HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.

10th Edition of International Conference on Neurology and Brain Disorders

October 21-23, 2024

October 21 -23, 2024 | Baltimore, Maryland, USA
INBC 2018

Hiroko Ikeshima Kataoka

Speaker at Neurology Conferences - Hiroko Ikeshima Kataoka
Kieo University, Japan
Title : Astrocyte Reactivation is Concerned in BBB Recovery from Breakdown


Brain is not easy to cure when it has damage or inflammation occurs, because neurons are never regenerate after the degeneration. We have been focusing on one of the glial cells, astrocytes which has the important role in the central nervous system to transfer some of the nutrition or Ca2+ signaling between neurons and blood vessels. However, astrocytes become active when the brain had injury or inflammation though the functional significance of the astrocytic activation is not yet clarified. To examine the functional role of reactive astrocytes, we used some of the gene deficient mice with stab wound injury on the cerebral cortex with needle from rostral to caudal axis. By the immuno-fluorescent analysis on the brain sections using antibody against bromo-deoxy-uridine for proliferating cells, GFAP for astrocytes, Iba1 for microglial cells, and IgG for blood brain barrier breakdown, IgG leakage level and reactivation level was almost correlated. Furthermore, expression levels of some molecules concerned in the BBB integrity was well paralleled to IgG leakage. From these results, reactivation of astrocytes might be concerned in recovery of BBB breakdown caused by stab wound injury to the brain.


Dr. Ikeshima-Kataoka was graduated from Keio Univ. Sch. Med. (Dept. of Microbiology) and received Ph.D. on development of transgenic mice and analyzed in the brain. For the postdoctoral fellow (NIN, Japan), researched on the neuronal development using fly genetics. Then, promoted back to Keio Univ. Sch. Med. (Dept. Neuroanat.) and started to focus on “reactive astrocytes” and performed neuroimmunological analysis in injured mouse brains and found molecules at Keio Univ. Sch. Med. (Dept. Pharmacol. & Neurosci.). Furthermore, performed in vivo imaging analysis on mouse brains with two photon laser microscopy to analyze functional role of “reactive astrocytes” at Waseda Univ.