Title : Developmental outcome and peri-natal diagnosis of agenesis of the corpus callosum
Abstract:
BACKGROUND AND AIM:
Agenesis of the corpus callosum can lead to varied neurodevelopmental outcomes. The prevalence of isolated agenesis of the corpus callosum (iACC) is not known; selection bias in reported series as well as changes in how ACC was diagnosed prenatally, and lack of consensus on the best threshold to diagnose iACC means it is possible a significant number of individuals with iACC have escaped detection.
The study aim was to systematically review the evidence published on the developmental outcomes of a pre-natal diagnosis of isolated ACC and review the peri-natal diagnostic methods.
METHOD:
A systematic search using the electronic databases PubMed, Cochrane, and Medline was carried out. The search was restricted to English language publications in peer-reviewed journals. PRISMA guidelines were followed. Seventeen studies met the inclusion criteria.
RESULTS:
Pooled rates of neurodevelopmental delay were 29.6% (95% CI, 24.8-34.3) and normal outcome was 70.3% (95% CI, 66.2-74.3) in iACC (figure 1). Post-natal MRI detected additional abnormalities in 67/207 (31.4%; 95% CI, 24.7-38) apparently isolated cases.
CONCLUSIONS:
A prenatal diagnosis of isolated ACC may in fact carry a favourable prognosis. MRI is needed to confirm presence of isolated ACC after ultrasonographic prenatal diagnosis, as up to 31.4% may have additional anomalies which can significantly impact outcomes. More studies with long term follow up are needed to clarify the true prognosis in isolated ACC.
What will audience learn from your presentation?
- The audience will gain awareness of agenesis of corpus callosum, it’s ideal diagnostic methods and developmental outcomes
- The audience will gain understanding of the importance in documenting conditions of complete agenesis of the corpus callosum such that future research is aided with more cases in the literature
- The presentation will provide new information on developmental outcomes and pre-natal diagnosis of agenesis of corpus callosum
- Awareness of developmental outcomes will help guide the audiences’ approach to prenatal counselling
