Interplay between chronic stress and multiple sclerosis: Mechanisms and therapeutic approaches

Multiple Sclerosis (MS) is a chronic, immune-mediated neurodegenerative disorder characterized by inflammation and demyelination of the central nervous system. This literature review evaluates the intricate relationship between chronic stress and MS, particularly its role in the progression of the disease and relapse rates. Chronic stress has been shown to dysregulate the immune system by increasing pro-inflammatory cytokines, such as IL-6 and TNF-α, and inducing oxidative stress, thereby exacerbating MS pathology.

This discussion highlights the importance of addressing both physiological and psychological stressors in the clinical management of MS. Evidence-based therapeutic interventions, including mindfulness practices, yoga, targeted dietary approaches, and exercise programs, have shown potential in reducing stress and its detrimental effects on MS patients. For instance, dietary strategies focusing on antioxidant-rich foods, such as curcumin and vitamin D, have demonstrated efficacy in mitigating oxidative stress and neuroinflammation. Similarly, structured exercise regimens improve mobility, alleviate fatigue, and enhance overall quality of life in MS patients.

In addition to therapeutic interventions, psychosocial factors such as education level, socioeconomic status, and access to healthcare significantly influence the disease experience and outcomes. Understanding these variables is crucial for developing equitable, patient-centered care strategies. This presentation will provide attendees with a comprehensive overview of how stress impacts MS at a mechanistic level, explore practical interventions to mitigate its effects, and highlight the need for future studies aimed at personalizing stress management approaches.

Attendees will leave with actionable insights into integrating stress-reduction techniques into MS management, as well as an understanding of the need for interdisciplinary approaches that consider both physiological and psychosocial determinants of health in MS patients.