HYBRID EVENT: You can participate in person at Orlando, USA or Virtually from your home or work.

6th Edition of International Conference on Neurology and Brain Disorders

October 24 -26, 2022

October 24 -26, 2022 | Orlando, Florida, USA
INBC 2022

Manuel Narváez Peláez

Speaker at Neurology and Brain Disorders 2022 - Manuel Narváez Peláez
University of Malaga, Spain
Title : New preclinical findings in depression and neurodegenerative diseases: Role for Galanin and Neuropeptide Y interaction in the hippocampus.

Abstract:

Accumulating evidence for Neuropeptide Y (NPY) and galanin (GAL) interaction was shown in various limbic system regions at molecular-, cellular- and behavioral-specific levels. Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases and depression, where boosting hippocampal neurogenesis in these patients emerges as a potential therapeutic approach. The purpose of the current work was to evaluate the role of NPY and GAL interaction in the neurogenic actions on the dorsal and ventral hippocampus. We studied the Y1R agonist and GAL effects on: hippocampal cell proliferation through the proliferating cell nuclear antigen (PCNA); the expression of neuroprotective and anti-apoptotic factors and the survival of neurons and neurite outgrowth on hippocampal neuronal cells. The functional outcome was evaluated in the object-in-Place task and the forced swimming test. We demonstrated that the Y1R agonist and GAL and promote cell proliferation and the induction of neuroprotective factors. These effects were mediated by the interaction of NPYY1 (Y1R) and GAL2 (GALR2) receptors, which mediate the increased survival and neurites outgrowth observed on neuronal hippocampal cells. These cellular effects are linked to the improved spatial-memory effects after the Y1R agonist and GAL coinjection at 24 hours in the object-in-place task and in the forced swimming test. Our results suggest the development of heterobivalent agonist pharmacophores, targeting Y1R-GALR2 heterocomplexes, therefore acting on the neuronal precursor cells of the DG in the dorsal hippocampus for the novel therapy of neurodegenerative cognitive-affecting and depressive diseases.

What will audience learn from your presentation? 

•    Understanding Neuropeptide Y and GAL interaction through Y1R-GALR2 heteroreceptor complex.
•    How the the Y1R agonist and GAL may promote cell proliferation in the DG of the dorsal and ventral hippocampus and the induction of neuroprotective factors, such as BDNF and Bcl-2. 
•    How Y1R-GALR2 heteroreceptor complexes mediate survival and neurites outgrowth on neuronal hippocampal cells.
•    How these cellular effects may be linked to spatial-memory and antidepressant effects.
•    The development of heterobivalent agonist pharmacophores, targeting Y1R-GALR2 heterocomplexes, therefore acting on the neuronal precursor cells of the DG in the dorsal and ventral hippocampus for the novel therapy of neurodegenerative cognitive-affecting and depressive diseases.

 

Biography:

Manuel Narvaez Peláez cursed Medicine and surgery with the best academic record of his promotion. Our team has contributed to the GPCR receptor-receptor interactions field focus in CNS diseases, such as depression, Parkinson, addiction drugs and Alzheimer. As professor, he is performing an independent and emergent line of research, aim to understand the molecular mechanisms and potential relevance of Y1R heterocomplexes interactions in depression and Alzheimer disease, in line with my pioneering work in this field. The research results have been published successively in congresses of international and national relevance. In addition, innovative articles have been published, including in the first quartile of impact index in its category and with quality indices, including high cite numbers. I belong to the CTS-156 of the Junta de Andalucía and the Malaga Biomedical Research Institute (IBIMA). I have reviewed international research projects from CONACYT, Mexico and recently as evaluator for the Call 'Marie Skłodowska-Curie Actions Doctoral Networks' (HE-MSCA-DN-2021).

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