HYBRID EVENT: You can participate in person at Orlando, USA or Virtually from your home or work.

6th Edition of International Conference on Neurology and Brain Disorders

October 24 -26, 2022

October 24 -26, 2022 | Orlando, Florida, USA
INBC 2022

Vanessa Veronica

Speaker at Neurology and Brain Disorders 2022 - Vanessa Veronica
Duta Wacana Christian University, Indonesia
Title : Leukocyte Count and Neutrophil-to-Lymphocyte Ratio as Simple Hematologic Predictors of Stroke Severity and Functional Outcome in Acute Ischemic Stroke Patients

Abstract:

Background. It has long been recognized that inflammation plays a critical role in the pathogenesis of ischemic stroke. However, whether leukocyte count and neutrophil-to-lymphocyte ratio are related to stroke severity and functional outcome is uncertain.

Objective. This clinical study aimed to evaluate the association of leukocyte count and neutrophil-to-lymphocyte ratio with stroke severity and functional outcome in acute ischemic stroke patients.

Methods. This hospital-based, retrospective observational study included 112 subjects with acute ischemic stroke. All subjects had their demographic, clinical, and laboratory data obtained. The leukocyte count and neutrophil-to-lymphocyte ratio were evaluated to stroke severity on admission and 3-month functional outcome. The severity of stroke at admission was measured using the National Institutes of Health Stroke Scale (NIHSS), whereas the Barthel Index was used to measure 3-month functional outcome (BI). We conducted a regression analysis, adjusting for any confounding variables.

Results. Higher leukocyte count was significantly associated with increased risk of stroke severity (odds ratio [OR] 1.391, 95% confidence intervals [CI], 1.121-1.725, p: 0.003) and unfavorable functional outcome (OR 1.434, 95% CI, 1.068-1.925, p: 0.017). Higher neutrophil-to-lymphocyte ratio was not significantly associated with increased risk of stroke severity (OR 1.181, 95% CI, 0.947-1.474, p: 0.140) and unfavorable functional outcome (OR 1.246, 95% CI, 0.905-1.716, p: 0.177).

Conclusion. Our study indicates that leukocyte count is an independent predictor of stroke severity on admission and unfavorable functional outcome.

Keywords: Ischemic stroke; Inflammation; Leukocyte count; Neutrophil-to-lymphocyte ratio; Prognosis.

What will audience learn from your presentation?

  • Prognosis assessment of acute ischemic stroke patients sooner and accurately may minimize the consequences of ischemic stroke.
  • Our study indicates that leukocyte count is an independent predictor of stroke severity on admission and unfavorable functional outcome.
  • The findings of this study provide possibilities for future study into the potential utility of anti-inflammatory therapy for patients with acute ischemic stroke.

Biography:

Vanessa Veronica,B.Med studied medicine at Duta Wacana Christian University, School of Medicine Yogyakarta. She obtained his bachelor of medicine degree in 2021 as the best graduate and is currently undergoing a clinical clerkship and will obtain a medical doctor degree in 2023. She has been actively conducting research in the field of neurology since 2019 and has published 9 studies in international journals.

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