A Basal Ganglia disease is a neurological disorder that results in abnormal shaking, decreased coordination, and problems with motor control. It is a disorder of the brain that affects movement and coordination. Basal ganglia diseases are most commonly caused by mutations in genes responsible for the production of proteins that are involved in proper brain function, though environmental factors may also play a role. The basal ganglia are a collection of structures within the brain, including the striatum, globus pallidus, thalamus, and subthalamic nucleus. These structures are primarily responsible for motor control and movement. Damage to the basal ganglia can cause abnormal movements, such as tremors or twitches. It can also cause difficulty with muscle coordination, such as difficulty walking or speaking. Depending on the severity of the damage, some people may experience changes in their ability to recognize faces, read, or comprehend spoken language. Basal ganglia diseases often present with difficulties in the ability to make voluntary movements, and a wide variety of symptoms may be seen, including rigidity, tremor, dystonia, akinesia, bradykinesia, chorea, and dystonia. Rigidity is characterized by stiff muscles, and tremor is an involuntary, rhythmic shaking, usually taking place in an arm or leg. Dystonia is a type of movement disorder in which certain muscle groups contract involuntarily, causing a twisting or sustained spasm of the muscle. Akinesia is the absence or limitation of voluntary movement, and bradykinesia is slowness of voluntary movement. Chorea is a type of involuntary movement that can result from damage to the basal ganglia and can take the form of quick, uncontrollable jerks. In addition to motor problems, basal ganglia diseases may also cause cognitive disturbances such as dementia, disorientation, and apathy. Additionally, a person may experience emotional changes, such as anxiety, depression, and emotional liability. Treatment for basal ganglia diseases may vary depending on the disease type, symptoms, and severity. Options may include drugs such as anticonvulsants, dopamine agonists, and monoamine-oxidase inhibitors, as well as surgery, physical therapy, and in some cases deep brain stimulation. Overall, basal ganglia diseases are complex disorders with a wide range of clinical features.
Title : A case of vile vindictive primary CNS vasculitis
George Diaz, Memorial Healthcare Systems, United States
Title : Novel important cellular responses, signaling mechanisms and therapeutic options in vascular dementia
Yong Xiao Wang, Albany Medical College, United States
Title : The role of beliefs, perception, and behavioural patterns in the evolution of psychophysical disorders
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
Title : Narrative medicine: A communication therapy for the communication disorder of Functional Seizures (FS) [also known as Psychogenic Non-Epileptic Seizures (PNES)]
Robert B Slocum, University of Kentucky HealthCare, United States
Title : How have we eliminated infection: From the bone to brain?
Thomas J Webster, Interstellar Therapeutics, United States
Title : Cervical stenosis-induced chronic cerebrospinal fluid flow restriction as a contributing cause of dementia
Joe Sam Robinson, Mercer University, United States