Title : Neuropsychiatric and Cognitive aspects of behcet's syndrome : A systematic review on recent studies
Background: Behcet's syndrome (BS) is an idiopathic vasculitis disease, which causes a wide spectrum of different focal and systemic symptoms. This review aimed to investigate the neuropsychiatric and cognitive aspects of this syndrome.
Method: Using the keywords "psychiatric disorders and Behcet's syndrome", "cognitive deficits and Behcet's syndrome" and related sub-categories, We searched among the articles of PubMed, Google Scholar, and Scopus databases . By removing duplicates and using inclusion-exclusion criteria, 35 articles were finally chosen to be reviewed.
Results: Investigating the prevalence of mood disorders, especially depression and bipolar disorder among patients with BS, compared to the control group has monopolized the largest portion of these studies. Their results show a higher frequency of mood disorders in patients with BS compared to the healthy control group.
In performing cognitive tests related to measuring memory, learning abilities and decision making, patients with Behcet's syndrome scored lower than the control groups.
In another study, complaints of sleep disorders in patients with BS were significantly more seen than in the control group.
Also, the amount of complaints about sexual disorders, in general, is higher among patients with BS compared to control groups. Most of these complaints are erectile dysfunction in males.
Conclusion: A short review of recent studies shows we need more reliable clinical research to redefine Behcet syndrome due to its cognitive and behavioral aspects. However, future studies are also facing many challenges, among which we can point out the wide variety of symptoms, access and long-term follow-up of patients, and the inevitable presence of Confounding bias.
What will audience learn from your presentation?
- Despite it seems we know all aspects of Behçet's syndrome very well. But the cognitive and behavioral aspects of Behcet´s are mostly hidden from the attention of clinical experts. This review article is an attempt to learn more about the less seen aspects of this disease
- This study can be helpful for clinical specialists to have a comprehensive look at Behcet´s in the path of diagnosis and also treatment.
- Also, this topic can be a spark for researchers in the interdisciplinary fields of neuroimmunology and neurorheumatology