Abstract:
Traumatic brain injury is an important concern in the realm of neurological diseases. At present, our understanding of TBI and its downstream effects both acutely and chronically is limited, although in the past decade, many recent advancements have presented. Current treatment regimens have largely followed academic society guidelines with a special emphasis on intensive care unit management. Its diverse etiology in disease presentation has lent its way to difficulty in seeing promising advancements succeed in clinical development, although our understanding of this disease course and the therapeutic targets currently in development continues to grow. These areas of interest include excitotoxicity, oxidative stress, blood brain barrier disruption, neuroinflammation, and white matter degeneration. At present, emerging treatments have included cell-based therapies and the neuroprotective agents focused on recovery following inflammatory damage. The current review highlights in detail the advancements in our understanding in the pathophysiology of TBI, the current treatment regimens, and the emerging treatments in development.
Biography:
Brandon Lucke-Wold was born and raised in Colorado Springs, CO. He graduated magna cum laude with a BS in Neuroscience and distinction in honors from Baylor University. He completed his MD/PhD, Master’s in Clinical and Translational Research, and the Global Health Track at West Virginia University School of Medicine. His research focus was on traumatic brain injury, neurosurgical simulation, and stroke. At West Virginia University, he also served as a health coach for the Diabetes Prevention and Management program in Morgantown and Charleston, WV, which significantly improved health outcomes for participants. In addition to his research and public health projects, he is a co-founder of the biotechnology company Wright-Wold Scientific, the pharmaceutical company CTE cure, and was a science advocate on Capitol Hill through the Washington Fellow’s program. He has also served as president of the WVU chapters for the American Association of Pharmaceutical Scientists, Neurosurgery Interest group, and Erlenmeyer Initiative Entrepreneur group. In addition, he has served as vice president for the graduate student neuroscience interest group, Nu Rho Psi Honor Society, and medical students for global health. He was an active member of the Gold Humanism Honor Society and Alpha Omega Alpha Honor Society. He is currently a member of the UF House Staff Council, Positive Culture Committee, Quality Improvement Committee, Board of Directors Alachua County Medical Society, and Accreditation Requirements Review Committee. He is married to Noelle Lucke-Wold and has two children. As a family, they enjoy running with their dogs, rock climbing, and traveling. In his spare time, Brandon frequently runs half marathons and 10ks together with is wife. Brandon also enjoys reading, playing piano, discussing philosophy, and playing chess. He is currently a Pgy5 neurosurgery resident at University of Florida with pursuing endovascular enfolded training and was awarded the Dempsey Cerebrovascular Research Fellowship.
