HYBRID EVENT: You can participate in person at Orlando, Florida, USA or Virtually from your home or work.

12th Edition of International Conference on Neurology and Brain Disorders

October 20-22, 2025

October 20 -22, 2025 | Orlando, Florida, USA

The Decline Theory

The Decline Theory

The Decline Theory  in neurology states that the pathophysiology of neurological diseases results in an overall decrease in brain activity. It is an alternative to the Excitotoxicity Theory, which suggests that increased neuron activity is a primary cause of neurodegenerative diseases. The Decline Theory suggests that the decrease in brain activity is due to decreased synaptic communication between neurons and a decreased release of neurotransmitters. There are three main components of the Decline Theory. First, neuronal networks and connections become weakened as the interactions between neurons slow down. This results in less information being exchanged between neurons leading to a decrease in brain activity. Secondly, decreased release of neurotransmitters can occur due to a decrease in neurotransmitter production, or because of neuronal dysfunction. Finally, the degeneration of axons can lead to disruption and damage to neural networks resulting in a decrease of brain activity. The Decline Theory has been proposed in neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. It is often suggested to be a more comprehensive explanation for the pathogenesis of these diseases than the Excitotoxicity Theory, as it takes into account both the decreased activity of neurons and the decline in the networks that these neurons are connected to. In addition, the Decline Theory suggests that therapies for neurological diseases should focus on both restoring the function of existing neurons and connecting them effectively, as well as forming new, strong neuronal networks. This differs from the Excitotoxicity Theory, which suggests therapies should focus solely on restoring excitatory activity. A better understanding of the molecular pathways and mechanisms of the Decline Theory could lead to improved treatments and interventions for neurological diseases.

Committee Members
Speaker at Neuroscience Conference - Ken Ware

Ken Ware

NeuroPhysics Therapy Institute and Research Centre, Australia
Speaker at Neurology and Brain Disorders - Joe Sam Robinson

Joe Sam Robinson

Mercer University, United States
Speaker at Neurology Conferences - Robert B Slocum

Robert B Slocum

University of Kentucky HealthCare, United States
INBC 2025 Speakers
Speaker at Brain Disorders Conference - Thomas J Webster

Thomas J Webster

Interstellar Therapeutics, United States
Speaker at Neuroscience Conference - Roger H Coletti

Roger H Coletti

Interventional Health, PA, United States
Speaker at Neuroscience Conference - Stephen Grossberg

Stephen Grossberg

Boston University, United States
Speaker at Brain Disorders Conference - George Diaz

George Diaz

Memorial Healthcare Systems, United States

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