Neurotransmitters are chemical messengers that allow neurons in the brain to communicate with one another. They have widespread effects in the body, from influencing cognitive processes like memory and concentration, to contributing to the regulation of hormones, body temperature, appetite, and more. Neurotransmitters act as a bridge between neurons, carrying a message from one neuron to another, or even to multiple neurons. They can be either excitatory — when they cause increased activity or responses in the neurons — or inhibitory — when they decrease activity or responses in the neurons. The most well-known neurotransmitters are the small molecules acetylcholine, glutamate, and dopamine. Acetylcholine plays a role in learning, memory and muscle control, and is responsible for many of the processes associated with attention. Glutamate is responsible for the excitatory signals between neurons, and is involved in muscle control and determining how we respond to sensory stimuli. Dopamine is a catecholamine neurotransmitter and is associated with learning, reward, and motivation. The function of neurotransmitters depends on the type and amount released by the pre-synaptic neuron. If too much or too little is released, the message transmitted from the neuron to the target neuron may become distorted or interrupted. There are several factors that contribute to neurotransmitter release, such as environmental stimuli, genes, and hormones. Neurotransmitters play an essential role in normal brain function. Imbalances in neurotransmitter levels can lead to neurological disorders such as depression, anxiety, and addiction. To address these issues, medications are often used to regulate levels of the chemicals. In some cases, lifestyle changes such as reducing stress or improving nutrition can also help to improve the functioning of neurotransmitters.
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Title : A multiscale systems biology framework integrating ODE-based kinetics and MD-derived structural affinities to model mBDNF–proBDNF-mediated bifurcation dynamics in CNS neurotrophin signaling
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Title : A multiscale systems biology framework integrating ODE-based kinetics and MD-derived structural affinities to model mBDNF–proBDNF-mediated bifurcation dynamics in CNS neurotrophin signaling
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Title : A multiscale systems biology framework integrating ODE-based kinetics and MD-derived structural affinities to model mBDNF–proBDNF-mediated bifurcation dynamics in CNS neurotrophin signalling
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