be simple and should act as a framework that allows for more complexity. I propose a simple model of neurotransmitter function that exhibi [....] » Read More
In the hippocampus, new neurons are generated throughout life via a process called adult hippocampal neurogenesis (AHN). In mild cognitive impairment (MCI) and mild to moderate AD (early AD), AHN is significantly reduced suggesting that AHN impairment compromises hippocampal func [....] » Read More
An acute disseminated encephalomyelitis (ADEM) is very challenging to diagnose. ADEM is rare, inflammatory and demyelinating disease that affects the central nervous system (CNS) with a typically white matter damage. ADEM often occurs following a viral or bacterial infection, or [....] » Read More
Background: Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and linings in food cans. BPA has been reported to have neurotoxic properties that may increase the risk of neurodegenerative diseases by inducing neuroinflammation. Auricularia polytricha (A [....] » Read More
Purpose: The purpose of this qualitative study was to describe the lived experience of African American informal caregivers of family members of Alzheimer’s Disease and Related Dementias (ADRD) in a home environment. Design and Method: This phenomenological descriptive [....] » Read More
The stress response involves multiple organ systems like central nervous system, autonomic nervous system, endocrine system, cardiovascular system and immune system. Individual’s responses to stressors are conditioned by the genetic, environmental and developmental factors. [....] » Read More
Parkinson's disease (PD) is a neurodegenerative disorder that affects predominately dopaminergic neurons in a specific area of the brain called substantia nigra which controls movement. A hallmark feature of PD is the degeneration of the dopamine neurons in the substanti [....] » Read More
Epilepsy is one of the most common neurological disorders and is more common in developing countries as compared to developed one. Epilepsy has a various types of phenotype depends upon the pathways involved in the signaling process. Epilepsy is a group of neurological disorders [....] » Read More
In electrophysiological experiments, we previously found that a local focus of excitation caused by instillation of a 2% strychnine solution into the Basolateral Amygdala (BLA) led to an increase in the amplitude parameters of evoked potentials (EP) in the Visual Cortex and Lat [....] » Read More
Stroke is the second most leading cause of mortality and disability across the globe. Stroke is one of the major public health problems especially in developing countries like India that pose multiple challenges to the stroke survivors, their care-givers and to the team of heal [....] » Read More
Background: Stroke is a disabling disease due to its functional impairments and complications. In this study, we aimed to examine the clinical profiles, practical outcomes, and complications during rehabilitation of patients hospitalized with stroke. Methods: In this single ce [....] » Read More
Background: Multidetector CT angiography (MDCTA) is widely used for the detection of large vessel occlusion in acute ischaemic stroke. This modality has not been used in the assessment of lenticulostriate (LSA) or anterior choroidal artery (AChA) occlusion that results in basal g [....] » Read More
Background Venous thromboembolism(VTE) prophylaxis is a recognised part of stroke management in European Stroke Organisation (ESO) guidelines[1], and a component in the NICE Stroke pathway[2]. The practicalities of the prescribing and application of these modalities whether phar [....] » Read More
Rubral tremors, or Holmes’ tremors, are a type of movement disorder that appear post-cerebellar/thalamic injury. Optimal treatment approaches for rubral tremors are still being understood and include pharmacological options such as dopamine precursors, anticonvulsants, and [....] » Read More
Late-onset Alzheimer’s disease (LOAD) and early-onset Alzheimer’s disease (EOAD) are different subtypes of AD. This study aimed to build and validate radiomics models of the hippocampus for EOAD and LOAD. Thirty-six EOAD patients, 36 LOAD patients, 36 YCs, and 36 OCs [....] » Read More
Background: Creutzfeldt Jakob disease (CJD) is a fatal and rare neurodegenerative disease, It is classified into 3 subgroups: sporadic, genetic and acquired. Sporadic CJD is the most common form, which may be manifested with misleading neuropsychiatric symptoms and resulting in [....] » Read More
Currently, there is a large increase in the number of cases of coronavirus infection caused by COVID-19. A severe complication of diabetes is diabetic polyneuropathy, which is exacerbated by a new coronavirus infection. Purpose of the study began to evaluate the possibilities [....] » Read More
Background Severe acute respiratory syndrome coronavirus 2 is a coronavirus that has recently appeared, rapidly spreads, and results in coronavirus disease 2019 (COVID-19). Moderna mRNA-1273 and Pfizer-BioNTech BNT162b2 vaccines are among the most widely used and effective va [....] » Read More
Correct identification and analysis of intracranial masses is of high clinical importance especially when it comes to treating acute illnesses and focal neurological deficits, while preventing further deterioration. We present a rare case of a giant thrombosed aneurysm in the [....] » Read More
Background: A diagnosis of manifest Huntington’s disease (HD) is based primarily on motor symptoms, but early cognitive decline is common in the pre-manifest HD period (preHD). Early symptom detection in HD has important implications for monitoring both disease pr [....] » Read More
Neurodegenerative diseases (NDs) are the age-related diseases which represent a major cause of mortality in aging population nowadays. Previous studies have shown that glutamate, the most abundant excitatory neurotransmitter, significantly increases in extracellular fluid of the [....] » Read More
Alzheimer’s disease (AD) is one of the most common types of dementia, which accounts for an estimated 60 to 80% of all dementia cases. Though pathways including alteration in the cholinergic system, amyloid precursor protein (APP) processing and tau hyperphosphorylation are [....] » Read More
Stress is generally defined as a real or interpreted threat to the psychological or physiological integrity of an individual that results in physiological and/or behavioral responses. Threatening stimuli trigger neuronal responses in the brain that cause an immediate adaptive sys [....] » Read More
Introduction : PHARC is an acronym that describes the major features of an early onset neurodegenerative disease marked by Cataract, Hearing loss, Retinitis pigmentosa and involvement of central and peripheral nervous systems, including sensorimotor PolyNeuropathy and cer [....] » Read More
Background. It has long been recognized that inflammation plays a critical role in the pathogenesis of ischemic stroke. However, whether leukocyte count and neutrophil-to-lymphocyte ratio are related to stroke severity and functional outcome is uncertain. Objective. This clini [....] » Read More
Background: Antiphospholipid antibody (APLA) syndrome is an autoimmune disorder predisposing to thrombotic complications affecting CNS either by arterial vasooclusion or venous thrombosis. Cerebral venous sinus thrombosis (CVST) secondarily cause raised intracranial pressure ( [....] » Read More
Throughout the years epidemiological studies have been used to assess the burden of neurological disorders and disease conditions. Although many advancements have been made in the field, not enough data is available on intervention and reduction of the comorbid conditions of neur [....] » Read More
Multiple Sclerosis (MS) is an autoimmune disease targeting myelin in the central nervous system. Most disease modifying therapies (DMTs) for MS function via immunomodulation by a variety of modalities, some of which are immunosuppressive and some which are not. In this study we c [....] » Read More
Neurofibromatosis type 2 (NF2) is a genetic disorder that predisposes individuals to multiple tumors of the nervous system. The most common of these are bilateral vestibular schwannomas; intracranial and spinal meningiomas, and spinal cord ependymomas. The condition is caused by [....] » Read More
Elevated intracranial pressure (ICP) has been described in patients with demyelinating diseases of the central nervous system (CNS). Elevated ICP is classified into idiopathic intracranial hypertension (IIH), where a clear precipitant is not found; and secondary intracranial hype [....] » Read More
Parkinson 's d isease is a second most commo n age-related neurodegenerative d isorder characterized by tbe loss of dopaminergic nemons in the substantia nigra pars compacta region of the midbrain. Doxophylline is a non-selective PDE inhibitor and thus expected to be benefici [....] » Read More
Spinal surgery is the final option recommended to individuals with spinal conditions when conservative treatment has failed in treating patients’ symptoms. The purpose of this study is to examine the factors contributing to patients’ readiness to undergo recommended s [....] » Read More
The SLU AMSAD is a previously validated depression tool that consists of 5-items and takes less than 2 minutes to administer. The Cornell Scale for Depression in Dementia (CSDD) is the gold standard for assessing depression in dementia patients, but is lengthy, taking nearly 20 m [....] » Read More
Metachromatic leukodystrophy (MLD) is a rare genetic disorder that affects the central nervous system white matter. MLD is caused by recessive mutations in ARSA encoding arylsulfatase A. Low activity of arylsulfatase A results in the accumulation of sulfatides in the central and [....] » Read More
Meningiomas are the most frequent primary tumors arising in the central nervous system. They typically follow a benign course, with an excellent prognosis for grade I lesions through surgical intervention. Although radiotherapy is a good option for recurrent, progressive, or in [....] » Read More
Parkinson’s is a neurodegenerative progressive disease it affects human brain functionality as the disease progresses. It mostly affects movement, slows down the functionality of motor areas, and increases the difficulty in performing any task for the patients. Resting stat [....] » Read More
Aging is associated with reduced neuromuscular function, which may be due in part to altered corticospinal excitability. Regular physical activity (PA) may ameliorate these age-related declines, but the influence of PA on corticospinal excitability is unknown. The purpose of this [....] » Read More
Neurons and glial cells work in conjunction with each other during information processing in brain. Stimulation of neurons can cause calcium oscillations in astrocytes which in-turn can affect neuronal calcium dynamics. The “glissandi” effect is associated with a decr [....] » Read More
Traumatic brain injury (TBI) is defined as a traumatically-induced structural brain injury or physiological disruption of brain function caused by an external force. Traumatic brain injury is a neuropsychiatric disorder that breaks down the remaining barriers between neurology an [....] » Read More
Introduction Since the beginning of the COVID-19 pandemic, studies have shown a reduction in the number of stroke hospitalizations in the US and around the world. Several studies note fear of exposure as a contributing factor for this decline and concerns regarding stroke care [....] » Read More
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Penetrating brain injury (PBI), represents ~ 12% of all TBI cases. Typically, PBI is associated with many symptoms including coma. The mechanisms underlying these pathologic changes include excitotox [....] » Read More
Keywords Inhalants, Glue , neuropsychiatric manifestation ,Silsion ,Sudan. Introduction Inhalants abuse is the behaviour of sniffing or huffing of volatile psychoactive substances to reach an euphoric feelings. Inhalants use reported to have so many neurological&nb [....] » Read More
Research is core of science and improving methodology leads to realistic findings. Assessing the impact of main factors on a given factor is important in various fields of psychological research. There are some methodological and statistical methods to tackle that problem. [....] » Read More
Background and aims: Sleep quality is a key aspect of the overall psychological health. Sleep quality can affect mental health in many aspects, causing major psychological disorders, such as: depression and anxiety. Objectives: to assess the overall psy [....] » Read More
Identified Problems: Parkinson Disorder (PD) is the most common neurodegenerative disorder after Alzheimer Disease. There is no specific test for diagnosis of PD which increases the complexity of manual physical examination with less validation. PD does not have cure but its prog [....] » Read More
Introduction: Percutaneous iliosacral screw fixation in posterior pelvic ring fractures is a challenging operation and commonly performs under fluoroscopy or navigation techniques. The purpose of this study was to assess the safety and efficacy of percutaneous iliosacral screw im [....] » Read More
Introduction: The effect of systemic tranexamic acid (TXA) administration on blood loss reduction during spine surgeries has been widely published over the past decade. However, topical use of TXA during cervical spine surgery is rarely investigated. We aimed to assess the role o [....] » Read More
Background: Fibromyalgia (FM) is a chronic disorder with persistent manifestation of pain, mood swings, fatigue, depression and attention deficits that affects one’s activity of daily living. Objective: The present study aimed to find prevalence and diagnosis of Fibromya [....] » Read More
A 23-year-old Caucasian male with a past medical history of anxiety, pilonidal cyst removal from the lower back in 2 years ago, and EBV infection 1 month ago presents to an on-campus eye institute after 1 week of binocular diplopia, headache, intermittent muscle weakness, neck so [....] » Read More
In economically developed countries of the world, cardiovascular diseases nowadays represent the general factor of mortality. From year to year, in the order of 15 million people, acute cerebrovascular accident (ONMC) is formed. In various countries of the earth, the incidence of [....] » Read More
Background: Hemifacial spasm (HFS), characterized by unilateral, intermittent contractions of the muscles of facial expression occurs due to vascular compression of the facial nerve at the root exit zone. Few studies demonstrated the total prevalence of HFS in range of 9.8 [....] » Read More
Background Increased intracranial pressure is a common and possibly fatal complication of neurologic and systemic diseases. Diagnosis is made mainly based on clinical and neuroimaging findings. There are medical and surgical treatment options. Early diagnosis and prompt [....] » Read More
Autism spectrum disorder (ASD) is a neurodevelopmental disorder inexplicably biased towards males. Although prenatal exposure to bisphenol A (BPA) has recently been associated with the ASD risk, whether BPA dysregulates ASD-related gene that known to be involved in neuronal viabi [....] » Read More
McLeod neuroacanthocytosis syndrome is a ultra rare genetic disorder that occurs almost exclusively in males.It affects brain and spinal cord. Affected individual develops jerky movements of arms, legs, dystonia of face ,tongue which ultimately leads to swallowing difficulty. It [....] » Read More
The novel Coronavirus (COVID-19) was first reported by officials in Wuhan City, in December of 2019. It has rapidly widespread with confirmed cases in almost every country across the world and has become a new global public health crisis.1 Weekly epidemiological update of the Wor [....] » Read More
Background: Parkinson’s disease (PD) is usually more prevalent in men than in women, which has been explained in terms of environmental, hormonal and genetic influences, but little has been reported in terms of clinical characteristics among sex. Objective: to analyze mo [....] » Read More
Currently, there is a large increase in the number of cases of coronavirus infection caused by COVID-19. A severe complication of diabetes is diabetic polyneuropathy, which is exacerbated by a new coronavirus infection. Purpose of the study began to evaluate the possibilities [....] » Read More
Background : Patent Foramen Ovale (PFO) has been associated with Embolic Stroke of Undetermined Source (ESUS). It remains uncertain whether PFO is the direct etiology or an incidental finding. The aim of our study was to analyze the incidence and characteristics of PFO in [....] » Read More
Background. Considering the characteristics of Type A personality such as being impatient, competitive, short tempered, compulsive to time, easy to anger, etc., it could be assumed that people of Type A easily get stressed in their everyday lives, which could affect high blood pr [....] » Read More
Background and aims To clarify the role of the al-subunit of the neuronal sodium channel (SCN1A) gene in the development of catamenial epilepsy in the patients we examined, the study analyzed the associations of polymorphic DNA loci D2S2330 and D2S124 linked to the SCN1A gene and [....] » Read More
Multiple sclerosis (MS) is a chronic, degenerative inflammatory disease of the central nervous system characterised by demyelination. Genetic factors have been implicated in its pathogenesis, however their association with MS remains unclear. Genetic variants in the i [....] » Read More
Introduction: Neurosarcoidosis is an uncommon manifestation and should be suspected in any patients with sarcoidosis with new neurological symptoms. We present a rare case of probable neurosarcoidosis, which was diagnosed by exclusion and elevated acetylcholinesterase (ACE) le [....] » Read More
Background. Optic neuritis and optic neuropathy can cause a reduced color-sensitivity. Therefore, in clinical routine the patient's perception of the red color is tested in order to evaluate the function of the optic nerve. Red desaturation is traditionally tested by presenti [....] » Read More
Title : Rogue Percepts = Rogue Responses: What Are the Possible Sets of Initial Conditions That Give Rise to Willis-Ekbom Disease - Restless Legs Syndrome (RLS), And Can RLS be Therapeutically Pacified? - A NeuroPhysics Therapy Study and Hypothesis Based Upon Observations and Outcomes -
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
The human central nervous system (CNS) fundamentally does something elegant and simple and is programmed to abide by some simple sets of rules and initial conditions. Fundamentally, the CNS takes in and perceives information coming in from the outside world and responds to it. Ho [....] » Read More
Title : Application of activity-based probe, MV151, in the mammalian nervous system reveals new insight into proteasome changes in human Alzheimer’s disease brain
Fulya Turker, Johns Hopkins University School of Medicine, United States
Proteasome complexes play a critical role in human brain health and disease. Despite enormous effort, a deep understanding of proteasome composition, activity, and abundance in the human brain remains poorly understood. Here, we describe a series of tools that can measure the cat [....] » Read More
Title : Studies with the use of the Hyperbaric Oxygen Therapy (HBOT) and its influence on cerebral Neuroplasty: Effects after ischemic and hemorrhagic stroke.
Jose Iranildo Sales, Mauricio de Nassau University of Medicine, Brazil
Background: Recent studies have raised the possibility and clinical feasibility of using treatments using oxygen therapies in hyperbaric chambers (HBOT) for the analysis of functional and cognitive improvements in patients after ischemic and hemorrhagic strokes. The effects in ce [....] » Read More
Title : Treatment with novel Hippo Signaling inhibitor, Xmu-mp-1, ameliorates cognitive impairments in sporadic Alzheimer Disease rats
Manas Ranjan Sahu, Jawaharlal Nehru University, India
Alzheimer's disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder associated with aging. Persons with Alzheimer's face some serious problems associated with memory, thinking, motor movements, language, and behavior due to neurodegen [....] » Read More
Title : The Importance of Writing as a (Cognitive) Therapy Aid To help Determine a Stroke Survivors' Journey of Discovery
Simon Barton, Talking Magnets LLC, United States
Those of us fortunate enough to have survived a (massive) stroke event often embark on the post-stroke “journey of recovery” without the correct tools to properly manage it. We will hear and retain certain messaging repeatedly, for example, “I cannot tell you h [....] » Read More
Title : Studies with the use of the hyperbaric oxygen therapy (HBOT) and its influence on cerebral neuroplasty: Effects after ischemic and hemorrhagic stroke
Maria Gerliane Cavalcante, Mauricio de Nassau University of Medicine, Brazil
Background: Recent studies have raised the possibility and clinical feasibility of using treatments using oxygen therapies in hyperbaric chambers (HBOT) for the analysis of functional and cognitive improvements in patients after ischemic and hemorrhagic strokes. The effects in ce [....] » Read More
Title : Inside the Mind of a 32 year old Stroke Survivor Living with Moya Moya Disease
Michelle Herman, Michelle Herman Speaks, United States
At the age of 32, and 6 months postpartum from having her first child, Michelle walked into the ER with impaired motor skills on the left side of her body, a horrible headache and slurred speech. She was diagnosed with a migraine and discharged. Two days later she had a massive I [....] » Read More
Title : Multi-Characteristic Opsin Gene Delivery for Neuromodulation of Inflammatory and Persistent Pain Sensation in Rodent Model
Arman John Fijany, TCU School of Medicine, United States
Pain is an uncomfortable sensation perceived by the nervous system that can have a variety of different causes. Pain can be seen as a complication of disease, emotional states and even as a standalone pathology. The neuroscience of pain is poorly understood. Multiple levels of co [....] » Read More
Title : Manual perturbation compared with proprioceptive neuromuscular facilitation for trunk stability & lower extremity function in post stroke: A randomized clinical trial.
Nawaj Pathan, MGM School Of Physiotherapy, Aurangabad, India
The Stroke survivor’s biggest challenges are to deal with muscle weakness which is primarily in upper limb, trunk, and lower limb. Additionally, the altered muscle tone, abnormal synergy pattern, impaired coordination and postural control delays the recovery of clients. The [....] » Read More
Title : Effect of motor learning augmented cues on cognitive functions in Parkinson
Lama Saad El-Din Mahmoud, October 6 University, Egypt
Background/Aims: Parkinsonism characterized by deficits in cognitive functions that affect the motor control. The main aim was to assess the effect of motor learning feedback with augmented cues of motor learning on cognitive functions and motor performance in patients with Parki [....] » Read More
Title : Optimizing Deep Brain Stimulation Parameters in Intractable Epilepsy: An EEG Based Innovative Approach
Harinder Jaseja, NIMS University, India
Deep brain stimulation (DBS) of anterior thalamic nucleus (ATN) has established as an effective adjunctive therapy for patients with intractable epilepsy (IE) not suitable for epilepsy brain surgery and/or vagal nerve stimulation. The judicious selection of DBS parameters (DBSPs) [....] » Read More
Title : VWF regulates the expression of adhesion molecules, modulating vascular permeability in endothelial cells after a TBI.
Marina Martinez Vargas, Michael E. DeBakey VA Medical Center, Houston, United States
von Willebrand factor (VWF) is a multimeric protein that mediates thromboinflammation and has been linked to traumatic brain injury (TBI), specifically in the pathogenesis of early brain injury. Activated endothelium secretes VWF multimers as long hyperadhesive strings. During TB [....] » Read More
Title : Investigating the effects of blast traumatic brain injury on the hypothalamus in a porcine model
Kunal Bhanot, Imperial College London, United Kingdom
The increasing prevalence of blast traumatic brain injury (bTBI) in military personnel has stimulated further research into this field. The neuroendocrine system can be severely affected in blast survivors and anterior pituitary dysfunction has been characterised in soldiers retu [....] » Read More
Title : Information Extraction from EHR and EEG Signals in search of a Potential Biomarker for ADHD diagnosis
Armaan Saith, Temple University, United States
ADHD is the most common neurobehavioral disorder of childhood characterised by inattention, impulsivity and motor hyperactivity. The estimated number of children ever diagnosed with ADHD, according to a national 2016 parent survey is 6.1 million (9.4%). An estimated 8.7 million a [....] » Read More
Title : The apt diagnosis of progressive supranuclear palsy with frontal predominance: A case report
Solomon Nittala DO MS, Larkin Community Hospital Palm Springs Campus, United States
Originally described in 1964, progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy with a prevalence of approximately 45% among other parkinsonian-plus syndromes. PSP can be categorized into various phenotypes among which 6% belong to the PSP-frontal predominan [....] » Read More
Title : A rare case of neurotoxoplasmosis in an immunocompetent elderly patient
Maria R Cochran Perez, Universidad Central del Caribe Internal Medicine Residency Program, Puerto Rico
Introduction Neurotoxoplasmosis is an infection caused by Toxoplasma gondii, an intracellular protozoan that is often associated with immunocompromised patients, being rare in immunocompetent patients and often undetected. Toxoplasmosis is an obligate intracellular, food-borne [....] » Read More
Title : A headache that makes a grown man cry: Cerebral sinus thrombosis secondary to coronavirus disease 2019
Ana Martes Bermúdez, UCC Internal Medicine Residency Program, Puerto Rico
Introduction: There have been increasing reports associating coronavirus disease 2019 (COVID-19) with thromboembolic phenomenon including cerebral venous thrombosis (CVT), which is a rare neurovascular emergency often found in critically ill patients, yet its true incidence [....] » Read More
Title : Could We See Alzheimer’s Disease Through the Eye?
Aygun BadaLova, University College London, United Kingdom
One of the most common and prevalent neurodegenerative disorders are Alzheimer's and Dementia which are considered significant causes of mortality and morbidity in today’s society particularly among the elderly population.(Erkkinen, Kim et al. 2018)The etiologic and pat [....] » Read More
Title : Gait and balance among people with de novo vs. mild to moderate Parkinson’s disease
Beata Lindholm, Lund University, Sweden
We have investigated how a de novo cohort of people with Parkinson’s disease (PD) differs in terms of balance and gait function as well as frequency of near falls and falls in comparison to a cohort with mild to moderate PD that has been medicated for several years. Prelimi [....] » Read More
Title : COVID Infection and the Surprise Guillain Barre Syndrome Diagnosis
Neil Gerts , Los Robles Regional Medical Center, United States
The World Health Organization declared COVID-19 a pandemic in February 2020, and it has affected the life of each and everyone. COVID-19 is designated as severe respiratory syndrome coronavirus 2 (SARS-CoV-2). It causes an acute inflammatory process in the body, which is hypothes [....] » Read More
Title : The Association between Intolerance of Uncertainty with Social Interaction Anxiety and Performance Anxiety - Mediating Factors
Flavia I Spiroiu, McMaster University, Canada
BACKGROUND: Despite the potential importance of intolerance of uncertainty (IU) as a transdiagnostic feature that may contribute specifically to social anxiety, empirical data on the construct has been relatively scant and focused largely on Generalized Anxiety Disorder (GAD) and [....] » Read More
Title : Investigation of low frequency thalamic and pallidal local field potential correlation with voluntary movement in children with dystonia
Maral Kasiri, University of California, United States
Understanding the relationship between neural activity and voluntary movement provides new insights into understanding the mechanism underlying neural control of movement in both healthy people and those with movement disorders. To investigate the relationship between deep brain [....] » Read More
Title : Improving Stroke Quality Metrics at Robert Packer Hospital
Rebecca Lees, Guthrie Robert Packer Hospital, United States
Stroke is the number one preventable cause of disability and a leading cause of death in both men and women; rapid assessment and treatment is critical to improve outcomes for patients. Guthrie Robert Packer Hospital received The Joint Commission Primary Stroke Center certificati [....] » Read More
Title : Multiple Autoimmune Syndrome: Combination of Neuromyelitis Optica Spectrum Disorder with Myastenia Gravis, Systemic Lupus Erythamatosis and Hashimato Tiroiditis
Vildan Tuncbilek, Tekirdağ Namık Kemal University , Turkey
Autoimmunity reflects an altered immune status, therefore the presence of more than one disorder is not uncommon. The coexistence of three or more autoimmune diseases in a patient constitutes multiple autoimmune syndrome (MAS). This is an interesting case of a middle-aged female [....] » Read More
Title : NF-kB is a critical mediator of age-dependent white matter loss
Judith Stefanie Scheller, Institute of Physiological Chemistry, Ulm University, Germany
Inflammaging represents an accepted concept where the immune system shifts to a low-grade chronic proinflammatory state without overt infection upon aging. In the CNS, inflammaging is mainly driven by glia cells and associated with neurodegenerative processes. White matter degene [....] » Read More
Title : Cognitive and Behavioral Mechanisms of Transcranial Direct Current Stimulation in Obsessive-Compulsive Disorder
Flavia I Spiroiu, McMaster University, Canada
Background. Obsessive-compulsive disorder (OCD) is a common and severe psychiatric disorder. Cognitive behavior therapy (CBT) with exposure and response prevention (ERP) is the gold standard intervention for OCD, but more than 40% of patients with this disorder remain impaired ev [....] » Read More
Title : Prevalence and outcomes of autoimmune encephalitis in a tertiary hospital in Baguio city, Philippines
Jaidi Sagay, BGHMC, Philippines
INTRODUCTION: Autoimmune Encephalitis is a debilitating neurological disorder that develops as a rapidly progressive encephalopathy, occurring usually less than 6 weeks, caused by brain inflammation. There are limited data on the autoimmune cases in the locality. This study aims [....] » Read More
Title : Neuroprotective effect of L-Theanine against Tramadol Induced Parkinson’s like symptoms in experimental Rats
Khadga Raj Aran, ISF College of Pharmacy, Moga, India
Introduction Parkinson’s disease (PD) is a chronic neurodegenerative disorder triggered by degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc). Low antioxidant level, mitochondrial failure and neuroinflammation are the major pathological mechani [....] » Read More