HYBRID EVENT: You can participate in person at Orlando, USA or Virtually from your home or work.

6th Edition of International Conference on Neurology and Brain Disorders

October 24 -26, 2022

October 24 -26, 2022 | Orlando, Florida, USA
INBC 2022

Mohamed Kamel

Speaker at Neurology and Brain Disorders 2022 - Mohamed Kamel
Cairo University , Egypt
Title : Glial Fibrillary Acidic Protein (GFAP) and Cleaved Tau Protein (CTP) biomarkers as a Forensic Tool for detection and assessement of Traumatic Brain Injury


Traumatic brain injury (TBI) is defined as a traumatically-induced structural brain injury or physiological disruption of brain function caused by an external force. Traumatic brain injury is a neuropsychiatric disorder that breaks down the remaining barriers between neurology and psychiatry. Several biomarkers have been developed to directly determine the pathology of the nerve cells in the central nervous system (CNS) when it is injured. This review recent research on brain injury biomarkers could be used for rapid and accurate diagnostics of TBI in easily accessible fluid.

Objectives: The purpose of this study was to assess utility of GFAP-BDP for the diagnosis of intracranial injury in patients with a positive clinical screen for head injury across the spectrum of TBI typically presenting to ED in Kasr- Alainy hospital.

SUBJECTS & METHODS: This prospective cohort study was based on the data collected from 90 cases presented to Kasr Al-Aini Hospitals Emergency Department, Cairo University, with history of traumatic brain injury through the period from April 2017 to Mars 2019. According to age, they were classified into 3 age groups; age group A (18-35 years), age group B (36-50 years) and age group C (> 50 years). Data were analyzed with respect to socio-demographic data, type of head injury, clinical presentations, radiological investigation, and management of TBI in relation to serum specific biomarkers level (GFAP, C-tau).

RESULTS: The most common age group was age group B (18-35 years) (70%). Males were more common than females (71.1% and 28.9% respectively). The most common cause of trauma was fall from height (33.3%). Serum GFAP level and C-tau levels in studied groups show high significant correlation between them (p value <0.001).

CONCLUSION AND RECOMMENDATIONS: The combination of the two biomarkers or more may be more useful than either biomarker in isolation for predicting intracranial lesions on CT scanning therefor decreases unwanted CT head scanning and radiological bad effect especially in young ages.

Keywords: Traumatic brain injury, Serum, GFAP, C-tau and CT scanning




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