HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.

10th Edition of International Conference on Neurology and Brain Disorders

October 21-23, 2024

October 21 -23, 2024 | Baltimore, Maryland, USA
INBC 2019

Young Kyung Seo

Speaker at Neuroscience Conference - Young Kyung Seo
Daejeon University, Korea, Republic of
Title : An experimental study on the antidepressant effect of gami-jigyultang

Abstract:

Depressive disorder results in enormous social loss like treatment cost, family burden and workplace inefficiency.

Depression is explained by various mechanisms, but among them, the lack of monoamine-based neurotransmitters such as serotonin and epinephrine is considered to be important mechanism.

Several antidepressants like TCAs, SSRIs, and MAOIs have been marketed and used but they have side effects such as nausea, vomiting, insomnia, anxiety, and sexual dysfunction.

Therefore, there is a growing need to develop a new therapeutic agent with fewer side effects.

In this study, we investigated the antidepressant effect of Gami-Jigyultang, the herbal extract known to treat depression in Korean medicine.

We used C57BL/6 mice and randomly divided into several groups according to the dose of induced drug. Except for normal, depression was induced by applying restraint stress like trapped in a narrow space during 2 weeks. The stressed mice were taken Gami-Jigyultang or Antidepressants or saline in oral administration 2 hours before the stress situation. After that, they were exposed to forced swimming test(FST) and open field test(OFT) and the serum corticosterone, BDNF mRNA, protein, and serotonin mRNA levels were measured and compared.

The mice taking Gami-Jigyultang showed more active behaviors in the FST than saline or amitriptyline induced mice.

In OFT, Gami-Jigyultang-fed mice showed a significant increase in the number of movements in contrast to amitriptyline and saline.

It can be concluded that Gami-Jigyultang inhibited the release of corticosterone without significant difference in the concentration, and through this, it had an antidepressant effect and was more effective than amitriptyline.

Biography:

03/2018-currently a Ph.D student at Daejeon University, Daejeon, Korea

07/2017-02/2018 Researcher, Clinical Trial Center, Dunsan Korean Medicine Hospital, Daejeon, Korea

02/2014 M.A. in Korean Medicine, Pusan National University, Pusan, Korea

02/2008 B.A. in Biology, Catholic University, Bucheon, Korea

09/2017 A Survey of the Recognition on the Practice Pattern, Diagnosis, and Treatment of Korean Medicine of Dementia and Mild Cognitive Impairment - Focusing on the Differences between Neuropsychiatrists of Korean Medicine and General Physicians – Co-1st author. J of Oriental Neuropsychiatry

03/2018 A Research to Evaluate the Safety and Efficacy of Yukwool-tang (Liuyu-tang) for Major Depression in Women: A Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Clinical Trial. Co-1st author. J of Oriental Neuropsychiatry

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