Background: Cognitive decline and Alzheimer’s disease are major public health concerns among older adults in the U.S. and Puerto Rico. Racial and ethnic disparities in cognitive health outcomes highlight the need for a better understanding of these differences. Methods: [....] » Read More
This study explores the application of Artificial Neural Networks (ANN) combined with the Harmony Search Algorithm (HSA) to enhance data analysis in neuroscience, particularly for detecting and classifying anomalies in neurological datasets. Data for this research were obtained f [....] » Read More
Innovative neuromodulation technologies like Neurofeedback and Transcranial Pulse Stimulation (TPS) are offering hope for individuals diagnosed with severe depression. These non-invasive approaches target specific brain regions involved in mood regulation and emotional processing [....] » Read More
Neurodevelopmental Disorders (NDDs) are disabilities primarily caused by impairment of the neurological system and brain functioning. They are characterized by impairments in cognition, communication, behavior and/or motor skills as a result of abnormal brain development usually [....] » Read More
Glioblastoma multiforme (GBM) is one of the most aggressive and treatment-resistant forms of brain cancer. Current therapeutic strategies, including surgery, chemotherapy, and radiotherapy, often fail due to the tumor’s ability to develop resistance. The proteins YAP-1 (Yes [....] » Read More
In accounts of the development and progression of psychophysical disorders such as Hereditary Spastic Paraplegia (HSP) and Facioscapulohumeral Muscular Dystrophy (FSHD), the role of beliefs, perceptions, and behavioural patterns has often been overlooked in favour of a geneticall [....] » Read More
Patients with Functional Seizures (FS) (also known as Psychogenic Non-Epileptic Seizures (PNES), have involuntary paroxysmal episodes that resemble epileptic seizures but without organic etiology. Many patients with FS have a history of sexual, physical, or emotional abuse or oth [....] » Read More
The hard problem of consciousness is the problem of explaining how we experience qualia or phenomenal experiences, such as seeing, hearing, and feeling, and knowing what they are. To solve this problem, a theory of consciousness needs to link brain to mind by modeling how emergen [....] » Read More
Prior to WWII the majority patients with tSCI died in hospitals. There was however no shortage of Clinicians experimenting with the management of the injured spine. During WWII L. Guttmann (a well-trained aggressive Neurosurgeon) was given the task of looking after injured sol [....] » Read More
MicroRNAs are small non-coding RNA (18-24 nt long) that fine-tune gene expression at the post-transcriptional level. With the advent of "multi-omics" analysis and sequencing approaches, they have now been implicated in every facet of basic molecular networks, including [....] » Read More
Background: Autism spectrum disorders (ASD) are a series of neurodevelopmental disorders characterized by social disorders, rigid behaviors and narrow interests.The World Health Organization (WHO) estimates that the prevalence of ASD has been increasing over the past 50 years. Wi [....] » Read More
Brain cancer and its treatments bring a unique threat to the patient’s identity and quality of life by challenging their essential identity in significant ways, possibly including impaired cognitive skills, loss of memory, reduced coordination, altered feeling states, and l [....] » Read More
Alcohol Use Disorder is a chronic disease that causes an individual to lose control of their ability to stop drinking, diagnosed by state markers and biomarkers. We analyzed a publicly available RNA-seq dataset comparing patients with Alcohol Dependence (now AUD) to controls. W [....] » Read More
Bismuth encephalopathy is a rare cause of neurological dysfunction that can result in confusion, gait disturbances, myoclonus, and dysarthria. Due to the rarity of this condition, a bismuth toxicology workup is usually not immediately initiated upon presentation of neurological s [....] » Read More
Statement of the Problem: Women who suffer mental health issues, because of Autism Spectrum Disorder has a significant impact on their lives, especially if they’ve suffered trauma because of the bullying/discrimination/cruel remarks & actions from other people. Autis [....] » Read More
Background: People with neglect suffer from various spatial deficits in several modalities, which in many cases impair everyday functioning. Virtual reality (VR) is a form of interaction between humans and computers in which a real or imaginary environment is simulated. Users int [....] » Read More
Background: Burnout is associated with cognitive impairment. Research has shown a link between burnout and difficulties in executive functions in daily life, as well as changes in underlying neural processes. This cross-sectional study aimed to examine the impact of burnout on co [....] » Read More
Migraine is a recurrent neurovascular illness characterized by acute pain that lasts for prolonged periods, nausea, vomiting, and problems with the autonomic nervous system. The study aims to explore the prevalence of migraine among Bangladesh's university students, predict t [....] » Read More
Background: Pterocarpus mildbraedii Harms (P. mildbraedii) was believed to have multiple benefits, including antioxidant, antipyretic, antalgic, anti-convulsant, and anxiolytic effects. People traditionally believe it can boost immunity, eliminate free radicals that cause cance [....] » Read More
Deep brain stimulation (DBS) surgery is an elective surgery offered to Parkinson disease (PD) patients who meet certain symptom criteria. Despite the success of DBS and increasing use, racial disparities in utilization are prevalent [1, 2]. To date, no study has carefully examine [....] » Read More
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the gradual decline in both motor and cognitive functions. Affected individuals exhibit cortical lesions as well as heightened iron deposition in the midbrain, a phenomenon attributed to a [....] » Read More
In Hungary, the process of diagnosing dementia is slow and time-consuming. Currently, there are no well-developed systems and strategies at the local level for screening, and there is no artificial intelligence algorithm that could determine early signs of dementia based on the p [....] » Read More
Parkinson’s disease (PD) is one of the most common diseases of the central nervous system. This disease stems from damage to the dopaminergic neurons in the substantia nigra (SN). Patients with PD experience a spectrum of motor and non-motor symptoms. Common motor symptoms [....] » Read More
Title : Novel important cellular responses, signaling mechanisms and therapeutic options in vascular dementia
Yong Xiao Wang, Albany Medical College, United States
Vascular contributions to cognitive impairment and dementia (VCID) have high morbidity and mortality, and diabetes is a leading factor for VCID. The signaling mechanisms for diabetes-induced VCID are largely unknown, and the current treatments for VCID are neither very specific n [....] » Read More
Title : How have we eliminated infection: From the bone to brain ?
Thomas J Webster, Interstellar Therapeutics, United States
Implant infection is rising with the U.S. Centers for Disease Control predicting one person every three seconds will die from a bacteria infection by 2050. Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundr [....] » Read More
Title : A case of vile vindictive primary CNS vasculitis
George Diaz, Memorial Healthcare Systems, United States
Introduction/Objective: Primary Angiitis of the Central Nervous System (PACNS) is rare and causes inflammation of the small and medium vessels of the brain, leptomeninges and spinal cord. We present a case of PACNS, demonstrate the diagnostic challenges, and appreciate outco [....] » Read More
Title : Outcomes and prognostic factors of surgical decompression in neurological foot drop: A systematic review and meta-analysis.
Abbas Khizar Khoja, University of Nottingham, United Kingdom
Objective: To evaluate the outcomes of surgical decompression and determine the factors predicting post-operative motor recovery in patients with unilateral footdrop and to propose a critical time frame for operative management. Design: Systematic review and meta-analysis (usi [....] » Read More
Title : An audit on the assessment and management of osteoporosis in a parkinson’s and related diseases clinic in Australia
Nethmi Nuwanji Amarasekera, Imperial College London, United Kingdom
Osteoporosis is characterised by low bone mineral density and is associated with minimal trauma fractures. Patients with Parkinson’s disease (PD) and atypical parkinsonian syndromes are at increased risk of falls and should be actively screened and treated for osteoporosis. [....] » Read More
Title : A case of probable Progressive Supranuclear Palsy Frontal type (PSP-F) presenting as psychosis
Ala Bashir, Worcestershire Acute Hospitals NHS Trust, United Kingdom
Background: Progressive supranuclear palsy (PSP) is the second most common parkinsonian disorder after idiopathic Parkinson’s disease; yet, it remains frequently misdiagnosed, with only 4,000 confirmed cases reported in the UK by the PSP Association .While neuropsychiatric [....] » Read More
Title : Clinical efficacy analysis of implantable VNS stimulation rehabilitation therapy for the patients with hemiplegia after ischemic stroke
Dawei Zang, Capital Medical University, China
Purpose: Currently there are no effective rehabilitation therapies for the upper limb movement disorders of the patients after ischemic stroke in clinical; it is difficult for these patients to return to society and work. Implantable VNS (Vagus Nerve Stimulation?VNS) is widely us [....] » Read More
Title : New trends in migraine management: Transcending the traditional divide between acute and preventive treatments
Jiying Zhou, The First Affiliated Hospital of Chongqing Medical University, China
Migraine treatment is categorized into acute and preventive approaches. The primary goal of acute treatment is to alleviate headache and associated symptoms rapidly while minimizing adverse effects, allowing patients to return to normal functioning. Preventive treatment focuses o [....] » Read More
Title : STING is significantly increased in high-grade glioma with high risk of recurrence
Qingyuan Yang, Shanghai Jiao Tong University School of Medicine, China
To our knowledge, the potential relationships among the frequently mutated genes, well-known homologous recombination repair (HRR) proteins, and immune proteins in glioma from a clinical perspective have not been explored. Here, a total of 126 surgical tissues from patients initi [....] » Read More
Title : Safety, tolerability and efficacy of ALMB-0166 in the patients with acute Spine Cord Injury (SCI): a multicenter, randomized, placebo-controlled, phase I/II study
Jinqian Liang, Peking Union Medical College Hospital, China
Introduction: There are currently significant unmet medical needs for therapies that improve the recovery of neurological function after suffering a severe SCI. ALMB-0166 is a first-in-class humanized monoclonal IgG antibody that block connexin-43 (Cx43) hemichannels in spinal co [....] » Read More
Title : Aspartame-induced cognitive dysfunction: Unveiling role of microglia-mediated neuroinflammation and molecular
Waseem Dar, Shiv Nadar University, India
Aspartame, an artificial sweetener, is consumed by millions of people globally. There are multiple reports of aspartame and its metabolites affecting cognitive functions in animal models and humans, which include learning problems, headaches, seizures, migraines, irritable moods, [....] » Read More
Title : Geriatric care for individuals with neurological & brain disorders in carehomes /assisted living facilities
Akankunda Veronicah Karuhanga, Golden Age Elderly Homes Kampala, Uganda
Care homes play a crucial role in providing specialized care and support to individuals with neurological conditions such as Alzheimer's disease, Parkinson's disease, and stroke survivors. These facilities offer a safe and structured environment, tailored to meet the uniq [....] » Read More
Title : Social engagement and cognitive functions: An association between religious attendance and cognitive functions in old age
Henry Chahwanda, Individual, United Kingdom
The purpose of this study is to investigate the association between religious attendance as one of the main forms of social engagement and cognitive functions in old age. The risk of cognitive impairments, a forerunner dementia and Alzheimer which lead to death and disability in [....] » Read More
Title : Neuroprotective effect of andrographolide combination with piperine against streptozotocin induced alzheimer’s disease
Royal Patel, SVN Institute of Pharmacy, India
Streptozotocin (STZ) is a widely used neurotoxin in experimental models of Alzheimer’s disease (AD) due to its ability to induce cognitive dysfunction and neurodegeneration. STZ administration leads to the accumulation of amyloid-beta (Aβ) plaques and the development o [....] » Read More
Title : The impact of screen exposure on attention capacities in Moroccan schoolchildren: A neurocognitive approach
Zakaria Abidli, International University of Casablanca, Morocco
In all cognitive tasks, attention is crucial for processing and learning information. This study aims to examine the harmful impact of growing screen use among children in Morocco on their attentional capacities and educational outcomes. It provides a neurocognitive perspective t [....] » Read More
Title : Revolutionizing alzheimer's early detection: Bridging gaps with multi-modal imaging, AI innovations, and ethical insights
Moufiq Abdulrasoul Hasan, Abdullah Thafer Hospital, Libyan Arab Jamahiriya
Background: Early detection of Alzheimer's disease (AD) is crucial for timely intervention and improved patient outcomes. Despite advancements in neuroimaging and AI, significant gaps remain in the early diagnosis of AD. Aims: This session aims to explore the integration o [....] » Read More
Title : The effects of cognitive behavioral therapy with biofeedback therapy on the quality of life, anxiety, depression and somatic symptoms in patients with dyssynergic defecation: A randomized controlled trial
Afsaneh Nikjooy, Iran University of Medical Sciences, Iran (Islamic Republic of)
Background and Objectives: Dyssynergic defecation (DD) is a major cause of chronic functional constipation. Patients with DD have greater psychological distress and an impaired health-related quality of life compared with the general population. This study aimed to evaluate the e [....] » Read More
Title : Variations in neural and cardiac responses to reward processing in parkinson’s disease with depressive symptoms
Gloria Chen, Cornell University, United States
Parkinson’s disease (PD) is the second most common and fastest-growing neurodegenerative disease in the world. Although commonly recognized as a motor disorder, non-motor symptoms such as apathy and anhedonia are equally as prevalent. Depressive symptoms may result from neu [....] » Read More
Title : A case of AQP4-MOG double-positive neuromyelitis optica spectrum disorder
Sarah Butler, Monash University, Australia
Neuromyelitis optica spectrum disorder (NMOSD) is an immune-mediated disorder of the central nervous system (CNS) characterized by frequent involvement of the optic nerves and spinal cord. Autoantibodies against aquaporin-4 channels on astrocytes (Anti-AQP4) are the hallmark of t [....] » Read More
Title : Evaluating factor levels of fibrinogen, D-Dimer, and hs-CRP in serum or plasma of patients with ischemic or hemorrhagic stoke
Huiqing Hou, Capital Medical University, China
Purpose: Elevated levels of fibrinogen, D-Dimer, and High-sensitivity C-reactive Protein (hs-CRP) have been observed previously in the serum or plasma of patients with stroke, but the associations of these inflammatory cytokines with cognitive impairment after stroke are still [....] » Read More
Title : Interplay between chronic stress and multiple sclerosis: Mechanisms and therapeutic approaches
Shreya R Kethiri, Meenakshi Medical College Hospital and research Institute, India
Multiple Sclerosis (MS) is a chronic, immune-mediated neurodegenerative disorder characterized by inflammation and demyelination of the central nervous system. This literature review evaluates the intricate relationship between chronic stress and MS, particularly its role in th [....] » Read More
Title : “No kicking in the body bag”: Determination of brain death with the aid of nuclear medicine scintigraphy
Waleed Bashir, Inspira Health Network, United States
Background: The gold standard of ancillary imaging in determining brain death is Digital Subtraction Angiography (DSA) of the four cerebral vessels, which boasts a near 100% sensitivity and specificity. However, its use is limited due to its time-intensive nature, need for transf [....] » Read More
Title : The use of cephalexin to inhibit alpha-synuclein aggregation: A new paradigm in parkinson's disease
Divya Jayam, The Wheatley School, United States
Introduction: Parkinson’s Disease (PD) is characterized by the degeneration of dopaminergic neurons due to the aggregation of a protein named α-Synuclein in the substantia nigra region of the brain. Current therapies for PD do not address this pathology. This paper pr [....] » Read More
Title : Functional brain hubs are related to age: A primer study with rs-FMRI
María Dolores Figueroa Jiménez, Universidad de Guadalajara, Mexico
Background/Objective: Research on the ontogenetic development of brain networks using resting state has shown to be useful for understanding age-associated changes in brain connectivity. This work aimed to analyze the relationship between brain connectivity, age and intelligence. [....] » Read More
Title : Elementary school teachers’ knowledge and attitude towards attention deficit hyperactivity disorder: A multi-institutional study, Ethiopia
Daniel Ayelegne Gebeyehu, University of Gondar, Ethiopia
Background: A child suffering from attention deficit hyperactivity disorder (ADHD) faces many difficulties in social as well as academic performances. School teachers’ knowledge and attitude towards ADHD play a vital role in early detection and referral of the child to tr [....] » Read More