Focused Ultrasound (FUS), especially when amplified by Microbubbles (MB), offers non-invasive options for treating deep-seated and brain tumors and other neurodisorders, by enabling targeted surgical ablation and/or local blood-brain-barrier opening (BBBO) for effective drug deli [....] » Read More
Background: Brain tumors are the second leading cause of cancer deaths among children and young adults, with an estimated 1 million Americans living with a brain tumor. Each year, 95,000 new cases are diagnosed, of which 30% are malignant with a survival rate of only 35%. Fe [....] » Read More
Introduction: Chordomas are rare, locally aggressive tumors which arise from embryological remnants of the notochord. Found in the craniocervical junction (C1-C2), mobile spine, and sacrum, they are particularly uncommon in pediatric and adolescent patients, especially those whic [....] » Read More
Suicide is a leading cause of death in the United States yet historically, scientific inquiry has focused on psychological theory. Brain research image studies reveal significant differences in GMV (Gray Matter Volume) in the bilateral MFG across patients with suicidal attempts a [....] » Read More
Glioblastoma multiforme (GBM), a deadly brain cancer with a median survival of only 15-18 months, presents a significant hurdle for personalized treatment. Accounting for nearly half of primary central nervous system tumors, GBM is conventionally treated through surgical resectio [....] » Read More
Muscular myopathies affect various aspects of a patient's life and have even been implicated in impacting a patient’s obstetric experience as well. For example, facioscapulohumeral muscular dystrophy (FSHD) and myotonic dystrophy (DMD) have both been associated with an [....] » Read More
The literature describes a close relationship between cognitive executive functions and daily activity. Adults with specific learning disabilities (SLDs) (e.g., dyslexia, dysgraphia, and dyscalculia) reveal limitations in daily activity in various life domains including decreased [....] » Read More
Autoimmune Encephalitis (AIE) is closely associated with antibodies against neuronal cell-surface proteins, receptors, and ion channels. However, some forms of disorder have no known antibody presently. In children neurological manifestations are prominent initial presentation as [....] » Read More
In the Philippine Pediatric Society Registry, there were 27 cases of Intracerebral with Intraventricular hemorrhage and 8 cases of Acute Kidney Injury with Acute Tubular Necrosis under 28 days of age from 2006-2022 that were discharged. However, there were no data on procedures s [....] » Read More
Background: Guillain-Barre syndrome (GBS) commonly presents with progressive ascending weakness of the extremities and can also present with dysautonomia, that is associated with longer hospital stay and higher mortality rates than those without dysautonomia. Objectives: Our s [....] » Read More
Poorly controlled diabetes is associated as cause and poor outcome of stroke. High blood sugar reduces cerebral blood flow, increases intracranial pressure, cerebral edema and neuronal death, especially among patients with poorly controlled diabetes. SGLT2 inhibitors are associat [....] » Read More
Introduction: Poorly controlled diabetes is associated with cause and poor outcome of stroke. High blood sugar reduces cerebral blood flow, increases intracranial pressure, cerebral edema and neuronal death, especially among patients with poorly controlled diabetes.1 SGLT2 inhibi [....] » Read More
Subjects & Methods: A cross sectional study was conducted on 240 elderly patients aged ≥ 60years both males and females who were included in home health care program in Aseer central hospital, south Saudi Arabia . All participants underwent comprehensive geriatric assessme [....] » Read More
The presentation titled "Direction-Dependent Neural Coupling in the Brain: Implications for Neuronal Synchronization and Brain Disorders" explores the intricate mechanisms of neural communication and synchronization within the brain. It specifically examines the role of [....] » Read More
Introduction: Dementia is an age mental disorder that makes victims lose normal functionality that need delicate attention. It has been technically defined as a clinical syndrome characterised by a cluster of symptoms manifested by difficulties in memory, disturbances in speech a [....] » Read More
This research paper explores the impact of the "Let's Talk" series on the mental health of students at Makerere University. The "Let's Talk" series, initiated as a peer-support program, aims to address the increasing mental health concerns among univer [....] » Read More
The COVID-19 pandemic has caused an unprecedented impact on global health, affecting millions of people worldwide. In effect to tackling the devastating outcomes of the disease, the development of vaccines was the primary focus of health researchers worldwide. Thus, a f [....] » Read More
Background: Dyssynergic defecation (DD) is a major cause of chronic functional constipation. Patients with DD have greater psychological distress and impaired health-related quality of life compared with the general population. This study aimed to evaluate the effectiveness of co [....] » Read More
More than 20 new anti-seizure medications have been approved by the FDA in the past 3 decades; however, epilepsy remains drug resistant in up to 40% of patients. The probability of achieving seizure freedom declines rapidly after two adequate doses of anti-seizure medication, and [....] » Read More
Children with cerebral palsy (CP) have weak physical abilities and their limitations may have an effect on performing everyday motor activities. One of the most important and common debilitating factors in CP is the malfunction in the upper extremities to perform motor skills and [....] » Read More
Introduction: The burden of stroke is higher in low- and middle-income countries (LMICs) than in high-income countries due to the lack of stroke care centers, stroke specialist, and rehabilitation access. One way to increase access to stroke care in LMICs is through the use of te [....] » Read More
OCD (Obsessive Compulsive Disorder) is characterised by a continuum of traits – the most significant being compulsive behaviour. Compulsions are actions an individual feels compelled to perform in order to prevent a threat to themselves or others. We designed a novel task t [....] » Read More
Neurofibromatosis type 1 (NF1) is the most common tumor predisposition syndrome and glioma is one of the prevalent tumors associated with it. Gliomagenesis in NF1 patients results in a heterogeneous spectrum of neoplasms, ranging from low- to high-grade, that can occur throughout [....] » Read More
Introduction: The investigation of rigidity physiology in Parkinson's Disease (PD) involves the examination of reflexes. Parkinsonian patients often demonstrate reduced sensitivity in polysynaptic reflexes within the leg extensor muscles, which is correlated with their postur [....] » Read More
Background: ADHD is a behavioural disorder with symptoms of inattention, impulsivity and hyperactivity. A low dopaminergic and noradrenergic activity is noted in ADHD. The etiopathogenesis is not completely understood. A physiological role of IL- 6 on neuronal stem cell migration [....] » Read More
Objective: This experiment aims to systematically review the recent advances in the treatment of acute post-circulatory progressive ischemic stroke using novel thrombolytic drugs. Additionally, it explores the future research trends to provide a scientific foundation for enhancin [....] » Read More
Treatment resistant Schizophrenia (TRS) affects approximately 30% of patients with Schizophrenia often results in increase in relapses, functional impairment, and lowers quality of life. Convergent findings show that patients with TRS suffer from pathogenetically “non-dopam [....] » Read More
Background and Aims: Ischemic stroke is a major public health concern, contributing significantly to global morbidity and mortality. Recent studies suggested that alterations in liver enzymes may be linked to the risk of developing a stroke. However, the relationship between live [....] » Read More
Background: Incidence of Autism Spectrum Disorders (ASD) in children as a neurodevelopmental abnormality is growing. Compounded by equivocal deductions from several genetic and environmental studies aimed at establishing its aetiology, it is becoming a global medical challenge. T [....] » Read More
Background and Aim: Stroke is the most common cause of cerebrovascular disease, the third leading cause of death and the second leading cause of disability in developed countries, leading to physical, sensory, cognitive, psychological, functional and social changes in individuals [....] » Read More
Manganese (Mn) is an essential heavy metal in the human body, while excess Mn leads to neurotoxicity, as observed in this study, where 100 μM of Mn was administered to the human neuroblastoma (SH-SY5Y) cell model of dopaminergic neurons in neurodegenerative dise [....] » Read More
Background: Access to the common carotid artery is crucial for any neuro-interventional procedures. Bovine aortic arch followed by an acutely angled proximal common carotid artery (CCA) can pose a great challenge. Owing to urgency, we resorted to a non-conventional me [....] » Read More
Case A: A previously healthy male with 11 years old was taken to a community hospital with parasomnia and focal motor to bilateral tonic-clonic epileptic seizures, was diagnosed with epilepsy, medicated with valproic acid, without showing clinical improvement. Days later, pa [....] » Read More
Background: Alzheimer's Disease (AD) treatment modalities address symptoms aleviation through neurotransmitter modulation. Ayurveda, utilizing plant-derived compounds with neuroprotective properties, offers a promising avenue. This study explores integrating&nb [....] » Read More
Deep Brain Stimulation (DBS) offers a promising therapeutic option for Parkinson's Disease (PD), significantly improving both motor and non-motor symptoms. However, disparities in DBS access and utilization persist, particularly related to gender and patient education. This r [....] » Read More
Introduction: Apoptosis is a form of programmed cell death, that underlies the wide range of symptoms investigated in neurological disorders from stroke to neurodegenerative diseases such as Alzheimer’s. Caspases are shown to be capable of producing inflammasomes along [....] » Read More
Introduction: Childhood stroke is associated with high mortality and serious morbidity for the survivors. Traumatic brain injury (TBI) has been reported to be a possible cause of childhood stroke or post traumatic cerebral infarction (PTCI). The precise frequency of cerebral [....] » Read More
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Although the etiology of PD remains elusive, mounting evidence suggests a complex interplay of genetic and [....] » Read More
The simultaneous occurrence of two distinct intracranial neoplasms within a single patient presents a unique and exceedingly rare clinical scenario. This case report details the diagnostic challenges, therapeutic considerations, and clinical outcomes in a patient harboring two co [....] » Read More
Introduction: Acute Ischemic Stroke (AIS) is a medical emergency that affects people globally. In the Philippines, it remains as the third leading cause of mortality due to delays in its identification and lack of prognostic materials. This study aims to determine the use of plat [....] » Read More
Introduction: Opercular Syndrome also known as Foix-Chavany-Marie Syndrome (FCMS) is a rare cortical form of pseudobulbar palsy that preserves reflexive and autonomic functions but results in voluntary paralysis of the masticatory, lingual, pharyngeal, and facial muscles. Th [....] » Read More
Background and Aims: Migraine, a condition causing moderate to severe headaches, ranks as the second most burdensome neurological disorder among Asians in regards to DALYs. It is usually associated with trigger factors like photophobia, phonophobia, or nausea and vomiting. T [....] » Read More
Cerebral venous thrombosis is a rare neurological disorder that can be diagnosed clinically and neuro-radiologically. The prognosis of this disease is good in most cases. However, if it is complicated by a stroke, it can lead to death or disability. Cerebral vein thrombosis accou [....] » Read More
Multiple sclerosis (MS) is a debilitating, inflammatory and demyelinating disease of the central nervous system influenced by environmental and genetic factors. Around 2.8 million people worldwide are affected in MS due to its challenging diagnosis and treatment. Our study invest [....] » Read More
Cognitive function plays a crucial role in daily life. Traditional methods for enhancing cognition requires dedicated practice and can be challenging to maintain. This research explores the potential of Electroencephalography (EEG) technology, specifically neurofeedback, as a too [....] » Read More
Introduction: Postural stability is maintained through a complex interplay of long-loop reflexes and higher brain centers. Long-loop reflexes, involving transcortical pathways, provide rapid, context-dependent responses to perturbations. Higher centers, including the cerebellum, [....] » Read More
Background: Length of hospital stay (LOS) is the time between admission and discharge. Several risk factors can influence the LOS for psychiatric hospitalized patients, their compliance for psychiatric medications, pharmacogenetic guiding and other variables. Ethnicity can affect [....] » Read More
Introduction: Finding a non-invasive and repeatable tool has been recommended to make an accurate diagnosis of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Methods: 70 volunteers participated in three groups: 24 with mild dementia of AD, 24 [....] » Read More
Objective: The atlantoaxial instability is a serious problem that can be solved in most recent studies posterior reduction and fixation surgery. There are many described techniques for C1- C2 fixation. In this work C1-C2 segmental screws was used aiming to study it.s efficen [....] » Read More
NeuroPhysics Therapy (NPT) is a fascinating field that delves into the discrete functionality and behaviour of the human nervous system. It explores how our nervous system perceives and responds to the environment, and through the development and application of specialized techni [....] » Read More
It has been noted by multiple researchers that there is Spontaneous Electrical Activity (SEA) at painful trigger points. This author has studied chronic muscle spasm and found that SEA is always present and appears to be the cause for the chronic nature of muscle spasm and result [....] » Read More
Patients with Functional Seizures (FS) (also known as Psychogenic Nonepileptic Seizures (PNES), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Many patients with FS have a history of sexual, physical, or emotional abuse or othe [....] » Read More
Unlike the brains of humans, animal brains are subject to extremes of environment – and must keep neural function intact during and after extreme conditions. Frogs and turtles totally freeze in winter, displaying no measurable brain activity and a flat-lined hea [....] » Read More
The incidence of Traumatic spinal cord injuries (TSCI) is small and ranges between 10-50/million population/year. Prior to the second WW the great majority of patients died within two years of injury. Since the 2nd WW, due to the efforts of the pioneers who dedicated their profes [....] » Read More
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Objective: To investigate the effect of and Acupuncture on brain plasticity and motor development in children with cerebral palsy. Investigate effect on mechanismof apoptosis of brain nerve cells, regulating the expression of neurotrophic factors, promoting the remodelingof nerve [....] » Read More
A major hallmark of Alzheimer's Disease (AD) is the gradual accumulation and aggregation of toxic soluble and insoluble Aβ species in the brain. Amide Proton Transfer (APT) imaging is a relatively new protein-based molecular MRI technique that is based on endogenous mobi [....] » Read More
Introduction: While adult-onset seizures are commonly due to structural brain lesions, strokes, vascular abnormalities, or infections, there may be a less common etiology hiding within a patient’s neonatal history. Neonatal meningitis can cause seizures later in life; [....] » Read More
Affecting 60-70% of the 55 million dementia patients in the world, Alzheimer's Disease (AD) has established itself as one of the most profound neurodegenerative diseases in today's society. Research has revealed a major reduction in neurochemicals like Brain-Derived Neuro [....] » Read More
Background: Spinal cord injury (SCI) often results in motor impairments and neuropathic pain. Not only are these conditions irreversible, they disrupt a crucial pathway for transmitting signals between the brain and the rest of the body, affecting movement, sensation, and autonom [....] » Read More
Objective: Post-operative seizures can occur in 2.6% to 23% of patients with chronic subdural hematomas (cSDH). Hematoma size, midline shift, worse clinical status at admission, and craniotomy with membranectomy have been described as risk factors for its development; however, th [....] » Read More
Glioblastoma multiforme (GBM), a Stage IV brain cancer, poses a significant clinical challenge, with less than 5% of patients surviving five years after diagnosis despite aggressive therapies. This poor prognosis is driven by factors such as angiogenesis, the blood-brain barrier, [....] » Read More
Background: The severity of Carpal Tunnel Syndrome (CTS) may be categorised in a number of ways utilising one of a range of presently available grading tools. The grading systems proposed by Bland and Padua are the most commonly used, however, both have limitations, which [....] » Read More
(+)-4-Propyl-9-hydroxynaphthoxazine ((+)PHNO) is a high affinity agonist at dopamine D3 and, less potently, D2 receptors. In the nineteen eighties and nineties, this naphthoxazine compound was amongst the most promising, non-ergot derivatives in the pipeline for the treatment of [....] » Read More
Hormetic nutrition for enhancing stress resilience and overall human health, recently, have received much attention. Redoxomics has been successfully applied to study neurodegeneration of ganglion neurons of the inner ear for the identification of potential biomarkers and novel m [....] » Read More
Although the regulation of cholesterol homeostasis in the body has been extensively studied, there is little information on how this regulation takes place in the brain. Cholesterol does not cross the blood-brain barrier; therefore cholesterol metabolism in the brain is [....] » Read More
Cerebral Visual Impairment (CVI) has been defined as a verifiable visual dysfunction which cannot be attributed to disorders of the anterior visual pathways or any potentially co-occurring ocular visual issue. Recent research has indicated that as many as one child in every mains [....] » Read More
Background: Traumatic Brain Injury (TBI) is considered one of the main causes of disability and mortality in the worldwide1,2,3. For its prompt diagnosis and adequate management, it is essential to have the necessary technology as well as experienced health professionals. The mai [....] » Read More
Guidelines for treating chronic low back pain are directly related to changing habits and carrying out patient-centered exercise programs, using passive resources such as manual therapy, for example, to aid treatment. In previous studies, it was possible to observe changes in [....] » Read More
Introduction: Neural tube defects (NTDs) are secondary abnormalities during the embryogenic development of the central nervous system (CNS). Between the 17th and the 28th day after fertilization, neurulation happens in two moments: primary and secondary neurulation. Secondar [....] » Read More
Introduction: Cavernous angiomas are benign vascular malformations characterized by abnormally dilated vessels that lack interposing neural tissue. The presentation can occur in any region of the central nervous system, but most commonly, supratentorial. This report details a rar [....] » Read More
New daily persistent headache (NDPH) is a challenging condition to treat, characterized by a continuous and unremitting headache from onset. Traditional pharmacological treatments for NDPH often yield suboptimal results, prompting the exploration of novel therapeutic approaches. [....] » Read More
Tumor progression refers to the gradual development and growth of cancerous cells within the body. Understanding this process is crucial for effective diagnosis, treatment planning, and patient management. Traditional methods often rely on qualitative assessments and static imagi [....] » Read More
Objective: We analysed seizure control in reproductive age group women on Valproic acid (VPA) and studied the difference in seizure control between VPA maintenance and after changing to other Anti-seizure medications (ASMs), because of reproductive age group or impending pre [....] » Read More
Depression is a chronic disease afflicting ~245 million individuals worldwide, of which 30-40% patients remain dissatisfied despite 70 years of research, >5 antidepressant drug classes, and 3 trillion healthcare-budget. Fluoxetine, an SSRI alone and with Olanzapine, is the fir [....] » Read More
Objective: TLE accounts for about 50-73% of cases being referred for epilepsy surgery. The objective is to find, whether the classical semiology in TLE has a role in predicting the post operative outcome in patients with refractory epilepsy. Methods: We included 684 patie [....] » Read More
Deep brain stimulation (DBS) of anterior thalamic nucleus (ATN) has established as an effective adjunctive therapy for patients with intractable epilepsy (IE) not suitable for epilepsy brain surgery and/or vagal nerve stimulation. The judicious selection of DBS parameters (DBSPs) [....] » Read More
Intractable epilepsy (IE) continues to pose a medical challenge even today. Deep brain stimulation (DBS) is establishing as an effective adjunctive therapy in a selected category of patients with IE. Currently DBS of anterior thalamic nucleus in IE is FDA approved and newer targe [....] » Read More
Literature on the clinical features of autism spectrum disorder (ASD) in India are rare. This study addresses this gap by examining the clinical characteristics of 120 children with ASD in India. The children involved in this study are from three centers in specializing in the ma [....] » Read More
Background: Persons with epilepsy are in general considered to have poor dental hygiene which can be contributed by severity of epilepsy, ignoring oral health issues or the medications used. A continuing need exists for better understanding the effects of antiepileptic medication [....] » Read More
Background: With no randomised controlled trials or consensus guidelines for the treatment of anti-NMDAR encephalitis, the heterogeneity in the treatment stratagem has not yet reported any evidence on the therapeutic option of choice when infections ensue during the immunosuppres [....] » Read More
Purpose: To estimate the prevalence of personality disorders in persons with idiopathic generalized epilepsy (IGE) and to compare it with the general population. Method: The study was conducted in a super specialty epilepsy care center in a tertiary care hospital in Sout [....] » Read More
Aims: Gelastic seizures (GS) constitute <1% prevalence of which those due to non-hypothalamic hamartomas (HH) are rarer. There is scanty data regarding the spectrum. We aimed to assess prevalence of GS due to non HH, electroclinical (EC) localization and predictors of out [....] » Read More
The brain is a masterpiece, often referred to as the king organ, as it governs the entire body. When the brain ceases to function, it marks the end of an individual's vitality, essentially rendering them a "vegetable." This profound importance raises a crucial quest [....] » Read More
Background: In the disease development & evolution of diabetic neuropathy, oxidative stress contributes a major part. Vitex negundo is capable of enhancing antioxidant mechanism. The current investigation aimed to examine the protective potential outcomes of the extract of vi [....] » Read More
Hypoxic neurological sequelae are common in newborns with birth asphyxia, oxygen is the only therapy for hypoxia/asphyxia hence Lalana Newborn resuscitation by sustained nasal oxygen inflation prevents both hypoxia and asphyxia in newborns. ‘Lalana Newborn Resuscitation&rsq [....] » Read More
Post-menopausal women experience a myriad of physiological and psychological changes that significantly impact their cognitive functions and overall well-being. Cognitive neuroscience and psychology play crucial roles in understanding these changes, providing insight into how hor [....] » Read More
The effect of nerve regeneration after peripheral nerve injury is closely related to the functional state of Schwann cells (SCs), especially related to interactions between enhancers and transcription factors. Our current study found that mRNA expression of C/EBPβ in the ear [....] » Read More
With the progress of science and technology, new technologies and equipment are continuously transformed and entered clinical use. The current clinical related surgical techniques have been greatly improved, the surgical effect and the prognosis of patients have been greatly impr [....] » Read More
Objective: This study explored whether the event-related potential (ERP) components of N170, VPP, LPP, and P3 could be sensitive neurophysiological markers for assessing depression in temporal lobe epilepsy (TLE). Methods: Patients with TLE were divided into two groups with ma [....] » Read More
Depression has become one of the most common types of psychological disorders, characterized by prolonged depressed mood, which severely limits people's psychosocial abilities and greatly reduces the quality of life. Although there are a variety of depression treatment drugs, [....] » Read More
Background: The Dextroscope is a VR workstation that can provide 3-dimensional information to choose a surgical approach. The dextroscope technique as an intervention has emerged as a promising tool in transsphenoidal surgery for sellar tumors, potentially offering improved visua [....] » Read More
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the primary cause of dementia, characterized by declining memory and cognitive function. Research has identified significant genes and risk alleles associated with AD, which shares common inf [....] » Read More
Background: Melanocytes, responsible for melanin production, originate from the neural crest and can give rise to malignant tumors known as melanoma. Primary Central Nervous System Melanoma (pCNSM) is a rare occurrence, with an incidence of 0.005 cases per 100,000 individuals ann [....] » Read More
Background: Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare autoimmune neuro-inflammatory disorder characterized by recurrent attacks of demyelination affects the optic nerve and spinal cord with often incomplete recovery. Numerous medications have emerged as a potential [....] » Read More
Background: People with neglect suffer from various spatial deficits in several modalities, which in many cases impair everyday functioning. Virtual Reality (VR) is a form of interaction between humans and computers in which a real or imaginary environment is simulated. Users int [....] » Read More
Black tea, known for its antioxidant properties, has garnered attention for its potential therapeutic effects on brain disorders. In this study, we delve into the specific role of black tea antioxidants, focusing on their compositional analysis, extraction methods, and neuroprote [....] » Read More
Importance: Temporal lobe epilepsy (TLE) is a prevalent condition impacting numerous individuals globally and drug-resistant cases present a formidable obstacle. Conventional surgical interventions come with inherent risks and potential cognitive repercussions due to the necessit [....] » Read More
Parkinson's disease (PD) is a chronic disease of the central nervous system that affects almost 1% of the elderly population. In recent years, phytocomponents have aroused considerable interest in research for PD treatment as they provide a variety of active compounds, includ [....] » Read More
In this study, we present a novel approach to model epileptic seizures using a perturbed Lorenz attractor combined with Bessel filtering. The Lorenz attractor, known for its chaotic behavior, is modified by introducing stochastic perturbations to simulate the irregular and comple [....] » Read More
This study examines the use of Bessel functions as activation functions within multi-dendritic neurons. Activation functions are fundamental components of neural networks, introducing crucial non-linearity for learning complex patterns in data. Traditional activation functions su [....] » Read More
Traumatic brain injury (TBI) is the leading cause of death among all traumatic injuries. While there are some treatments, such as nonsteroidal anti-inflammatory drugs (NSAIDs), most cause debilitating side effects including cerebral ischemia and neurodegenerative diseases. Altern [....] » Read More
Objective: Fellowship program websites have become a major source of information for potential applicants, especially after the COVID-19 pandemic. However, previous studies have shown that websites for other residency and fellowship programs lack key information important to [....] » Read More
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are distinguished by the progressive loss of motor capabilities, cognitive abilities, or both. The specific origins of neurodegenerative disorders are often unclear; however, they can include genetic, enviro [....] » Read More
Glioblastoma’s are the most common type of primary brain tumour in adults and are the most lethal and least successfully treated solid tumours. Recently, research into the area of stem cells in brain tumour development has gained moment. However, due to the relatively new a [....] » Read More
Human balance is essential for maintaining overall health and functional independence, particularly in populations with neurological disorders such as Multiple Sclerosis (MS). As MS progresses, individuals often experience deteriorating balance, leading to increased falls an [....] » Read More
Background: Lymphomatosis cerebri is a variant of primary central nervous system lymphoma that is characterized by diffuse infiltrates without a mass formation that is often seen. It poses a diagnostic challenge because the radiological findings are not typical for lym [....] » Read More
Background: Alzheimer's disease (AD) constitutes a formidable challenge, profoundly affecting the fabric of individuals' lives and intricately entwined with disturbances in their quality of life. The intricate interplay between lifestyle and the relentless progression of [....] » Read More
Introduction: Patients with demyelinating lesions in the brain and spinal cord exhibit various symptoms. Differentiating between demyelinating diseases is challenging, necessitating thorough evaluations for proper management and prognosis. Limited literature on this topic in [....] » Read More
Guillain-Barré syndrome/Miller Fishe syndrome (GBS/MFS) overlap syndrome is an extremely rare variant of Guillain-Barré syndrome (GBS) in which Miller Fisher syndrome (MFS) coexists with other characteristics of GBS, such as limb weakness, paresthesia, and facial pa [....] » Read More
Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative disease characterized by the progressive loss of motor neurons, leading to impaired motor function and, ultimately, death. A key pathological feature of ALS is the accumulation of synaptic glutamate, the prim [....] » Read More
Introduction: Swallowing is a fundamental physiological process for individual health and survival. The cerebellum has an integral function in regulating motor control and coordination; however, its specific role in swallowing physiology remains poorly characterized in humans. Th [....] » Read More
OwnLife is a leadership development business that combines human analytics with executive coaching to help individuals optimize how they live and maximize their cognitive performance. We hypothesized that physical exercise which materially elevates the heart rate is associated&nb [....] » Read More
Background: Stroke, the second-leading cause of mortality and the third-leading cause of mortality and disability, imposes a substantial financial burden, exceeding $721 billion1. Addressing underlying causes and mitigating stroke-related consequences are crucial aspects of strok [....] » Read More
The utilization of Artificial Intelligence (AI) in enhancing modern day technology has garnered increasing research interest, particularly in the field of medicine. Lucid dreaming, where the dreamer is aware of their dream and can control what occurs in one, holds significant the [....] » Read More
Background: Pontine strokes present a unique set of challenges in diagnosis and management as the clinical presentation can vary significantly. Along with the classic symptoms of dizziness, dysarthria, dysmetria, and weakness of the legs, there have been numerous case report [....] » Read More
Background: The safety of aspartame, a widely consumed low-calorie artificial sweetener, has been heavily debated for human consumption. Published research has demonstrated its breakdown products, aspartic acid and phenylalanine, are associated with potential neurotoxicity due to [....] » Read More
Background: Alzheimer’s Disease (AD) has been shown to lead to deposition of Amyloid Aβ plaques and neurofibrillary tangles (NFT) in the cerebral cortex and hippocampus of the brain. These have the potential to cause neurological damage and suggests a relationship to t [....] » Read More
This research project focuses on a computational analysis of neurological biomarkers for mental health disorders, with an emphasis on epilepsy. Epilepsy, characterized by recurrent seizures, affects neurological and psychological well-being. Our study aims to identify and analyze [....] » Read More
Background: Protoplasmic astrocytoma (PA) is an extremely rare subtype of astrocytoma composed of malignant cells similar to protoplasmic astrocytes. Although rare, the slow-growing course of PA can often delay diagnosis and treatment, worsening survival rates. Radiologicall [....] » Read More
Introduction: Traumatic brain injury (TBI) affects an estimated 27 to 69 million people worldwide annually1,2 with the majority of cases being classified as mild.3 Mild TBI (mTBI) is caused by blunt trauma or acceleration or deceleration forces to the head or body with resulting [....] » Read More
Introduction: Toxic Leukoencephalopathy (TL) is cerebral white matter damage caused by toxic agents. It affects higher cerebral function resulting in forgetfulness, inattention, changes in personality, dementia, coma, and even death, and is detectable on MRI. Preservation of lang [....] » Read More
Optogenetic stimulation of hippocampal circuitry has been increasingly used to study sequence learning and memory (Geiller et al., 2023). Prolongation of spontaneously occurring sharp wave ripples (SPW-Rs) within the CA3 subregion of the hippocampus through optogenetic stimulatio [....] » Read More
Ulnar nerve entrapment across the elbow (UNEAE) and across wrist (UNEAW) is the second most common entrapment of the hand after carpal tunnel syndrome. There are few gradings available for UNEAE and lesser in UNEAW. The aim of this research is: To create a clinical [....] » Read More
Recent technological advancements are revolutionizing the understanding, diagnosis, and management of Parkinson’s disease (PD). This presentation highlights pioneering studies leveraging artificial intelligence (AI) and machine learning to enhance early prediction [....] » Read More
Introduction: The cervical spine presents the highest segmental mobility of all spinal regions. At present, in Poland there are no studies focusing on the assessment of the reliability of the Zebris MCS. Various methods measuring the range of motion of the spine are used to ident [....] » Read More
The study's objectives were to calculate the prevalence of cognitive impairment in older adults in rural areas of Haryana, India, and to ascertain how it related to impairments, alcohol use, and smoking. A clinical diagnosis of mild cognitive impairment reflects a physicia [....] » Read More
Objective: Tumefactive Multiple Sclerosis (TMS) is a rare subtype of multiple sclerosis (MS) with an incidence of 1-3 per 1000 MS patients. Here, we aimed to review the literature to present data on the epidemiology of TMS. Background: The annual incidence of tumefa [....] » Read More
The case report highlights the diagnostic challenges encountered in a 30- year- old female presenting with fever followed by Wernicke's aphasia without any other focal neurological deficits, ultimately diagnosed as tumefactive demyelination (TD). TD is a rare neurological con [....] » Read More
Chikungunya encephalitis, though rare, warrants clinical attention due to its severe complications. Early identification and appropriate management are crucial for improved outcomes in patients with this rare manifestation of chikungunya virus (CHIKV) infection. CHIKV infection i [....] » Read More
Although chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the Western world, neurological complications directly involving the nervous system are exceedingly rare, reported in only 1% of CLL patients. Ocular manifestations in CLL, whether direct or indirect, a [....] » Read More
Objective: The ASPECTS score serves as a semi-quantitative instrument for assessing acute ischemic strokes within the middle cerebral artery (MCA-AIS) territory, and DWI-ASPECTS has been found to exhibit superior sensitivity and precision. The primary objective of this study was [....] » Read More
Background: Receptor-interacting protein kinase 1 (RIPK1) is a serine/threonine protein kinase that regulates inflammatory signalling and induces apoptosis and necroptosis. Activation of RIPK1 has been observed in human pathological samples from individuals with neurodegener [....] » Read More
Muscular Dystrophy (MD) is a group of hereditary disorders characterized by progressive generalized muscle weakness and degeneration. Recent studies evaluated the role of Givinostat in treating MD. So, we aimed in our systematic review to assess the efficacy of Givinostat in MD. [....] » Read More
Stiffness-person syndrome (SPS) is a neurological disease causing symptoms of rigidity and painful muscle spasms. It is caused by increased serum anti-glutamic acid decarboxylase antibodies (anti-GAD). Persistent muscle stiffness can lead to difficulty walking and recurrent falls [....] » Read More
A 29-year-old gentleman diagnosed with Rosai-Dorfman disease (RDD) on corneal biopsy, 2 years ago, presented with fluctuating left-sided numbness, intermittent slurred speech, and urinary incontinence, progressively worsening over the past three months. Magnetic resonance imaging [....] » Read More
Hirayama Disease, also known as Monomelic Amyotrophy (MMA), is a lower motor neuron disease that typically presents with an insidious onset of muscle weakness and atrophy most commonly in the upper limbs including the thenar, hypothenar, and forearm muscles.9 Neurologic sensation [....] » Read More
Autoimmune limbic encephalitis (AILE) is a rare form of encephalitis that manifests with atypical neuropsychiatric symptoms. Anti-NMDA receptor, anti-LGI1, and anti-GAD65 antibodies are associated with abnormal inflammation of the limbic system, leading to focal neurological defi [....] » Read More
The brain’s ability to process complex real-world phenomena relies on its operation across multiple timescales, which have been shown to be organized hierarchically across various brain regions. At present, the relation between the topography of intrinsic neural t [....] » Read More
Background: Virtual Reality (VR) technology has great impact across various fields. Electroencephalography (EEG) feedback, on the other hand, measures brain activity and offers insights into cognitive and emotional states. Combining VR and real-time EEG feedback has become a [....] » Read More
Background: The occurrence of Diogenes syndrome in the context of psychosis is scarcely described in the literature. This syndrome is most frequently observed in elderly individuals with frontotemporal dementia. Methods: We present three new cases of Diogenes syndrome treated [....] » Read More
Background: Interest in examining Internet gaming disorder (IGD) and its association with gaming motivation has surged. Eleven studies were conducted between 2018 and 2021 with a sample size of 4,065 individuals across various cultural contexts. Methods: Utilizing the Onl [....] » Read More
Background: The presence of other health conditions can create difficulties in diagnosing and treating individuals with multiple sclerosis (MS). Sickle cell disease (SCD) and MS are both inflammatory disorders characterized by immune system dysregulation. It is important to inves [....] » Read More
This research aims at providing an overview of schizophrenia and psychotic disorders, elucidating the complex interplay between neurobiological, environmental, and psychological factors contributing to hallucinations and reality distortion. Additionally, it explores the phenome [....] » Read More
Alzheimer’s is a cognitive degeneration, analysed using Hurst exponent (HE) parameter, also called a long-range dependence parameter. HE is computed based on the time-domain measure of the electrical activity of the human brain. The electroencephalogram (EEG) healthy contro [....] » Read More
Background: Dementia is a major health issue in the elder population. It is characterized by a decline in cognition involving one or more cognitive domains (learning and memory, language, executive function, complex attention, perceptual-motor, social cognition). Piano practice i [....] » Read More
Introduction: Different neurologic manifestations have been observed during the Coronavirus disease (COVID-19) pandemic. However, only a handful cases of Guillain Barre syndrome (GBS) in a COVID-19 patient have been reported. No case has been reported in the Philippines. This rep [....] » Read More
Introduction: Parkinson's disease, as a severe neurodegenerative pathology, has a negative impact on the quality and life expectancy of people. One of the criteria characterizing the medical and social severity of the disease, is the probability of survival after i [....] » Read More
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease and is expected to impose an increasing social and economic burden on societies as populations age. The ground-breaking developments in stem cell resear [....] » Read More
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Title : Neural nanomedicine: Fighting stroke, improving stem cell delivery, healing nerves and using artificial intelligence
Thomas J Webster, Interstellar Therapeutics, United States
Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For exa [....] » Read More
Title : Human understanding and machine intelligence: A systems neuroscience perspective
Yan M Yufik, Virtual Structures Research, Inc, United States
Aristotle’s “Metaphysics” starts with a pronouncement “Humans desire to understand”, establishing understanding capacity as the defining characteristic of human intellect separating humans from the other species. Throughout history, cognitive capacit [....] » Read More
Title : Novel stem cell therapy to boost recovery from ischemic brain injury
Xiaofeng Jia, University of Maryland School of Medicine, United States
Ischemic brain injury after Cardiac Arrest (CA) remains challenging with high mortality and disability and causes irreversible neurological dysfunction in over 90% of CA survivors. Current medical treatments do not effectively combat neuronal loss. Neural Stem Cell (NSC) engrafti [....] » Read More
Title : Cannabis/CBD for treating neurological disorders
Jag H Khalsa, GWU School of Medicine and Health Sciences, United States
Cannabis is the most used illegal drug in the world with an estimated 2.5% of the world’s population (180 million) using it regularly (World Drug Report 2017)1. Medicinal and/or recreational cannabis use is associated with significant health consequences) (WHO, 20162; Volko [....] » Read More
Title : Therapeutic inhibition of PI3K? attenuates neuronal endoplasmic reticulum stress improves functional recovery after traumatic brain injury in mice
Guohong Li, Penn State College of Medicine, United States
Traumatic brain injury (TBI) is a major cause of death and disability, often leading to persistent motor and cognitive deficits. Phosphoinositide 3-kinase γ (PI3Kγ), primarily expressed in immune cells, has been implicated in neuroinflammation in various neuropatholog [....] » Read More
Title : Therapeutic efficacy of cinnamein in controlled cortical impact mouse model of TBI
Jit Poddar, Rush University, United States
Traumatic brain injury (TBI) remains a major health concern which causes long-term neurological disability particularly in war veterans, athletes and young adults in United States. Despite of intense clinical and research investigations, there is no effective therapy to cease the [....] » Read More
Title : A case of nitrous oxide induced vitamin B12 deficiency with secondary myelopathy
George Diaz, Memorial Healthcare Systems, United States
Objective: To present a unique case of nitrous oxide (NO2)-induced vitamin B12 deficiency with secondary myelopathy. Background: Nitrous oxide (NO2), commonly known as “laughing gas”, is frequently used as an anesthetic agent, but is also abused recreationally in t [....] » Read More
Title : miR-590-3p delivery via nanoparticle technology inhibits recurrent GBM tumor growth by targeting multiple oncogenic nodes downstream of TGFBR2
Sophie Sall, Kennedy Krieger Institute, United States
Glioblastoma (GBM) is the most common central nervous system cancer diagnosed in adults. Heterogeneous and aggressive in nature, GBM is often found to resist standard of care (SOC) treatment and is almost guaranteed to recur. Upon recurrence, treatment options are very limited an [....] » Read More
Title : Neurochemical and behavioral effects of olanzapine in a high-risk schizophrenia mouse model
Sindhu Sriramoji Virdi, Rutgers University, New Jersey Medical School, United States
Schizophrenia is a mental disorder affecting behavior, cognition, and emotion. While schizophrenia is characterized by the dysregulation of dopamine in the brain, specifically the striatum, its physiology is undetermined. Olanzapine, an atypical antipsychotic, is commonly prescri [....] » Read More
Title : Serum levels of ferritin, iron and TIBC in cerebral venous sinus thrombosis
Nazanin Azizi, University of California Davis, United States
Background: Cerebral venous sinus thrombosis (CVST) is a potentially life-threatening condition with a wide range of clinical presentations from localized headache (the most common symptom) to mental status disturbances, seizure and coma. The main purpose of this study is to eval [....] » Read More
Title : Choroid plexus volume and microstructural changes in prodromal parkinson’s disease: Insights from 7 Tesla MRI
Firdaus Fabrice Hannanu, Massachusetts General Hospital and Harvard Medical School, United States
The choroid plexus (ChP) is increasingly recognized as a pivotal contributor to neurosecretory and neuroimmune processes. Alteration in ChP volume has been extensively studied in the context of aging, psychiatric disorders, and Alzheimer's disease, and it has been recently li [....] » Read More
Title : Clinical characteristics and management practices of pediatric status dystonicus
Karissa Chesky, Baylor College of Medicine, United States
Objective: We present 20 cases of pediatric status dystonicus at a major pediatric center and describe their clinical course. Background: Status dystonicus (SD) is a rare, life-threatening neurological emergency characterized by continuous, severe episodes of general [....] » Read More
Title : Intermittent hypoxic conditioning-induced exosome: Intervention for ischemic stroke treatment
Myoung-gwi Ryou, Tarleton State University, United States
Ischemic stroke is a leading cause of death and adult disability worldwide. Currently, the only FDA-approved treatment is tissue plasminogen activator (tPA). Over two decades ago, normobaric Intermittent Hypoxic Training (nIHT) was identified as beneficial for ischemia and reperf [....] » Read More
Title : Autism spectrum disorder detection using FMRI imaging with convolutional neural networks
Xiao Chang, Tuskegee University, United States
Purpose: Autism spectrum disorder (ASD) is a neurological and developmental disorder that affects how people interact with others, communicate, learn, and behave. The number of children diagnosed with autism spectrum disorder (ASD) has risen consistently and dramatically since th [....] » Read More
Title : Targeting oncogenic YY1 in resistant glioblastoma multiforme
Inesa Navasardyan, Western University of Health Sciences, United States
Background: The oncogenic transcription factor Yin Yang 1 (YY1) is critical in the pathogenesis of glioblastoma multiforme (GBM), a highly aggressive brain tumor Given the poor response of GBM to current treatments, there is an urgent need for a new therapeutic intervention. [....] » Read More
Title : Application of AI and computational approaches supporting new generation healthcare aiming at prevention with focus on gender differences
Erwin L J Roggen, ToxGenSolutions BV, Netherlands
ToxGenSolutions is a biotech company focused on developing novel and innovative methods to drive the discovery of impactful and personalized early-stage diagnostics and therapeutics with focus on prevention of chronic disease (Alzheimer’s disease, pain syndromes and long-CO [....] » Read More
Title : Auricular vagal nerve stimulation in patients with mild cognitive impairment due to alzheimer’s disease: A randomized placebo double-blind study
Adam Broncel, Neuromedical, Poland
Background: This study was conducted on patients who were diagnosed with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). Methods: Auricular transcutaneous vagal nerve stimulation (atVNS) was applied using a VGuard device specifically designed to minimize m [....] » Read More
Title : Biomarkers in alzheimer´s disease – New perspectives
Gustavo Alves A dos Santos, Sao Leopoldo Mandic Araras, Brazil
The development of an early and assertive diagnosis of Alzheimer’s Dementia can contribute to a better quality of life for patients, mainly by providing targeted therapy with measurable results. Biomarkers can be detected in blood levels and, more recently, the feasibility [....] » Read More
Title : Intracranial vein of galen malformation and its management: A case report
Jubran Al Hooti, University College Dublin, Ireland
Introduction: Vein of Galen Malformation (VOGM) is a rare congenital arteriovenous malformation affecting the pediatric population. It is characterized by a fistula between the diencephalon and a dilated vein of Galen. VOGMs occur when the prosencephalic vein of Markowski, the fe [....] » Read More
Title : Development of novel miR-dependent genome-editing Adeno-associated virus that selectively eradicates glioblastoma-initiating cells
Toru Kondo, Hokkaido University, Japan
Glioblastoma (GBM), one of the most malignant human cancers, frequently recurs despite multimodal treatment with surgery and chemo/radiotherapies. One of the reasons of why GBM recues is likely the existence of GBM-initiating cells (GICs) that have strong proliferative and tumori [....] » Read More
Title : Necrobotics 360: Shaping the future of healthcare
Raul V Rodriguez, Woxsen University, India
Necrobotics 360: Shaping the Future of Healthcare" presents a transformative vision where cutting-edge artificial intelligence (AI) technologies converge with healthcare, redefining the future of medical practices. It is an innovative approach that integrates AI, machine lea [....] » Read More
Title : The role of the circadian rhythm in alzheimer's disease and aging
Mohamad Sultan Khan, University of Hyderabad, India
During the course of evolution and earth’s rotation round its axis, the surface inhabitants are exposed to daily a predictable light and dark condition which impose specific demands on the physiology and influences the behaviour of an organism. Such cyclic patterns in the p [....] » Read More
Title : A collaborative innovation in developing the novel Head And Trunk Control Rehabilitation (HATCoRe) device for children with cerebral palsy: Revolutionizing pediatric rehabilitation
Shristi Shakya, Manipal College of Health Professions, India
Background and objectives: A delay in achieving head and trunk control can present numerous challenges in the activities of daily living for children with Cerebral Palsy (CP). This frequently require extended therapy, which may become repetitive, leading to decreased engagement i [....] » Read More
Title : Probiotics and rTMS synergistically alleviate cognitive and motor deficits in 6-OHDA-induced parkinson’s disease rats
Shweta Sharma, All India Institute of Medical Sciences, India
Introduction: Non-invasive repetitive Transcranial Magnetic Stimulation (rTMS) and probiotics intervention have been demonstrated to improve motor functions and alleviate cognitive deficits in 6-OHDA rat model of Parkinson’s disease (PD). Despite this, it is still unknown w [....] » Read More
Title : Microglial activation visualized by 18F-DPA714 PET is a potential marker of severity and prognosis for Anti-LGI1 encephalitis
Jingguo Wang, Fudan University, China
Background and Purpose: Whether microglial activation plays important role in the pathogenesis of autoimmune encephalitis (AE), such as anti-leucine-rich, glioma-inactivated-1 (LGI1) encephalitis, remains unknown. 18F-DPA714 PET targeting the translocator protein (TSPO [....] » Read More
Title : Insomnia and its correlates in migraine patients with or without aura
Khalid Alquliti, Taibah University, Saudi Arabia
Introduction: Migraine, the second leading cause of disability, is a primary headache disease prevalent throughout the world, causing malaise, loss of quality of life, and a substantial cost in medical care Migraine and sleep disturbances are widely prevalent, and usually bidirec [....] » Read More
Title : Developing an online task to examine how attention to detail affects learning dynamics
Mary Avella, Hunter College, United States
Autism Spectrum Disorder is a neurological disorder that affects how a person communicates and interacts with others. One way people on the spectrum are different from neurotypical people is in their attentional focus. In particular, those on the spectrum have been shown to pay c [....] » Read More
Title : Projective testing as windows to the mind: Unveiling anxiety's expression through artistic mediums in teenagers
Aryan Shah, William P. Clements High School, United States
Nearly one in three of all Americans aged 13 to 18 experience an anxiety disorder. It is important now to accurately diagnose anxiety in adolescents. Current methods of diagnosis involve psychological evaluations and questionnaires. However, unconscious bias and stereotypes can i [....] » Read More
Title : Projective testing as windows to the mind: Unveiling anxiety's expression through artistic mediums in teenagers
Rhea Ahuja, William P Clements High School, United States
Nearly one in three of all Americans aged 13 to 18 experience an anxiety disorder. It is important now to accurately diagnose anxiety in adolescents. Current methods of diagnosis involve psychological evaluations and questionnaires. However, unconscious bias and stereotypes can i [....] » Read More
Title : A case of normal pressure hydrocephalus in an elderly male
Michael Sulaiman, Edward Via College of Osteopathic Medicine, United States
Normal pressure hydrocephalus is a rare neurologic disorder primarily impacting older adults, classically presenting with clinical triad of gait dysfunction, cognitive impairment, and urinary incontinence, in addition to hydrocephalus on brain imaging. Normal pressure hydrocephal [....] » Read More
Title : Traumatic iatrogenic posterior interosseus nerve axonotmesis due to peripheral intravenous insertion: A case report
Dominique Smith, Loma Linda University Education & Health Consortium, United States
We present a case of a 43-year-old patient with a past medical history of intravenous drug abuse who presented with one month of numbness, pain, and paresthesia localized to the left posterior forearm and dorsum of hand. The patient also endorsed subjective weakness affecting gri [....] » Read More
Title : Decoding complexity: Readability analysis of public online health information on common neurological diagnoses
Puja Punukollu, Augusta University, United States
Neurological disorders, comprising conditions like dementia, migraines, and stroke, pose significant health challenges globally. In the digital age, individuals increasingly turn to online platforms for health information. Given the intricate nature of neurological conditions, ev [....] » Read More
Title : Evaluate the efficacy of AXL inhibitor bemcentinib in the rNLS8 mouse model of amyotrophic lateral sclerosis
Guyin Chen, University of Pennsylvania, United States
Aim and Methods: We aim to evaluate if the pharmacological inhibition of the myeloid/microglial receptor tyrosine kinase AXL could be used as a novel therapeutic approach for Amyotrophic Lateral Sclerosis (ALS). The objective of the present research is to evaluate the efficacy of [....] » Read More
Title : Effect of lower extremity proprioceptive neuromuscular facilitation on stair ambulation in persons with stroke: A pre-post study
Rikesh Shrestha, Sentara Health, United States
Background and objectives: Persons with stroke often encounter challenges in ambulation due to impaired motor function and coordination. The aftermath of stroke can significantly affect a person’s ability to ambulate independently, necessitating tailored intervention for re [....] » Read More
Title : Innovative sEEG based device for neural recordings, ablation and drug delivery into the brain
Guadalupe Zepeda, NeuroOne Medical Technologies, United States
Stereoelectroencephalography (sEEG) electrodes are routinely used to identify the epileptogenic zone (EZ) in patients with drug resistant epilepsy. The sEEG electrodes are FDA-cleared for temporary (<30 days) neural activity monitoring, recording and stimulation. Here we prese [....] » Read More
Title : A rare case of paroxysmal kinesigenic dyskinesia
Abhishek Pant, Texas Tech University of Health Science Center El Paso- Transmountain, United States
Introduction: Paroxysmal Kinesigenic Dyskinesia (PKD) is a rare neurologic disorder characterized by transient, episodic, involuntary hyperkinetic movements such as chorea, dystonia, myoclonus, or ballism. It is triggered by sudden voluntary movements, commonly present in yo [....] » Read More
Title : Taekwondo as a transformative treatment plan for mental disabilities and disorders
William Breska, University of Central Florida, United States
The application and study of combat sports and martial arts can be found throughout human history. From the development of wrestling in Greece over the course of millennia to the 1950s and the development of taekwondo in Korea, martial arts are a cornerstone of human development [....] » Read More
Title : IgG4-related hypophysitis: A unique presentation of a rare disease
Maxime A Braun, University of Connecticut School of Medicine, United States
Immunoglobulin G4-related disease (IgG4-RD) is an autoimmune condition in which IgG4-positive plasma cells locally or systemically infiltrate tissues and cause damage through inflammation and fibrosis. While IgG4-RD has been reported in nearly every organ, it preferentially manif [....] » Read More
Title : Mapping brain responses to emotional stimuli: ERP investigation of children with reading difficulties during affectively modulated Go/No-Go
Anesa Shahid, Syracuse University, United States
Having reading difficulties during early childhood significantly impacts both academic performance and daily functioning. Children with reading difficulties often struggle to perform well in school activities compared to their peers. In their daily lives, they encounter challenge [....] » Read More
Title : Investigating visuospatial working memory for facial emotion and identity
BriAnna Lowe, Western Kentucky University, United States
The central executive plays a key role in the encoding of visual stimuli in working memory, including the memory for faces in a social context. Faces often contain important details about the identity of social targets as well as the emotion that these targets are expressing. Enc [....] » Read More
Title : The effects of exam question formats on teenage neurodivergent student performance
Suhani Gupta, Neuro Health Alliance, United States
As of 2024, up to 30% of teenagers worldwide are neurodivergent, not even including comorbid conditions such as anxiety and depression. This study investigates the impact of different exam question formats on the academic performance of neurodivergent teenagers compared to their [....] » Read More
Title : miR30c-mimic ameliorates acute ischemic stroke in mice by reducing thromboinflammation and attenuating neuronal ER stress
Rong Jin, Penn State Hershey Medical Center, United States
Decreased expression of endogenous miR-30c has been linked to numerous pathological conditions in both patients and animal models, including various cancers, hyperlipidemia, atherosclerosis, hyperglycemia, and diabetes. Systemic administration of a miR-30c mimic has been de [....] » Read More
Title : J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress via the AMPK/ SREBP-1 pathway
Rong Jin, Penn State Hershey Medical Center, United States
Endoplasmic Reticulum (ER) stress is recognized as a crucial contributor to the progression of Traumatic Brain Injury (TBI) and represents a potential target for therapeutic intervention. This study aimed to assess the potential of J147, a novel neurotrophic compound, in alleviat [....] » Read More
Title : Golexanolone, a GABAA receptor-modulating steroid antagonist, improves microglia activation and tyrosine hydroxylase levels in substantia nigra, dopamine in striatum and several motor and non-motor alterations in 6-OHDA rats
Magnus Doverskog, Umecrine Cognition AB, Sweden
There are no drugs available for Parkinson’s disease (PD) that alter progression of disease. Current symptomatic treatments provide imperfect relief and have side effects. Enhanced GABAergic neurotransmission contributes to PD pathogenesis. In animal models, GABA levels are [....] » Read More
Title : Diagnostic cerebral and spinal digital subtraction angiography at Punjab institute of neurosciences Lahore: A single center experience
Rana Muhammad Usama, Punjab Institute of Neurosciences, Pakistan
For cerebrovascular diseases, catheter based cerebral and spinal digital subtraction angiography (DSA) prevails as the the preferred imaging modality. The role of digital subtraction angiography is flourishing since the incorporation of diverse endovascular therapeutic approaches [....] » Read More
Title : CNS coccidiomycosis in an individual with multiple sclerosis on fingolimod – A case report
Pantea Sazegar, University of Arizona College of Medicine - Tucson, United States
Introduction: Fingolimod is an FDA-approved oral disease-modifying therapy for relapsing-remitting forms of multiple sclerosis and works through inhibition of lymphocyte egress from secondary lymphoid organs, reducing circulating levels of lymphocytes. While Fingolimod, and [....] » Read More
Title : The neurobiology of cognitive load: A comparative study of neurodivergent and neurotypical brains
Christina Barrios Arguello, University of California, United States
Working memory is essential for various important cognitive processes, including reasoning and decision-making. While changes in working memory have been noted among neurodivergent groups, there is a lack of comprehensive and focused research outlining how cognitive load and the [....] » Read More