Neurodermatitis is a skin condition which starts with an itchy patch in the skin. This itch-scratch cycle makes the affected skin to become thick and leathery. it may also develop several itchy spots, mainly on the neck, wrists, forearms, legs or anal region. It is also known as lichen simplex chronicus is not life-threatening or contagious. But the itching can be so intense or recurrent that it disrupts your sleep, sexual function and quality of life.