Joao Victor Ribeiro, Sao Leopoldo Mandic Medical School, Brazil
Introduction: Cavernous angiomas are benign vascular malformations characterized by abnormally dilated vessels that lack interposing neural tissue. The presentation can occur in any region of the central nervous system, but most commonly, supratentorial. This report details a rar [....] » Read More
Title : Neural nanomedicine: Fighting stroke, improving stem cell delivery, healing nerves and using artificial intelligence
Thomas J Webster, Interstellar Therapeutics, United States
Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For exa [....] » Read More
Title : Human understanding and machine intelligence: A systems neuroscience perspective
Yan M Yufik, Virtual Structures Research, Inc, United States
Aristotle’s “Metaphysics” starts with a pronouncement “Humans desire to understand”, establishing understanding capacity as the defining characteristic of human intellect separating humans from the other species. Throughout history, cognitive capacit [....] » Read More
Title : Artificial Intelligence/Machine Learning (AI/ML) models could predict the risks for brain tumors months ahead of diagnosis using routine blood markers
Raj Gopalan, BSRM Consulting, United States
Background: Brain tumors are the second leading cause of cancer deaths among children and young adults, with an estimated 1 million Americans living with a brain tumor. Each year, 95,000 new cases are diagnosed, of which 30% are malignant with a survival rate of only 35%. Fe [....] » Read More
Title : 3DYNAFS-MBAFUS: A virtual lab of microbubble-amplified focused ultrasound for noninvasive treatments of neurodisorders
Jingsen Ma, Dynaflow, Inc, United States
Focused Ultrasound (FUS), especially when amplified by Microbubbles (MB), offers non-invasive options for treating deep-seated and brain tumors and other neurodisorders, by enabling targeted surgical ablation and/or local blood-brain-barrier opening (BBBO) for effective drug deli [....] » Read More
Title : Cannabis/CBD for treating neurological disorders
Jag H Khalsa, GWU School of Medicine and Health Sciences, United States
Cannabis is the most used illegal drug in the world with an estimated 2.5% of the world’s population (180 million) using it regularly (World Drug Report 2017)1. Medicinal and/or recreational cannabis use is associated with significant health consequences) (WHO, 20162; Volko [....] » Read More
Title : Therapeutic inhibition of PI3K? attenuates neuronal endoplasmic reticulum stress improves functional recovery after traumatic brain injury in mice
Guohong Li, Penn State College of Medicine, United States
Traumatic brain injury (TBI) is a major cause of death and disability, often leading to persistent motor and cognitive deficits. Phosphoinositide 3-kinase γ (PI3Kγ), primarily expressed in immune cells, has been implicated in neuroinflammation in various neuropatholog [....] » Read More
Title : Therapeutic efficacy of cinnamein in controlled cortical impact mouse model of TBI
Jit Poddar, Rush University, United States
Traumatic brain injury (TBI) remains a major health concern which causes long-term neurological disability particularly in war veterans, athletes and young adults in United States. Despite of intense clinical and research investigations, there is no effective therapy to cease the [....] » Read More
Title : A case of nitrous oxide induced vitamin B12 deficiency with secondary myelopathy
George Diaz, Memorial Healthcare Systems, United States
Objective: To present a unique case of nitrous oxide (NO2)-induced vitamin B12 deficiency with secondary myelopathy. Background: Nitrous oxide (NO2), commonly known as “laughing gas”, is frequently used as an anesthetic agent, but is also abused recreationally in t [....] » Read More
Title : miR-590-3p delivery via nanoparticle technology inhibits recurrent GBM tumor growth by targeting multiple oncogenic nodes downstream of TGFBR2
Sophie Sall, Kennedy Krieger Institute, United States
Glioblastoma (GBM) is the most common central nervous system cancer diagnosed in adults. Heterogeneous and aggressive in nature, GBM is often found to resist standard of care (SOC) treatment and is almost guaranteed to recur. Upon recurrence, treatment options are very limited an [....] » Read More
Title : Neurochemical and behavioral effects of olanzapine in a high-risk schizophrenia mouse model
Sindhu Sriramoji Virdi, Rutgers University, New Jersey Medical School, United States
Schizophrenia is a mental disorder affecting behavior, cognition, and emotion. While schizophrenia is characterized by the dysregulation of dopamine in the brain, specifically the striatum, its physiology is undetermined. Olanzapine, an atypical antipsychotic, is commonly prescri [....] » Read More
Title : Serum levels of ferritin, iron and TIBC in cerebral venous sinus thrombosis
Nazanin Azizi, University of California Davis, United States
Background: Cerebral venous sinus thrombosis (CVST) is a potentially life-threatening condition with a wide range of clinical presentations from localized headache (the most common symptom) to mental status disturbances, seizure and coma. The main purpose of this study is to eval [....] » Read More
Title : Choroid plexus volume and microstructural changes in prodromal Parkinson’s disease: Insights from 7 Tesla MRI
Firdaus Fabrice Hannanu, Massachusetts General Hospital and Harvard Medical School, United States
The choroid plexus (ChP) is increasingly recognized as a pivotal contributor to neurosecretory and neuroimmune processes. Alteration in ChP volume has been extensively studied in the context of aging, psychiatric disorders, and Alzheimer's disease, and it has been recently li [....] » Read More
Title : Clinical characteristics and management practices of pediatric status dystonicus
Karissa Chesky, Baylor College of Medicine, United States
Objective: We present 20 cases of pediatric status dystonicus at a major pediatric center and describe their clinical course. Background: Status dystonicus (SD) is a rare, life-threatening neurological emergency characterized by continuous, severe episodes of general [....] » Read More
Title : Intermittent hypoxic conditioning-induced exosome: Intervention for Ischemic stroke treatment
Myoung-gwi Ryou, Tarleton State University, United States
Ischemic stroke is a leading cause of death and adult disability worldwide. Currently, the only FDA-approved treatment is tissue plasminogen activator (tPA). Over two decades ago, normobaric Intermittent Hypoxic Training (nIHT) was identified as beneficial for ischemia and reperf [....] » Read More
Title : Autism spectrum disorder detection using FMRI imaging with convolutional neural networks
Xiao Chang, Tuskegee University, United States
Purpose: Autism spectrum disorder (ASD) is a neurological and developmental disorder that affects how people interact with others, communicate, learn, and behave. The number of children diagnosed with autism spectrum disorder (ASD) has risen consistently and dramatically since th [....] » Read More
Title : Application of AI and computational approaches supporting new generation healthcare aiming at prevention with focus on gender differences
Erwin L J Roggen, ToxGenSolutions BV, Netherlands
ToxGenSolutions is a biotech company focused on developing novel and innovative methods to drive the discovery of impactful and personalized early-stage diagnostics and therapeutics with focus on prevention of chronic disease (Alzheimer’s disease, pain syndromes and long-CO [....] » Read More
Title : Auricular vagal nerve stimulation in patients with mild cognitive impairment due to Alzheimer’s disease: A randomized placebo double-blind study
Adam Broncel, Neuromedical, Poland
Background: This study was conducted on patients who were diagnosed with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). Methods: Auricular transcutaneous vagal nerve stimulation (atVNS) was applied using a VGuard device specifically designed to minimize m [....] » Read More
Title : Intracranial vein of galen malformation and its management: A case report
Jubran Al Hooti, University College Dublin, Ireland
Introduction: Vein of Galen Malformation (VOGM) is a rare congenital arteriovenous malformation affecting the pediatric population. It is characterized by a fistula between the diencephalon and a dilated vein of Galen. VOGMs occur when the prosencephalic vein of Markowski, the fe [....] » Read More
Title : Biomarkers in alzheimer´s disease – New perspectives
Gustavo Alves A dos Santos, Sao Leopoldo Mandic Araras, Brazil
The development of an early and assertive diagnosis of Alzheimer’s Dementia can contribute to a better quality of life for patients, mainly by providing targeted therapy with measurable results. Biomarkers can be detected in blood levels and, more recently, the feasibility [....] » Read More
Title : Development of novel miR-dependent genome-editing Adeno-associated virus that selectively eradicates glioblastoma-initiating cells
Toru Kondo, Hokkaido University, Japan
Glioblastoma (GBM), one of the most malignant human cancers, frequently recurs despite multimodal treatment with surgery and chemo/radiotherapies. One of the reasons of why GBM recues is likely the existence of GBM-initiating cells (GICs) that have strong proliferative and tumori [....] » Read More
Title : Relationships between sensory patterns, executive functions, and decreased time organization abilities among adults with specific learning disabilities
Kineret Sharfi, Ben-Gurion University, Israel
The literature describes a close relationship between cognitive executive functions and daily activity. Adults with specific learning disabilities (SLDs) (e.g., dyslexia, dysgraphia, and dyscalculia) reveal limitations in daily activity in various life domains including decreased [....] » Read More
Title : Necrobotics 360: Shaping the future of healthcare
Raul V Rodriguez, Woxsen University, India
Necrobotics 360: Shaping the Future of Healthcare" presents a transformative vision where cutting-edge artificial intelligence (AI) technologies converge with healthcare, redefining the future of medical practices. It is an innovative approach that integrates AI, machine lea [....] » Read More
Title : The role of the circadian rhythm in alzheimer's disease and aging
Mohamad Sultan Khan, University of Hyderabad, India
During the course of evolution and earth’s rotation round its axis, the surface inhabitants are exposed to daily a predictable light and dark condition which impose specific demands on the physiology and influences the behaviour of an organism. Such cyclic patterns in the p [....] » Read More
Title : A collaborative innovation in developing the novel Head And Trunk Control Rehabilitation (HATCoRe) device for children with cerebral palsy: Revolutionizing pediatric rehabilitation
Shristi Shakya, Manipal College of Health Professions, India
Background and objectives: A delay in achieving head and trunk control can present numerous challenges in the activities of daily living for children with Cerebral Palsy (CP). This frequently require extended therapy, which may become repetitive, leading to decreased engagement i [....] » Read More
Title : The impact of the "Let's Talk" series on mental health among students at Makerere University
Rwakiseta Herbert, Golden Age Elderly Homes Kampala, Uganda
This research paper explores the impact of the "Let's Talk" series on the mental health of students at Makerere University. The "Let's Talk" series, initiated as a peer-support program, aims to address the increasing mental health concerns among univer [....] » Read More
Title : Probiotics and rTMS synergistically alleviate cognitive and motor deficits in 6-OHDA-induced parkinson’s disease rats
Shweta Sharma, All India Institute of Medical Sciences, India
Introduction: Non-invasive repetitive Transcranial Magnetic Stimulation (rTMS) and probiotics intervention have been demonstrated to improve motor functions and alleviate cognitive deficits in 6-OHDA rat model of Parkinson’s disease (PD). Despite this, it is still unknown w [....] » Read More
Title : Microglial activation visualized by 18F-DPA714 PET is a potential marker of severity and prognosis for Anti-LGI1 encephalitis
Jingguo Wang, Fudan University, China
Background and Purpose: Whether microglial activation plays important role in the pathogenesis of autoimmune encephalitis (AE), such as anti-leucine-rich, glioma-inactivated-1 (LGI1) encephalitis, remains unknown. 18F-DPA714 PET targeting the translocator protein (TSPO [....] » Read More
Title : Developing an online task to examine how attention to detail affects learning dynamics
Mary Avella, Hunter College, United States
Autism Spectrum Disorder is a neurological disorder that affects how a person communicates and interacts with others. One way people on the spectrum are different from neurotypical people is in their attentional focus. In particular, those on the spectrum have been shown to pay c [....] » Read More
Title : Projective testing as windows to the mind: Unveiling anxiety's expression through artistic mediums in teenagers
Aryan Shah, William P. Clements High School, United States
Nearly one in three of all Americans aged 13 to 18 experience an anxiety disorder. It is important now to accurately diagnose anxiety in adolescents. Current methods of diagnosis involve psychological evaluations and questionnaires. However, unconscious bias and stereotypes can i [....] » Read More
Title : Projective testing as windows to the mind: Unveiling anxiety's expression through artistic mediums in teenagers
Rhea Ahuja, William P Clements High School, United States
Nearly one in three of all Americans aged 13 to 18 experience an anxiety disorder. It is important now to accurately diagnose anxiety in adolescents. Current methods of diagnosis involve psychological evaluations and questionnaires. However, unconscious bias and stereotypes can i [....] » Read More
Title : A case of normal pressure hydrocephalus in an elderly male
Michael Sulaiman, Edward Via College of Osteopathic Medicine, United States
Normal pressure hydrocephalus is a rare neurologic disorder primarily impacting older adults, classically presenting with clinical triad of gait dysfunction, cognitive impairment, and urinary incontinence, in addition to hydrocephalus on brain imaging. Normal pressure hydrocephal [....] » Read More
Title : Traumatic iatrogenic posterior interosseus nerve axonotmesis due to peripheral intravenous insertion: A case report
Dominique Smith, Loma Linda University Education & Health Consortium, United States
We present a case of a 43-year-old patient with a past medical history of intravenous drug abuse who presented with one month of numbness, pain, and paresthesia localized to the left posterior forearm and dorsum of hand. The patient also endorsed subjective weakness affecting gri [....] » Read More
Title : Decoding complexity: Readability analysis of public online health information on common neurological diagnoses
Puja Punukollu, Augusta University, United States
Neurological disorders, comprising conditions like dementia, migraines, and stroke, pose significant health challenges globally. In the digital age, individuals increasingly turn to online platforms for health information. Given the intricate nature of neurological conditions, ev [....] » Read More
Title : Evaluate the efficacy of AXL inhibitor bemcentinib in the rNLS8 mouse model of amyotrophic lateral sclerosis
Guyin Chen, University of Pennsylvania, United States
Aim and Methods: We aim to evaluate if the pharmacological inhibition of the myeloid/microglial receptor tyrosine kinase AXL could be used as a novel therapeutic approach for Amyotrophic Lateral Sclerosis (ALS). The objective of the present research is to evaluate the efficacy of [....] » Read More
Title : Effect of lower extremity proprioceptive neuromuscular facilitation on stair ambulation in persons with stroke: A pre-post study
Rikesh Shrestha, Sentara Health, United States
Background and objectives: Persons with stroke often encounter challenges in ambulation due to impaired motor function and coordination. The aftermath of stroke can significantly affect a person’s ability to ambulate independently, necessitating tailored intervention for re [....] » Read More
Title : Innovative sEEG based device for neural recordings, ablation and drug delivery into the brain
Aura Kullmann, NeuroOne Medical Technologies, United States
Stereoelectroencephalography (sEEG) electrodes are routinely used to identify the epileptogenic zone (EZ) in patients with drug resistant epilepsy. The sEEG electrodes are FDA-cleared for temporary (<30 days) neural activity monitoring, recording and stimulation. Here we prese [....] » Read More
Title : A rare case of paroxysmal kinesigenic dyskinesia
Abhishek Pant, Texas Tech University of Health Science Center El Paso- Transmountain, United States
Introduction: Paroxysmal Kinesigenic Dyskinesia (PKD) is a rare neurologic disorder characterized by transient, episodic, involuntary hyperkinetic movements such as chorea, dystonia, myoclonus, or ballism. It is triggered by sudden voluntary movements, commonly present in yo [....] » Read More
Title : Taekwondo as a transformative treatment plan for mental disabilities and disorders
William Breska, University of Central Florida, United States
The application and study of combat sports and martial arts can be found throughout human history. From the development of wrestling in Greece over the course of millennia to the 1950s and the development of taekwondo in Korea, martial arts are a cornerstone of human development [....] » Read More
Title : IgG4-related hypophysitis: A unique presentation of a rare disease
Maxime A Braun, University of Connecticut School of Medicine, United States
Immunoglobulin G4-related disease (IgG4-RD) is an autoimmune condition in which IgG4-positive plasma cells locally or systemically infiltrate tissues and cause damage through inflammation and fibrosis. While IgG4-RD has been reported in nearly every organ, it preferentially manif [....] » Read More
Title : Mapping brain responses to emotional stimuli: ERP investigation of children with reading difficulties during affectively modulated Go/No-Go
Anesa Shahid, Syracuse University, United States
Having reading difficulties during early childhood significantly impacts both academic performance and daily functioning. Children with reading difficulties often struggle to perform well in school activities compared to their peers. In their daily lives, they encounter challenge [....] » Read More
Title : Investigating visuospatial working memory for facial emotion and identity
BriAnna Lowe, Western Kentucky University, United States
The central executive plays a key role in the encoding of visual stimuli in working memory, including the memory for faces in a social context. Faces often contain important details about the identity of social targets as well as the emotion that these targets are expressing. Enc [....] » Read More
Title : A case report on coexisting meningioma and glioma in the same patient
Rey Alexis M Sususco, University of the East Ramon Magsaysay Memorial Medical Center, Philippines
The simultaneous occurrence of two distinct intracranial neoplasms within a single patient presents a unique and exceedingly rare clinical scenario. This case report details the diagnostic challenges, therapeutic considerations, and clinical outcomes in a patient harboring two co [....] » Read More
Title : Improving DBS access and postoperative experience in parkinson’s disease through patient education: A perspective review
Udeept Sindhu, Kasturba Medical College, India
Deep Brain Stimulation (DBS) offers a promising therapeutic option for Parkinson's Disease (PD), significantly improving both motor and non-motor symptoms. However, disparities in DBS access and utilization persist, particularly related to gender and patient education. This r [....] » Read More
Title : In vitro efficacy studies of Bacopa monnieri and Rosemarinus officinalis to evaluate their neuroprotective and neurotrophic properties in the management of Alzheimers Disease
Nidhi Gupta, CSIR-National Physical Laboratory, India
Background: Alzheimer's Disease (AD) treatment modalities address symptoms aleviation through neurotransmitter modulation. Ayurveda, utilizing plant-derived compounds with neuroprotective properties, offers a promising avenue. This study explores integrating&nb [....] » Read More
Title : Epidemiology, Imageology and treatment strategies in tumefactive mulitple sclerosis: A systematic review of literature
Nived Jayaraj Ranjini, Government Medical College, India
Objective: Tumefactive Multiple Sclerosis (TMS) is a rare subtype of multiple sclerosis (MS) with an incidence of 1-3 per 1000 MS patients. Here, we aimed to review the literature to present data on the epidemiology of TMS. Background: The annual incidence of tumefa [....] » Read More
Title : Caspase inhibition: A trailblazer armament to treat neurodegenerative disorders
Amaan Javed, University College of Medical Sciences, India
Introduction: Apoptosis is a form of programmed cell death, that underlies the wide range of symptoms investigated in neurological disorders from stroke to neurodegenerative diseases such as Alzheimer’s. Caspases are shown to be capable of producing inflammasomes along [....] » Read More
Title : Stroke after pediatric traumatic brain injury and its association with outcome at hospital discharge: A retrospective chart review
Suparna Bharadwaj, National Institute of Mental Health and Neurosciences, India
Introduction: Childhood stroke is associated with high mortality and serious morbidity for the survivors. Traumatic brain injury (TBI) has been reported to be a possible cause of childhood stroke or post traumatic cerebral infarction (PTCI). The precise frequency of cerebral [....] » Read More
Title : CHCHD2 p.Thr61Ile knock-in mice exhibit motor defects and neuropathological features of Parkinson’s disease
Li-Yuan Fan, Zhengzhou University, China
Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Although the etiology of PD remains elusive, mounting evidence suggests a complex interplay of genetic and [....] » Read More
Title : Clinical profile of cerebral venous thrombosis
Naranchimeg Gendendagva, The Third State Central Hospital of Mongolia, Mongolia
Cerebral venous thrombosis is a rare neurological disorder that can be diagnosed clinically and neuro-radiologically. The prognosis of this disease is good in most cases. However, if it is complicated by a stroke, it can lead to death or disability. Cerebral vein thrombosis accou [....] » Read More
Title : Opercular syndrome as a sequelae of herpes simplex virus infection: A case report
Nischal Neupane, Tribhuvan University Institute of Medicine, Nepal
Introduction: Opercular Syndrome also known as Foix-Chavany-Marie Syndrome (FCMS) is a rare cortical form of pseudobulbar palsy that preserves reflexive and autonomic functions but results in voluntary paralysis of the masticatory, lingual, pharyngeal, and facial muscles. Th [....] » Read More
Title : Clinical profile of migraine in South Asian countries: A systematic review
Abhishek Chapagain, Tribhuvan University Teaching Hospital, Nepal
Background and Aims: Migraine, a condition causing moderate to severe headaches, ranks as the second most burdensome neurological disorder among Asians in regards to DALYs. It is usually associated with trigger factors like photophobia, phonophobia, or nausea and vomiting. T [....] » Read More
Title : J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress via the AMPK/ SREBP-1 pathway
Rong Jin, Penn State Hershey Medical Center, United States
Endoplasmic Reticulum (ER) stress is recognized as a crucial contributor to the progression of Traumatic Brain Injury (TBI) and represents a potential target for therapeutic intervention. This study aimed to assess the potential of J147, a novel neurotrophic compound, in alleviat [....] » Read More
Title : miR30c-mimic ameliorates acute ischemic stroke in mice by reducing thromboinflammation and attenuating neuronal ER stress
Rong Jin, Penn State Hershey Medical Center, United States
Decreased expression of endogenous miR-30c has been linked to numerous pathological conditions in both patients and animal models, including various cancers, hyperlipidemia, atherosclerosis, hyperglycemia, and diabetes. Systemic administration of a miR-30c mimic has been de [....] » Read More