13th Edition of International Conference on Neurology and Brain Disorders
October 19-21, 2026
Neurobiology of Sleep
The neurobiology of sleep delves into the intricate mechanisms governing the fundamental biological process of sleep. Sleep regulation involves a complex interplay of neuronal circuits, neurotransmitters, and various brain regions. Key players like the brainstem, hypothalamus, and thalamus orchestrate the initiation and regulation of sleep cycles. The sleep-wake cycle hinges on the interaction between the sleep-promoting system, including the ventrolateral preoptic nucleus (VLPO) in the hypothalamus, and the wake-promoting system, which involves brainstem and hypothalamic histaminergic neurons. Neurotransmitters such as serotonin, dopamine, norepinephrine, and acetylcholine modulate these systems, influencing sleep stages and transitions. Serotonin and norepinephrine help maintain wakefulness, whereas gamma-aminobutyric acid (GABA) and adenosine promote sleep. Sleep comprises distinct stages characterized by specific brain wave patterns and physiological changes, encompassing non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Understanding the neurobiology of sleep is crucial for unraveling sleep-related disorders and developing targeted interventions to improve sleep quality and overall health. Researchers continue to explore the intricate mechanisms underlying sleep regulation to pave the way for more effective therapeutic strategies.
Ken Ware
NeuroPhysics Therapy Institute and Research Centre, Australia
Yong Xiao Wang
Albany Medical College, United States
Joe Sam Robinson
Mercer University, United States
Daniel Curry
Texas Children’s Hospital, United States
Steven Benvenisti
Davis, Saperstein Salomon, PC, United States
Andrzej Stanislaw Cieplak
Independent researcher, United States
Younok Dumortier Shin
OnusBio, United StatesSubmit your abstract Today
Title : Atypical presentation of Juvenile myoclonic epilepsy in a 16-year-old female: A case report
George Diaz, Memorial Healthcare Systems, United States
Title : Triple-network dysfunction, ME/CFS, and the NeuroPhysics Treatment Process “A dynamical systems perspective on psychophysical organization and environmental interaction”
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
Title : Beyond plaques: 10-nanometer-scale pathoconnectomics of Alzheimer’s disease
Ons M Saad, Panluminate Inc., United States
Title : Results from the global phase 3 trial (IB1001-303) evaluating levacetylleucine in children and adults with ataxia-telangiectasia
Chidinma Ejim, IntraBio, United States
Title : A phase 3, multinational, randomized, placebo-controlled, double-blind, crossover trial (IB1001-304) evaluating levacetylleucine in CACNA1A
Chidinma Ejim, IntraBio, United States
Title : Clinical and molecular phenotype of PTRHD1-associated juvenile parkinsonism
Bhavan A Modi, Barrow Neurological Institute at Phoenix Children's, United States