HYBRID EVENT: You can participate in person at Orlando, USA or Virtually from your home or work.

6th Edition of International Conference on Neurology and Brain Disorders

October 24 -26, 2022

October 24 -26, 2022 | Orlando, Florida, USA
INBC 2022

Kayleigh Jessop

Speaker at Neurology and Brain Disorders 2022 - Kayleigh Jessop
East Kent Hospitals University NHS Foundation Trust, United Kingdom
Title : Case report: Intravenous magnesium sulphate inducing acute respiratory failure in a patient with myasthenia gravis


A woman in her 90s with a background of myasthenia gravis and atrial fibrillation presented to hospital following a fall. Whilst in ED it was noted that she was in atrial fibrillation with a fast-ventricular response and as part of her management was given intravenous (IV) magnesium. Following this she developed acute respiratory failure and required intubation and ventilation. The patient recovered quickly and was extubated in ITU the next day. On subsequent days the patient received two further doses of IV magnesium before the link was identified. On both of these occasions she again developed respiratory failure which were managed with non-invasive ventilation. This case highlights the importance of all members of the team being aware of the drugs that can induce a myasthenic crisis. It also stimulates further research into the development of a guide of how to safely treat symptomatic hypomagnesemia in patients with myasthenia gravis.  

What will audience learn from your presentation? 

•    This case report highlights the potential life-threatening consequences of giving intravenous magnesium to patients with myasthenia gravis. It is therefore vitally important that healthcare professionals are aware of the medications used to treat cardiac conditions that can exacerbate a myasthenic crisis. These include: 
-    Beta blockers (both selective and non-selective and topical agents such as timolol)
-    Magnesium 
-    Antiarrhythmics (procainamide, quinidine, lidocaine) 
-    Antimuscarinics (including atropine and glycopyrrolate) 
-    Calcium channel blockers 
•    Most of the data describing drugs that can worsen myasthenia gravis is in the form of case reports and so it is difficult to develop firm guidelines on how to safely use them or treat symptomatic hypomagnesemia in these patients. This report will hopefully contribute to wider learning and research into this area. 



Dr Jessop studied medicine at Brighton and Sussex Medical School, England and graduated in 2017. Since graduating she has worked in multiple specialties and is currently an anaesthetic trainee in Margate.