Synaptic plasticity, the cornerstone of the brain's adaptability and learning prowess, refers to the dynamic changes occurring at neuronal junctions in response to activity. Long-term potentiation (LTP) and long-term depression (LTD) represent pivotal facets of synaptic plasticity, orchestrating the strengthening and weakening of synaptic connections, respectively. These mechanisms are fundamental to encoding and retaining information, forming the bedrock of memory and learning. However, dysregulation of synaptic plasticity is implicated in various neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, depression, and addiction, underscoring its significance in understanding disease pathogenesis and treatment development. Researchers are fervently exploring innovative strategies to modulate synaptic plasticity, aiming to rectify aberrant synaptic function in diseased states. By elucidating these mechanisms, targeted interventions could emerge, offering hope for ameliorating neural deficits associated with such disorders and enhancing patient outcomes.
Title : A case of vile vindictive primary CNS vasculitis
George Diaz, Memorial Healthcare Systems, United States
Title : Novel important cellular responses, signaling mechanisms and therapeutic options in vascular dementia
Yong Xiao Wang, Albany Medical College, United States
Title : The role of beliefs, perception, and behavioural patterns in the evolution of psychophysical disorders
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
Title : Narrative medicine: A communication therapy for the communication disorder of Functional Seizures (FS) [also known as Psychogenic Non-Epileptic Seizures (PNES)]
Robert B Slocum, University of Kentucky HealthCare, United States
Title : How have we eliminated infection: From the bone to brain?
Thomas J Webster, Interstellar Therapeutics, United States
Title : Cervical stenosis-induced chronic cerebrospinal fluid flow restriction as a contributing cause of dementia
Joe Sam Robinson, Mercer University, United States