Non-invasive brain stimulation by transcranial pulse stimulation as a coadjunctive treatment in alzheimer's disease

Title : Non-invasive brain stimulation by transcranial pulse stimulation as a coadjunctive treatment in alzheimer's disease

Abstract:

The study protocol describes a randomized, double-blind, sham-controlled clinical trial conducted by the Institute of Psychiatry (IPq) and the Institute of Physical Medicine and Rehabilitation (IMREA) at the Hospital das Clinicas, Faculty of Medicine, University of São Paulo. The trial aims to evaluate the effectiveness of transcranial pulse stimulation in individuals with Alzheimer's disease. Participants will be classified based on the disease stage, with a total of 50 volunteers randomly assigned to two study groups. The intervention consists of ten sessions using the Storz Medical NEUROLITH® equipment for transcranial pulse stimulation. The trial includes a sham-controlled group for comparison. The researchers will assess the clinical course, conduct imaging examinations, and use functional and cognitive disability scales to evaluate the intervention's effectiveness. Additionally, preliminary data from an open-label study with ten patients showed statistically significant improvement in behavioral scores after transcranial pulse stimulation.

Audience Take Away

• The audience will learn about the effectiveness of Transcranial Pulse Stimulation (TPS) in individuals with Alzheimer's disease
• They will understand how TPS can be applied in clinical practice to improve cognitive function
• Overall, the presentation provides valuable insights, practical applications, and potential benefits for individuals with Alzheimer's disease

Biography:

Gilson Shinzato graduated from the University of Sao Paulo Medical School in 1988, specializing in Physical Medicine and Rehabilitation in 1992, obtaining a Master's degree from FMUSP in 1998. He has been an assistant at IMREA/HCFMUSP since 1992, working at the areas of chronic pain treatment, acupuncture, myofascial Fischer block, ENMG, and isokinetic dynamometry, with a focus on improving and promoting Extracorporeal Shock Wave Treatment since 2007, learning directly from the inventor of TPS Henning Lohse-Busch in 2015, and leading the Brazilian research in TPS treatment for Alzheimer`s Disease since 2020, in collaboration with the Institute of Psychiatry of HCFMUSP.