Spinal cord compression (SCC) is an neurological and neurosurgical emergency which occurs either when tumour, abscess or haematoma spreads into the spinal canal or from fracture of vertebra causing spinal cord compression. There is potentially devastating and irreversible damage [....] » Read More
Over the past 10-15 years, a huge amount of works on the study of meditation has been accumulated. A number of scientists acknowledge that voluntary control of attention plays a key role in meditation practices. And this "high-level" voluntary attention processes during [....] » Read More
Spinal cord compression (SCC) is an neurological and neurosurgical emergency which occurs either when tumour, abscess or haematoma spreads into the spinal canal or from fracture of vertebra causing spinal cord compression. There is potentially devastating and irreversible damage [....] » Read More
During the premanifest stages of HD (pre-HD), pre-HD individuals show significant neurodegenerative anomalies. In pre-HD, structural brain changes are present many years prior to disease onset, and are known to contribute to motor, cognitive, and psychiatric impairments. What yet [....] » Read More
Alzheimer's disease (AD) is believed to contribute to 60–70% of neurodegenerative dementia cases. The pathogenesis of AD is associated with increased oxidative stress and inflammatory response. Neurons are particularly sensitive to oxidative disturbances caused by incre [....] » Read More
Background:Chromosomal rearrangements (duplication/deletion) were described as a cause of neurodevelopmental diseases in 7 – 10 % of cases. The impact of these changes mainly depends on overlapped genes. SRY-Box Transcription Factor 3 (SOX3, *313430) is locat [....] » Read More
The End-Stage Renal Disease (ESRD) is a worldwide public health problem. For about 70 years, the scientific community has been aware of and has focused on the study of kidney function deficiencies and cognitive decline. There is empirical evidence that ESRD is associated with var [....] » Read More
Osmotic demyelination syndrome (ODS) is a condition which occurs due to rapid osmotic changes which result in myelinolysis of the nervous system. The myelinolysis commonly involves the pontine region resulting in central pontine myelinolysis. Rarely the myelinolysis could involve [....] » Read More
Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting approximately 1% of the population over age 50. Exposure to environmental toxins has been found to be a risk factor for sporadic PD. Herbicide rotenone has been shown to cause Parkinsoni [....] » Read More
This study is about reporting annual events of strokes, myocardial infarctions and deaths, in patients who had been hospitalized due to TIA/stroke in 1986 and followed up until February 2011; with or without cancer, and in patients with assessed lipid values after admission also [....] » Read More
The visualization of nerve cells is important for the advancement of neurological research and the comprehension of the foundations of the functioning of the human brain. At the cellular level, dendritic spines are the smallest multifunctional units that reflect cellular connecti [....] » Read More
Evidences point to the notion that the complex PSD-95/NMDA receptor/nNOS seems to play a key role in normal neuronal functions like synaptic plasticity, learning and memory, as well as in brain disorders such as stroke, pain and autism. PSD-95 is one of the two most abundan [....] » Read More
Neurons rely almost exclusively on ATP synthesis from the mitochondrial respiratory chain and oxidative phosphorylation to fulfill their energy requirements for neurotransmitter synthesis, release and reuptake. Besides providing energy, mitochondria are also involved in intracell [....] » Read More
Neuroanthropologists understand the dynamic enculturation of brain and cognitive functions in their external and internal environment. It necessitates the researchers to analyse big data for seeking proper understanding. Artificial intelligence (AI) is far better at predicting be [....] » Read More
Introduction: Both neurologic and neuromuscular diseases as Parkinson disease (PD) and sporadic inclusion body myositis (sIBM) usually affect patients at elderly stages of life and share common molecular etiology. Inflammation, proteostasis deregulation, degenerative autopha [....] » Read More
Globally, polyphenols have been explored extensively for their therapeutic potential and proved effectual against various maladies. However, their neuroprotective effect yet has not been extensively explored. Likewise, quest for the identification and utilization of biomolecules [....] » Read More
Alzheimer’s disease (AD) is an illness manifested by a number of pathological and clinical features, which including amyloid beta (Aβ) peptide deposits, neurofibrillary tangles (NFTs), dystrophic neurites, cholinergic impairment and neuronal death. To date, three ace [....] » Read More
Background: COVID-19 or coronavirus is a global pandemic, which is correlated with anosmia. This study aimed to summarize the Brain MRI finding in patients with anosmia due to COVID-19. Methods: This systematic review was performed following the Preferred Reporting Items for S [....] » Read More
21 yr male presented with no co morbidities presented with witnessed seizure(seminology characterized by jerky movements of left angle of mouth and left upper limb with up rolling eyeball and tongue bite followed by post ictal confusion).Managed conservatively by antiepileptic, a [....] » Read More
Resilience to stress is the ability to quickly adapt to adversity. There is evidence that exposure to prolonged stress triggers neuroinflammation what produces individual differences in stress vulnerability. However, the relationship between stress resilience, neuroinflammation, [....] » Read More
Title : A pilot study to examine the impact of Yoga-based mindfulness intervention (YBM) for older people with mild cognitive impairment (MCI)
Maryam Farhang, Faculty of Health and Social Sciences, Chile
Background: Research shows that mindfulness and yoga have been associated with a range of positive outcomes in older adults with mild cognitive impairment (MCI). The aims of the study was to adapt and pilot a mindfulness-based yoga intervention (YBM) for older adults with MCI. [....] » Read More
Title : Long-term treatment with indomethacin increases the number of SP-immunoreactive porcine duodenal neurons
Marta Czajkowska, University of Warmia and Mazury, Poland
Gastrointestinal inflammation resulting from prolonged NSAID drugs treatment constitutes a worldwide medical problem. Recently the role of enteric neuroactive substances involved in this process has gained attention. Therefore the aim of the study was to determine the effec [....] » Read More
Title : Proinflammatory cytokines in psychiatric disorders comorbid with Hashimoto’s thyroiditis
Polina Sobolevskaia, Saint Petersburg State University, Russian Federation
We have analyzed 27 patients with Hashimoto’s thyroiditis (HT) associated with psychiatric disorders.We also studied different parameters of immunoendocrine reactivity: thyroid hormones, prolactin, TSH, antithyroid antibodies, anti-alpha-enolase antibodies (anti-ENO1 Ab) an [....] » Read More
Title : Neuro-Behcet disease complicated by steroid-induced bilateral femoral head avascular necrosis
Yahia Al Turk, Henry Ford Hospital, United States
Behçet disease was first described in 1924 by a Turkish dermatologist, Dr. Hulusi Behçet. Oral and skin lesions are present in >75% of patients, and genital lesions are the most specific manifestation, and neurologic disease occurs in less than 10% of patients wi [....] » Read More
Title : Diagnosis and treatment of Rasmussen’s Encephalitis pose a big challenge: Two case reports and Literature review
Ali Hammed, Tishreen university hospital, Syrian Arab Republic
Rasmussen encephalitis (RE) is a rare disease of unknown etiology that causes severe chronic unihemispheric inflammatory disease of the central nervous system mainly in children. It leads to intractable seizures, cognitive decline and progressive neurological deficits in the affe [....] » Read More
Title : Neuroprotective effects of Chrysophyllum perpulchrum bark extract in AD like rats model of ?-amyloid 1-40 intrahippocampal injection
Pacome Kouadio NGo, Pelefero Gon Coulibaly University, Ivory coast, Morocco
Background: Alzheimer Disease (AD) is a threatening disease of upcoming years among african populations because of the increase of their expectancy life. Because no therapeutic drugs existing, it is now worthwhile to investigate on new effective drugs derived from natural product [....] » Read More
Title : Therapeutic ketosis and the broad field of applications for the ketogenic diet: Ketone ester applications & clinical updates
Raffaele Pilla, St. John of God Hospital, Italy
It has been recently shown that nutritional ketosis is effective against seizure disorders and various acute/chronic neurological disorders. Physiologically, glucose is the primary metabolic fuel for cells. However, many neurodegenerative disorders have been associated with impai [....] » Read More
Title : Integration of digital phenotyping with clinical (endo) phenotypes in children with neuro developmental disorders
Vanessa Douet Vannucci, University of Côte-d’Azur University, and CSO at Crocosgodigital, France
Abstract: Neurodevelopmental disorders (NDD) such as attention deficit hyperactivity disorder (ADHD), or social communication disorder, although most commonly studied in childhood, have complex clinical (endo)phenotypes with an important social context and can be lifelo [....] » Read More
Title : Mechanosensory stimulation evokes acute concussion-like behaviour by activating GIRKs coupled to muscarinic receptors in a simple vertebrate
Wen-Chang Li, School of Psychology and Neuroscience, United Kingdom
Most vertebrates show concussion responses when their heads are hit suddenly by heavy objects. Previous studies have focused on the direct physical injuries to the neural tissue caused by the concussive blow. We study a similar behaviour in a simple vertebrate, the Xe [....] » Read More
Title : Bilateral Facial Palsy: A case study to exceedingly rare and difficult diagnosis
Gaurav Jha, Queen’s Hospital, BHRUT, United Kingdom
Unilateral facial palsy is a fairly common diagnosis with an incidence of 20-25 per 100,000 population, whereas Bilateral facial nerve palsy (FNP) is exceedingly rare and only accounts for less than 2% (0.3%- 2%) all facial palsy cases. Facial paralysis depicts the result of a di [....] » Read More
Title : Affective disorders after stroke and traumatic brain injury in the long term perspective
Wilfried Schupp, Friedrich-Alexander University Erlangen-Nuremberg, Germany
Affective disorders are frequent after acquired brain lesions like stroke and traumatic brain injury (TBI). Depression had been more often been studied than anxiety although incidence and prevalence of both is nearly equal, and a high comorbidity between both exists. Most researc [....] » Read More
Title : Human Immunodeficiency Virus-1 Tat exerts its neurotoxic effects by downregulating Sonic Hedgehog signaling
Vir Singh, Albany College of Pharmacy and Health Sciences, United States
HIV-1 can alter the expression of tight junction proteins by downregulating Sonic hedgehog (Shh) signaling, thereby disrupting BBB integrity. In this study, we employed a conditional, CNS specific, transgenic murine model to investigate if Tat, a known neurotoxic HIV protein, is [....] » Read More
Title : Care course assessment nationwide exhaustive study: example of effectiveness assessment of neuro degenerative disease rehabilitation in France
Dubois Jeremy, National Institute of Health and Medical Research, France
Care course improves interprofessional coordination, care quality and decreases costs. Système National des Données de Santé (SNDS), a medical administrative big data base, allows us to rebuild and study care course for hospital care and home care. We will ta [....] » Read More
Title : Effect of scapular dyskinesia on the scapular balance angle and upper extremity sensorimotor function in stroke patients with spasticity
Lama Saad El Din Mahmoud, October 6 University, Egypt
Background: Post-stroke scapular dyskinesia is a predisposing factor for the affection of motor and somatosensory functions of the hemiparetic upper extremity. Objective: The purpose of the study was to investigate the effect of scapular dyskinesia on the scapular balance angl [....] » Read More
Title : A Glimmer of hope from insulin NPs in vitro and ex vivo studies for the successful insulin delivery to the brain
Hussein Akel, University of Szeged, Hungary
Drug delivery to the brain is still forming the major drawback facing the successful management of neurodegenerative disorders, counting Alzheimer’s disease (AD) that represents most dementia cases in the elderly population worldwide. Nasal application with the aim of direc [....] » Read More
Title : Intranasal administration of secretome derived from preconditioned human mesenchymal stem cells reduces the depressive behavior in a rat model of chronic unpredictable mild stress
Alba Liliana Ávila Suárez, Universidad del Desarrollo, Chile
Chronic stress exposure can induce in susceptible individuals maladaptive physiological responses, that can yield to changes in their emotional state, motivation and mental focus among others. Eventually these symptoms can worsen and became the central symptoms of the mayor depre [....] » Read More
Title : New ideas and approaches in treatments for chronic and complex neurological conditions
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
An initial study involving a random selection of 5 patients who were diagnosed MND positive and who were in at a moderately advanced stage (e.g. not able to walk unassisted, voice impedance and moderate upper limb and discriminative fine motor impairments), was implemented initia [....] » Read More
Title : Physiological correlates of the altered states of consciousness at different types of meditation at skilled practitioners
Svyatoslav Medvedev, Institute of the Human Brain RAS, Russian Federation
Importance of physiological researches of the altered states of consciousness (ASC) arising at adaptation of the person to performance of a certain activity is known (for example illusions of monototy in pilots, cosmonauts, operators of complex systems). This importance follows a [....] » Read More