HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.

10th Edition of International Conference on Neurology and Brain Disorders

October 21-23, 2024

October 21 -23, 2024 | Baltimore, Maryland, USA
INBC 2018

Luca Malfassi

Speaker at Neuroscience Conference - Luca Malfassi
La Cittadina Fondazione Studi e Ricerche Veterinarie, Romanengo, Italy and Azienda Socio Sanitaria Territoriale di Lodi, Italy
Title : Frameless stereotactic radiotherapy alone and combined with temozolomide for canine gliomas


We evaluated stereotactic volume modulated arc radiotherapy (VMAT RT) for canine gliomas, alone (RT) and in combination with temozolomide (RT+TMZ), compared to palliation. Overall and disease-specific survival times were estimated. Thirty dogs were palliated, 22 dogs were treated with RT and 20 with RT+TMZ. Complete and partial responses were observed in 63.2% and 90.9% of patients in the RT and RT+TMZ arms, respectively, that were alive at one year. Median survival in the palliation arm was 94 days. Median survivals of the RT arm (383 days) and RT+TMZ arm (420 days) were not significantly different (p=0.61). Positive correlation with survival was found both for the ratio between target and brain (relative) volume of the tumor of <5% (p=0.013) and for a clinical presentation with normal mentation (p=0.032). Volume modulated arc radiotherapy is feasible and effective for canine brain gliomas. Combining this therapy with TMZ did not elicit any additional improvement in survival time.


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