Did the patient genetically inherit their complex psychophysical pathological condition/s or are they simply adopting and/or mirroring other members of their family who have the complex psychophysical condition that the patient is exhibiting? Over several decades it has been f [....] » Read More
Recovery from brain trauma is in part dependent upon the brain’s ability to adapt to new and challenging experiences. The brain’s capacity to structurally and functionally reorganize nerve cells and spontaneously develop new neuronal networks defines neuroplasti [....] » Read More
Olfactory loss is a key symptom in the prodromal and early stages of Parkinson’s disease. Noninvasive imaging biomarkers can provide a powerful tool for diagnosing the diseases, monitoring the progression, and evaluating potential therapeutics. In this talk, I will first de [....] » Read More
Background: Since the COVID-19 pandemic, many studies have reported severe neurologic effects of the infection on the brain. Intracerebral haemorrhage (ICH) is a particular pathology that can result in these devastating neurologic effects and affected patients are more likely to [....] » Read More
Background: Dyssynergic defecation (DD) is a major cause of chronic functional constipation. Patients with DD have greater psychological distress and impaired health-related quality of life compared with the general population. This study aimed to evaluate the effectivene [....] » Read More
Subarachnoid Hemorrhage (SAH) continues to be a leading cause of morbidity and mortality, with cerebral vasospasm as a common etiology of worse clinical progression. The purpose of this study was to evaluate and review the current literature concerning the effective treatment of [....] » Read More
Von Willebrand factor (VWF) is a multimeric protein that mediates thromboinflammation and has been linked to traumatic brain injury (TBI), specifically in the pathogenesis of early brain injury. Activated endothelium secretes VWF multimers as long hyperadhesive strings. During TB [....] » Read More
Background: Parkinson´s Disease (PD) is a progressive neurodegenerative disease manifesting itself in motor and nonmotor symptoms. With disease progression, cognitive deficits ranging from mild cognitive impairment (MCI) to dementia (Galtier et al., 2016) as well as [....] » Read More
Charcot-Marie-Tooth (CMT) disorder is a hereditary neurological condition characterized by progressive muscle weakness, sensory loss, and motor dysfunction. Current treatment op:ons primarily focus on managing symptoms and improving quality of life. However, unprecedented results [....] » Read More
The human body tumour lesions are almost ordinary events in its life. Almost every people has moles. The moles are in fact small tumours, which normally doesn’t grow but in certain condition, triggered say by mechanical or radioactive events may become to have an uncontroll [....] » Read More
Traumatic brain injury (TBI) induced coma is a key factor in poor clinical prognosis and poses a significant burden to families and society. However, there is a lack of first-line wake-promoting therapies with proven efficacy and ultra-early intervention. Acupuncture has been cer [....] » Read More
Introduction: Susac syndrome; It is a rare disease that is characterized by the triad of encephalopathy, sensorineural hearing loss and branch retinal artery occlusion, which is thought to develop due to immune-mediated microangiopathy. It is more common in patients aged 16-40 [....] » Read More
Sporadic Creutzfeldt-Jakob Disease (CJD) is one of the diseases that should be considered in dementia-related processes seen between the ages of 50-70. It can be distinguished from other diseases with dementia with its clinical features, typical electroencephalography (EEG) findi [....] » Read More
Introduction: Hyponatraemia after subarachnoid haemorrhage (SAH) is common, however the incidence, and association of hyponatraemia with vasospasm, morbidity, and mortality, has yet to be defined. We aimed to identify incidence of hyponatraemia after SAH, and association with me [....] » Read More
A patient diagnosed with Ankylosing Spondylitis on long-term etanercept treatment presented in the Emergency Department with subacute progressive cognitive dysfunction and personality change. He further developed psychiatric symptoms, autonomic dysfunction and orofacial dyskinesi [....] » Read More
The current strategies to mitigate the toxicity of misfolded SOD1 in familial ALS via blocking SOD1 expression in the CNS are indiscriminative for misfolded and intact proteins, and as such, entail a risk of depriving CNS cells of their essential antioxidant potential. As an a [....] » Read More
Globalization and technological advancements have contributed a shift towards hyperspecialization--the division of work into more specialized pieces done by multiple people--to achieve improvements in quality, efficiency, and cost in the labor market. However, there is a mismatch [....] » Read More
Most common yet undefeatable, age-associated neurodegenerative disease AD can be prevented with the help of accessible, fruitful, easily learnable and competent 5,000 years old practice of meditation. There are numerous research cues advocating intervention of this ancient trad [....] » Read More
Background: Blast-explosion may cause traumatic brain injury (TBI), that may lead to post-concussion syndrome (PCS) in individuals exposed to the explosion. In military personnel, PCS symptoms are highly similar to those occurring in post-traumatic-stress-disorder (PTSD), questi [....] » Read More
Decreased cerebral blood flow (CBF) is one of the major hemodynamic alterations leading to neurodegeneration and age-related cognitive decline. Nitric Oxide (NO)-dependent vasomotor reactivity is central in regulating cerebrovascular hemodynamics and adequate brain blood per [....] » Read More
Introduction: Brain microvascular endothelial cells in the CNS develop special barrier properties that help maintain CNS homeostasis. Ischemia-reperfusion injury is a serious neurological disorder involving blood-brain barrier (BBB) disruption with acute ischemic events and wors [....] » Read More
Previous work in humanized mouse models of human immunodeficiency virus type-1 (HIV-1) has demonstrated that knocking down the matricellular protein Osteopontin (OPN) in vivo leads to a robust increase in the expression of proinflammatory markers TSPO and AIF-1, suggesting that O [....] » Read More
M80T mutation of triose phosphate isomerase (TPI) presents one potential contributory pathway for developing Alzheimer’s disease (AD). M80T effects the triose phosphate isomerase (TPI) enzyme activity within the glycolysis pathways producing enhanced levels of methylglyoxal [....] » Read More
Vascular dementia, also known as vascular contributions to cognitive impairment and dementia (VCID), is a neurodegenerative disease. VCID has high morbidity and mortality. Diabetes is a leading factor in the development of VCID. However, the cellular and molecular mechanisms unde [....] » Read More
Focused Ultrasound (FUS), especially when combined with Microbubbles (MB), offers non-invasive options for treating deep-seated brain tumors and other neurodisordersm, by enabling targeted surgical ablation and/or local blood-brain-barrier opening (BBBO) for effective drug delive [....] » Read More
In 1996, in this same city, Posterior Reversible Encephalopathy Syndrome (PRES) was presented as a new neurological condition. PRES has long been described as a benign clinico-radiological syndrome. However, in recent years, it has had an associated global mortality rate up to 19 [....] » Read More
In this talk I first review several different notions of the “unity of consciousness” such as subject unity, object unity, spatial unity, and perhaps most common “phenomenal unity” which is the general notion that, from the first-person point of view, we e [....] » Read More
Traumatic spinal cord injuries (TSCI) are life-changing events from medical, physical, psychological, social, financial, vocational, environmental & matrimonial effects. The combination of consequent generalised physiological impairment, multi-system malfunction, multiple dis [....] » Read More
Creutzfeldt–Jakob disease (CJD) is a rare form of rapidly progressive, neurodegenerative disease that results from the misfolding and accumulation of an aberrant, disease-associated prion protein (PrPD). CJD affects 1–1.5 cases per million per year with the sporadic-t [....] » Read More
Cannabis continues to be the most abused illicit drug in the world with an estimated 2.5% of the world’s population (180 million) using it regularly (World Drug Report 2017)1. Medicinal and/or recreational cannabis use is associated with significant health consequences) (WH [....] » Read More
Objective: In this study, we aimed to directly compare the safety and efficacy potential of two novel investigational treatment regimens for cerebral ischemia - rhFGF18 and rhGDF11, using a model of ischemic stroke. Background: Despite recent advances in prevention and treat [....] » Read More
Alzheimer’s Disease (AD) is a progressive neurological disorder that gradually deteriorates cognitive abilities and leads to the inability to carry out simple tasks. However, the molecular mechanisms and causes of this disease are still unclear. This research aims to use th [....] » Read More
Hyponatremia has been reported in various central nervous system infections like tuberculous meningitis and found to be associated with poor outcome. So far, no study has been conducted on hyponatremia in acute encephalitis syndrome (AES) in children. This study was planned to st [....] » Read More
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity among individuals under 45 years of age worldwide. In the United States alone, approximately 1.7 million traumatic events occur annually, resulting in 50,000 deaths. This high prevalence of TBI poses a sig [....] » Read More
There are many types of brain diseases, from injuries and infections to brain tumors. They can impact your ability to function and carry out daily activities. Outcomes vary widely depending on the type of brain disease, location and severity of the condition. The brain is [....] » Read More
Brain aging is related to oxidative stress that leads to neuronal apoptosis and cognitive dysfunction. Neurogenesis occurs throughout the lifespan in the subgranular zone of the hippocampal dentate gyrus and it is gradually reduced in brain aging. Long term administration of D-ga [....] » Read More
Neuromyelitis Optica Spectrum Disorder (NMOSD), is a rare auto-immune demyelinating disorder of the Central Nervous System. A circulating auto-antibody (AQP4-IgG) against aquaporin-4 (AQP4) is found in more than 80% patients. Other auto-antibodies like the one against Myelin ol [....] » Read More
Introduction: Stroke is still a major cause of debilitating disability despite advancements in available clinical therapies. Raised admission blood glucose concentration is associated with poor outcomes of stroke, even in non diabetics. Hence, reporting stroke burden and outcome [....] » Read More
Rationale: New-onset refractory status epilepticus (NORSE) is a neurologic emergency and potentially life-threatening syndrome described as continuous seizures in a previously healthy patient. Despite extensive workup, no specific etiology is found in over half of cases of NORS [....] » Read More
Microglia are resident macrophages of the brain parenchyma that is involved in many critical CNS functions, ranging from supporting neurogenesis and synapse remodeling to direct modulation of myelination and phagocytosis. Due to its reactive response to disease state and neuronal [....] » Read More
Introduction: We use “tautology” to denote the effect of mutations capable of producing diverse phenotypes, which shared genes, common pathways, gene interaction, pleiotropy, and epistasis could explain. We evaluated a large family in which six different neurologic [....] » Read More
Introduction: Essential Tremor (ET) is the most common form of movement disorder, resulting in pathologic tremor of hands and other body parts. The prevalence of Essential Tremor progressively increases with age (from 0.04% among those under 20 years to 2.87% among those over 80 [....] » Read More
In temporal lobe epilepsy, the ability of the dentate gyrus to limit excitatory cortical input to the hippocampus breaks down, leading to seizures. The dentate gyrus is also thought to help discriminate between similar memories by performing pattern separation, but whether epilep [....] » Read More
Ziconotide is a synthetic, water-soluble cone snail venom-derived peptide with a molecular weight of 2,639 Daltons. It is a nonopioid analgesic that selectively binds to N-type voltage-sensitive calcium channels on primary nociceptive afferent nerves in the dorsal horn of the spi [....] » Read More
Background: Depressive symptoms are common in Alzheimer's disease (AD) and are associated with cognitive function. Amygdala functional connectivity (FC) and radiomic features related to depression and cognition. However, studies have yet to explore the neural mec [....] » Read More
The human brain has developed different neural mechanisms to perceive time in twelve scales. Neural population clocks and ramping activity are the mechanisms responsible for perceiving subsecond timing, which includes speech recognition and internal discrimination. The human brai [....] » Read More
Background: People with neglect suffer from various spatial deficits in several modalities, which in many cases impair everyday functioning. Virtual reality (VR) is a form of interaction between humans and computers in which a real or imaginary environment is simulated. Users in [....] » Read More
Introduction: Creutzfeldt-Jakob Disease (CJD) is a rare and rapidly progressive neurodegenerative disorder with diverse clinical presentations. Timely diagnosis of CJD remains a challenge due to its nonspecific symptoms and lack of widely available definitive tests. This abstrac [....] » Read More
Arnold-Chiari malformation is a rare neurological developmental disorder that presents at birth. No such cases have been reported in support of microbial infections causing Chiari malformation; yet there is evidence how microorganisms can lead to brain abscess, brain empyema, and [....] » Read More
The standard of care for multiple sclerosis is to perform surveillance MRI to monitor disease activity, given that subclinical or ‘silent’ lesions can often occur. In two rare demyelinating diseases, neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendr [....] » Read More
Alzheimer’s disease (AD) is a neurodegenerative disease that causes cognitive impairment, characterized by progressive cognitive decline, memory loss, and neuronal death in the cerebral cortex, hippocampus, and other brain regions. Hallmarks of its pathology are amyloid bet [....] » Read More
Introduction: Leucine-rich glioma-inactivated 1 (LGI1)-antibody encephalitis can be difficult to diagnose. It should be considered when there is clinical presentation of brief, unilateral jerking of the face and arm, termed faciobrachial dystonic seizures (FBDS), which is a hall [....] » Read More
Neuralgic amyotrophy, or Parsonage-Turner syndrome (PTS), is a rare autoimmune inflammatory disorder of the brachial plexus. Patients will present with episodes of extreme shoulder pain with eventual development of paresis and atrophy of the innervated muscle. These symptoms may [....] » Read More
Transverse myelitis is a rare but documented sequela of heroin use. While the underlying etiology is not clearly elucidated, the prevailing pathophysiologic mechanism amongst existing literature suggests an immune mediated hypersensitivity reaction due to heroin insufflation fo [....] » Read More
Summary/Objective: To describe a patient who developed refractory vestibular migraine after a motor vehicle accident (MVA) and COVID-19 infection with subsequent improvement while on multiple CGRP antagonists with off-label dosing and to provide support for the role of CGRP in v [....] » Read More
Background: Parkinson’s disease (PD) is a chronic neurodegenerative disease affecting more than 10 million people worldwide. PD is commonly associated with motor symptoms like bradykinesia and non-motor symptoms like autonomic changes. Oftentimes, these symptoms can be rec [....] » Read More
Maternal tobacco use and nicotine exposure during pregnancy have been associated with adverse birth outcomes in infants and can lead to preventable pregnancy complications. Exposure to nicotine and other compounds in tobacco and electronic cigarettes (e-cigarettes) has been shown [....] » Read More
Background: Traumatic Brain Injury (TBI) is an injury to the brain caused by a blow to the head, which is commonly seen in motor vehicle accidents, sports injuries, falls, and assaults. Studies have shown that emotional states such as agitation can result in a longe [....] » Read More
Introduction In the literature, there are not so many cases that connected Atherosclerosis to MMDandit hasn’t been assured by pathological studies as well. Moya Moya disease is a uniquecerebrovascular disease characterized by progressive large intracranial artery narrowing [....] » Read More
Objective: Generalized anxiety disorder (GAD) is a typical multisystem disease characterized by decreased activity in the left dorsolateral prefrontal cortex (DLPFC). Transcranial near-infrared stimulation (tNIRS) was used to stimulate the left DLPFC to relieve anxiety, and tran [....] » Read More
Frontotemporal dementia (FTD) is the second most common form of presenile dementia; however, its diagnosis has been poorly investigated. Previous attempts to diagnose FTD using quantitative electroencephalography (qEEG) have yielded inconsistent results in both spectral and funct [....] » Read More
Stroke is ranked as the second major cause of death and a major cause of disability in the world with increasing annual numbers. Ischemic stroke (IS) being the most prevalent form of stroke, the role of COVID-19 in the risk of complications and outcomes for patients with IS is st [....] » Read More
Multiple sclerosis (MS), a debilitating inflammatory disease of the central nervous system, afflicts approximately 2.5 million people worldwide. Manifesting through a variety of symptoms including gait and balance impairments, the progression of MS notably exacerbates balance dif [....] » Read More
Introduction: Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disorder that classically presents with sudden onset of visual disturbances, seizures, headaches, and altered mentation in the context of uncontrolled hypertension. The diagnosis of PRES can [....] » Read More
Title : Use of MRI-navigated Transcranial Pulse Stimulation (TPS) as an alternative treatment for alzheimer’s disease and other psychiatric diseases
Ulrich Sprick, Alexius/Josef Clinic, Germany
Dementia is still one of the most common serious psychiatric disorders in old age. A dementia of the Alzheimer's type is still considered to be a progressive irreversible disease which cannot be treated causally. However, in the meantime it has been shown that novel non-invas [....] » Read More
Title : Introducing 4D printing for stem cell delivery to and function in the brain: Improving viability, differentiation, and brain function
Thomas J Webster, Interstellar Therapeutics, United States
Stem cells have not provided the universal, effective solution to neurological diseases that they were once thought to provide. In particular, maintaining stem cell viability during and after implantation into the brain has proved problematic. The use of enzymes (such as trypsin) [....] » Read More
Title : Finding anatomical relations between brain regions using AI/ML techniques and the ALLEN NLP API
Bharath Kumar Nagaraj, Revature LLC, United States
Introduction The brain is a complex organ with a vast network of interconnected neurons. These connections allow different brain regions to communicate with each other, which is essential for many cognitive functions. However, the anatomical relationships between brain regions [....] » Read More
Title : Finding anatomical relations between brain regions using AI/ML techniques and the ALLEN NLP API
Naveen Kunchakuri, EchoStar Corporation, United States
Introduction The brain is a complex organ with a vast network of interconnected neurons. These connections allow different brain regions to communicate with each other, which is essential for many cognitive functions. However, the anatomical relationships between brain regions [....] » Read More
Title : Combatting “Neurophobia”: A proposed educational model to promote “Neurophilia”
Richard I. Suarez, Florida International University, United States
When we reflect on medical education as a whole, novelty in structure and content promotes growth and enhances student outcomes. The teaching of neurology is no different and presents a more unique hurdle in its instruction considering the well-described phenomenon of “neur [....] » Read More
Title : A cost utility analysis comparing endovascular coiling to neurosurgical clipping in the treatment of aneurysmal subarachnoid haemorrhage
Alexis Tang, University of Edinburgh, United Kingdom
Endovascular coiling (EC) has been identified in systematic reviews and meta-analyses to produce more favourable clinical outcomes in comparison to neurosurgical clipping (NC) when surgically treating a subarachnoid haemorrhage from a ruptured aneurysm. Cost-effectiveness analyse [....] » Read More
Title : Astrocytes have neuroimmunological function in the stab wound mouse brain
Hiroko Ikeshima Kataoka, Kieo University, Japan
Background: Some glial cells such as astrocytes and microglial cells activated when the traumatic injury occurred to the brain. After the stab wound to the mouse brain, those glial cells proliferate and secrete some of the inflammatory cytokines, however the functional role of th [....] » Read More
Title : Oxygen extraction fraction: Review on different computational methods based on mGRE sequences and clinical manifestations
Farsana F J, Digital University Kerala, India
Oxygen extraction fraction (OEF) is a physiological biomarker reflecting the percentage of oxygen extracted from the blood supply, which is directly associated with cerebral oxygen metabolism. It can also provide information about the relative deficiencies in cerebral blood suppl [....] » Read More
Title : Optimal duration for recording pediatric EEG: An observational study
Arvinder, AIIMS, New Delhi, India
Objective To evaluate optimal duration for recording pediatric EEG in outpatient settings for children and adolescents aged 1month-18years. Methods Setting: Outpatient EEG Laboratory at Department of Pediatrics at a tertiary care teaching centre in north India. Exclusion cr [....] » Read More
Title : Systematic review on the role of the glymphatic system in sleep-related disorders
Sagarika Gopalkrishnan, Einstein Medical Centre, United States
Objective: The aim of the study is to assess the implication of dysfunction in the glymphatic system in patients suffering from sleep-related disorders. The secondary aim is to understand the association between the glymphatic system and cognitive decline in patients with sleep- [....] » Read More
Title : Artificial intelligence / Machine Learning (AI/ML) has the potential to predict the risk for stroke, days before the symptoms appear
Raj Gopalan, BSRM Consulting, United States
Background There are 12 million new stroke occurrences every year. 100 million people are living with stroke aftermath worldwide. $900 million are spent on stroke every year. 85% of strokes have no warning signs. 2 million neurons are lost every minute after stroke. If the tre [....] » Read More
Title : Addressing education and medication adherence for stroke survivors
Mikaela Atkins, Arizona State University, United States
At one of the largest hospitals in Arizona, who care for individuals suffering from neurological diseases and houses a Joint Commission Comprehensive Stroke Center, the Comprehensive Stroke Program Quality Team has been working in conjunction with an Arizona State University Doct [....] » Read More
Title : Estrogen Receptor Alpha (ER?) signaling in dendritic cells modulates autoimmune encephalomyelitis disease phenotype in mice
Shehata Anwar, University of Illinois at Urbana Champaign, United States
Estrogen is a disease-modifying factor in multiple sclerosis (MS), and its animal model, the experimental autoimmune encephalomyelitis (EAE), via estrogen receptor alpha (ERα). However, the mechanisms by which ERα signaling contributes to changes in disease pathogenes [....] » Read More
Title : Mechanisms of T cell-mediated brain neuronal damage in murine cryptococcus-associated iris
Jinyan Zhou, University of Illinois at Urbana Champaign, United States
Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS) is a condition that frequently occurs in immunocompromised patients infected with Cryptococcus neoformans (Cn), whose immune systems become overreactive upon reconstitution. Patients contracted with C-IR [....] » Read More
Title : CCR5-mediated T Cell infiltration into the brain triggers pulmonary dysfunction in murine cryptococcus-associated IRIS
Makoto Inoue, University of Illinois at Urbana-Champaign, United States
Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS) is identified upon immune reconstitution in immunocompromised patients who have previously contracted an infection of Cryptococcus neoformans (Cn). C-IRIS can be lethal, but how the immune system t [....] » Read More
Title : Neuro-exergaming for parkinson’s: Clinic-observed trend of cognitive improvement after pedal-n-play with the interactive Physical and Cognitive Exercise System (iPACES)
Cay Anderson-Hanley, Union College & iPACES, United States
Given that approximately 40% of Parkinson’s patients may meet criteria for mild cognitive impairment (MCI) and 80% may progress to dementia (Kenney et al., 2022), researchers have pursued interventions that might stave off or ameliorate neuropsychological decline. Numerous [....] » Read More
Title : Prunus domestica L. extract diminishes deteriorations of memory and hippocampal neurogenesis in D-gal-induced aging in a rat model
Jariya Umka Welbat, Khon Kaen University, Thailand
Memory loss is the most common symptom found in aging. Studies of brain aging have revealed upregulation of the reactive oxygen species levels, which induce oxidative stress, neuronal damage, and neuronal apoptosis linked to memory decline. In animal studies, Dgalactose (D-gal) c [....] » Read More
Title : Post covid headache, in 510 cases presented in emergency department on regional hospital durres, albania in period november 2020 –november 2022
Edlira Shemsi (Harizi), Regional Hospital Durres, Albania
SARSCoV2 the virus responsible for the COVID19 pandemic had not only respiratory symptoms,butalso neurological symptoms, and headache is a frequent complaint.Pathophysiologyof headache in the context of COVID 19 has some mechanisms that can be involved in persistence of headache [....] » Read More
Title : The neuroprotective properties of rosmarinic acid against cognitive impairments and hippocampal neurogenesis caused by L-methionine in adult rats
Apiwat Sirichoat, Khon Kaen University, Thailand
L-methionine (L-met) is one of the nine essential amino acids. A high dose of supplementary methionine administration over a long period can promote oxidative stress due to increasing base levels of metabolites, such as homocysteine (Hcy). Homocysteine contributes to neuronal cel [....] » Read More
Title : Chronic subdural hematoma drainage under local vs. General anesthesia: Systematic review and meta-analysis
Amy Zhou, University of Saskatchewan, Canada
Introduction Chronic subdural hematoma (cSDH) is one of the most encountered conditions seen in neurosurgery. Although mainstay treatment of cSDH has been burr hole drainage, no consensus yet exists on optimal anesthesia technique for surgical treatment. Currently, the decision t [....] » Read More
Title : Behind the symptoms: Decoding moyamoya disease in an adult female
Dominique Hayduk Montecino, Lakeland Regional Health, United States
Background: We report a case of a middle-aged woman admitted due to near syncope who presented with transient neurological symptoms for months, but had an unremarkable initial neurological examination in the emergency room. Subsequent advanced imaging unveiled a diagnosis of Mo [....] » Read More
Title : Center of pressure oscillations reveal the potential factors of loss of automaticity in older adults
Alexander Guo, Boise State University, United States
Falls are a significant global health issue for older adults. Most falls among older adults occur during dual-task activities. This could be attributed to the reduced automaticity in postural control among older adults. Identifying potential factors contributing to the loss of au [....] » Read More
Title : Familial CJD in three generations.
Neetika Sharma, PGIMER, India
59 yrs old male presented with 11 months history of ataxia followed by 3 months history of bilateral hand action tremors. 9 month into illness he started to have cognitive decline followed by myoclonic jerks . He also had fragmented sleep with decreased total sleep duration. He h [....] » Read More
Title : Mild carotid stenosis creates gradual, progressive, lifelong brain and eye damage: An experimental laboratory rat model
Arieh Sorin Solomon, Tel Aviv University, Israel
In humans, carotid stenosis of 70% and above might be the cause of clinical symptoms such as transient ischemic attack and stroke. No clinical or animal studies have evaluated mild carotid occlusion, and few examined unilateral occlusion. Here, Wistar rats underwent bilateral or [....] » Read More
Title : Cerebrospinal fluid microRNAs as potential biomarkers in alzheimer’s disease
Ghaith Adi, Alfaisal University, Saudi Arabia
Alzheimer’s disease (AD) is the leading form of dementia worldwide, but its early detection and diagnosis remain a challenge. MicroRNAs (miRNAs) are a group of small endogenous RNA molecules that regulate mRNA expression. Recent evidence suggests miRNAs play an important ro [....] » Read More
Title : Non-invasive brain stimulation by transcranial pulse stimulation as a coadjunctive treatment in alzheimer's disease
Gilson Tanaka Shinzato, University of Sao Paulo, Brazil
The study protocol describes a randomized, double-blind, sham-controlled clinical trial conducted by the Institute of Psychiatry (IPq) and the Institute of Physical Medicine and Rehabilitation (IMREA) at the Hospital das Clinicas, Faculty of Medicine, University of São Pau [....] » Read More
Title : Transcranial pulse stimulation in neurological rehabilitation: Exploring potential benefits for stroke, parkinson's disease and brain trauma patients within a multiprofessional rehabilitation team
Leandro Heidy Yoshioka, University of Sao Paulo, Brazil
The initial phase of the research project exploring transcranial pulse stimulation (TPS) in individuals with stroke, Parkinson's disease, and brain trauma within the complex rehabilitation setting holds significant importance within the context of a multiprofessional rehabili [....] » Read More
Title : New perspectives for TPS treatment – long COVID and chronic pain syndromes / knee osteoarthritis
Marta Imamura, University of Sao Paulo, Brazil
This abstract presents two study protocols focused on the potential effectiveness of Transcranial Pulse Stimulation (TPS) in individuals with different health conditions: long COVID with cognitive impairment and chronic pain with knee osteoarthritis. The randomized, double-blind, [....] » Read More
Title : Transcranial Pulse Stimulation (TPS) – advancements, applications, and current status
Thi Lan Marina Freedman, STORZ Medical AG, Switzerland
Shock waves, single acoustic mechanical pulses utilized in medical treatments since 1980, have demonstrated therapeutic effects in localized tissue regions. Research indicates that shock waves stimulate mechanotransduction, triggering the release of Growth Factors (VEGF) and Nitr [....] » Read More
Title : Transcranial pulse stimulation of the brain – a new strategy of noninvasive treatment
Ulrich Sprick, Alexius/Josef Clinic, Germany
The treatment of various severe neurodegenerative diseases including Alzheimer’s Disease is a real challenge in clinical practice. A new method of brain stimulation using noninvasive Transcranial Pulse Stimulation (TPS) based on ultra-short shockwaves has recently become av [....] » Read More