Title : Mild carotid stenosis creates gradual, progressive, lifelong brain and eye damage: An experimental laboratory rat model
Abstract:
In humans, carotid stenosis of 70% and above might be the cause of clinical symptoms such as transient ischemic attack and stroke. No clinical or animal studies have evaluated mild carotid occlusion, and few examined unilateral occlusion. Here, Wistar rats underwent bilateral or unilateral carotid occlusion of 28%-45%. Long term effects were evakuated 9-1 months later. We conducted cognitive evaluation using spatial learningin a water maze and exploration behaviour in an open field. Morphology of the brain was examined by MRI using diffusion –tensor imaging (DTI) and immunohistochemistry staining of the brain and eyes. Cognitive deficit was found in spatial memory and exploration behaviour in both occluded groups. Brain and eye histology presented severe damage in the bilateral occluded compared wih unilateral. The results support our hypothesis that gradual formation of mild carotid stenosis along life course leads to progressive damage that may create different degenerative diseases at later age.
Audience Take Away
- Those people who are related to medicine or even in para medical work will be aware in the everyday activity and take in consideration the existence of mild carotid occlusion that may have an impact in their research
- They will do their job in a better way
- Other faculty may take as a goal to find methods of preventing the damage of carotid occlusion
- The presented research is an alarm to try and approach carotid occlusion from a completely other angle of view than of today and create a new protocol of treatment for that pathology
