HYBRID EVENT: You can participate in person at Boston, Massachusetts, USA or Virtually from your home or work.

8th Edition of International Conference on Neurology and Brain Disorders

October 19-21, 2023

October 19 -21, 2023 | Boston, Massachusetts, USA
INBC 2018


Speaker at International Conference on Neurology and Brain Disorders 2018 - Hiroko IKESHIMA-KATAOKA
WASEDA University, Faculty of Science and Engineering, Japan
Title : Astrocyte Reactivation is Concerned in BBB Recovery from Breakdown


Brain is not easy to cure when it has damage or inflammation occurs, because neurons are never regenerate after the degeneration. We have been focusing on one of the glial cells, astrocytes which has the important role in the central nervous system to transfer some of the nutrition or Ca2+ signaling between neurons and blood vessels. However, astrocytes become active when the brain had injury or inflammation though the functional significance of the astrocytic activation is not yet clarified. To examine the functional role of reactive astrocytes, we used some of the gene deficient mice with stab wound injury on the cerebral cortex with needle from rostral to caudal axis. By the immuno-fluorescent analysis on the brain sections using antibody against bromo-deoxy-uridine for proliferating cells, GFAP for astrocytes, Iba1 for microglial cells, and IgG for blood brain barrier breakdown, IgG leakage level and reactivation level was almost correlated. Furthermore, expression levels of some molecules concerned in the BBB integrity was well paralleled to IgG leakage. From these results, reactivation of astrocytes might be concerned in recovery of BBB breakdown caused by stab wound injury to the brain.


Dr. Ikeshima-Kataoka was graduated from Keio Univ. Sch. Med. (Dept. of Microbiol.) and got Ph.D. on the functional analysis of calmodulin genes using transgenic mice. At the National Institute of Neuroscience researched on the molecular mechanism of neuronal development using fly genetics. Then, promoted back to Keio Univ. Sch. Med. (Dept. Neuroanat.) and started to focus on the “reactive astrocytes” in injured mouse brain. At Jikei Univ. Sch. Med., focus on neuroimmunological analysis in injured brain. Promoted back to Keio Univ. Sch. Med. (Dept. Pharmacol. & Neurosci.) and found that some important molecules are concerned in neuroimmunological functions of astrocytes. Now, using in vivo imaging with mouse to analyze functional role of “reactive astrocytes” at Waseda Univ., Facul. Sci. and Engin.