HYBRID EVENT: You can participate in person at Orlando, USA or Virtually from your home or work.

6th Edition of International Conference on Neurology and Brain Disorders

October 24 -26, 2022

October 24 -26, 2022 | Orlando, Florida, USA
INBC 2022

Bhanu Sharma

Speaker at Neurology and Brain Disorders 2022 - Bhanu Sharma
Delhi University, India
Title : Energetics and emergent calcium dynamics in an astrocyte-neuronal network coupled via nitric oxide molecule


Neurons and glial cells work in conjunction with each other during information processing in brain. Stimulation of neurons can cause calcium oscillations in astrocytes which in-turn can affect neuronal calcium dynamics. The “glissandi” effect is associated with a decrease in infraslow fluctations, in which synchronized calcium oscillations propagate as a wave in hundreds of astrocytes. Nitric oxide (NO) produced by astrocytes contribute to synaptic functions based on astrocyte-neuron interactions. In this work, defining an astrocyte-neuronal (A-N) unit as an integrated circuit of one neuron and one astrocyte, we developed a minimal model of neuronal stimulus dependent calcium oscillations in astrocytes. Incorporating inter-unit communication via NO molecules, a coupled network of 1,000 such A-N units is developed in which multiple stable regimes were found to emerge in astrocytes. Present study is intended to explore the emergence of calcium waves in astrocytes by nitric oxide molecule in a couple ensemble of A-N network. Herein, we observe synchronization between astrocyte’s calcium oscillations which are dependent upon neuronal stimulus and coupling strength. We examined the ranges of neuronal stimulus strength and coupling strength between A-N units that give rise to such dynamical behaviours. We also report that there exists a range of coupling strength, wherein units not receiving stimulus also start showing oscillations and become synchronized. Our results support the hypothesis that “glissandi” like phenomena exhibiting synchronized calcium oscillations in astrocytes help in efficient synaptic transmission by reducing the energy demand of the process.


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