Title : Role of serum vitamin D in ADHD
Abstract:
Attention Deficit Hyperactivity Disorder (ADHD) is among the most prevalent neurodevelopmental disorders globally. Vitamin D deficiency (VDD) is a global pandemic. Our study connects VDD and cognitive deficit in ADHD, in the context of the irisin and galectin-3 levels. We aim to study the role of serum levels of vitamin D, irisin and galectin-3 in ADHD. An observational study in South Indian children with ADHD. This case-control observational study enrolled 152 children (n= 76 each in: ADHD and healthy control). Symptoms of ADHD were assessed using the Vanderbilt ADHD (parent and teacher) rating scale. Irisin and galectin-3 serum levels were also estimated within subgroups viz. ADHD (n=35) and controls (n=35). The median serum 25(OH) vitamin D levels, in children with ADHD, (16.99 (IQR 11.91-23.98) ng/mL) was significantly lower than in children without ADHD (22.55 (IQR 18.92-28.81) ng/mL). VDD was more common among ADHD (n=46; 60.5%) than healthy controls (n=22; 28.9%). Though ADHD children showed reduced serum irisin and increased serum galectin levels, the difference was not statistically significant. Highly significant correlation between serum irisin and galectin-3 levels in ADHD were observed. High prevalence of VDD points out the importance of vitamin D and vitamin D supplementation in ADHD.
