Title : Risk of Stroke With Mitral Stenosis: The Underlying Mechanism, Treatment, and Prevention
Abstract:
Mitral stenosis (MS), a valvular heart disease, is defined by the narrowing of the mitral valve orifice. The common risk factors for stroke include mitral annular calcification (MAC), diabetes mellitus (DM), male gender, hypertension (HTN), hyperlipidemia, and obesity. Endothelial damage, hypercoagulability, and blood stasis in the left atrium promote the development of the thrombus. Among all the risk factors described, MAC is the independent predictor of stroke. The complicated mechanisms responsible for thromboembolism, predisposing factors for thromboembolism, the risk of cerebrovascular accident (CVA) in MS patients, advanced standardized assessment models for identifying those at risk for stroke, and the possible advantages and disadvantages of available therapies have all been discussed in this review article. We have also discussed newer oral anticoagulants (NOACs) like dabigatran, edoxaban, apixaban, and rivaroxaban. Non-pharmacological therapies are also highlighted such as left atrial appendage ligation and occlusion devices. We also conducted a thorough review of the literature on the efficacy and safety of various NOACs in reducing the risk of stroke.
What will audience learn from your presentation?
- We believe this study can help overcome the challenges by taking
- A comprehensive view of the correlation between the two elements (MS and stroke) and highlighting the pathogenesis, contributing factors, and management options.
- The risk can be calculated using the CHA2DS2-VASC scoring system.
- Summing up, treatment options for MS include VKAs such as warfarin and NOACs and surgical treatment.
- Successful stroke prevention treatment remains a challenge in high-risk patients, necessitating additional evidence from future research.
