Oxygen-ozone therapy and cognitive frailty: A non-pharmacological approach to potentially resolve immune and inflammatory dysfunctions

Title : Oxygen-ozone therapy and cognitive frailty: A non-pharmacological approach to potentially resolve immune and inflammatory dysfunctions

Abstract:

As the world’s population ages, Cognitive Frailty (CF) is becoming one of the most serious health problems and elucidating its biological mechanisms along with prevention and treatments becomes increasingly important also considering the associated health costs. We thus performed a clinical randomized trial where CF subjects received a non-pharmacological therapy based on the regenerative properties of ozone (O₃) known to act on immune/inflammation processes, strongly altered in CF.

A cohort of 75 patients was stratified in non-, mildly- or severely frail rate and treated with placebo, oxygen (O₂) or O₂-O₃. The serum levels of 27 peculiar pro- and anti-inflammatory cytokines and chemokine cell signalling molecules were measured by using the Bio-Plex Pro Human Cytokine 27-plex immunoassay. The student’s t-test and analysis of variance (ANOVA) followed by Tukey’s post hoc test were used for comparison of means between the groups.

Preliminary analyses evidenced the implication, at different levels, of some molecules in relation to the frailty rate. Noteworthy, we observed modulations of immune (i.e interleukin, IL-9) and inflammation (i.e IL-1β) biomarkers at baseline and after treatment. Correlations between clinical CF profiles and peripheral levels of the considered biomarkers are ongoing in order to predict the response to O₂-O₃ therapy.

Although preliminary, these results confirm that the immune-inflammation systems are involved in the aetiopathogenetic mechanisms of CF, and that the related molecules could be potential therapeutic targets/biomarkers for the O₂-O₃ therapy. These data will further permit to validate a potential new non-pharmacological treatment approach for this condition.

Biography:

Dr. Antonio Carlo Galoforo graduated in medicine and surgery from the University of Brescia in 1991. Urologist at the San Donato Group, for more than 30 years he has been dealing with the potential of the application of ozone in medicine and in the environment, both in clinical practice and in scientific research.

Since 2018, as part of his training course on neurodegenerative diseases, he has been part of the research group c/o IRCCS - Istituto di Ricovero e Cura a Carattere Scientifico Fatebenefratelli for the project relating to cognitive fragility. Since 2013 he has been a teacher of the 2nd level Master in Oxygen Ozone Therapy at the University of Pavia. Scientific manager and tutor for ozone therapy c/o Pio Albergo Trivulzio (Milan) and accredited speaker at the World Health Organization for ozone therapy for Buruli ulcer.

He is a member of the Sioot board of directors, the Scientific Society of Oxygen Ozone Therapy. He has been and is a speaker at national and world conferences with scientific works relating to the results of oxygen ozone therapy both in research and experimentation, one of which is the World Intelligent Medicine Congress in Beijing with a focus on the treatment of Covid-19. It currently operates at the Clinical Institute of the City of Brescia and at clinics in Milan, Brescia, Manerbio and Castiglione d/Stiviere. Performs specialist visits for treatment with oxygen ozone therapy applied in all the protocols provided by Sioot (local and systemic applications - Gaet).