Neuroinflammation, on the other hand, pertains to inflammation within the central nervous system (CNS), involving immune system cells and molecules. While inflammation is a natural response to injury or infection, chronic neuroinflammation can adversely affect brain function and contribute to various neurological disorders. Microglia, the CNS's resident immune cells, are pivotal in neuroinflammation. Upon activation, microglia release pro-inflammatory molecules like cytokines, chemokines, and reactive oxygen species, potentially harming neurons and other brain cells. Astrocytes, another glial cell type, can also contribute to neuroinflammation when activated. Neuroinflammation is implicated in numerous neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and traumatic brain injury, where chronic inflammation exacerbates neuronal damage and disease progression. Understanding the mechanisms underlying neuroinflammation is crucial for developing novel therapeutic strategies. Researchers explore various approaches to modulate neuroinflammation, including targeting specific inflammatory molecules, regulating immune cell activation, and promoting neuroprotective pathways. These efforts hold promise for developing treatments to slow or halt the progression of neuroinflammatory disorders and foster brain health.
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