4th International Conference on Neurology and Brain Disorders

September 09-11, 2021

September 09 -11, 2021 | Virtual Event
INBC 2017

Jong Wook Chang

Speaker at International Conference on Neurology and Brain Disorders 2017 - Jong Wook Chang
Samsung Medical Center, Korea, Republic of
Title : The application of human mesenchymal stem cell for alzheimer’s disease


Various groups have presented findings that human mesenchymal stem cells (MSCs) have both immunomodulatory and trophic properties. MSCs tend to act indirectly at sites of injury or damage through the secretion of paracrine factors in vitro & in vivo. For example, our studies have been done using a transgenic Alzheimer’s disease mouse model where intraparenchymal injections of MSCs resulted in the reduction of amyloid plaque levels, anti-apoptosis, activation of endogenous neural stem cell and also activate proteasome in neuron. In addition, efficient MSC delivery also is significant issue for human study. By possessing a broad range of functions, MSCs hold great potential in being used as a novel treatment for various diseases including neurodegenerative disorders.


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