HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.

10th Edition of International Conference on Neurology and Brain Disorders

October 21-23, 2024

October 21 -23, 2024 | Baltimore, Maryland, USA
INBC 2018

Swetlana Sirko

Speaker at Neurology Conferences - Swetlana Sirko
Ludwig-Maximilians-University Munich, Germany
Title : Astrocytes as the pivotal damage---management and repair cells after focal injury in the CNS


Astrocytes have a critical role in ensuring optimal brain functions,from supporting neuronal metabolism and survival to maintenance of blood?brain barrier. However, it took along time to recognize the central role of astrocytes in response to diverse types of CNS damage, such as traumatic brain injury or neurodegenerative diseases.Due to the multiple roles of astrocytes in such context, I will discuss some aspects of region-­? and pathology specific reactivity of astroglial cells: in particular I will focus on the subset of reactive astrocytes that acquire proliferative capacity and stem cell potential in the injured brain. This leads to examine our current knowledge on the role of injury-­?induced astrocytes proliferation in regulating inflammation and restoration of blood-­? brain barrier, as well as their impact on the area adjacent to the damage site, and on scar formation. The last part of my talk will consider how astrocyte plasticity changes during the aging process and how this affects the severity of tissue damage as well as post-­?traumatic structural and functional recovery.


Dr. Sirko studied first Medicine and then Biology & Biotechnology. During her PhD, she linked the neural stem cell (NSC) behavior of radial glia to the expression of receptor protein tyrosine phosphatase zeta/beta, and discovered on method for isolation of NSCs from the embryonic and adult brain. Upon graduation, she joined the Magdalena Götz’ Laboratory at Institute for Stem Cell Research (Helmholtz Center Munich) and the Department of Physiological Genomics at the LMU Munich. During her postdoctoral work, she investigated the endogenous plasticity of reactive astrocytes in the injured brain and identified the Sonic Hedgehog Signaling as a key determinant of NSC-­‐properties in these cells. In March 2016, Dr.Sirko obtained venia legendi at the Medical Faculty of LMU, where she is currently Professor of Physiology. Her research focuses on elucidating key mechanisms of astroglial plasticity in the adult mouse and human brain, in the hope of activating post-­‐injury mechanisms that instruct endogenous regeneration after brain injury.