HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.

10th Edition of International Conference on Neurology and Brain Disorders

October 21-23, 2024

October 21 -23, 2024 | Baltimore, Maryland, USA
INBC 2018

Anthony E. Kline

Speaker at Neuroscience Conference - Anthony E. Kline
University of Pittsburgh, United States
Title : Continued refinement of environmental enrichment as a preclinical model of neurorehabilitation after experimental brain trauma


Traumatic brain injury (TBI) affects two million people in the United States each year and several million more worldwide, making it a significant health care issue. Brain traumas range from mild to severe with the former being the case in most occurrences and generally not displaying marked behavioral symptoms, while the latter occurs less often, but presents significant motor and/or cognitive dysfunction. Numerous preclinical pharmacotherapies have been evaluated, but have not translated to the clinic. Rehabilitation is currently the best option for TBI patients. Hence, in this presentation, environmental enrichment (EE), a preclinical model of neurorehabilitation that has been shown to confer motor, cognitive, and histological benefits after TBI will be discussed. Specifically, EE studies that range from the early and continuous exposure paradigm (i.e., typical EE) to some of the latest work where delayed and abbreviated EE, that more likely mimics the clinic, will be described. The data presented are derived from anesthetized adult male/female rats that received a cortical impact of moderate severity or sham injury and were then randomly assigned to EE or standard (STD) housing. The results generally show that motor and cognitive function is significantly improved in the EE vs. vehicle control groups and that EE can be considered a robust preclinical model of neurorehabilitation.


Anthony E. Kline, Ph.D., is a Professor in the Departments of Physical Medicine and Rehabilitation, Critical Care Medicine, and the Safar Center for Resuscitation Research at the University of Pittsburgh. Dr. Kline's research includes neurobehavioral recovery and learning after traumatic brain injury (TBI). Therapeutic strategies that include pharmacotherapy and environmental enrichment are utilized alone or in combination to restore function and/or attenuate TBI-induced deficits. Another interest is the evaluation of pharmacological agents that may alter TBI and to elucidate potential mechanisms for the observed effects.