HYBRID EVENT: You can participate in person at Orlando, USA or Virtually from your home or work.

6th Edition of International Conference on Neurology and Brain Disorders

October 24 -26, 2022

October 24 -26, 2022 | Orlando, Florida, USA
INBC 2022

Priyanka Puri

Speaker at Neurology and Brain Disorders 2022 -  Priyanka Puri
Punjab university, India
Title : Neuroprotective effect of doxophylline in rotenone induce experimental Parkinson’s disease in rats.


Parkinson 's d isease is a second most commo n age-related neurodegenerative d isorder characterized by tbe loss of dopaminergic nemons in the substantia nigra pars compacta region of the midbrain. Doxophylline is a non-selective PDE inhibitor and thus expected to be beneficial in cognitive and movement disorders. Therefore, this study was designed to explore neuroprotective potential of doxopbyU ine aga inst rotenone induced Parkinsonism Like symptoms in rats. Rats were administrated with rotenone (2 mg/kg/day; s.c.) daily for a period of 28 days. Doxophylline (25, 50 and 100 mg/kg p.o.) was administered daily starting from issi day one hour after to rotenone administrat ion. Behaviora l parameters (body weight, rotaroad, na1Tow beam walk and open field test) were assessed on weekly basis. On 29th day, anima ls were sacrificed and stiiatum were isolated for biochemical and neurochemica l analysis. Rotenone significantly impai red motor functions and caused elevation in stTiatal oxidative stress, pro-inflammation cytokine levels and a significant deficit in catecho lamine levels. Doxopbylline treatment significantly attenuates behavioral, biochemical and neurochemical deficit induced by rotenone. The outcome of the current study iJ1dicates neuroprotective potential of doxophylline and suggesting that it could usefu l cand idate molecule in the management of movement disorder.


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