HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.

10th Edition of International Conference on Neurology and Brain Disorders

October 21-23, 2024

October 21 -23, 2024 | Baltimore, Maryland, USA
INBC 2023

Muhammad Yahya Saif

Speaker at Brain Disorders Conference - Muhammad Yahya Saif
Muhammad Yahya Saif
Aston University, United Kingdom
Title : Investigating the molecular mechanisms involved in early events of cellular dysfunction in alzheimer's disease

Abstract:

Alzheimer’s Disease (AD) is a progressive neurological disorder that gradually deteriorates cognitive abilities and leads to the inability to carry out simple tasks. However, the molecular mechanisms and causes of this disease are still unclear. This research aims to use the proteomic signature of the 5xFAD AD mouse model to identify early changes in protein expression in the AD brain compared to the wild type. Lysates from the cerebral cortex of 3 months-old 5xFAD and wild-type mice were analysed by LC-MS/MS and investigated for protein candidates over- or under- expressed in AD mice compared to wild-type: Cryab, MAPK8/9, and VGLUT1/3 were identified as the proteins with the most altered expression in transgenic mice. These candidates were studied in differentiated SH-SY5Y cells upon treatment with amyloid-beta oligomers to mimic AD pathology. This study investigates molecular mechanisms and suggests new insights into the pathogenesis of AD.

Biography:

In 2019, I started pursuing a Bachelor of Science (BSc) degree in Biomedical Science at Aston University. During my undergraduate studies, I developed a strong interest in neuroscience, particularly in the fields of neurodegeneration and Alzheimer's Disease. This prompted me to pursue a Master of Research in Neuroscience, focusing specifically on these areas.

After completing my master's degree, I have recently embarked on a career as a Researcher at the University of Oxford. My research primarily centers around brain damage, where I aim to contribute to a deeper understanding of the mechanisms underlying such conditions. Simultaneously, I have enrolled in a postgraduate medicine course at the University of Warwick, further expanding my knowledge and skills in the medical field.

Throughout my academic and professional journey, I have gained valuable experience in the biomedical industry. Notably, I have worked with renowned organizations such as the NHS, where I served as an Associate Researcher and as a Scientist at the UK Health Security Agency (UKHSA).

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