Abstract:
Diseases of the central nervous system (CNS) still remain among the most challenging pathologies known to mankind, having limited therapeutic possibilities and a very pessimistic prognosis. Stem cells technologies has passed a long and exciting way from the discovery, to preclinical and clinical applications. Here, will be discussed the data from preclinical and clinical research involving adult stem cells (bone marrow MSCs) and the latest results from our research focusing on the regenerative/neuroprotective properties of induced pluripotent stem cells (iPS). We will demonstrate an extracellular matrix (ECM) involvement into the pathogenesis of ALS and will show an important modulating influence of human MSCs and NP-iPS on the host ECM-related genes and proteins that could have a potential diagnostic and therapeutic application in patients. We will also present results of the study evaluating neuroprotective and neuroregenerative influence of human NP-iPS transplantation into the pre-/symptomatic SOD1-transgenic rats and will present a novel mechanisms of Ca2+ channels/receptors involvement in the differentiation of neural precursors’ toward motorneurons.
Biography:
2005 I have graduated (with honors) a Faculty of Medicine, Ternopil’ State Medical University, Ukraine. 2005-2008 employed at the Department of Surgery as a resident-surgeon at the internship program General Surgery. 2008-2012 employed as a Ph.D-student at the 2nd Faculty of Medicine, Charles University in Prague and Institute of Experimental Medicine ASCR, Czech Republic. 2009-2010 Marie Curie Fellowship program CORTEX, under the Marie Curie Action of the FP 6. 2012 successfully defended a doctoral thesis and received a Ph.D. title in Neuroscience. 2012-2015 received a postdoctoral research fellowship in the project Development of Research Teams of IEM AS CR for the BIOCEV“, at the IEM ASCR, v.v.i. and was granted a Postdoctoral research project at Department of Neuroscience, Charles University in Prague. During my postdoctoral studies attended a 6 months internship under the supervision of Professor James Fawcett in the John van Geest Centre for Brain Repair, University of Cambridge, UK. In 2014 FENS Young Investigator Training Programme (YITP) Fellowship at the Neuroscience Institute Cavalieri Ottolenghi (NICO), Turin, Italy. 2013 a laboratory visit with the training in the group of Professor Steven Badylak at McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA. From 2015-present employed at the position of a Junior Research Scientist at the IEM ASCR, Czech Republic.
