Mild carotid stenosis creates gradual, progressive, lifelong brain and eye damage: An experimental laboratory rat model

Title : Mild carotid stenosis creates gradual, progressive, lifelong brain and eye damage: An experimental laboratory rat model

Abstract:

In humans, carotid stenosis of 70% and above might be the cause of clinical symptoms such as transient ischemic attack and stroke. No clinical or animal studies have evaluated mild carotid occlusion, and few examined unilateral occlusion. Here, Wistar rats underwent bilateral or unilateral carotid occlusion of 28%-45%. Long term effects were evakuated 9-1 months later. We conducted cognitive evaluation using spatial learningin a water maze and exploration behaviour in an open field. Morphology of the brain was examined by MRI using diffusion –tensor imaging (DTI) and immunohistochemistry staining of the brain and eyes. Cognitive deficit was found in spatial memory and exploration behaviour in both occluded groups. Brain and eye histology presented severe damage in the bilateral occluded compared wih unilateral. The results support our hypothesis that gradual formation of mild carotid stenosis along life course leads to progressive damage that may create different degenerative diseases at later age.

Audience Take Away

• Those people who are related to medicine or even in para medical work will be aware in the everyday activity and take in consideration the existence of mild carotid occlusion that may have an impact in their research
• They will do their job in a better way
• Other faculty may take as a goal to find methods of preventing the damage of carotid occlusion
• The presented research is an alarm to try and approach carotid occlusion from a completely other angle of view than of today and create a new protocol of treatment for that pathology

Biography:

Arieh S Solomon is an MD graduate of Hadassah Medical School of the Hebrew University Jerusalem and a PhD graduate of the Faculty of Medicine of Tel Aviv University. He was a visiting Assistant Professor at the Medical College of Pennsylvania in 1989, creating a project related to regeneration of the spinal cord. He is active as an eye doctor and a researcher of basic translational research related to eye and brain He created a number of animal models for research that are an important platform for applicative research in human. Member of ARVO and Neuroscience. Reviewer of important journals in the field. Arieh S Solomon had published 115 peer reviewed articles and participated in 11 chapters in books.