Biography:
Dr. Singh is a virologist with special interest in molecular mechanisms that are involved in HIV replication and neuropathogenesis. He received his PhD in Biotechnology from Savitribai Phule Pune University (India) in 2009. Subsequently, during his postdoctoral training at Roswell Park Cancer Institute (RPCI), he studied the phenomenon of genomic imprinting and investigated the mechanism of establishment of maternal methylation at KvDMR1 Imprinting control region (ICR). This study proposed a potential mechanism of loss of methylation at KvDMR1 that results in a developmental disorder known as Beckwith Wiedemann syndrome. Further, he moved to University of Rochester Medical Center, Rochester, NY, where he worked for over 7 years, first as a postdoc and eventually promoted to Research Assistant Professor. During this time, he investigated the molecular mechanisms involved in HIV associated neurological disorder. Currently, Dr. Singh is employed as Assistant Professor of Microbiology at Albany College of Pharmacy and Health Sciences. Collectively, he has acquired an extensively diverse experience in investigating the molecular mechanisms implicated in various diseases including anemia, developmental growth syndromes predisposed to cancer, and HIV pathogenesis. As an independent investigator, Dr. Singh’s research interests include understanding the basic molecular mechanisms involved in- i) HIV associated neurological disorder, ii) HIV latency, and iii) Viral infection induced developmental defects.
Title : Human Immunodeficiency Virus-1 Tat exerts its neurotoxic effects by downregulating Sonic Hedgehog signaling