The intersection of neurology and systemic disorders offers a deeper understanding of how diseases affecting the entire body, such as diabetes, thyroid disorders, and infections, can manifest with neurological symptoms. Systemic conditions often exacerbate neurological disorders, leading to increased morbidity and more complex treatment challenges. Research into the pathophysiology of these interactions is revealing how factors like immune response, metabolic imbalances, and cardiovascular health contribute to neurological dysfunction. For example, uncontrolled diabetes can lead to diabetic neuropathy, while hypertension is a major risk factor for stroke. By advancing knowledge in both neurology and systemic diseases, clinicians are better equipped to provide comprehensive care that addresses both the neurological and systemic aspects of these conditions, enhancing patient management and quality of life.