Activity-dependent neuroprotective protein (ADNP) is essential for cortical development. Heterozygous pathogenic ADNP variants cause Helsmoortel-Van der Aa syndrome (aka ADNP syndrome), a neurodevelopmental disorder that commonly includes intellectual disability, delayed speech a [....] » Read More
Vascular dementia (VD) has high morbidity and mortality. Diabetes is a leading factor for VD. The cellular responses and signaling mechanisms for diabetes-induced VD are largely unknown, and the current treatments for VD are neither very specific nor effective. Dysfunctions of ce [....] » Read More
Symptomatic hydrocephalus has been treated primarily with cerebrospinal fluid (CSF) diversion since the 1950s. Ventriculoperitoneal and related shunting procedures have been highly effective at relieving acute, life-threatening elevations in intracranial pressure (ICP). However, [....] » Read More
Gene therapy is reshaping the treatment of pediatric neurological disease, offering durable, non-destructive correction of conditions long considered untreatable. This lecture reviews the spectrum of intracerebral gene therapy strategies—gene addition, modification, deletio [....] » Read More
Background: Cerebral glucose hypometabolism, measured with 18F-fluorodeoxyglucose (FDG) PET, is a hallmark of Alzheimer’s disease (AD). While FDG-PET changes are highly effective at differentiating dementia types, the pathological bases for metabolic changes are complex. Hy [....] » Read More
Survival after cardiac arrest has improved substantially with advances in resuscitation techniques and post–cardiac arrest care. However, hypoxic–ischemic brain injury (HIBI) remains a major cause of mortality and long-term neurological disability among survivors. Con [....] » Read More
Background: Anti-amyloid monoclonal antibodies, including lecanemab and donanemab, represent an emerging disease-modifying treatment approach for early Alzheimer’s disease. However, treatment is associated with amyloid-related imaging abnormalities (ARIA), including ARIA wi [....] » Read More
Alzheimer’s neuropathology is commonly described by lesion burden, yet cognitive decline emerges from the disruption of neural circuits. Amyloid-β (Aβ) plaques are associated with local dendritic spine loss, excitatory synapse depletion, impaired axonal transport, [....] » Read More
Survival after cardiac arrest has improved substantially with advances in resuscitation techniques and post–cardiac arrest care. However, hypoxic–ischemic brain injury (HIBI) remains a major cause of mortality and long-term neurological disability among survivors. Con [....] » Read More
Background: Health-related behaviors, including diet, outdoor activity, screen time, and sleep, are important determinants of child health and development, yet little is known about the associations between these behaviors and autism spectrum disorder (ASD) among young children. [....] » Read More
Background/Aims: Patients requiring a tracheostomy following a neurological insult undergo structured weaning and decannulation through a multidisciplinary approach in hyperacute neurorehabilitation. Despite these efforts, some patients are discharged with a tracheostomy. We [....] » Read More
Hexaraphane (HXN; 6-methylsulfinylhexyl isothiocyanate) is an isothiocyanate compound derived from the rhizomes and roots of wasabi (Eutrema japonicum). Accumulating evidence demonstrates that HXN exerts potent antioxidant, anti-inflammatory, and neuroprotective activities, suppo [....] » Read More
Background and Objective: Early identification and intervention for childhood developmental disorders, particularly autism spectrum disorder (ASD), depend on a deep understanding of sensory information processing mechanisms. Existing methods still have limitations in terms o [....] » Read More
Background: Vertebral artery dissecting aneurysms (VADA) are an uncommon but life-threatening cause of subarachnoid hemorrhage and posterior-circulation stroke. Covered stents are an effective, economical option where flow-diverter availability is limited, but unlike porous flow- [....] » Read More
Background: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare, autoimmune central nervous system disease causing inflammatory demyelination and neurologic damage. Approximately 50-60% of patients experience a relapsing disease course. A single [....] » Read More
Traumatic brain injury is the silent epidemic of our time. In spite of over 1.7 million people sustaining a T.B.I. every year in our country, only a very small minority of medical professionals, legal scholars, employers, educators and people understand the reality of what the su [....] » Read More
Nanotechnology has revolutionized numerous industries from space exploration to medicine. This talk will emphasize how nanoparticles can be synthesized by traditional precipitation techniques or by cells to pass through the blood brain barrier to treat brain cancer, brain infecti [....] » Read More
Objective: This study aims to explore the role and mechanism of Lactobacillus rhamnosus GG (LGG) in alleviating brain damage caused by inflammation in premature mice. Methods: Premature mice were induced by intraperitoneal injection of lipopolysaccharide (LPS). The groups includ [....] » Read More
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and related post-viral conditions such as Long Covid are associated with complex disturbances involving cognition, autonomic regulation, fatigue perception, emotional processing, sensory integration, and motor function. [....] » Read More
Patients with Functional Seizures (FS) (also known as Psychogenic Non-Epileptic Seizures (PNES), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Many patients with FS have a history of sexual, physical, or emotional abuse, or ot [....] » Read More
For realizing pervasive and ubiquitous health and social care services, health and social care system have to undergo an organizational, methodological and technological transformation towards personalized, participative, preventive, predictive precision medicine. For designing a [....] » Read More
Traumatic spinal cord injuries (TSCI) are life-changing events from their medical, physical, psychological, social, financial, vocational, environmental & matrimonial effects. Although the clinical symptoms and signs of the condition was documented in the Edwin Smith papyrus [....] » Read More
Over the course of history, healthcare and thus healthcare philosophy have been focused predominantly on efforts to probe the already diseased individual by focusing down on a type of disorder (nosology) rather than on health or so-called pre-illness conditions. Much less effort [....] » Read More
Background: Autism spectrum disorders (ASD) are a series of neurodevelopmental disorders characterized by social disorders, rigid behaviors and narrow interests.The World Health Organization (WHO) estimates that the prevalence of ASD has been increasing over the past 50 year [....] » Read More
Current treatments for dementia remain slow?acting, limited, and often unable to meaningfully change the quality of life for patients and caregivers. Families living with dementia frequently endure a prolonged period of decline that can last many years, marked by progressive cogn [....] » Read More
Background: We aim to investigate the incidence and perinatal risk factors of cranial ultrasound(CUS) abnormalities in hospitalized neonates,build new reference values of cerebral parameters in newborns. Methods: All CUS data of newborns hospitalized in the First Affil [....] » Read More
Approximately 6.9 million Americans are living with Alzheimer’s disease (AD), and by 2050, this number is projected to reach nearly 13 million. A significant number of people with AD have coexisting pathologies caused by diseases including, diabetes, hypertension, and cardi [....] » Read More
Neuromuscular disorders are a class of conditions that deteriorate the nerves controlling voluntary skeletal muscle, contributing to progressive motor dysfunction, losses in mobility and coordination, and muscle atrophy. According to the National Institutes of Health, it is estim [....] » Read More
Human midbrain organoids are 3-dimension neural tissues derived from iPSC-stem cells. As they self-assemble into layered neural networks, these models capture key aspects of developing human dopaminergic circuitry in a controlled in-vitro setting, enabling mechanistic studies tha [....] » Read More
Over the past two decades, neuroscience research has increasingly demonstrated that the adult brain retains the capacity for reorganization following acquired brain injury (ABI). Despite this growing body of evidence, rehabilitation practice often shifts quickly toward compensato [....] » Read More
Background: Female glioblastoma (GBM) patients consistently outlive males by 3 to 5 months even after controlling for age, surgical extent, and MGMT methylation status. The biological mechanism driving this survival gap remains unresolved. Nearly all existing research examines gl [....] » Read More
Epilepsy affects over 50 million people worldwide. Approximately one-third of patients are resistant to current treatments with many experiencing adverse side effects. Mutations in the prickle gene, particularly the prickle-spiny-legs (pksple) isoform in Drosophila, produce spont [....] » Read More
Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a rare autoimmune encephalopathy characterized by heterogeneous neuropsychiatric manifestations. We describe the case of a 59-year-old woman with a history of anxiety and severe alcohol use disord [....] » Read More
Neuro-Fencing is a therapeutic framework integrating Sport-Based Intervention (SBI) with the technical demands, interpersonal dynamics, and neurocognitive requirements of competitive fencing, designed to enhance executive function, emotional regulation, and social engagement in c [....] » Read More
38-year-old female with Mitochondrial Recessive Ataxia Syndrome (MIRAS, homozygous POLG A467T mutation), diagnosed in her late twenties, was transferred to us from another hospital. She was intubated and sedated for suspected status epilepticus. Her condition had led to progressi [....] » Read More
Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a rare but increasingly recognized cause of acute encephalopathy, often masquerading as infectious meningoencephalitis. We present a case of a 45-year-old man with prediabetes, psoriasis, and recent-onset seizures, who [....] » Read More
Introduction: Central retinal artery occlusion (CRAO) or ocular stroke, has an incidence between 1-10 per 100,000, causing sudden and painless vision loss. Following CRAO there is an increased risk of cerebral stroke, rendering it a potential sight and life-threatening event. Int [....] » Read More
Kaempferol, a flavonoid present in many food products, has chemical and cellular antioxidant properties that are beneficial for protection against the oxidative stress caused by reactive oxygen and nitrogen species. Kaempferol administration to model experimental animals provides [....] » Read More
Background: The neurological and psychiatric sequelae of Traumatic Brain Injury (TBI) have become an increasing concern. However, the long-term effects of TBI on brain glucose metabolism, particularly in individuals more than a decade after injury, remain poorly understood. This [....] » Read More
A central question in neuroscience is how complex, structured brain architectures emerge from local cellular interactions during development. Here, we demonstrate that local developmental optimization alone is sufficient to generate realistic brain organization and stable neurodi [....] » Read More
The facial nerve is one of the most commonly damaged cranial nerves. Loss of facial expression and deformation of facial paralysis have serious implications for the physical and psychological well-being of patients. Peripheral facial nerve paralysis is often treated as an aesthet [....] » Read More
Biomarkers enable pre-early diagnosis, guide targeted therapy and monitor the active ty and therapeutic responses across the diseases. Among the best-validated predictive biomarkers are autoimmunity-related ones to predict and prognosticate risks of the chronification, complicati [....] » Read More
Dysregulation of autophagy have been shown in several diseases, like atherosclerosis (Yaribejgy et al., 2023), inborn lysosomal storage diseases (Francelle and Mazzulla, 2022) and diabetes Type 2 (Korolenko et al., 2021), concentrating attention at lysosomes as a potential target [....] » Read More
Epilepsy is increasingly recognized as a disorder of large-scale brain network dysfunction rather than a purely focal pathology. Advances in Network Neuroscience have revealed reproducible alterations in functional connectivity, graph topology, and network dynamics across epilept [....] » Read More
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder in which soluble β?amyloid (Aβ) oligomers are key upstream drivers of synaptic dysfunction and cognitive decline. ALZ?801 (valiltramiprosate) is an oral valine?Conjugated prodrug of tra [....] » Read More
The gut brain axis represents a complex, bidirectional communication network integrating the enteric nervous system and the central nervous system through neural, endocrine, immune, and metabolic pathways. Beyond its anatomical connections, this dynamic system operates via the au [....] » Read More
The current neuroscience studies have produced more than ever before, in terms of quantity of brain data, due to the avenues of neuroimaging used such as fMRI, EEG, MEG, and the new brain-computer interfaces. The traditional informed consent models that were developed many decade [....] » Read More
Background: Spasticity is a major motor impairment in children with cerebral palsy (CP), limiting functional mobility and joint range of motion. Transcutaneous electrical nerve stimulation (TENS) has been suggested as a non-invasive modality to modulate muscle tone through s [....] » Read More
Background: Normal Pressure Hydrocephalus (NPH) is a neurological condition characterized by the enlargement of the lateral ventricles in the brain despite normal cerebrospinal fluid pressure. Although this condition is treatable, it is often underdiagnosed due to its similarity [....] » Read More
Multiple Sclerosis (MS) is an autoimmune disease that affects children and adults nationwide. The goal of this research is to improve the quality of life for patients living with the sometimes debilitating symptoms of MS, specifically through the use of the mRNA-1195 vaccine (als [....] » Read More
Focal Cortical Dysplasia (FCD) causes epilepsy in 4 million newborns yearly. Treatments are surgical removal of malformed brain tissue, which fails for 40% of patients and causes permanent cognitive defects. FCD arises when neural progenitor cells (NPCs) commit to regional brain [....] » Read More
Autism spectrum disorder (ASD) lacks fast and reliable blood and molecular detection methods, making early diagnosis difficult. The purpose of this project was to design avimer molecules to bind to the au sm-associated protein CNTF using structure-guided computational modeling. T [....] » Read More
Background: Frequent or disproportionately elevated psychological distress can be a sign of mood disorders, such as Major Depressive Disorder and anxiety disorders. Due to its availability and non-invasive nature, salivary cortisol content is often used as an indicator of psychol [....] » Read More
Selective serotonin reuptake inhibitors (SSRIs) are first-line treatments but have delayed onset and may initially worsen symptoms; benzodiazepines are sometimes co-prescribed to provide immediate relief. Despite this, research on co-prescription is fragmented across study types [....] » Read More
Hand Foot and Mouth Disease is a common and highly contagious febrile infection mostly secondary to Coxsackievirus A16. The virus can spread to adults and one of the major complications is viral meningitis. This case describes a case of an adult patient who developed viral mening [....] » Read More
Pontocerebellar hypoplasia is a rare neurodevelopmental disorder that results from differences in formation and function of the pons, cerebellum and cerebrum. It can be diagnosed prenatally or postnatally with a combination of clinical, neuroimaging and genetic data obtained over [....] » Read More
Objective: We present a rare case of alexia without agraphia in the setting of cerebral venous thrombosis and review the neuroanatomical basis, diagnostic considerations, and clinical relevance of this uncommon presentation. Background: Alexia without agraphia is a rar [....] » Read More
Background: Burst suppression is an EEG pattern commonly targeted during treatment of refractory status epilepticus with anesthetic agents, characterized by brief bursts of cerebral activity interspersed with 10-second periods of suppression. In true pharmacologic burst supp [....] » Read More
Objective: We aim to assess if ChatGPT can be a reliable resource for individuals with neurologic disorders, who may have limited access to registered dietitians, to seek to for a therapeutic nutrition plan. Background: Medical nutrition therapy (MNT) can be a key component for [....] » Read More
Background: Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder typically characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. Prenatal exposure to elevated androgen levels, particularly testosterone, has been linked to changes in brain [....] » Read More
Background: Huntington's disease (HD) is a fatal autosomal-dominant neurodegenerative disorder with no approved disease-modifying therapy. Ankylosing spondylitis (AS) is a chronic systemic spondyloarthropathy causing progressive functional disability. Their co-occurrence [....] » Read More
Purpose/Objective(s): Glioblastoma (GBM) remains associated with poor prognosis despite multimodality treatment. Real-world cohorts may provide complementary evidence regarding outcomes outside highly selected clinical trial populations. We evaluated clinical characteristics, tre [....] » Read More
Background: Niemann-Pick Disease type C (NPC) is a genetic, lysosomal storage disorder characterized by an inability to transport cholesterol and lipids inside cells. This causes a patient-unique set of visceral and neurological symptoms that can include hepatosplenomegaly, demen [....] » Read More
Objective: To analyze the characteristics of patients with dementia admitted as inpatients in the U.S. in 2022. Intro/Background: According to the World Health Organization, 57 million people around the world live with dementia. The symptoms of dementia include impaired short-te [....] » Read More
Introduction: Scientists continue to explore novel therapies for epilepsy since the current treatment options like medications, epilepsy surgery, neuromodulation and ketogenic diet do not always offer complete seizure control and are associated with side effects. Auditory st [....] » Read More
Title : The role of compromised cerebrospinal fluid circulation in sleep apnea
Joe Sam Robinson, Mercer University, United States
Since its first literary description by Charles Dickens in 1833, followed by its first scientific description in 1949, interest in sleep disturbances has skyrocketed (over 40,000 documented scientific papers have discussed the problem). Sleep apnea, however, remains an incomplete [....] » Read More
Title : Atypical presentation of Juvenile myoclonic epilepsy in a 16-year-old female: A case report
George Diaz, Memorial Healthcare Systems, United States
Background: Juvenile myoclonic epilepsy (JME) is a common idiopathic generalized epilepsy syndrome that typically manifests during adolescence, with onset most often between the ages of 12 and 18 years. It accounts for approximately 5–10% of all epilepsies and up to 26 [....] » Read More
Title : A phase 3, multinational, randomized, placebo-controlled, double-blind, crossover trial (IB1001-304) evaluating levacetylleucine in CACNA1A
Beth Zanrucha, IntraBio, United States
Objective: To assess the efficacy, safety, and tolerability of levacetylleucine in people with CACNA1A-related disorders. Background: CACNA1A-related disorders refer to a range of rare, progressive, neurological and neurodevelopmental disorders with pathogenic mutations in the c [....] » Read More
Title : Results from the global phase 3 trial (IB1001-303) evaluating levacetylleucine in children and adults with ataxia-telangiectasia
Beth Zanrucha, IntraBio, United States
Objective: To report efficacy and safety results from the pivotal, Phase 3 trial investigating levacetylleucine in people living with Ataxia-Telangiectasia (A-T). Background: A-T is a rare, autosomal recessive cerebellar ataxia. Levacetylleucine (N-acetyl-L-leucine) is a modifie [....] » Read More
Title : Non-pharmacologic management of orthostatic hypotension in inpatient rehabilitation: A quality improvement initiative
Laura Steakin, Rehabilitation Institute at Sinai, United States
Orthostatic hypotension (OH) is frequently encountered during inpatient rehabilitation following ischemic stroke and is associated with dizziness, instability, and therapy disruption during this critical stage of neurorecovery. On our neurorehabilitation unit, OH was identified a [....] » Read More
Title : Non-pharmacologic management of orthostatic hypotension in inpatient rehabilitation: A quality improvement initiative
Mackenzie Weber, Rehabilitation Institute at Sinai, United States
Orthostatic hypotension (OH) is frequently encountered during inpatient rehabilitation following ischemic stroke and is associated with dizziness, instability, and therapy disruption during this critical stage of neurorecovery. On our neurorehabilitation unit, OH was identified a [....] » Read More
Title : State-dependent cortical responses to one-day accelerated i-TBS with NMDA receptor priming: A TMS-EEG study
Giuseppe Varone, McLean Hospital, United States
In Major Depressive Disorder (MDD), intermittent theta-burst stimulation (iTBS) is used to induce LTP-like plasticity that is at least partly dependent on NMDA receptor–mediated synaptic mechanisms, but the temporal dynamics of these effects and their dependence on ongoing [....] » Read More
Title : The CI-HI & CICR-HI: Development and validation of patient and caregiver-reported outcome measures for Alzheimer’s disease, mild cognitive impairment, and Dementia
Matthew Rathbun, University of Rochester Center for Health + Technology (CHeT), United States
Background: As new therapies are developed across the Alzheimer’s disease (AD) continuum, it is critical that patient and caregiver-reported changes in symptomatic health are incorporated into clinical trials. The US FDA encourages the use of patient and observer-reported o [....] » Read More
Title : ECRG4 is a potential initiator of amyloid pathology in Alzheimer’s disease and a novel diagnostic plasma marker for the disease
Toru Kondo, Hokkaido University, Japan
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ) and the formation of neurofibrillary tangles. Although the amyloid cascade hypothesis underscores the centrality of Aβ accumulation, the p [....] » Read More
Title : Bone marrow-derived microglia may have a clinical value for treatment of Alzheimer’s disease
Beka Solomon, Tel Aviv University, Israel
The CXCRS/CXL12 axis is a major signal transduction involved in inflammation, cell migration, haematopoiesis and cell homing in the bone marrow. Inhibition of this axis with AMD3100, a reversible antagonist of CXCR4, attenuates the neuroinflammation and mobilizes endogenous hemat [....] » Read More
Title : Therapeutic approaches for prion diseases: A systematic review
Rafaela Mingione, Universidade Santo Amaro, Brazil
Background: Prionic diseases, such as Transmissible Spongiform Encephalopathies (TSEs) and Creutzfeldt-Jakob disease (CJD), are rare and fatal neurodegenerative disorders caused by the abnormal buildup of misfolded prion protein (PrPsc). Currently there are no efficient therapies [....] » Read More
Title : Neurotango: The dance of social inclusion & brain connection
Maria Teresa Gil Ogliastri, Universidad Nacional Artes De Buenos Aires, Argentina
Neurotango is a therapeutic framework that integrates the principles of Dance Movement Therapy (DMT) with the rituals, interpersonal dynamics, and kinetic qualities of Argentine tango, aiming to enhance communication, social interaction, and psychophysical regulation in neurodive [....] » Read More
Title : Venous hypertensive encephalopathy presenting as rapidly progressive dementia and parkinsonism secondary to a torcular herophili Dural arteriovenous fistula: A reversible stroke mimic
Gao Yang, Yancheng People No1 Hospital, China
Background: Dural arteriovenous fistulas (DAVFs) involving the torcular Herophili are rare intracranial vascular malformations that may produce venous hypertensive encephalopathy (VHE). Because patients frequently present with cognitive decline, gait disturbance, and parkinsonian [....] » Read More
Title : Efficacy of rasagiline as an adjunct therapy in chronically treated Parkinson’s disease: A meta analysis
Yatri S Patel, SVP Hospital Ahmedabad, India
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the basal ganglia, leading to disabling motor and non-motor symptoms. Long-term dopaminergic therapy, including levodopa and dopami [....] » Read More
Title : Efficacy and safety of erenumab in preventive and therapeutic treatment of patients suffering from migraine: A meta analysis
Yatri S Patel, SVP Hospital Ahmedabad, India
Background: Erenumab, (AMG 334) is a first fully human monoclonal antibody that targets and blocks the canonical Calcitonin Gene related peptide (CGRP) receptor approved for use in migraine. CGRP plays a very pivotal role in patho-physiology of migraine. The objective was to [....] » Read More
Title : Neuro-exergaming for non-verbal autism spectrum: A case study of neuropsychological function after 15 sessions of pedal-n-play iPACES
Cay Anderson Hanley, iPACES, United States
Youth on the autism spectrum (ASD) display varying degrees of deficits in cognitive, motor, and social functioning, areas often targeted with various therapy modalities, most efficiently provided as early interventions. Exercise has long been examined as a potential therapy modal [....] » Read More
Title : Mild cognitive impairment (MCI) in Parkinson’s disease: Prevalence given MDS criteria
Cay Anderson Hanley, iPACES, United States
The prevalence of mild cognitive impairment (MCI) in Parkinson’s Disease (PD) has been wide ranging, from 15-90% across reports, likely due to a number of key variables, including age at evaluation, and time since symptom onset (Jellinger, 2024). Additionally, the criteria [....] » Read More
Title : COVID-19 pandemic-related adversity, error-related neural activity, and cognitive control in children
Amelie Guinee, Colorado State University, United States
The COVID-19 pandemic introduced widespread disruptions to children’s social, educational, and home environments, often increasing exposure to adversity. Pandemic-related adversity has been broadly associated with differences in children’s general cognitive and mental [....] » Read More
Title : Decoding cognitive decline: A multimodal AI approach to distinguishing Alzheimer’s disease, Dementia with Lewy bodies, and PSP Using Tau oligomers
Pavan Patel, Stephen F. Austin High School, United States
Neurodegenerative diseases affect over 55 million people worldwide, yet accurately distinguishing Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and progressive supranuclear palsy (PSP) remains difficult due to overlapping clinical symptoms and limited disease-spe [....] » Read More
Title : Decoding cognitive decline: A multimodal AI approach to distinguishing Alzheimer’s disease, Dementia with Lewy bodies, and PSP Using Tau oligomers
Shreyan Shah, William P. Clements High School, United States
Neurodegenerative diseases affect over 55 million people worldwide, yet accurately distinguishing Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and progressive supranuclear palsy (PSP) remains difficult due to overlapping clinical symptoms and limited disease-spe [....] » Read More
Title : In silico structural mapping of endothelial LRP1 cluster II variants: Quantifying the biophysical mechanisms of impaired amyloid-beta efflux at the blood-brain barrier
Giriish Purushothaman, Bridgeland High School, United States
This study aims to characterize how specific, clinically unannotated human missense mutations within the ligand-binding Cluster II domain of Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) alter its 3D structural conformation and binding affinity for Amyloid-Beta (A&bet [....] » Read More
Title : Je Ne Sais Quoi — Autoimmune encephalitis in a 19-year-old male: A case report
Jonathan E Sy, World Citi Medical Center, Philippines
A 19-year-old Filipino male with no significant past medical history presented with a 1-week history of intermittent headache followed by sudden right-sided weakness, vomiting, twitching, tremors, upward eye-rolling, and spasms with transient loss of consciousness and disorientat [....] » Read More
Title : You should not start young: A case of a 25-year old presenting with ischemic infarcts and a chronic intracranial hemorrhage
Jerico Ryan M Pura, World Citi Medical Center, Philippines
Patient J.Y, a 25 year old male, came in due to a chief complaint of weakness and no verbal output. 2 days prior to consultation, the patient complained of occasional headaches and right-hand numbness however still apparently well at the time. It was elicited from history that th [....] » Read More
Title : The malignant Marburg malady of Manila: A case of acute fulminant multiple sclerosis (Marburg Variant) in a 38-year-old Filipino female
Daniel Christopher P Maan, World Citi Medical Center, Philippines
Background: Multiple Sclerosis (MS) is a demyelinating disease which is particularly rare in tropical regions like the Philippines, where epidemiologic incidence is 10 to 20 times lower than in temperate zones. Fulminant and tumefactive MS variants, such as the Marburg Variant, p [....] » Read More
Title : A mind under attack: A rare case of autoimmune anti-NMDA receptor encephalitis in a 19-year-old male
Divine Fajardo, World Citi Medical Center, Philippines
A 19-year-old Filipino male presented with a one-week history of intermittent headache, followed by focal neurologic symptoms including right-sided lip twitching, right-sided weakness, and vomiting. This progressed to a one-minute episode of generalized tremors, musculoskeletal s [....] » Read More
Title : The ascending storm: Clinical management of rapidly progressive AMSAN GBS with early bulbar “red flags”
Jed Hiram Rosales, World Citi Medical Center, Philippines
Introduction: Guillain-Barré Syndrome (GBS) is a rare but potentially fatal immune-mediated polyneuropathy typically characterized by symmetrical ascending paralysis. Approximately 20% to 30% of patients experience a rapid "ascending storm" of symptoms leading to [....] » Read More
Title : CNS crisis in a pediatric patient: navigating the inflammatory-vasculitic variant of pediatric Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) and the role of biomarker-driven differentials
Jed Hiram Rosales, World Citi Medical Center, Philippines
Background: Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) in the pediatric population is characterized by a more aggressive clinical course and higher morbidity compared to adult-onset disease. Diagnostic clarity is often obscured by the mimicry of central nervous system [....] » Read More
Title : A vascular catastrophe: A case of a 72-year-old Filipino male who developed ACS-STEMI after hemorrhagic conversion of an ischemic stroke
Miguel Quial Ordonez, World Citi Medical Center, Philippines
The patient is R.M., 72-year-old, Filipino male, who came in with a chief complaint of dizziness. Four hours prior to admission, he was walking home when he noted sudden onset non-rotatory dizziness with no associated nausea, vomiting, loss of consciousness, headaches or body wea [....] » Read More