HYBRID EVENT: You can participate in person at Orlando, USA or Virtually from your home or work.

6th Edition of International Conference on Neurology and Brain Disorders

October 24 -26, 2022

October 24 -26, 2022 | Orlando, Florida, USA
INBC 2022

Hamdiollah Hassanlouei

Speaker at Neurology and Brain Disorders 2022 - Hamdiollah Hassanlouei
Shahid Beheshti University, Iran (Islamic Republic of)
Title : Physical activity and corticospinal excitability in elderly


Aging is associated with reduced neuromuscular function, which may be due in part to altered corticospinal excitability. Regular physical activity (PA) may ameliorate these age-related declines, but the influence of PA on corticospinal excitability is unknown. The purpose of this study was to determine the influence of age, sex and PA on corticospinal excitability by comparing the stimulus-response curves of motor evoked potentials (MEP) in 28 young (22.4±2.2 yrs, 14 women, 14 men) and 50 old adults (70.2±6.1 yrs, 22 women, 28 men) who varied in activity levels. Transcranial magnetic stimulation was used to elicit MEPs in the active vastus lateralis muscle (10% maximal voluntary contraction, MVC) with 5% increments in stimulator intensity until the maximum MEP amplitude. Stimulus-response curves of MEP amplitudes were fit with a 4-parameter sigmoidal curve, and the maximal slope calculated (slopemax). Habitual PA was assessed with tri-axial accelerometry, and participants categorized into either those meeting current PA guidelines for optimal health benefits (>10,000 steps?day (-1), high-PA, n=21) or those not meeting guidelines (<10,000 steps?day(-1), low-PA, n=41). The MEP amplitudes and slopemax were greater in the low-PA compared with the high-PA group (P<0.05). Neither age nor sex influenced the stimulus-response curve parameters (P>0.05) suggesting that habitual PA influenced the excitability of the corticospinal tract projecting to the lower limb similarly in both young and old adults. These findings provide evidence that achieving the recommended PA guidelines for optimal health may mediate its effects on the nervous system by decreasing corticospinal excitability.

What will audience learn from your presentation?

  • the audience will be familiar with measurements of corticospinal excitability
  • this research will help audience to understand the effect of aging/physical activity on excitability of corticospinal tract.
  • It will give an overview for future studies to better understand the mechanisms underlying the excitability of corticospinal tract



Dr. Hassanlouei studied motor control at the university of Aalborg, Denmark and graduated as PhD in 2013. He then joined neuromuscular physiology lab at Marquette University, WI. He then obtained the position of an assistant professor at Shahid Beheshti University, Tehran, Iran. He has published more than 20 research articles in SCI (E) journals. position of an Associate Professor at the IGIC. She has published more than 70 research articles in SCI(E) journals.)