4th International Conference on Neurology and Brain Disorders

September 09-11, 2021

September 09 -11, 2021 | Virtual Event
INBC 2017

Barbara R. Cardoso

Speaker at International Conference on Neurology and Brain Disorders 2017 - Barbara R. Cardoso
University of Sao Paulo, Brazil
Title : Selenium and Alzheimer’s disease: Facts and effects

Abstract:

Oxidative stress has a central role in the pathogenesis of neurodegeneration. Thus deficient status of antioxidants is associated with cognitive decline and risk of dementia. Here, we show the association between selenium status in two different populations (Australian and Brazilian) and cognition, and discuss the possible variables implicit in the search for selenium-based biomarkers in Alzheimer’s disease. Additionally, we present data regarding two independent pilot trials that used different selenium sources - Brazil nuts, a naturally high selenium food source, and sodium selenate - aiming to improve selenium status and cognition. Indeed, mild cognitively impaired elderly who received Brazil nuts for 6 months improved cognition performance measured by constructional praxis and verbal fluency tests. Moreover, Alzheimer’s disease patients treated with sodium selenate for 24 weeks presented higher selenium concentration in CSF, which was associated with better performance on MMSE. Our data shows the relevance of selenium as strategy to slow the progression of cognitive decline and the onset of dementia.

Audience take away:

  • I will report strategies that can be used to reduce the risk for Alzheimer’s disease, which has increased prevalence worldwide
  • The data I will present will foster future research on Alzheimer’s disease diagnosis and treatment
  • This work reinforces selenium as strategy to modulate ferroptosis, the newly discovered cell death pathway involved in neurodegeneration.

Biography:

Dr Barbara Rita Cardoso received her BS as a nutritionist for the Federal University of Santa Catarina (Brazil). She has Master’s degree in Human Applied Nutrition and finished her Ph.D in Food Science Program at the University of São Paulo (Brazil). Since 2007 she has been studying the association between selenium and Alzheimer’s disease, and in 2014 obtained a fellowship to work at Florey Institute of Neuroscience (Melbourne – Australia) for further researching the association between selenium status and cognition in The Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) study, which has the purpose to discover which biomarkers, cognitive characteristics, and health and lifestyle factors determine subsequent development of symptomatic AD. She is currently postdoctoral research scientist at the Nutrition-Minerals Lab at the Faculty of Pharmaceutical Science – University of Sao Paulo (Brazil) and seeks the effects of selenium status and intake on cognition

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