Recovery from brain trauma is in part dependent upon the brain’s ability to adapt to new and challenging experiences. The brain’s capacity to structurally and functionally reorganize nerve cells and spontaneously develop new neuronal networks defines neuroplasti [....] » Read More
In this talk I first review several different notions of the “unity of consciousness” such as subject unity, object unity, spatial unity, and perhaps most common “phenomenal unity” which is the general notion that, from the first-person point of view, we e [....] » Read More
Subarachnoid Hemorrhage (SAH) continues to be a leading cause of morbidity and mortality, with cerebral vasospasm as a common etiology of worse clinical progression. The purpose of this study was to evaluate and review the current literature concerning the effective treatment of [....] » Read More
Background: There is an expanding body of literature implicating heart disease and stroke as a risk factor for Alzheimer disease (AD), highlighting significant pathways. Hawaii state has the most diverse ethnic population in the US and there exists significant racial health dis [....] » Read More
In temporal lobe epilepsy, the ability of the dentate gyrus to limit excitatory cortical input to the hippocampus breaks down, leading to seizures. The dentate gyrus is also thought to help discriminate between similar memories by performing pattern separation, but whether epilep [....] » Read More
Background: Parkinson´s Disease (PD) is a progressive neurodegenerative disease manifesting itself in motor and nonmotor symptoms. With disease progression, cognitive deficits ranging from mild cognitive impairment (MCI) to dementia (Galtier et al., 2016) as well as [....] » Read More
Endovascular coiling (EC) has been identified in systematic reviews and meta-analyses to produce more favourable clinical outcomes in comparison to neurosurgical clipping (NC) when surgically treating a subarachnoid haemorrhage from a ruptured aneurysm. Cost-effectiveness analyse [....] » Read More
Ziconotide is a synthetic, water-soluble cone snail venom-derived peptide with a molecular weight of 2,639 Daltons. It is a nonopioid analgesic that selectively binds to N-type voltage-sensitive calcium channels on primary nociceptive afferent nerves in the dorsal horn of the spi [....] » Read More
The human body tumour lesions are almost ordinary events in its life. Almost every people has moles. The moles are in fact small tumours, which normally doesn’t grow but in certain condition, triggered say by mechanical or radioactive events may become to have an uncontroll [....] » Read More
Background: People with neglect suffer from various spatial deficits in several modalities, which in many cases impair everyday functioning. Virtual reality (VR) is a form of interaction between humans and computers in which a real or imaginary environment is simulated. Users in [....] » Read More
Introduction: Mild Traumatic Brain Injury (mTBI) or concussion is a common yet undermanaged and underreported condition. This systematic review and meta-analysis aim to determine the efficacy of Vestibular Rehabilitation Therapy (VRT) as a treatment option for mTBI. Methods: [....] » Read More
Alzheimer’s disease (AD) is a neurodegenerative disease that causes cognitive impairment, characterized by progressive cognitive decline, memory loss, and neuronal death in the cerebral cortex, hippocampus, and other brain regions. Hallmarks of its pathology are amyloid bet [....] » Read More
Background and purpose: SWI can help in the diagnosis of thrombus within the vessel in acute ischemic stroke (AIS) known as susceptibility vessel sign (SVS) and detection of SVS within the vessel can predict treatment modality and outcome. In this study, the purpose is to correl [....] » Read More
Introduction: We present a case of pseudoaneurysm of the facial artery after tonsillectomy managed with successful endovascular coiling. Presentation of Case: 41-year-old lady presented with a history of throat pain and 3 episodes of hematemesis on the 3rd, 4th, and 7th post [....] » Read More
Introduction: Infantile Neuronal Ceroid Lipofuscinosis (INCL, also known as CLN1 Batten Disease, or CLN1) is a rare, devastating neurodegenerative disease affecting infants and children. CLN1 is caused by mutations in the CLN1 gene, which encodes the enzyme palmitoyl-prote [....] » Read More
Previous work in humanized mouse models of human immunodeficiency virus type-1 (HIV-1) has demonstrated that knocking down the matricellular protein Osteopontin (OPN) in vivo leads to a robust increase in the expression of proinflammatory markers TSPO and AIF-1, suggesting that O [....] » Read More
Glioblastoma (GBM) is a fatal brain cancer in adults with ineffective existing treatment methods. Cell adhesion molecules (CAMs) are proteins that are expressed on the surface of cells and enable them to communicate and interact with one another and the surrounding environment. I [....] » Read More
M80T mutation of triose phosphate isomerase (TPI) presents one potential contributory pathway for developing Alzheimer’s disease (AD). M80T effects the triose phosphate isomerase (TPI) enzyme activity within the glycolysis pathways producing enhanced levels of methylglyoxal [....] » Read More
Design to facilitate the recognition of congruent prosthetic movements, context-to-motion translations guided by image, verbal prompt, users nonverbal communication as facial expressions, gestures, paralinguistics, scene context and object recognition contributes to this process& [....] » Read More
Studies have shown differences in neuropsychiatric symptoms (NPSs) of Alzheimer’s disease?AD? between the males and females. However, we do not know whether this difference is influenced by disease severity. Method: Patients with AD who visited the Memory Cl [....] » Read More
Objective: Generalized anxiety disorder (GAD) is a typical multisystem disease characterized by decreased activity in the left dorsolateral prefrontal cortex (DLPFC). Transcranial near-infrared stimulation (tNIRS) was used to stimulate the left DLPFC to relieve anxiety, and tran [....] » Read More
Introduction: We present a case of chronic subdural hematoma refractory to burr hole surgery treated successfully with middle meningeal artery embolization. Presentation of Case: 61-year-old gentleman presented with a history of headaches and single episodes of vomiting. Ne [....] » Read More
Background: Intramedullary spinal cord ependymomas (IMSCE) are rare tumors that mostly occur in adult patients. Management strategies and related outcomes are heterogeneously reported across the literature, demanding a comprehensive analysis to standardize guidelines. We system [....] » Read More
Title : Introducing 4D printing for stem cell delivery to and function in the brain: Improving viability, differentiation, and brain function
Thomas J Webster, Interstellar Therapeutics, United States
Stem cells have not provided the universal, effective solution to neurological diseases that they were once thought to provide. In particular, maintaining stem cell viability during and after implantation into the brain has proved problematic. The use of enzymes (such as trypsin) [....] » Read More
Title : The role beliefs, perception, biases, prejudices and patterns of behaviour play in the incubation of and the evolution of psychophysical diseases and disorders
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
Did the patient genetically inherit their complex psychophysical pathological condition/s or are they simply adopting and/or mirroring other members of their family who have the complex psychophysical condition that the patient is exhibiting? Over several decades it has been f [....] » Read More
Title : Studies on traumatic brain injury: Fragments of VWF regulate the expression of adhesion molecules and modulate vascular permeability in stimulated endothelial cells
Marina Martinez Vargas, Baylor College of Medicine, United States
Von Willebrand factor (VWF) is a multimeric protein that mediates thromboinflammation and has been linked to traumatic brain injury (TBI), specifically in the pathogenesis of early brain injury. Activated endothelium secretes VWF multimers as long hyperadhesive strings. During TB [....] » Read More
Title : Effects of transcranial pulse stimulation on autism spectrum disorder: a double-blind, randomized, sham-controlled trial
Teris Cheung, The Hong Kong Polytechnic University, Hong Kong
Transcranial pulse stimulation (TPS) has been proven effective to improve cognition, memory and depressive symptoms on Alzheimer’s disease, but supporting evidence on other neurological diseases or neuropsychiatric disorders remains limited. We aimed to investigate the effe [....] » Read More
Title : Evaluating the efficacy of Electrical Vestibular Stimulation (VeNS) on insomnia adults: A double-blind, randomized, sham-controlled trial
Teris Cheung, The Hong Kong Polytechnic University, Hong Kong
Insomnia is a common health problem in the general population. There are different ways to improve sleeping habits and quality of sleep, however; there is no clinical trial using transdermal neurostimulation to treat individuals with symptoms of insomnia in Asia. This gave us the [....] » Read More
Title : To evaluate the effect of endothelin receptor agonist IRL-1620 alone and in combination with donepezil in modulating neurodegeneration produced by amyloid-? in rats
Eshani Mahajan, Postgraduate Institute of Medical Education and Research-PIGMER, India
IRL-1620 is a chemical entity that have neuroprotective activity as it increases growth factors VEGF and NGF. The Present study hypothesis is to evaluate the effect of IRL-1620 on Aß induced memory loss in the rat model of Alzheimer’s disease. We have taken 58 males a [....] » Read More
Title : Oxygen extraction fraction: Review on different computational methods based on mGRE sequences and clinical manifestations
Farsana F J, Digital University Kerala, India
Oxygen extraction fraction (OEF) is a physiological biomarker reflecting the percentage of oxygen extracted from the blood supply, which is directly associated with cerebral oxygen metabolism. It can also provide information about the relative deficiencies in cerebral blood suppl [....] » Read More
Title : Prospective observational study on hyponatremia in Acute Encephalitis Syndrome (AES) in children: it's occurrence and effect on outcome
Nikita Diwan, King Georges's Medical University, India
Hyponatremia has been reported in various central nervous system infections like tuberculous meningitis and found to be associated with poor outcome. So far, no study has been conducted on hyponatremia in acute encephalitis syndrome (AES) in children. This study was planned to st [....] » Read More
Title : Expanding the phenotypic spectrum of apmr4 syndrome caused by a novel variant in lss gene and review of literature
Engy Asem Ashaat, National Research Centre, Egypt
Alopecia intellectual disability syndromes 4 (APMR4) is a very rare autosomal recessive condition caused by a mutation in the LSS gene present on chromosome 21. This syndrome has a clinical heterogeneity mainly exhibited with variable degrees of intellectual disability (ID) [....] » Read More
Title : Length-dependent RNA foci formation and repeat associated non-AUG dependent translation in SCA12 patient derived neural stem cells: hallmarks to pathogenesis
Manish kumar, CSIR-IGIB, India
Spinocerebellar ataxia type-12 (SCA12) is a neurodegenerative disease and one of the most prominent SCA-subtype in India that exhibits a unique progressive tremor/ataxia syndrome induced by triplet (CAG) repeat expansion in 5’ UTR region of PPP2R2B. So far, no study has bee [....] » Read More
Title : Management of adolescent idiopathic scoliosis in neurological disorder patient
Stephen Onyancha Kamanda, Kenyatta National Hospital, Kenya
Scoliosis is commonly described as a 3D spinal deformity resulting in a curvature of 10 degress or more with a rotational spin. All the bones in the body have three cells that work together for the proper growth of the bone: The osteocyte,cell that coordinates the osseous work [....] » Read More
Title : The effects of cognitive behavioral therapy with biofeedback therapy on the quality of life, anxiety, depression and somatic symptoms in patients with dyssynergic defecation: A randomized controlled trial
Afsaneh Nikjooy, Iran university of medical sciences, Iran (Islamic Republic of)
Background: Dyssynergic defecation (DD) is a major cause of chronic functional constipation. Patients with DD have greater psychological distress and impaired health-related quality of life compared with the general population. This study aimed to evaluate the effectivene [....] » Read More
Title : Intracerebral hemorrhage and COVID-19 infection: clinical characteristics and mortality from intensive care patients: Retrospective cohort review
Mohamed Fathi Al Gharyani, Benghazi Medical Center, Libyan Arab Jamahiriya
Background: Since the COVID-19 pandemic, many studies have reported severe neurologic effects of the infection on the brain. Intracerebral haemorrhage (ICH) is a particular pathology that can result in these devastating neurologic effects and affected patients are more likely to [....] » Read More
Title : Post-COVID 19 vaccination gullian barre syndrome: The doctor being the patient
Nahom, FelgeHiwot Referal Hospital, Ethiopia
The COVID-19 pandemic has caused an unprecedented impact on global health, affecting millions of people worldwide. In effect to tackling the devastating outcomes of the disease, the development of vaccines was the primary focus of health researchers worldwide. Thus, a few brands [....] » Read More
Title : Effects of amantadine on acute stroke: A randomized, double blind, placebo-controlled trial
Mehdi Sheikhi, AJA University of Medical Sciences, Iran (Islamic Republic of)
Stroke is a leading cause of morbidity and second cause of mortality worldwide. Early participation in rehabilitation treatments such as neurostimulant drugs showed to be beneficial. Amantadine usually used as Parkinson disease treatment, is prescribed in patients with traumatic [....] » Read More
Title : The role of gut microbes in vascular dementia
Navdeep Kaur, Cleveland Clinic Foundation, United States
Stroke is the second most common cause of cognitive impairment and dementia. Vascular dementia (VaD), a cognitive impairment following a stroke is common and substantially affects the quality of life. We recently demonstrated via gut microbe transplant studies that the gut microb [....] » Read More
Title : Economic impact of the first pass effect in mechanical thrombectomy for acute ischaemic stroke treatment
Eva Maria Gonzalez Diaz, Cruces University Hospital, Spain
Objective: The clinical benefit of mechanical thrombectomy(MT) in acute ischemic stroke treatment, is correlated to the degree of reperfusion achieved. The First Pass Effect (FPE) is defined as complete/near revascularisation of the large-vessel occlusion [modified Thrombolysis [....] » Read More
Title : Addressing education and medication adherence for stroke survivors
Mikaela Atkins, Arizona State University, United States
At one of the largest hospitals in Arizona, who care for individuals suffering from neurological diseases and houses a Joint Commission Comprehensive Stroke Center, the Comprehensive Stroke Program Quality Team has been working in conjunction with an Arizona State University Doct [....] » Read More
Title : Cryoneurolysis in restless legs syndrome: A case report of intermediate to long-term relief in 2 patients
Carmen Vogt, University of Nebraska Medical Center, United States
Restless Legs Syndrome (RLS) is associated with uncomfortable sensations in limbs that result in a sudden urge to move. The underlying etiology is unknown but is thought to be influenced by genetics, pregnancy, iron deficiency, and alterations in nerve hyperexcitability or inhibi [....] » Read More
Title : Moya moya and atherosclerosis
Aliaa Mousa, Capital Health, United States
Introduction In the literature, there are not so many cases that connected Atherosclerosis to MMDandit hasn’t been assured by pathological studies as well. Moya Moya disease is a uniquecerebrovascular disease characterized by progressive large intracranial artery narrowing [....] » Read More
Title : Chronic subdural hematoma drainage under local vs. General anesthesia: Systematic review and meta-analysis
Amy Zhou, University of Saskatchewan, Canada
Introduction Chronic subdural hematoma (cSDH) is one of the most encountered conditions seen in neurosurgery. Although mainstay treatment of cSDH has been burr hole drainage, no consensus yet exists on optimal anesthesia technique for surgical treatment. Currently, the decision t [....] » Read More
Title : Study of support for children with developmental dyslexia symptoms in Japanese and its effectiveness
Ayako Fukuda, Dokkyo University, Japan
There are three types of Japanese characters: hiragana, katakana and kanji. Of these, hiragana is said to be easier to be acquired because of its regularity and one-to-one correspondence between letters and sounds (Uno et al., 2009). Therefore, early identification and support of [....] » Read More
Title : Neurosteroid ganaxolone attenuates beta-amyloid toxicity by activating the liver X receptor in alzheimer’s disease
Divya Goel, Jamia Hamdard, India
Glioblastoma (GBM) is a fatal brain cancer in adults with ineffective existing treatment methods. Cell adhesion molecules (CAMs) are proteins that are expressed on the surface of cells and enable them to communicate and interact with one another and the surrounding environment. I [....] » Read More
Title : Familial CJD in three generations.
Neetika Sharma, PGIMER, India
59 yrs old male presented with 11 months history of ataxia followed by 3 months history of bilateral hand action tremors. 9 month into illness he started to have cognitive decline followed by myoclonic jerks . He also had fragmented sleep with decreased total sleep duration. He h [....] » Read More
Title : A comparative study of motor nerves conduction velocity between right handed and left handed subjects
Duaa Awad Ahmed Abdelsalam, University of Khartoum, Sudan
Motor Nerve conduction study is one of the electrophysiological tests performed to evaluate electrical conduction of motor nerves. Many studies involved nerve conduction velocity of peripheral nerves, but only few addressed this issue in relation to handedness with lots of contro [....] » Read More
Title : Triple stimulation technique for the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy
Juan Solano, University of Antioquia, Colombia
Introduction: A significant number of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) does not fulfill electrodiagnostic demyelination criteria. Evidence suggests that TST may increase the sensitivity of this electrodiagnostic studies by detecting [....] » Read More