NeuroPhysics Therapy (NPT) is a fascinating field that delves into the discrete functionality and behaviour of the human nervous system. It explores how our nervous system perceives and responds to the environment, and through the development and application of specialized techni [....] » Read More
In 1906, the Italian biologist and pathologist Camillo Golgi and the Spanish pathologist and histologist Santiago Ramóny Cajal shared the Nobel Prize for Medicine and Physiology ‘in recognition of their work on the structure of the nervous system&rsquo [....] » Read More
Patients with Functional Seizures (FS) (also known as Psychogenic Nonepileptic Seizures (PNES), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Many patients with FS have a history of sexual, physical, or emotional abuse or othe [....] » Read More
Unlike the brains of humans, animal brains are subject to extremes of environment – and must keep neural function intact during and after extreme conditions. Frogs and turtles totally freeze in winter, displaying no measurable brain activity and a flat-lined hea [....] » Read More
Cerebral Visual Impairment (CVI) has been defined as a verifiable visual dysfunction which cannot be attributed to disorders of the anterior visual pathways or any potentially co-occurring ocular visual issue. Recent research has indicated that as many as one child in every mains [....] » Read More
Depression has become one of the most common types of psychological disorders, characterized by prolonged depressed mood, which severely limits people's psychosocial abilities and greatly reduces the quality of life. Although there are a variety of depression treatment drugs, [....] » Read More
Objective: We analysed seizure control in reproductive age group women on Valproic acid (VPA) and studied the difference in seizure control between VPA maintenance and after changing to other Anti-seizure medications (ASMs), because of reproductive age group or impending pre [....] » Read More
Importance: Stroke and dementia frequently co-occur, with frailty serving as a critical risk factor for both conditions. However, the relationship between frailty and the progression trajectories of stroke-dementia comorbidity has not been definitively established. Objective: [....] » Read More
Objective: TLE accounts for about 50-73% of cases being referred for epilepsy surgery. The objective is to find, whether the classical semiology in TLE has a role in predicting the post operative outcome in patients with refractory epilepsy. Methods: We included 684 patie [....] » Read More
Background: Persons with epilepsy are in general considered to have poor dental hygiene which can be contributed by severity of epilepsy, ignoring oral health issues or the medications used. A continuing need exists for better understanding the effects of antiepileptic medication [....] » Read More
Depression is a chronic disease afflicting ~245 million individuals worldwide, of which 30-40% patients remain dissatisfied despite 70 years of research, >5 antidepressant drug classes, and 3 trillion healthcare-budget. Fluoxetine, an SSRI alone and with Olanzapine, is the fir [....] » Read More
Introduction: Parkinson's disease, as a severe neurodegenerative pathology, has a negative impact on the quality and life expectancy of people. One of the criteria characterizing the medical and social severity of the disease, is the probability of survival after i [....] » Read More
Background: The Dextroscope is a VR workstation that can provide 3-dimensional information to choose a surgical approach. The dextroscope technique as an intervention has emerged as a promising tool in transsphenoidal surgery for sellar tumors, potentially offering improved visua [....] » Read More
Introduction: Neural tube defects (NTDs) are secondary abnormalities during the embryogenic development of the central nervous system (CNS). Between the 17th and the 28th day after fertilization, neurulation happens in two moments: primary and secondary neurulation. Secondar [....] » Read More
Hormetic nutrition for enhancing stress resilience and overall human health, recently, have received much attention. Redoxomics has been successfully applied to study neurodegeneration of ganglion neurons of the inner ear for the identification of potential biomarkers and novel m [....] » Read More
Guidelines for treating chronic low back pain are directly related to changing habits and carrying out patient-centered exercise programs, using passive resources such as manual therapy, for example, to aid treatment. In previous studies, it was possible to observe changes in [....] » Read More
Glioblastoma multiforme (GBM), a deadly brain cancer with a median survival of only 15-18 months, presents a significant hurdle for personalized treatment. Accounting for nearly half of primary central nervous system tumors, GBM is conventionally treated through surgical resectio [....] » Read More
The literature describes a close relationship between cognitive executive functions and daily activity. Adults with specific learning disabilities (SLDs) (e.g., dyslexia, dysgraphia, and dyscalculia) reveal limitations in daily activity in various life domains including decreased [....] » Read More
Autism Spectrum Disorder is a neurological disorder that affects how a person communicates and interacts with others. One way people on the spectrum are different from neurotypical people is in their attentional focus. In particular, those on the spectrum have been shown to pay c [....] » Read More
Nearly one in three of all Americans aged 13 to 18 experience an anxiety disorder. It is important now to accurately diagnose anxiety in adolescents. Current methods of diagnosis involve psychological evaluations and questionnaires. However, unconscious bias and stereotypes can i [....] » Read More
Nearly one in three of all Americans aged 13 to 18 experience an anxiety disorder. It is important now to accurately diagnose anxiety in adolescents. Current methods of diagnosis involve psychological evaluations and questionnaires. However, unconscious bias and stereotypes can i [....] » Read More
Decreased expression of endogenous miR-30c has been linked to numerous pathological conditions in both patients and animal models, including various cancers, hyperlipidemia, atherosclerosis, hyperglycemia, and diabetes. Systemic administration of a miR-30c mimic has been de [....] » Read More
Endoplasmic Reticulum (ER) stress is recognized as a crucial contributor to the progression of Traumatic Brain Injury (TBI) and represents a potential target for therapeutic intervention. This study aimed to assess the potential of J147, a novel neurotrophic compound, in alleviat [....] » Read More
There are no drugs available for Parkinson’s disease (PD) that alter progression of disease. Current symptomatic treatments provide imperfect relief and have side effects. Enhanced GABAergic neurotransmission contributes to PD pathogenesis. In animal models, GABA levels are [....] » Read More
Background: Access to the common carotid artery is crucial for any neuro-interventional procedures. Bovine aortic arch followed by an acutely angled proximal common carotid artery (CCA) can pose a great challenge. Owing to urgency, we resorted to a non-conventional me [....] » Read More
Introduction: Apoptosis is a form of programmed cell death, that underlies the wide range of symptoms investigated in neurological disorders from stroke to neurodegenerative diseases such as Alzheimer’s. Caspases are shown to be capable of producing inflammasomes along [....] » Read More
Introduction: Childhood stroke is associated with high mortality and serious morbidity for the survivors. Traumatic brain injury (TBI) has been reported to be a possible cause of childhood stroke or post traumatic cerebral infarction (PTCI). The precise frequency of cerebral [....] » Read More
Case A: A previously healthy male with 11 years old was taken to a community hospital with parasomnia and focal motor to bilateral tonic-clonic epileptic seizures, was diagnosed with epilepsy, medicated with valproic acid, without showing clinical improvement. Days later, pa [....] » Read More
Introduction: Finding a non-invasive and repeatable tool has been recommended to make an accurate diagnosis of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Methods: 70 volunteers participated in three groups: 24 with mild dementia of AD, 24 [....] » Read More
The central executive plays a key role in the encoding of visual stimuli in working memory, including the memory for faces in a social context. Faces often contain important details about the identity of social targets as well as the emotion that these targets are expressing. Enc [....] » Read More
Background: Interest in examining Internet gaming disorder (IGD) and its association with gaming motivation has surged. Eleven studies were conducted between 2018 and 2021 with a sample size of 4,065 individuals across various cultural contexts. Methods: Utilizing the Onl [....] » Read More
Objective: The ASPECTS score serves as a semi-quantitative instrument for assessing acute ischemic strokes within the middle cerebral artery (MCA-AIS) territory, and DWI-ASPECTS has been found to exhibit superior sensitivity and precision. The primary objective of this study was [....] » Read More
Background: Receptor-interacting protein kinase 1 (RIPK1) is a serine/threonine protein kinase that regulates inflammatory signalling and induces apoptosis and necroptosis. Activation of RIPK1 has been observed in human pathological samples from individuals with neurodegener [....] » Read More
Objective: Tumefactive Multiple Sclerosis (TMS) is a rare subtype of multiple sclerosis (MS) with an incidence of 1-3 per 1000 MS patients. Here, we aimed to review the literature to present data on the epidemiology of TMS. Background: The annual incidence of tumefa [....] » Read More
Background: Stroke, the second-leading cause of mortality and the third-leading cause of mortality and disability, imposes a substantial financial burden, exceeding $721 billion1. Addressing underlying causes and mitigating stroke-related consequences are crucial aspects of strok [....] » Read More
Background: The safety of aspartame, a widely consumed low-calorie artificial sweetener, has been heavily debated for human consumption. Published research has demonstrated its breakdown products, aspartic acid and phenylalanine, are associated with potential neurotoxicity due to [....] » Read More
Background: Alzheimer’s Disease (AD) has been shown to lead to deposition of Amyloid Aβ plaques and neurofibrillary tangles (NFT) in the cerebral cortex and hippocampus of the brain. These have the potential to cause neurological damage and suggests a relationship to t [....] » Read More
OwnLife is a leadership development business that combines human analytics with executive coaching to help individuals optimize how they live and maximize their cognitive performance. We hypothesized that physical exercise which materially elevates the heart rate is associated&nb [....] » Read More
Introduction: Traumatic brain injury (TBI) affects an estimated 27 to 69 million people worldwide annually1,2 with the majority of cases being classified as mild.3 Mild TBI (mTBI) is caused by blunt trauma or acceleration or deceleration forces to the head or body with resulting [....] » Read More
Background: Pontine strokes present a unique set of challenges in diagnosis and management as the clinical presentation can vary significantly. Along with the classic symptoms of dizziness, dysarthria, dysmetria, and weakness of the legs, there have been numerous case report [....] » Read More
Background: Protoplasmic astrocytoma (PA) is an extremely rare subtype of astrocytoma composed of malignant cells similar to protoplasmic astrocytes. Although rare, the slow-growing course of PA can often delay diagnosis and treatment, worsening survival rates. Radiologicall [....] » Read More
Introduction: The cervical spine presents the highest segmental mobility of all spinal regions. At present, in Poland there are no studies focusing on the assessment of the reliability of the Zebris MCS. Various methods measuring the range of motion of the spine are used to ident [....] » Read More
Optogenetic stimulation of hippocampal circuitry has been increasingly used to study sequence learning and memory (Geiller et al., 2023). Prolongation of spontaneously occurring sharp wave ripples (SPW-Rs) within the CA3 subregion of the hippocampus through optogenetic stimulatio [....] » Read More
Introduction: Toxic Leukoencephalopathy (TL) is cerebral white matter damage caused by toxic agents. It affects higher cerebral function resulting in forgetfulness, inattention, changes in personality, dementia, coma, and even death, and is detectable on MRI. Preservation of lang [....] » Read More
The brain’s ability to process complex real-world phenomena relies on its operation across multiple timescales, which have been shown to be organized hierarchically across various brain regions. At present, the relation between the topography of intrinsic neural t [....] » Read More
Introduction: Postural stability is maintained through a complex interplay of long-loop reflexes and higher brain centers. Long-loop reflexes, involving transcortical pathways, provide rapid, context-dependent responses to perturbations. Higher centers, including the cerebellum, [....] » Read More
Ventilator-associated pneumonia (VAP) remains a significant complication in patients with acute brain injury (ABI) requiring mechanical ventilation, often leading to poor outcomes and increased healthcare costs. This presentation will focus on the results of the PROPHY-VAP trial, [....] » Read More
The incidence of Traumatic spinal cord injuries (TSCI) is small and ranges between 10-50/million population/year. Prior to the second WW the great majority of patients died within two years of injury. Since the 2nd WW, due to the efforts of the pioneers who dedicated their profes [....] » Read More
Objective: To investigate the effect of and Acupuncture on brain plasticity and motor development in children with cerebral palsy. Investigate effect on mechanismof apoptosis of brain nerve cells, regulating the expression of neurotrophic factors, promoting the remodelingof nerve [....] » Read More
It has been noted by multiple researchers that there is Spontaneous Electrical Activity (SEA) at painful trigger points. This author has studied chronic muscle spasm and found that SEA is always present and appears to be the cause for the chronic nature of muscle spasm and result [....] » Read More
Background: Brain tumors are the second leading cause of cancer deaths among children and young adults, with an estimated 1 million Americans living with a brain tumor. Each year, 95,000 new cases are diagnosed, of which 30% are malignant with a survival rate of only 35%. Fe [....] » Read More
Objective: This study explored whether the event-related potential (ERP) components of N170, VPP, LPP, and P3 could be sensitive neurophysiological markers for assessing depression in temporal lobe epilepsy (TLE). Methods: Patients with TLE were divided into two groups with ma [....] » Read More
Purpose: To estimate the prevalence of personality disorders in persons with idiopathic generalized epilepsy (IGE) and to compare it with the general population. Method: The study was conducted in a super specialty epilepsy care center in a tertiary care hospital in Sout [....] » Read More
Background: Lymphomatosis cerebri is a variant of primary central nervous system lymphoma that is characterized by diffuse infiltrates without a mass formation that is often seen. It poses a diagnostic challenge because the radiological findings are not typical for lym [....] » Read More
With the progress of science and technology, new technologies and equipment are continuously transformed and entered clinical use. The current clinical related surgical techniques have been greatly improved, the surgical effect and the prognosis of patients have been greatly impr [....] » Read More
Tumor progression refers to the gradual development and growth of cancerous cells within the body. Understanding this process is crucial for effective diagnosis, treatment planning, and patient management. Traditional methods often rely on qualitative assessments and static imagi [....] » Read More
Background: Melanocytes, responsible for melanin production, originate from the neural crest and can give rise to malignant tumors known as melanoma. Primary Central Nervous System Melanoma (pCNSM) is a rare occurrence, with an incidence of 0.005 cases per 100,000 individuals ann [....] » Read More
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the primary cause of dementia, characterized by declining memory and cognitive function. Research has identified significant genes and risk alleles associated with AD, which shares common inf [....] » Read More
Black tea, known for its antioxidant properties, has garnered attention for its potential therapeutic effects on brain disorders. In this study, we delve into the specific role of black tea antioxidants, focusing on their compositional analysis, extraction methods, and neuroprote [....] » Read More
Glioblastoma’s are the most common type of primary brain tumour in adults and are the most lethal and least successfully treated solid tumours. Recently, research into the area of stem cells in brain tumour development has gained moment. However, due to the relatively new a [....] » Read More
(+)-4-Propyl-9-hydroxynaphthoxazine ((+)PHNO) is a high affinity agonist at dopamine D3 and, less potently, D2 receptors. In the nineteen eighties and nineties, this naphthoxazine compound was amongst the most promising, non-ergot derivatives in the pipeline for the treatment of [....] » Read More
Introduction: The burden of stroke is higher in Low-and Middle-Income Countries (LMICs) than in high-income countries due to the lack of stroke care centers, stroke specialist, and rehabilitation access. One way to increase access to stroke care in LMICs is through the use of tel [....] » Read More
Objective: Post-operative seizures can occur in 2.6% to 23% of patients with chronic subdural hematomas (cSDH). Hematoma size, midline shift, worse clinical status at admission, and craniotomy with membranectomy have been described as risk factors for its development; however, th [....] » Read More
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are distinguished by the progressive loss of motor capabilities, cognitive abilities, or both. The specific origins of neurodegenerative disorders are often unclear; however, they can include genetic, enviro [....] » Read More
A major hallmark of Alzheimer's Disease (AD) is the gradual accumulation and aggregation of toxic soluble and insoluble Aβ species in the brain. Amide Proton Transfer (APT) imaging is a relatively new protein-based molecular MRI technique that is based on endogenous mobi [....] » Read More
Introduction: Paroxysmal Kinesigenic Dyskinesia (PKD) is a rare neurologic disorder characterized by transient, episodic, involuntary hyperkinetic movements such as chorea, dystonia, myoclonus, or ballism. It is triggered by sudden voluntary movements, commonly present in yo [....] » Read More
Although the regulation of cholesterol homeostasis in the body has been extensively studied, there is little information on how this regulation takes place in the brain. Cholesterol does not cross the blood-brain barrier; therefore cholesterol metabolism in the brain is [....] » Read More
Autoimmune limbic encephalitis (AILE) is a rare form of encephalitis that manifests with atypical neuropsychiatric symptoms. Anti-NMDA receptor, anti-LGI1, and anti-GAD65 antibodies are associated with abnormal inflammation of the limbic system, leading to focal neurological defi [....] » Read More
Human balance is essential for maintaining overall health and functional independence, particularly in populations with neurological disorders such as Multiple Sclerosis (MS). As MS progresses, individuals often experience deteriorating balance, leading to increased falls an [....] » Read More
The development of an early and assertive diagnosis of Alzheimer’s Dementia can contribute to a better quality of life for patients, mainly by providing targeted therapy with measurable results. Biomarkers can be detected in blood levels and, more recently, the feasibility [....] » Read More
Introduction: Cavernous angiomas are benign vascular malformations characterized by abnormally dilated vessels that lack interposing neural tissue. The presentation can occur in any region of the central nervous system, but most commonly, supratentorial. This report details a rar [....] » Read More
Background: Spinal cord injury (SCI) often results in motor impairments and neuropathic pain. Not only are these conditions irreversible, they disrupt a crucial pathway for transmitting signals between the brain and the rest of the body, affecting movement, sensation, and autonom [....] » Read More
Increases in the circulation of microparticles (MPs) indicate the progression of inflammation, immune cell activation, and the involvement of cell death pathways. Herein, in the current study, we investigated the role of MPs in Japanese Encephalitis Virus (JEV) infection. We foun [....] » Read More
Background: Traumatic Brain Injury (TBI) is considered one of the main causes of disability and mortality in the worldwide1,2,3. For its prompt diagnosis and adequate management, it is essential to have the necessary technology as well as experienced health professionals. The mai [....] » Read More
Title : Human understanding and machine intelligence: A systems neuroscience perspective
Yan M Yufik, Virtual Structures Research, Inc, United States
Aristotle’s “Metaphysics” starts with a pronouncement “Humans desire to understand”, establishing understanding capacity as the defining characteristic of human intellect separating humans from the other species. Throughout history, cognitive capacit [....] » Read More
Title : Cannabis/CBD for treating neurological disorders
Jag H Khalsa, GWU School of Medicine and Health Sciences, United States
Cannabis is the most used illegal drug in the world with an estimated 2.5% of the world’s population (180 million) using it regularly (World Drug Report 2017)1. Medicinal and/or recreational cannabis use is associated with significant health consequences) (WHO, 20162; Volko [....] » Read More
Title : 3DYNAFS-MBAFUS: A virtual lab of microbubble-amplified focused ultrasound for noninvasive treatments of neurodisorders
Jingsen Ma, Dynaflow, Inc, United States
Focused Ultrasound (FUS), especially when amplified by Microbubbles (MB), offers non-invasive options for treating deep-seated and brain tumors and other neurodisorders, by enabling targeted surgical ablation and/or local blood-brain-barrier opening (BBBO) for effective drug deli [....] » Read More
Title : Neural nanomedicine: Fighting stroke, improving stem cell delivery, healing nerves and using artificial intelligence
Thomas J Webster, Interstellar Therapeutics, United States
Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For exa [....] » Read More
Title : Novel stem cell therapy to boost recovery from ischemic brain injury
Xiaofeng Jia, University of Maryland School of Medicine, United States
Ischemic brain injury after Cardiac Arrest (CA) remains challenging with high mortality and disability and causes irreversible neurological dysfunction in over 90% of CA survivors. Current medical treatments do not effectively combat neuronal loss. Neural Stem Cell (NSC) engrafti [....] » Read More
Title : Intermittent hypoxic conditioning-induced exosome: Intervention for ischemic stroke treatment
Myoung-gwi Ryou, Tarleton State University, United States
Ischemic stroke is a leading cause of death and adult disability worldwide. Currently, the only FDA-approved treatment is tissue plasminogen activator (tPA). Over two decades ago, normobaric Intermittent Hypoxic Training (nIHT) was identified as beneficial for ischemia and reperf [....] » Read More
Title : A case of nitrous oxide induced vitamin B12 deficiency with secondary myelopathy
George Diaz, Memorial Healthcare Systems, United States
Objective: To present a unique case of nitrous oxide (NO2)-induced vitamin B12 deficiency with secondary myelopathy. Background: Nitrous oxide (NO2), commonly known as “laughing gas”, is frequently used as an anesthetic agent, but is also abused recreationally in t [....] » Read More
Title : Therapeutic efficacy of cinnamein in controlled cortical impact mouse model of TBI
Jit Poddar, Rush University, United States
Traumatic brain injury (TBI) remains a major health concern which causes long-term neurological disability particularly in war veterans, athletes and young adults in United States. Despite of intense clinical and research investigations, there is no effective therapy to cease the [....] » Read More
Title : Therapeutic inhibition of PI3K? attenuates neuronal endoplasmic reticulum stress improves functional recovery after traumatic brain injury in mice
Guohong Li, Penn State College of Medicine, United States
Traumatic brain injury (TBI) is a major cause of death and disability, often leading to persistent motor and cognitive deficits. Phosphoinositide 3-kinase γ (PI3Kγ), primarily expressed in immune cells, has been implicated in neuroinflammation in various neuropatholog [....] » Read More
Title : Neurochemical and behavioral effects of olanzapine in a high-risk schizophrenia mouse model
Sindhu Sriramoji Virdi, Rutgers University, New Jersey Medical School, United States
Schizophrenia is a mental disorder affecting behavior, cognition, and emotion. While schizophrenia is characterized by the dysregulation of dopamine in the brain, specifically the striatum, its physiology is undetermined. Olanzapine, an atypical antipsychotic, is commonly prescri [....] » Read More
Title : NF1-associated gliomas: Antioxidant treatments and spastin inactivation as possible therapeutic approaches
Cinzia Rinaldo, IBPM-CNR, Italy
Neurofibromatosis type 1 (NF1) is the most common tumor predisposition syndrome and glioma is one of the prevalent tumors associated with it. Gliomagenesis in NF1 patients results in a heterogeneous spectrum of neoplasms, ranging from low- to high-grade, that can occur throughout [....] » Read More
Title : miR-590-3p delivery via nanoparticle technology inhibits recurrent GBM tumor growth by targeting multiple oncogenic nodes downstream of TGFBR2
Sophie Sall, Kennedy Krieger Institute, United States
Glioblastoma (GBM) is the most common central nervous system cancer diagnosed in adults. Heterogeneous and aggressive in nature, GBM is often found to resist standard of care (SOC) treatment and is almost guaranteed to recur. Upon recurrence, treatment options are very limited an [....] » Read More
Title : Clinical characteristics and management practices of pediatric status dystonicus
Karissa Chesky, Baylor College of Medicine, United States
Objective: We present 20 cases of pediatric status dystonicus at a major pediatric center and describe their clinical course. Background: Status dystonicus (SD) is a rare, life-threatening neurological emergency characterized by continuous, severe episodes of general [....] » Read More
Title : Innovative sEEG based device for neural recordings, ablation and drug delivery into the brain
Guadalupe Zepeda, NeuroOne Medical Technologies, United States
Stereoelectroencephalography (sEEG) electrodes are routinely used to identify the epileptogenic zone (EZ) in patients with drug resistant epilepsy. The sEEG electrodes are FDA-cleared for temporary (<30 days) neural activity monitoring, recording and stimulation. Here we prese [....] » Read More
Title : Development of novel miR-dependent genome-editing Adeno-associated virus that selectively eradicates glioblastoma-initiating cells
Toru Kondo, Hokkaido University, Japan
Glioblastoma (GBM), one of the most malignant human cancers, frequently recurs despite multimodal treatment with surgery and chemo/radiotherapies. One of the reasons of why GBM recues is likely the existence of GBM-initiating cells (GICs) that have strong proliferative and tumori [....] » Read More
Title : Novel stress detection leveraging deep learning and multi-domain features on EEG signals
Prathyek Poojary, Cambridge Centre for International Research, United States
Stress is a very special state of being in that it can influence almost every bodily function and system in the most negative way, contributing to a wide range of health issues, from psychological disorders such as depression to physiological problems like indigestion. It has bee [....] » Read More
Title : In vitro efficacy studies of Bacopa monnieri and Rosemarinus officinalis to evaluate their neuroprotective and neurotrophic properties in the management of alzheimers Disease
Nidhi Gupta, CSIR-National Physical Laboratory, India
Background: Alzheimer's Disease (AD) treatment modalities address symptoms aleviation through neurotransmitter modulation. Ayurveda, utilizing plant-derived compounds with neuroprotective properties, offers a promising avenue. This study explores integrating&nb [....] » Read More
Title : Serum interleukins- 2,6 and tumor necrosis factor -alpha levels in children with attention deficit hyperactivity disorder
Rishabh Singh, VMMC and Safdarjung Hospital, India
Background: ADHD is a behavioural disorder with symptoms of inattention, impulsivity and hyperactivity. A low dopaminergic and noradrenergic activity is noted in ADHD. The etiopathogenesis is not completely understood. A physiological role of IL- 6 on neuronal stem cell migration [....] » Read More
Title : Right-sided ataxia in adolescent craniocervical chordoma with mass effect on the brain stem: A case-report
Amanda Brand, Washington Avenue Pediatrics, United States
Introduction: Chordomas are rare, locally aggressive tumors which arise from embryological remnants of the notochord. Found in the craniocervical junction (C1-C2), mobile spine, and sacrum, they are particularly uncommon in pediatric and adolescent patients, especially those whic [....] » Read More
Title : Neuroprotective strategies and cell-based biomarkers for manganese-induced toxicity in human neuroblastoma (SH-SY5Y) cells
Jack Rogers, Massachusetts General Hospital, United States
Manganese (Mn) is an essential heavy metal in the human body, while excess Mn leads to neurotoxicity, as observed in this study, where 100 μM of Mn was administered to the human neuroblastoma (SH-SY5Y) cell model of dopaminergic neurons in neurodegenerative dise [....] » Read More
Title : A case report of full term newborn with large intracranial hemorrhage surviving complex interventions of craniectomy and acute peritoneal dialysis in the neonatal period
Karen Obillo Calibuso, Armed Forces of the Philippines Victoriano Luna Medical Center, Philippines
In the Philippine Pediatric Society Registry, there were 27 cases of Intracerebral with Intraventricular hemorrhage and 8 cases of Acute Kidney Injury with Acute Tubular Necrosis under 28 days of age from 2006-2022 that were discharged. However, there were no data on procedures s [....] » Read More
Title : The impact of physical guidance on motor learning in children with cerebral palsy
Elham Azimzadeh, Shahid Beheshti University, Iran (Islamic Republic of)
Children with cerebral palsy (CP) have weak physical abilities and their limitations may have an effect on performing everyday motor activities. One of the most important and common debilitating factors in CP is the malfunction in the upper extremities to perform motor skills and [....] » Read More