HYBRID EVENT: You can participate in person at Boston, Massachusetts, USA or Virtually from your home or work.

8th Edition of International Conference on Neurology and Brain Disorders

October 19-21, 2023

October 19 -21, 2023 | Boston, Massachusetts, USA
INBC 2018

Baranowska-Bosiacka Irena

Speaker at International Conference on Neurology and Brain Disorders 2018 - Baranowska-Bosiacka Irena
Pomeranian Medical University in Szczecin, Poland
Title : Pre- and neonatal exposure to lead (Pb) induces alteration in energy metabolism in developing brain of rat offspring


Lead (Pb) is an environmental neurotoxin which particularly affects the developing brain but the molecular mechanism of its neurotoxicity is not fully understood. The aim of our study was to examine whether pre- and neonatal exposure to Pb (concentration of Pb in rat offspring blood below the “threshold level”) may affect the brain’s energy metabolism in neurons and astrocytes via the amount of available glycogen. We investigated the glycogen concentration in the brain, as well as the expression of the key enzymes involved in glycogen metabolism in brain: glycogen synthase 1 (Gys1), glycogen phosphorylase (PYGM, an isoform active in astrocytes; and PYGB, an isoform active in neurons) and phosphorylase kinase β (PHKB). Moreover, the expression of connexin 43 (Cx43) was evaluated to analyze whether Pb poisoning during the early phase of life may affect the neuron-astrocytes’ metabolic cooperation. This work shows for the first time that exposure to Pb in early life can impair brain energy metabolism by reducing the amount of glycogen and decreasing the rate of its metabolism. This reduction in brain glycogen level was accompanied by a decrease in Gys1 expression. We noted a reduction in the immunoreactivity and the gene expression of both PYGB and PYGM isoform, as well as an increase in the expression of PHKB in Pb-treated rats. Moreover, exposure to Pb induced decrease in connexin 43 immunoexpression in all the brain structures analyzed, both in astrocytes as well as in neurons. Our data suggests that exposure to Pb in the pre- and neonatal periods results in a decrease in the level of brain glycogen and a reduction in the rate of its metabolism, thereby reducing glucose availability, which as a further consequence may lead to the impairment of brain energy metabolism and the metabolic cooperation between neurons and astrocytes.


Irena Baranowska-Bosiacka works at the Department of Biochemistry and Medical Chemistry at the Pomeranian Medical University, Szczecin Poland. She is a researcher and university teacher. For many years she has been involved in the research related to the influence of environmental and epigenetic factors on the human and animal body. The main subject of the research are issues related to metallomics and toxicology, with emphasis on neurobiology and neurotoxicology. She has involved in many research projects explaining the molecular, biochemical and genetic mechanisms of adaptation to xenobiotics. At the cellular level, she conducts research on energy metabolism, oxidative stress, inflammatory and degenerative processes.