HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.

10th Edition of International Conference on Neurology and Brain Disorders

October 21-23, 2024

October 21 -23, 2024 | Baltimore, Maryland, USA
INBC 2018

Bartłomiej Stańczykiewicz

Speaker at Neurology Conferences - Bartłomiej Stańczykiewicz
Wroclaw Medical University, Poland
Title : Properties of the ovocystatin in APP/PS1 mice model


Cysteine proteases inhibitors play an important role in the neurodegenerative disorders. Cystatin isolated from chicken egg white, called ovocystatin has been widely used in pharmaceutical and medical research due to its structural and biological similarities to human cystatin C.  Moreover, it has been recently suggested that ovocystatin has procognitive properties in young rats (Sta?czykiewicz et al, 2017a), as well as may prevent aging-related cognitive impairment (Sta?czykiewicz et al., 2017b). Thus, the presented study focused on the histochemical and biological evaluation of the ovocystatin properties in APP/PS1 transgenic mice, including cognitive functions’ assessment. The study was conducted on transgenic B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax mice. Ovocystatin was administered intraperitoneally for four weeks (at a dose of 40/ mouse) to 35-weeks-old transgenic (AD) and wild type (NCAR) mice. The locomotor activity and cognitive functions were determined using an actimeter and the Morris water maze test, respectively. Histopathological evaluation comprised antibodies directed against Beta-Amyloid (1:400, SIG-39320-1000, Covance), Tau (1:4000, AHB0042, Invitrogen), RBFOX3/NeuN (1:1000, NBP1-77686, Novus Biologicals) and CD107b (1:100, 108502, BioLegend). The study was conducted within the framework of the POIG 01.03.01-00-133/08 „Innovative Technologies of production of biopreparations based on new generations of eggs (OVOCURA)”- Task 8. Assessing the biological activity of the obtained biopreparations. It was expected that the study may provide a significant contribution to the development of research on neurodegenerative disorders, by describing their effects on cognitive function and biological activity. The authors will present the results of the study and key findings.


Bartłomiej Stańczykiewicz, MSc in Biology, MA in Psychology, PhD in Medicine Science. Currently works as an assistant professor at Department of Nervous System Diseases, Faculty of Health Sciences, Wroclaw Medical University, Poland. He defended his PhD thesis in 2014 at Department of Psychiatry (Wroclaw Medical University). A major focus of research is to identify the possible factors that inhibit pathology development in neurodegenerative disorders. Additionally, his interests include inflammation in schizophrenia-spectrum and neurodegenerative disorders, supportive biological and psychological approach in mood and anxiety disorders, as well as in aged-related cognitive impairments.