There exist many theories regarding the basis of gait inertia and instability for people with Parkinson’s disease (PD). This presentation will use a video to demonstrate an alternative explanation for this occurrence together with a very simple mode of intervention, based o [....] » Read More
Ziconotide is a synthetic, water-soluble cone snail venom-derived peptide with a molecular weight of 2,639 Daltons. It is a nonopioid analgesic that selectively binds to N-type voltage-sensitive calcium channels on primary nociceptive afferent nerves in the dorsal horn of the spi [....] » Read More
Traumatic brain injury is an important concern in the realm of neurological diseases. At present, our understanding of TBI and its downstream effects both acutely and chronically is limited, although in the past decade, many recent advancements have presented. Current treatment r [....] » Read More
Rubral tremors, or Holmes’ tremors, are a type of movement disorder that appear post-cerebellar/thalamic injury. Optimal treatment approaches for rubral tremors are still being understood and include pharmacological options such as dopamine precursors, anticonvulsants, and [....] » Read More
BACKGROUND: Despite the potential importance of intolerance of uncertainty (IU) as a transdiagnostic feature that may contribute specifically to social anxiety, empirical data on the construct has been relatively scant and focused largely on Generalized Anxiety Disorder (GAD) and [....] » Read More
Background Venous thromboembolism(VTE) prophylaxis is a recognised part of stroke management in European Stroke Organisation (ESO) guidelines, and a component in the NICE Stroke pathway. The practicalities of the prescribing and application of these modalities whether pharmacolo [....] » Read More
Introduction: Cerebral amyloid angiopathy related inflammation (CAARI) is a rare but now increasingly recognised presentation of cerebral amyloid angiopathy (CAA). The clinical presentation is most commonly an acute or subacute onset of cognitive decline, rapidly progressive deme [....] » Read More
Background. Obsessive-compulsive disorder (OCD) is a common and severe psychiatric disorder. Cognitive behavior therapy (CBT) with exposure and response prevention (ERP) is the gold standard intervention for OCD, but more than 40% of patients with this disorder remain impaired ev [....] » Read More
To make possible a systemic methodology for the treatment of the neuromuscular pathology, some models must be developed to predict what stimulus can optimal interfere with the system function in order to modify its state. Stripped muscles are part of somatic system - the interact [....] » Read More
Deep brain stimulation (DBS) of anterior thalamic nucleus (ATN) has established as an effective adjunctive therapy for patients with intractable epilepsy (IE) not suitable for epilepsy brain surgery and/or vagal nerve stimulation. The judicious selection of DBS parameters (DBSPs) [....] » Read More
The increasing prevalence of blast traumatic brain injury (bTBI) in military personnel has stimulated further research into this field. The neuroendocrine system can be severely affected in blast survivors and anterior pituitary dysfunction has been characterised in soldiers retu [....] » Read More
The increasing prevalence of blast traumatic brain injury (bTBI) in military personnel has stimulated further research into this field. The neuroendocrine system can be severely affected in blast survivors and anterior pituitary dysfunction has been characterised in soldiers retu [....] » Read More
Reading is an important skill for mastery in social relationships, academic performance, emotional regulation and most types of work. Reading impairments, one of the most common neurodevelopmental disorders affecting approximately 5-10% of school-going children across languages, [....] » Read More
The present communication proposes are question how the family and the community are structuring actors in the management of chronic kidney disease; questions the habits and routines of a chronic renal patient based on the neurosciences approach and relates this information to co [....] » Read More
Accumulating evidence for Neuropeptide Y (NPY) and galanin (GAL) interaction was shown in various limbic system regions at molecular-, cellular- and behavioral-specific levels. Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases and depressi [....] » Read More
Light pollution has recently become a significant global environmental issue. Interestingly, several in vivo approaches and worldwide correlation studies of Parkinson disease onsets have shown to strongly correlate with the distribution of light pollution. In particular it has be [....] » Read More
Background: The main reason for neurological disability and death in young adults is traumatic brain injury (TBI), affecting about 60 million people annually. Recovery is directed by the intensity and severity of the lesion, as well as by the dimension of subsequent damage to inf [....] » Read More
Background: Meningiomas are the most common intracranial tumors, they can occur on any intracranial or spinal dural surfaces and even with benign predominance, are related to neurological deficits and decreased quality of life. Objectives: This paper aims to demonstrate the impo [....] » Read More
The number of cases reporting the frequent impact on the nervous system due to SARS-COV-2 infection is increasing and raising justifiable concerns. This impact, usually manifested in more severe cases of the disease, can lead to the most diverse neurological disorders. Among the [....] » Read More
Parkinson’s disease (PD) is a multisystem neurodegenerative disorder characterized by heterogenous clinical features associated with Lewy bodies and loss of dopaminergic neurons in the substantia nigra pars compacta. Currently, PD is managed using several disease-modifying [....] » Read More
Lebers hereditary optic neuropathy (LHON) is a mitochondrial genetic disease that preferentially causes blindness in young males, prevalence between 1 in 8500 and 1 in 50000. It is an inherited neuropathy characterized by bilateral subacute loss of central vision owing to focal d [....] » Read More
This is a cautionary tale about disciplinary allergies: a sorry tale from the psychology of reason-ing literature rejecting logic. Understanding a very little logic can be a great boost to empirical investiga-tions. Our goal here is to interest related disciplines in a major shif [....] » Read More
Introduction: Selective amygdalohippocampectomy (SA) is an effective treatment for drug-resistant cases of epilepsy due to hippocampal sclerosis (HS). However, its neurocognitive outcomes are inconsistent across previous studies, pointing to potential location-specific confounder [....] » Read More
Introduction: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is defined as an autoimmune disease of the CNS associated with a serological antibody against myelin oligodendrocyte glycoprotein (MOG). MOG is found within the CNS: the optic nerves, brain, and spinal co [....] » Read More
Background and Objectives: As the COVID-19 pandemic progresses, an increasing amount of research points towards the importance and prevalence of long-term neurocognitive symptoms following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Desig [....] » Read More
We have investigated how a de novo cohort of people with Parkinson’s disease (PD) differs in terms of balance and gait function as well as frequency of near falls and falls in comparison to a cohort with mild to moderate PD that has been medicated for several years. Prelimi [....] » Read More
As one of the major healthcare challenges worldwide, Alzheimer’s disease (AD) is a detrimental brain disorder of a multifactorial nature, with an etiopathogenesis still not completely clear, influenced by epigenetic and genetic variants combined with environmental and lifes [....] » Read More
Extramedullay hematopoiesis (EMH) is a common compensatory phenomenon to chronic hemolytic anemias. Commonly occurs in the liver, spleen, kidney, lymph nodes and also been reported in skin, adrenal gland, thymus, ovary, paraspinal regions of thorax, pelvic region and the process [....] » Read More
Approximately 50 million people are addicted to nicotine just in America, worldwide these numbers reach 1.1 billion with 6 million people dying each year from forms of smoking. Even though nicotine is generally known as the “bad guy”, it is important to recognize the [....] » Read More
Background: Parkinson’s disease (PD) is usually more prevalent in men than in women, which has been explained in terms of environmental, hormonal and genetic influences, but little has been reported in terms of clinical characteristics among sex. Objective: to analyze mo [....] » Read More
Background: ApoE4 is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). Previous studies have shown that innate immune dysfunction induced by ApoE4 plays an important role in brain Aβ deposition and AD. GWAS studies showed that mutations in genes re [....] » Read More
Introduction Parkinson’s disease (PD) is a chronic neurodegenerative disorder triggered by degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc). Low antioxidant level, mitochondrial failure and neuroinflammation are the major pathological mechani [....] » Read More
Background. It has long been recognized that inflammation plays a critical role in the pathogenesis of ischemic stroke. However, whether leukocyte count and neutrophil-to-lymphocyte ratio are related to stroke severity and functional outcome is uncertain. Objective. This clini [....] » Read More
GABA-ergic transmission is shown to be of importance for regulation of mood, memory, and food intake. The progesterone metabolite allopregnanolone (Allo) is a positive GABAA receptor modulating steroid with potent effects. In humans, disorders like premenstrual dysphoric disorder [....] » Read More
This is a case report of a 45 years old female patient with a past medical history of depression and poor oral intake presented for a single episode of unwitnessed seizure and 3 days of unsteady gait and vertigo. Then she had two episodes of seizure focal and then generalized ton [....] » Read More
Pediatric autoimmune encephalitis (AIE) is emerging to be more common than had previously been thought in children. Even though the underlying pathophysiology is similar, the presentation, antibody types, treatment and outcomes in children are very different from adult autoimmune [....] » Read More
Meningiomas are the most frequent primary tumors arising in the central nervous system. They typically follow a benign course, with an excellent prognosis for grade I lesions through surgical intervention. Although radiotherapy is a good option for recurrent, progressive, or in [....] » Read More
This study evaluated the relationship between executive function and adaptive coping strategies (ACS) in healthy adults between the ages of 43 and 52. The participants (n=104) 52 males and 52 females had no history of neurological or psychiatric illnesses or chronic conditions. N [....] » Read More
Characterizing the information processing capacity of the human brain is a key challenge in cognitive psychology and neuroscience. Most of the existing research in this area has focused on the capacity limit of short-term working memory, or how well an individual handles informat [....] » Read More
Background: Stroke is a disabling disease due to its functional impairments and complications. In this study, we aimed to examine the clinical profiles, practical outcomes, and complications during rehabilitation of patients hospitalized with stroke. Methods: In this single ce [....] » Read More
At the age of 32, and 6 months postpartum from having her first child, Michelle walked into the ER with impaired motor skills on the left side of her body, a horrible headache and slurred speech. She was diagnosed with a migraine and discharged. Two days later she had a massive I [....] » Read More
Neurodegenerative diseases are a group of progressive disorders that affect the central nervous system (CNS) such as Alzheimer, Parkinson, and multiple sclerosis. Inflammation plays a critical role in the onset and progression of these injuries. Periodontitis is considered [....] » Read More
Background: Obstructive sleep apnea (OSA) is a disorder caused by the repeated collapse of the upper airway during sleep. It is the most common cause of sleep-related breathing disorder, as OSA can cause loud snoring, daytime fatigue, or more severe problems such as high blood [....] » Read More
INTRODUCTION: COVID-19 has different clinical symptoms, with excessive inflammation and cardiovascular changes being common in severe cases. The use of transcutaneous atrial vagus nerve stimulation (taVNS) seems to be a viable treatment for these alterations. OBJECTIVE: To eva [....] » Read More
Background: Fibromyalgia (FM) is a chronic disorder with persistent manifestation of pain, mood swings, fatigue, depression and attention deficits that affects one’s activity of daily living. Objective: The present study aimed to find prevalence and diagnosis of Fibromya [....] » Read More
Background: Fat embolism syndrome (FES) is associated with long bone fractures, occurring with a variable frequency of 0,5 to 3,5% after surgical treatment. It affects 90% of open fractures of long bones, being 75% femoral and 19% tibial fractures. Hypoxic - ischemic enceph [....] » Read More
Background/Aims: Parkinsonism characterized by deficits in cognitive functions that affect the motor control. The main aim was to assess the effect of motor learning feedback with augmented cues of motor learning on cognitive functions and motor performance in patients with Parki [....] » Read More
Introduction: Transient global amnesia (TGA) involves a sudden onset of anterograde and retrograde amnesia, often accompanied by executive dysfunction, typically lasting up to 24 hours, and not linked to another neurological impairment. Case Presentation: A 52-year-o [....] » Read More
Introduction: Early aortic graft infections, which can arise within 4 months of endovascular graft repair, frequently present as high-grade infections. However, late infections can be challenging to detect due to nonspecific symptoms. This case report discusses a late aortic graf [....] » Read More
BACKGROUND AND AIM: Agenesis of the corpus callosum can lead to varied neurodevelopmental outcomes. The prevalence of isolated agenesis of the corpus callosum (iACC) is not known; selection bias in reported series as well as changes in how ACC was diagnosed prenatally, and lac [....] » Read More
Parkinson’s disease (PD) is a common progressive neurodegenerative movement disorder. The cardinal feature of Parkinson's is neuronal degeneration causing a dopamine deficit in the brain which leads to a host of clinical features in the patient. However, consensus over [....] » Read More
Mitral stenosis (MS), a valvular heart disease, is defined by the narrowing of the mitral valve orifice. The common risk factors for stroke include mitral annular calcification (MAC), diabetes mellitus (DM), male gender, hypertension (HTN), hyperlipidemia, and obesity. Endothelia [....] » Read More
Introduction: The effect of systemic tranexamic acid (TXA) administration on blood loss reduction during spine surgeries has been widely published over the past decade. However, topical use of TXA during cervical spine surgery is rarely investigated. We aimed to assess the role o [....] » Read More
Introduction: The thoracolumbar junction represents a transition zone of the spine that leads to a high incidence of fractures. The treatment of burst fractures remains controversial regarding the ideal management. This study assessed the postoperative radiological outcome of tho [....] » Read More
The World Health Organization declared COVID-19 a pandemic in February 2020, and it has affected the life of each and everyone. COVID-19 is designated as severe respiratory syndrome coronavirus 2 (SARS-CoV-2). It causes an acute inflammatory process in the body, which is hypothes [....] » Read More
Introduction: Neurosarcoidosis is an uncommon manifestation and should be suspected in any patients with sarcoidosis with new neurological symptoms. We present a rare case of probable neurosarcoidosis, which was diagnosed by exclusion and elevated acetylcholinesterase (ACE) le [....] » Read More
Neurofibromatosis type 2 (NF2) is a genetic disorder that predisposes individuals to multiple tumors of the nervous system. The most common of these are bilateral vestibular schwannomas; intracranial and spinal meningiomas, and spinal cord ependymomas. The condition is caused by [....] » Read More
Background & Purpose Knowledge surrounding inpatient costs of bacterial meningitis (BM) management is limited. We aimed to explore the financial burden of hospitalization due to BM, including cost trends over time and factors associated with higher costs. Methods We [....] » Read More
Multiple Sclerosis (MS) is an autoimmune disease targeting myelin in the central nervous system. Most disease modifying therapies (DMTs) for MS function via immunomodulation by a variety of modalities, some of which are immunosuppressive and some which are not. In this study we c [....] » Read More
Correct identification and analysis of intracranial masses is of high clinical importance especially when it comes to treating acute illnesses and focal neurological deficits, while preventing further deterioration. We present a rare case of a giant thrombosed aneurysm in the [....] » Read More
A 56 years old female patient presented with a few weeks of persistent nausea, vomiting, watery diarrhea, generalized itching and unintentional weight loss. She denied alcohol intake. Labs showed mild hypercalcemia at 10.6 mg/dl. Abdominal examination was benign. Investigations [....] » Read More
Objective: The purpose of this study was to evaluate the development of clinically diagnosed anxiety or depression within one year following a minor traumatic brain injury (mTBI). Design: A state-wide hospital system (Ochsner Health) retrospective cohort analysis Settin [....] » Read More
Background. Optic neuritis and optic neuropathy can cause a reduced color-sensitivity. Therefore, in clinical routine the patient's perception of the red color is tested in order to evaluate the function of the optic nerve. Red desaturation is traditionally tested by presenti [....] » Read More
Background: Behcet's syndrome (BS) is an idiopathic vasculitis disease, which causes a wide spectrum of different focal and systemic symptoms. This review aimed to investigate the neuropsychiatric and cognitive aspects of this syndrome. Method: Using the keywords "psy [....] » Read More
Title : Nanomedicine and the Brain: A Perfect Combination ?
Thomas J Webster, Interstellar Therapeutics, United States
Nanotechnology has revolutionized numerous industries, particularly medicine. Nanoparticles, nanotubes, drug delivery nanoparticles, and nanotextured neural probes are just several of many examples where nanomedicine is positively impacting neuroscience. This presentation will su [....] » Read More
Title : In vitro modelling of brain development and neurodegenerative diseases
Andreas Till, University of Bonn, Germany
Given the complex etiopathology of neurodegenerative diseases and the limited access to vital human brain cells as suitable research platform, there is an increasing demand of innovative human-specific model systems that help elucidating the causative mechanisms of these disorder [....] » Read More
Title : Rogue Percepts = Rogue Responses: What Are the Possible Sets of Initial Conditions That Give Rise to Willis-Ekbom Disease - Restless Legs Syndrome (RLS), And Can RLS be Therapeutically Pacified? - A NeuroPhysics Therapy Study and Hypothesis Based Upon Observations and Outcomes -
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
The human central nervous system (CNS) fundamentally does something elegant and simple and is programmed to abide by some simple sets of rules and initial conditions. Fundamentally, the CNS takes in and perceives information coming in from the outside world and responds to it. Ho [....] » Read More
Title : The case of jahi mcmath: Dilemmas and controversies in the diagnosis of brain death
Calixto Machado, Institute of Neurology and Neurosurgery, Cuba
I was a main expert in the case of Jahi McMath, who was diagnosed with brain death (BD). Nonetheless, ancillary tests performed nine months after the initial brain insult showed conservation of intracranial structures, EEG activity, and autonomic reactivity to the “Mother T [....] » Read More
Title : Prognostic indicators of spontaneous neurological recovery following Traumatic Spinal Cord Injuries and the role of the Neurologist
W S El Masri, Keele University, United Kingdom
Spontaneous Neurological Recovery is very common in patients with incomplete traumatic spinal cord injuries. This is provided no further mechanical and non-mechanical damage is inflicted onto the injured cord. Currently there is great deal of emphasis on the threats of the Biomec [....] » Read More
Title : Application of activity-based probe, MV151, in the mammalian nervous system reveals new insight into proteasome changes in human Alzheimer’s disease brain
Fulya Turker, Johns Hopkins University School of Medicine, United States
Proteasome complexes play a critical role in human brain health and disease. Despite enormous effort, a deep understanding of proteasome composition, activity, and abundance in the human brain remains poorly understood. Here, we describe a series of tools that can measure the cat [....] » Read More
Title : Multi-Characteristic Opsin Gene Delivery for Neuromodulation of Inflammatory and Persistent Pain Sensation in Rodent Model
Arman John Fijany, TCU School of Medicine, United States
Pain is an uncomfortable sensation perceived by the nervous system that can have a variety of different causes. Pain can be seen as a complication of disease, emotional states and even as a standalone pathology. The neuroscience of pain is poorly understood. Multiple levels of co [....] » Read More
Title : VWF regulates the expression of adhesion molecules, modulating vascular permeability in endothelial cells after a TBI.
Marina Martinez Vargas, Baylor College of Medicine, United States
von Willebrand factor (VWF) is a multimeric protein that mediates thromboinflammation and has been linked to traumatic brain injury (TBI), specifically in the pathogenesis of early brain injury. Activated endothelium secretes VWF multimers as long hyperadhesive strings. During TB [....] » Read More
Title : Optogenetic neuromodulation of allodynia and hyperalgesia pain responses in rodent model
Arman John Fijany, TCU School of Medicine, United States
Introduction: While pain is the body’s normal physiological response to tissue damage, it is a significant contributor to worldwide disability as well as physical and psychological distress. These deleterious effects are typically dictated by the duration and intensity of p [....] » Read More
Title : A new outlook on brain injury recovery
Mohammed Elamir, Aviv Clinics, United States
In this presentation, Dr. Mohammed Elamir and Dr. Amir Hadanny will present nearly a decade of research in the use of Hyperbaric Oxygen Therapy (HBOT) to treat chronic symptoms related to Traumatic Brain Injury (TBI) and concussion that can be cognitively and physically debilitat [....] » Read More
Title : A new outlook on brain injury recovery
Amir Hadanny, Aviv Clinics, United States
In this presentation, Dr. Mohammed Elamir and Dr. Amir Hadanny will present nearly a decade of research in the use of Hyperbaric Oxygen Therapy (HBOT) to treat chronic symptoms related to Traumatic Brain Injury (TBI) and concussion that can be cognitively and physically debilitat [....] » Read More
Title : MRI-navigated transcranial pulse stimulation (TPS) as an alternative option for severe treatment-resistant depression– a case report
Ulrich Sprick, Alexius/Josef Clinic, Germany
Patients with severe therapy-resistant depressive disorders repeatedly pose enormous treatment challenges in psychiatry and neurology. Transcranial pulse stimulation (TPS) as a new non-invasive therapy method could represent a new alternative to standard treatment such as ECT, ma [....] » Read More
Title : Could We See Alzheimer’s Disease Through the Eye?
Aygun BadaLova, University College London, United Kingdom
One of the most common and prevalent neurodegenerative disorders are Alzheimer's and Dementia which are considered significant causes of mortality and morbidity in today’s society particularly among the elderly population.(Erkkinen, Kim et al. 2018)The etiologic and pat [....] » Read More
Title : Screening of biomarkers for acute ischemic stroke using bioinformatics analysis
Lakshmi Sundeep, Hindustan Institute of Technology and Science, India
Acute Ischemic Stroke (AIS) is a life-threatening cerebrovascular illness. The cause of AIS is unknown, and treatment options are limited. The study is to find out which genes are expressed in AISs and use that information to guide future research and treatment. The raw datasets [....] » Read More
Title : Lived Experience of the African American Informal Caregivers of a Family Member with Alzheimer’s Disease and Related dementia
Dell G Mars, Southeastern Louisiana University School of Nursing, United States
Purpose: The purpose of this qualitative study was to describe the lived experience of African American informal caregivers of family members of Alzheimer’s Disease and Related Dementias (ADRD) in a home environment. Design and Method: This phenomenological descriptive [....] » Read More
Title : Mortality, length of stay, and cost of hospitalization among adult patients with multiple sclerosis: results from the National Inpatient Sample.
Alsu Zagorulko, Illinois Center for Neurological and Behavioral Medicine, United States
Introduction: The study was performed to evaluate factors associated with in-hospital mortality, length of stay (LOS), and hospitalization cost among adults with multiple sclerosis (MS). Methods. We used the National Inpatient Sample (2019) to identify adult hospitalizations w [....] » Read More
Title : The apt diagnosis of progressive supranuclear palsy with frontal predominance: A case report
Solomon Nittala DO MS, Larkin Community Hospital Palm Springs Campus, United States
Originally described in 1964, progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy with a prevalence of approximately 45% among other parkinsonian-plus syndromes. PSP can be categorized into various phenotypes among which 6% belong to the PSP-frontal predominan [....] » Read More
Title : Rapidly Progressive Sporadic Creutzfeldt-Jakob Disease (CJD): A Case Report and Literature Review
Elita Delbruck, California University of Science and Medicine,, United States
Prion diseases are rare and rapidly progressive neuro-degenerative disorders that are poorly understood. Universally fatal, diagnosis primarily focuses on the excluding other treatable diseases. This case of probable sporadic Creutzfeldt-Jakob Disease (sCJD) in an otherwise healt [....] » Read More
Title : A Mild Cognitive Impairment Diagnostic Tool In Comparison To The Unified Huntington’s Disease Rating Scale: Cognitive Battery
Luis A Sierra, Beth Israel Deaconess Medical Center, United States
Background: A diagnosis of manifest Huntington’s disease (HD) is based primarily on motor symptoms, but early cognitive decline is common in the pre-manifest HD period (preHD). Early symptom detection in HD has important implications for monitoring both disease pr [....] » Read More
Title : Improving Stroke Quality Metrics at Robert Packer Hospital
Rebecca Lees, Guthrie Robert Packer Hospital, United States
Stroke is the number one preventable cause of disability and a leading cause of death in both men and women; rapid assessment and treatment is critical to improve outcomes for patients. Guthrie Robert Packer Hospital received The Joint Commission Primary Stroke Center certificati [....] » Read More
Title : A New Methodological Approach to Improve the "Real Word" Effectiveness of Ketamine Infusion Therapy for Treatment-Resistant Depression
Gerald W. Grass, Ketamine Research Institute, United States
Objective: Ketamine is recognized as a rapidly acting antidepressant; however, discrepancies exist between the "Efficacy" reported in research studies (70-85%) versus significantly lower "Effectiveness" (18.3-45.5%) reported in community-based settings. To off [....] » Read More
Title : Pre-exposure to acute stress modulates the molecular response to a mild traumatic brain injury
Johanna Christina Reiners, Ulm University, Germany
Stress is generally defined as a real or interpreted threat to the psychological or physiological integrity of an individual that results in physiological and/or behavioral responses. Threatening stimuli trigger neuronal responses in the brain that cause an immediate adaptive sys [....] » Read More
Title : Investigation of low frequency thalamic and pallidal local field potential correlation with voluntary movement in children with dystonia
Maral Kasiri, University of California, United States
Understanding the relationship between neural activity and voluntary movement provides new insights into understanding the mechanism underlying neural control of movement in both healthy people and those with movement disorders. To investigate the relationship between deep brain [....] » Read More
Title : NF- ?B is a critical mediator of age-dependent white matter loss
Judith Stefanie Schlett, Institute of Physiological Chemistry, Ulm University, Germany
Infl ammaging represents an accepted concept where the immune system shifts to a low-grade chronic pro- infl ammatory state without overt infection upon aging. In the CNS, infl ammaging is mainly driven by glia cells and associated with neurodegenerative processes. White matter d [....] » Read More
Title : Imatinib as a treatment for prion disease: A historical case of Sporadic Creutzfeldt Jacob disease complicating chronic myeloid leukemia on Imatinib.
Smaili Rachid, University hospital of Tangier- Tétouan-Al Hoceima, France
Background: Creutzfeldt Jakob disease (CJD) is a fatal and rare neurodegenerative disease, It is classified into 3 subgroups: sporadic, genetic and acquired. Sporadic CJD is the most common form, which may be manifested with misleading neuropsychiatric symptoms and resulting in [....] » Read More
Title : Design and synthesis of novel psilocin prodrugs with improved metabolic and pharmacokinetic properties as candidate therapies for treatment-resistant anxiety disorders
Peter J. Facchini, Enveric Biosciences, Canada
The psychedelic compound psilocybin has shown therapeutic benefit in the treatment of several psychiatric diseases. A recent randomized clinical trial conducted at Johns Hopkins Bayview Medical Center demonstrated the efficacy of psilocybin-assisted therapy in the treatment of Ma [....] » Read More
Title : Isolation of a novel N-methyltransferase from psychedelic cane toad (Rhinella murina) deployable in bio-based production platforms for psychiatric drug discovery
Jillian M. Hagel, 1Enveric Biosciences, Inc, Canada
The skin and paratoid gland secretions of many toads in the Bufonidae family contain several natural products with importance to traditional medicine. Some of these compounds, such the indole amines 5-hydroxy-N,N-dimethyltryptamine (bufotenine) and 5-methoxy-N,N-dimethyltryptamin [....] » Read More
Title : Parsonage–Turner syndrome following COVID-19 vaccination: case series
Ilhan Yu, Nowon eulji university hospital, Korea, Republic of
Background Severe acute respiratory syndrome coronavirus 2 is a coronavirus that has recently appeared, rapidly spreads, and results in coronavirus disease 2019 (COVID-19). Moderna mRNA-1273 and Pfizer-BioNTech BNT162b2 vaccines are among the most widely used and effective va [....] » Read More
Title : A selective p38?/? MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5xFAD mouse
Min Sung Gee, Kyung Hee University, Korea, Republic of
Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal cell loss and cognitive impairment are pathological symptoms of Alzheimer’s disease (AD). Regarding these symptoms, resolution of neuroinflammation and inhibition of Aβ-driven pathology m [....] » Read More
Title : Multiple Autoimmune Syndrome: Combination of Neuromyelitis Optica Spectrum Disorder with Myastenia Gravis, Systemic Lupus Erythamatosis and Hashimato Tiroiditis
Vildan Tuncbilek, Tekirdağ Namık Kemal University, Turkey
Autoimmunity reflects an altered immune status, therefore the presence of more than one disorder is not uncommon. The coexistence of three or more autoimmune diseases in a patient constitutes multiple autoimmune syndrome (MAS). This is an interesting case of a middle-aged female [....] » Read More