Serotonin exhibits multiple non-neural functions involved in essential hypertension, early embryogenesis, follicle maturation and behaviour. Growth stimulatory effects of the neurotransmitter have been described for a variety cell types. 5-HT was found to induce migration of the [....] » Read More
Undernutrition with poor weight and height gain is frequently seen in patients with cerebral palsy (CP) and is a consequence of feeding and gastrointestinal problems that are poorly understood and investigated and therefore difficult to treat properly. Children with autism also h [....] » Read More
The aim of this study was to investigate the dynamics of clinical manifestations of posttraumatic stress disorders (PTSD) among combatants. We conducted a comparative study of two groups of patients: 1) with mental disorders due to brain damage and dysfunction (F06-F07) as a [....] » Read More
Stroke is the third commonest cause of death in the West yet by the year 2050 the WHO predicts that 80% of its occurrence will lay between India and China. These two most globally populous nations are home to an aging people with increasing risk factors for all cardiovascular dis [....] » Read More
The presenter will give an oral presentation on his music album he released in 2018 which was inspired by patients with neurological disorders to raise patient awareness and heal patients through music.
It is understood that long-term elevation of fear and avoidance gives rise to anxiety disorders, including PTSD and OCD. Conditioned fear stimuli and associated conditioned fear responses are widely understood factors. Behavioral conditioning methods have included fear extinction [....] » Read More
The brain is a distributed system where many functions involve several different parts of the brain. Activation of neuroplasticity can alter many features but some such as long-term memory, sexual preference and handedness seem to be "hard-wired."&nb [....] » Read More
Connexin and pannexin membrane channel proteins for gap junctions which are conduits that allow neuronal, glial, and vascular tissues interactions. In the brain, this interaction is highly critical for homeostasis and brain repair after injury. The main gap junction protein in th [....] » Read More
We will discuss about: 1) What are microRNAs; 2) How microRNAs are currently being studied in Multiple Sclerosis; 3) The relevance and demand of microRNAs as biomarkers in the disease; 4) The particularity of the effect on lymphocytes of Natalizumab therapy in the disease; 5) The [....] » Read More
Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in TDP-43 are present in familial ALS. Loss and gain of TDP-43 functions are implicated in pathogenesis but the mechani [....] » Read More
It is proposed that there are three major cellular pathways than contribute to brain aging. Activities of each overlap and are cross-linked. Age-related systemic changes moderate these mechanisms to variable extents. (1) Reduced growth factor activity, particularly BDNF and [....] » Read More
‘Baby brain’ is a term given to the phenomenon experienced by many pregnant women who feel that pregnancy has induced cognitive impairment. Investigation of cognitive deficits during pregnancy has focussed on subtypes of memory, but more recently has included th [....] » Read More
Anti-phospholipid syndrome (APS) is an autoimmune disease. Cerebral ischemia associated with APS occurs at a younger age than typical atherothrombotic cerebrovascular disease, is often recurrent, and is associated with high positive IgG anti-phospholipid (GPL) unit levels. This s [....] » Read More
Nowadays Klotho protein (KP) is actively researched by scientists but in the textbooks. There is a strong proof of KP biological functions in protection of the myelin sheath from damages and the reduction in synthesis of KP during the age. In the medical literature, there is a lo [....] » Read More
Efficient delivery of therapeutics to the central nervous system (CNS) is extensively limited by the blood brain barrier (BBB).Cell penetrating peptides (CPP) have gained recognition for enhancing the uptake of conjugated payloads into various cell types, however, the non-specifi [....] » Read More
Norman M. White employed the theory of learning and memory to explain the mechanism of drug addiction. Base on his theory, we can understand addiction as a kind of memory that associates a feeling of euphoria with the use of a substance or a certain behavior. Memory engram cells [....] » Read More
Background: Subjective memory complaints (SMC) are often detected in the elderly. APOE?4 genotype has been identified as the most important risk factor for late onset Alzheimer Disease (AD). We aimed to evaluate temporal change of Tau and Amyloid Beta (Aβ) in SMC with A [....] » Read More
Receptor-interacting protein 3 (RIP3) plays an important role in the necroptosis signalling pathway. Our previous studies have shown that RIP3/mixed lineage kinase domain-like protein (MLKL)-mediated necroptosis occurred in retinal ganglion cell line 5 (RGC-5) cells during oxygen [....] » Read More
These days, interplay between brain and gut is important role in brain related disorders. Immune system and tight junctions in gut are thought that there is a correlation with Central nerve system and brain. Two kinds of medicinal herbs, Rumex japonicus Houtt. (RJ) and& [....] » Read More
Objective: Dysphagia is an important issue in an aging society. Stroke is the most common cause, but dysphagia can occur without a stroke or underlying disease. Aging itself can cause or aggravate dysphagia and there have been many studies that describe the effect of aging on swa [....] » Read More
Depressive disorder results in enormous social loss like treatment cost, family burden and workplace inefficiency. Depression is explained by various mechanisms, but among them, the lack of monoamine-based neurotransmitters such as serotonin and epinephrine is considered to be [....] » Read More
Depressive disorder results in enormous social loss like treatment cost, family burden and workplace inefficiency. Depression is explained by various mechanisms, but among them, the lack of monoamine-based neurotransmitters such as serotonin and epinephrine is considered to be [....] » Read More
Backgrounds: Several recent studies demonstrated that microRNAs (miRNAs) are involved in pain processing pathways by using microarray-based approaches. However, a significant proportion of the computational predictions of miRNA targets are false-positive interactions. To incre [....] » Read More
Objective: Dysphagia is a common bulbar dysfunction in Parkinson’s disease. Recently efforts have been made to evaluate dysphagia using ultrasonography. Laryngeal elevation could be measured by identification of the hyoid bone and the thyroid cartilage. The aim of this [....] » Read More
The aim of our study was to evaluate the usefulness of MRI in patients presenting with a suspected diagnosis of acute stroke. We admitted 4400 patients with the diagnosis of acute stroke between Jan 2014 and June 2017 at Hamad Medical Corporation. A total of 2880 patients underwe [....] » Read More
Aim: This case illustrates exact clinico-radiological match with hyperacute left sided cephalo-brachial dystonia and right sided putaminal infarct. AMD symptoms resolved after thrombolysis and patient’s outcome was positive. Discussion: Though not uncommon it takes [....] » Read More
Introduction: Spinal muscular atrophies (SMA), prevalence of 1.5:100.000, recessive inheritance, neuromuscular diseases with anterior medullary horn degeneration, are caused by mutations in the survival of motor neuron protein, represented by SMN1 and SMN2 genes, supporting [....] » Read More
Introduction: The incidence of facial paralysis in children is 0,2%, trauma and infection includes the majority, and it can be diagnosed as a part of a syndrome or sole. However, non-traumatic congenital facial paralysis (NCFP) is quite rare. Developmental abnormality due to inte [....] » Read More
Introduction: Various research studies suggested an association between Obstructive Sleep Apnea (OSA) and various cognitive disorders, including Alzheimer disease. The degree of OSA has been directly correlated with the severity of cognitive impairment. Stroke and vascular diseas [....] » Read More
There are all kinds of physical and psychosocial symptoms in advanced patients diagnosed with cancer, some patients suffered a sudden stroke .The management of patients is very difficult for physicians, nurses and family of the patient. The following is what the presentation incl [....] » Read More
MENA (Middle East and North Africa) region extends from Morocco to Iran; in MENA , studies on epilepsy are lacking ; only 2 surveys examined epidemiology and neurology training programs in this vaste geographic area Objective 1) Describe the available data on Ep [....] » Read More
Lithium is an agent with established neuroprotective qualities, considerable epidemiological evidence supporting its use as a dementia prophylactic, and was strongly debated to be part of the UK’s national dementia strategy. Yet it has failed to enter regular clinical use f [....] » Read More
Screening studies of an infant population (n = 4329; 9 months of age) in primary health care with the aim to describe observed atypical behaviors that might be associated with autism spectrum disorders are sparsely reported. An observational tool, named SEEK developed for child h [....] » Read More
Slow oscillations are important for consolidation of memory during sleep, and Alzheimer’s disease (AD) patients experience memory disturbances. Thus, we sought to examine slow wave activity using the voltage-sensitive dye RH1691 in an animal model of AD (APP mice). The powe [....] » Read More
The geriatric patient’s neurological disease is often accompanied by psychiatric and behavioral symptoms which confound the diagnostic process and complicate medical treatment and its delivery. An aged patient is often at the nexus of systemic medical, psychiatric, psychoso [....] » Read More
Epilepsy is a disease characterized by an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition. Approximately 50 million people currently live with epilepsy worldwide. Close to 80% o [....] » Read More
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Title : Hypothesizing the Central Nervous Systems Genius to Trigger and Self-organize to Higher States of Complexity as Epitomized in the Case of Noah Wall the Boy Born With Only 2% of His Brain
Ken Ware, NeuroPhysics Therapy Institute and Research Centre, Australia
Noah was born with an estimated 2% of his brain as the result of a cephalic disorder, with the remainder of his cranial cavity being filled with cerebrospinal fluid. This signifies an extreme case of Hydranencephaly. Hydranencephaly is a condition that affects under 1 in 10,000 b [....] » Read More
Title : Synchronization & Bifurcations in Brain Activity
Marat Akhmet, Middle East Technical University, Turkey
Complexity and synchronization in models are necessary for research in neuroscience. In our talk the complexity will be present through special type of bifurcations - the medusas bifurcations in the Cowan-Wilson model, they have been introduced in our recent papers.&n [....] » Read More
Title : Brain dynamics of normal and abnormal learning and memory consolidation: Multiple hippocampal functions in cognitive, adaptively-timed cognitive-emotional, and navigational learning
Stephen Grossberg, Boston University, United States
This talk provides a self-contained summary of neural models of normal and abnormal learning and memory consolidation in which the hippocampus plays an important role. As heuristically described in the Multiple Trace Theory of Moscovitch and Nadel, the role of the hippocampus in [....] » Read More
Title : Opiate exposure in the developing brain and toxic stress in early childhood: How brain structure and function is altered and impacts life-long health
Mary Payne, Marshall University School of Medicine, United States
Toxins and stressful environments can alter brain structure and function. More importantly, the developing brain in utero is particularly susceptible to exposures to medications and substances of abuse. In my community in rural West Virginia, we have unfortunately experienced a d [....] » Read More
Title : Evaluation of short term treatment with NAD+ precursor Nicotinamide Riboside on cognitive and mitochondrial function in patients with MELAS
Natasa Dragicevic, University of Connecticut Health Center, United States
Primary goal of this study was to measure effectiveness of nicotinamide riboside as direct precursor for coenzyme NAD+ in patients with mitochondrial DNA mutation 3443 and MELAS (Mitochondrial Encephalopathy, lactic acidosis and stroke like episodes) syndrome. Primary outcome wer [....] » Read More
Title : CB1-Dependent LTD in Ventral Tegmental Area GABA Neurons: a Novel Target for Marijuana
Jeffrey Edwards, Brigham Young University, United States
The ventral tegmental area is necessary for reward behavior where dopamine cells are critical for reward motivated behavior and attaching salience to novel rewarding stimuli. These dopamine cells are regulated by neighboring inhibitory GABA cells. Synaptic modifications known as [....] » Read More
Title : Epigenetics and Mental Health; Implicating the role of DNA Methylation in Rett Syndrome
Mojgan Rastegar, University of Manitoba, Canada
In this presentation, I will mainly focus on an epigenetic neurological disorder that is caused by a genetic mutation, namely “Rett Syndrome (RTT)”. RTT is a neurodevelopmental disease that is caused by MECP2 gene mutations. The X-linked MECP2 gene [....] » Read More
Title : Reintegration of impaired motor-cognitive interactions in diseases and injuries of the brain buy the author’s method of kinesitherapy in the pneumatic suit “Atlant”
Valida Isanova, Kazan State Medical University, Russian Federation
The nervous system disorders and mental impairments still remain to be among the main causes of children and adults incapacity. Currently neurorehabilitation has a particular relevance and importance among people suffering from nervous system disorders, incapable of moving [....] » Read More
Title : Neuromodulation – invasive and noninvasive stimulation in the treatment of orofacial pain
Richard Rokyta, Charles University in Prague, Czech Republic
It will be described the contemporary neuromodulatory methods – e.i. both invasive and noninvasive ones. As a as stimulation were used electrical current (both alternative and constant current ) and magnetic field stimulation. Also the noninvasive stimulation using th [....] » Read More
Title : Typical benzene poisoning on brain magnetic resonance imaging
Yan Wang, Chengdu fifth people’s hospital Chengdu, China
Benzene poisoning is rare; acute and chronic benzene poisoning mainly result in damage to the central nervous system. Here we report a patient with benzene poisoning who is mainly affected by central nervous system damage. Case report A 38-year-old man who had been exposed [....] » Read More
Title : Surgical treatment of severe brain injury
Csókay András, Military Hospital, Chief of Neurosurgery Department, Hungary
One of the largest mistakes of the modern science may be the analyzing of the efficacy of the medical treatment by the rule of the evidence-based medicine in the state around the death. What are the most important bioethical rules in the lifethreatening extreme emergency or hopel [....] » Read More
Title : Misfolded Proteins in the Retina
Umur Kayabasi, Bahcesehir University, Turkey
Background: Recent research suggests that Tau is the culprit lesion along with neuroinflammation in the etiology of Alzheimer’ s Disease ( AD ). Retina is the extention of the brain and is the most easily approachable part of the central nervous system. Detection of th [....] » Read More